Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB82_LEIDO

TriTrypDb:

LdBPK_240300.1 , LdCL_240007900 , LDHU3_24.0340

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IB82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.567
CLV_NRD_NRD_1	18	20	PF00675	0.547
CLV_NRD_NRD_1	236	238	PF00675	0.536
CLV_NRD_NRD_1	84	86	PF00675	0.589
CLV_PCSK_KEX2_1	129	131	PF00082	0.608
CLV_PCSK_KEX2_1	18	20	PF00082	0.547
CLV_PCSK_KEX2_1	196	198	PF00082	0.394
CLV_PCSK_KEX2_1	236	238	PF00082	0.536
CLV_PCSK_KEX2_1	84	86	PF00082	0.589
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.393
CLV_PCSK_SKI1_1	236	240	PF00082	0.500
CLV_PCSK_SKI1_1	60	64	PF00082	0.780
DEG_APCC_DBOX_1	171	179	PF00400	0.564
DEG_APCC_DBOX_1	244	252	PF00400	0.347
DEG_SPOP_SBC_1	216	220	PF00917	0.585
DOC_CYCLIN_RxL_1	234	242	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.526
DOC_MAPK_gen_1	243	251	PF00069	0.321
DOC_PP2B_LxvP_1	163	166	PF13499	0.479
DOC_USP7_MATH_1	137	141	PF00917	0.671
DOC_USP7_MATH_1	250	254	PF00917	0.285
DOC_USP7_MATH_1	273	277	PF00917	0.529
DOC_USP7_MATH_1	89	93	PF00917	0.624
DOC_WW_Pin1_4	217	222	PF00397	0.531
DOC_WW_Pin1_4	33	38	PF00397	0.716
DOC_WW_Pin1_4	91	96	PF00397	0.537
LIG_14-3-3_CanoR_1	155	163	PF00244	0.590
LIG_14-3-3_CanoR_1	18	22	PF00244	0.601
LIG_14-3-3_CanoR_1	236	242	PF00244	0.488
LIG_14-3-3_CanoR_1	84	89	PF00244	0.644
LIG_CtBP_PxDLS_1	255	259	PF00389	0.462
LIG_FHA_1	233	239	PF00498	0.443
LIG_FHA_1	29	35	PF00498	0.506
LIG_FHA_1	45	51	PF00498	0.538
LIG_FHA_2	6	12	PF00498	0.777
LIG_LIR_Apic_2	117	123	PF02991	0.452
LIG_LIR_Gen_1	203	213	PF02991	0.328
LIG_LIR_Nem_3	203	208	PF02991	0.313
LIG_NRBOX	260	266	PF00104	0.336
LIG_Pex14_2	21	25	PF04695	0.636
LIG_Pex14_2	301	305	PF04695	0.311
LIG_SH2_PTP2	205	208	PF00017	0.326
LIG_SH2_PTP2	4	7	PF00017	0.649
LIG_SH2_STAP1	176	180	PF00017	0.398
LIG_SH2_STAT5	176	179	PF00017	0.466
LIG_SH2_STAT5	205	208	PF00017	0.326
LIG_SH2_STAT5	4	7	PF00017	0.649
LIG_SH3_3	164	170	PF00018	0.713
LIG_SH3_3	34	40	PF00018	0.607
LIG_SH3_3	47	53	PF00018	0.610
LIG_SH3_3	83	89	PF00018	0.517
LIG_SUMO_SIM_par_1	237	242	PF11976	0.361
LIG_SUMO_SIM_par_1	246	253	PF11976	0.340
LIG_SUMO_SIM_par_1	254	260	PF11976	0.447
MOD_CDK_SPK_2	217	222	PF00069	0.568
MOD_CK1_1	171	177	PF00069	0.612
MOD_CK1_1	72	78	PF00069	0.517
MOD_CK2_1	178	184	PF00069	0.374
MOD_CK2_1	266	272	PF00069	0.526
MOD_CK2_1	5	11	PF00069	0.627
MOD_Cter_Amidation	16	19	PF01082	0.532
MOD_DYRK1A_RPxSP_1	91	95	PF00069	0.642
MOD_GlcNHglycan	144	148	PF01048	0.586
MOD_GlcNHglycan	15	18	PF01048	0.592
MOD_GlcNHglycan	158	161	PF01048	0.548
MOD_GlcNHglycan	86	89	PF01048	0.700
MOD_GSK3_1	13	20	PF00069	0.570
MOD_GSK3_1	139	146	PF00069	0.641
MOD_GSK3_1	174	181	PF00069	0.443
MOD_GSK3_1	250	257	PF00069	0.281
MOD_GSK3_1	273	280	PF00069	0.668
MOD_GSK3_1	285	292	PF00069	0.432
MOD_LATS_1	68	74	PF00433	0.660
MOD_N-GLC_1	114	119	PF02516	0.592
MOD_N-GLC_1	307	312	PF02516	0.548
MOD_NEK2_1	151	156	PF00069	0.619
MOD_NEK2_1	54	59	PF00069	0.716
MOD_PKA_1	84	90	PF00069	0.543
MOD_PKA_2	128	134	PF00069	0.561
MOD_PKA_2	17	23	PF00069	0.564
MOD_PKA_2	171	177	PF00069	0.704
MOD_PKA_2	209	215	PF00069	0.573
MOD_PKA_2	69	75	PF00069	0.572
MOD_PKA_2	84	90	PF00069	0.722
MOD_Plk_1	285	291	PF00069	0.524
MOD_Plk_4	171	177	PF00069	0.481
MOD_ProDKin_1	217	223	PF00069	0.530
MOD_ProDKin_1	33	39	PF00069	0.715
MOD_ProDKin_1	91	97	PF00069	0.537
TRG_ENDOCYTIC_2	205	208	PF00928	0.326
TRG_ER_diArg_1	128	130	PF00400	0.550
TRG_ER_diArg_1	236	238	PF00400	0.568
TRG_ER_diArg_1	83	85	PF00400	0.560
TRG_NES_CRM1_1	246	260	PF08389	0.319
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G9	Leptomonas seymouri	62%	100%
A0A1X0NJB4	Trypanosomatidae	36%	100%
A0A3R7RTA5	Trypanosoma rangeli	37%	100%
A4HD87	Leishmania braziliensis	82%	100%
D0A6Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AH42	Leishmania infantum	100%	100%
E9AWM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAV0	Leishmania major	91%	100%
V5C0R1	Trypanosoma cruzi	39%	100%