RF-1 domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RF-1 domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB76_LEIDO

TriTrypDb:

LdBPK_211550.1 , LdCL_210021000 , LDHU3_21.1840

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IB76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB76

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003747	translation release factor activity	5	11
GO:0005488	binding	1	11
GO:0008079	translation termination factor activity	4	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.475
CLV_C14_Caspase3-7	490	494	PF00656	0.442
CLV_C14_Caspase3-7	563	567	PF00656	0.532
CLV_NRD_NRD_1	117	119	PF00675	0.587
CLV_NRD_NRD_1	138	140	PF00675	0.553
CLV_NRD_NRD_1	249	251	PF00675	0.434
CLV_NRD_NRD_1	257	259	PF00675	0.423
CLV_NRD_NRD_1	338	340	PF00675	0.390
CLV_NRD_NRD_1	512	514	PF00675	0.277
CLV_NRD_NRD_1	88	90	PF00675	0.685
CLV_PCSK_FUR_1	254	258	PF00082	0.448
CLV_PCSK_KEX2_1	101	103	PF00082	0.693
CLV_PCSK_KEX2_1	256	258	PF00082	0.480
CLV_PCSK_KEX2_1	338	340	PF00082	0.390
CLV_PCSK_KEX2_1	449	451	PF00082	0.476
CLV_PCSK_KEX2_1	512	514	PF00082	0.274
CLV_PCSK_KEX2_1	88	90	PF00082	0.685
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.587
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.476
CLV_PCSK_SKI1_1	162	166	PF00082	0.562
CLV_PCSK_SKI1_1	174	178	PF00082	0.595
CLV_PCSK_SKI1_1	200	204	PF00082	0.505
CLV_PCSK_SKI1_1	446	450	PF00082	0.577
CLV_PCSK_SKI1_1	495	499	PF00082	0.231
CLV_PCSK_SKI1_1	89	93	PF00082	0.644
DEG_APCC_DBOX_1	171	179	PF00400	0.404
DEG_Nend_UBRbox_3	1	3	PF02207	0.548
DEG_SPOP_SBC_1	226	230	PF00917	0.475
DEG_SPOP_SBC_1	60	64	PF00917	0.606
DOC_ANK_TNKS_1	458	465	PF00023	0.431
DOC_CYCLIN_RxL_1	507	519	PF00134	0.446
DOC_MAPK_gen_1	174	184	PF00069	0.407
DOC_MAPK_gen_1	254	264	PF00069	0.457
DOC_MAPK_MEF2A_6	256	264	PF00069	0.407
DOC_MAPK_RevD_3	124	140	PF00069	0.503
DOC_PP1_RVXF_1	510	517	PF00149	0.446
DOC_USP7_MATH_1	244	248	PF00917	0.505
DOC_USP7_MATH_1	394	398	PF00917	0.497
DOC_USP7_MATH_1	438	442	PF00917	0.353
DOC_USP7_MATH_1	458	462	PF00917	0.345
DOC_USP7_MATH_1	491	495	PF00917	0.443
DOC_USP7_MATH_1	58	62	PF00917	0.648
DOC_USP7_MATH_1	72	76	PF00917	0.715
DOC_USP7_MATH_1	79	83	PF00917	0.635
DOC_USP7_MATH_1	97	101	PF00917	0.526
DOC_USP7_UBL2_3	25	29	PF12436	0.527
DOC_WW_Pin1_4	423	428	PF00397	0.707
DOC_WW_Pin1_4	56	61	PF00397	0.615
DOC_WW_Pin1_4	62	67	PF00397	0.627
LIG_14-3-3_CanoR_1	200	209	PF00244	0.544
LIG_14-3-3_CanoR_1	273	283	PF00244	0.660
LIG_14-3-3_CanoR_1	364	374	PF00244	0.399
LIG_14-3-3_CanoR_1	383	393	PF00244	0.580
LIG_14-3-3_CanoR_1	450	454	PF00244	0.435
LIG_Actin_WH2_2	178	195	PF00022	0.463
LIG_BIR_III_2	391	395	PF00653	0.523
LIG_BRCT_BRCA1_1	368	372	PF00533	0.471
LIG_CaM_IQ_9	154	169	PF13499	0.428
LIG_FHA_1	227	233	PF00498	0.426
LIG_FHA_1	39	45	PF00498	0.659
LIG_FHA_1	420	426	PF00498	0.532
LIG_FHA_1	556	562	PF00498	0.561
LIG_FHA_2	163	169	PF00498	0.531
LIG_LIR_Gen_1	127	136	PF02991	0.406
LIG_LIR_Gen_1	228	238	PF02991	0.483
LIG_LIR_Gen_1	301	311	PF02991	0.399
LIG_LIR_Gen_1	348	356	PF02991	0.378
LIG_LIR_Gen_1	365	374	PF02991	0.355
LIG_LIR_Gen_1	473	484	PF02991	0.535
LIG_LIR_Nem_3	127	133	PF02991	0.407
LIG_LIR_Nem_3	145	150	PF02991	0.401
LIG_LIR_Nem_3	228	234	PF02991	0.569
LIG_LIR_Nem_3	301	307	PF02991	0.409
LIG_LIR_Nem_3	348	353	PF02991	0.404
LIG_LIR_Nem_3	365	370	PF02991	0.456
LIG_LIR_Nem_3	473	479	PF02991	0.535
LIG_NRBOX	233	239	PF00104	0.517
LIG_Pex14_2	402	406	PF04695	0.315
LIG_SH2_CRK	350	354	PF00017	0.340
LIG_SH2_CRK	476	480	PF00017	0.535
LIG_SH2_PTP2	231	234	PF00017	0.418
LIG_SH2_PTP2	333	336	PF00017	0.481
LIG_SH2_STAP1	350	354	PF00017	0.365
LIG_SH2_STAP1	404	408	PF00017	0.402
LIG_SH2_STAP1	476	480	PF00017	0.559
LIG_SH2_STAP1	487	491	PF00017	0.510
LIG_SH2_STAT3	148	151	PF00017	0.417
LIG_SH2_STAT5	231	234	PF00017	0.534
LIG_SH2_STAT5	333	336	PF00017	0.420
LIG_SH2_STAT5	340	343	PF00017	0.364
LIG_SH2_STAT5	366	369	PF00017	0.526
LIG_SH2_STAT5	487	490	PF00017	0.445
LIG_SH3_3	52	58	PF00018	0.718
LIG_SUMO_SIM_anti_2	181	188	PF11976	0.397
LIG_SxIP_EBH_1	23	35	PF03271	0.495
LIG_TRAF2_1	295	298	PF00917	0.579
LIG_TRAF2_1	521	524	PF00917	0.498
LIG_TRAF2_1	544	547	PF00917	0.405
LIG_UBA3_1	26	35	PF00899	0.544
LIG_WRC_WIRS_1	353	358	PF05994	0.443
MOD_CK1_1	106	112	PF00069	0.599
MOD_CK1_1	170	176	PF00069	0.413
MOD_CK1_1	195	201	PF00069	0.460
MOD_CK1_1	269	275	PF00069	0.515
MOD_CK1_1	419	425	PF00069	0.604
MOD_CK1_1	429	435	PF00069	0.263
MOD_CK1_1	496	502	PF00069	0.479
MOD_CK1_1	59	65	PF00069	0.738
MOD_CK1_1	73	79	PF00069	0.667
MOD_CK1_1	82	88	PF00069	0.594
MOD_CK2_1	110	116	PF00069	0.559
MOD_CK2_1	149	155	PF00069	0.476
MOD_CK2_1	162	168	PF00069	0.498
MOD_CK2_1	496	502	PF00069	0.478
MOD_GlcNHglycan	105	108	PF01048	0.597
MOD_GlcNHglycan	276	279	PF01048	0.481
MOD_GlcNHglycan	284	287	PF01048	0.470
MOD_GlcNHglycan	396	399	PF01048	0.434
MOD_GlcNHglycan	418	421	PF01048	0.595
MOD_GlcNHglycan	428	431	PF01048	0.475
MOD_GlcNHglycan	434	437	PF01048	0.467
MOD_GlcNHglycan	440	443	PF01048	0.425
MOD_GlcNHglycan	460	463	PF01048	0.145
MOD_GlcNHglycan	495	498	PF01048	0.231
MOD_GlcNHglycan	562	565	PF01048	0.311
MOD_GlcNHglycan	72	75	PF01048	0.606
MOD_GlcNHglycan	81	84	PF01048	0.559
MOD_GlcNHglycan	93	96	PF01048	0.565
MOD_GSK3_1	106	113	PF00069	0.594
MOD_GSK3_1	163	170	PF00069	0.566
MOD_GSK3_1	200	207	PF00069	0.600
MOD_GSK3_1	221	228	PF00069	0.609
MOD_GSK3_1	262	269	PF00069	0.403
MOD_GSK3_1	362	369	PF00069	0.407
MOD_GSK3_1	419	426	PF00069	0.582
MOD_GSK3_1	454	461	PF00069	0.479
MOD_GSK3_1	56	63	PF00069	0.679
MOD_GSK3_1	70	77	PF00069	0.646
MOD_N-GLC_1	103	108	PF02516	0.739
MOD_N-GLC_1	269	274	PF02516	0.476
MOD_N-GLC_1	38	43	PF02516	0.638
MOD_N-GLC_1	468	473	PF02516	0.227
MOD_N-GLC_1	516	521	PF02516	0.278
MOD_NEK2_1	103	108	PF00069	0.714
MOD_NEK2_1	192	197	PF00069	0.571
MOD_NEK2_1	202	207	PF00069	0.438
MOD_NEK2_1	262	267	PF00069	0.416
MOD_NEK2_1	274	279	PF00069	0.425
MOD_NEK2_1	4	9	PF00069	0.546
MOD_NEK2_1	406	411	PF00069	0.393
MOD_NEK2_1	431	436	PF00069	0.398
MOD_NEK2_1	516	521	PF00069	0.512
MOD_NEK2_1	91	96	PF00069	0.655
MOD_PIKK_1	200	206	PF00454	0.633
MOD_PIKK_1	293	299	PF00454	0.500
MOD_PIKK_1	4	10	PF00454	0.600
MOD_PIKK_1	470	476	PF00454	0.431
MOD_PK_1	449	455	PF00069	0.483
MOD_PKA_1	449	455	PF00069	0.483
MOD_PKA_2	192	198	PF00069	0.474
MOD_PKA_2	411	417	PF00069	0.482
MOD_PKA_2	449	455	PF00069	0.420
MOD_PKA_2	458	464	PF00069	0.436
MOD_Plk_1	167	173	PF00069	0.437
MOD_Plk_1	269	275	PF00069	0.560
MOD_Plk_1	516	522	PF00069	0.574
MOD_Plk_4	227	233	PF00069	0.483
MOD_ProDKin_1	423	429	PF00069	0.694
MOD_ProDKin_1	56	62	PF00069	0.617
MOD_SUMO_for_1	176	179	PF00179	0.407
MOD_SUMO_for_1	209	212	PF00179	0.621
MOD_SUMO_for_1	278	281	PF00179	0.504
MOD_SUMO_for_1	521	524	PF00179	0.491
MOD_SUMO_rev_2	155	164	PF00179	0.474
TRG_AP2beta_CARGO_1	127	137	PF09066	0.406
TRG_DiLeu_BaEn_1	524	529	PF01217	0.555
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.426
TRG_ENDOCYTIC_2	147	150	PF00928	0.595
TRG_ENDOCYTIC_2	231	234	PF00928	0.565
TRG_ENDOCYTIC_2	333	336	PF00928	0.395
TRG_ENDOCYTIC_2	350	353	PF00928	0.186
TRG_ENDOCYTIC_2	476	479	PF00928	0.535
TRG_ER_diArg_1	136	139	PF00400	0.510
TRG_ER_diArg_1	254	257	PF00400	0.431
TRG_ER_diArg_1	337	339	PF00400	0.381
TRG_ER_diArg_1	512	514	PF00400	0.486
TRG_ER_diArg_1	87	89	PF00400	0.673
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P368	Leptomonas seymouri	61%	89%
A0A0S4JFA6	Bodo saltans	37%	88%
A0A1X0NXZ0	Trypanosomatidae	44%	82%
A0A422NSQ1	Trypanosoma rangeli	44%	89%
A4HBY7	Leishmania braziliensis	81%	100%
A4HZC8	Leishmania infantum	99%	100%
D0A156	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	92%
E9AVB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QC65	Leishmania major	92%	100%
V5BLU1	Trypanosoma cruzi	44%	91%