Pre-RNA_processing_PIH1/Nop17_putative/Pfam:PF081 90

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB73_LEIDO

TriTrypDb:

LdBPK_181250.1 , LdCL_180017700 , LDHU3_18.1580

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IB73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.464
CLV_C14_Caspase3-7	376	380	PF00656	0.454
CLV_C14_Caspase3-7	487	491	PF00656	0.617
CLV_NRD_NRD_1	181	183	PF00675	0.315
CLV_NRD_NRD_1	264	266	PF00675	0.220
CLV_NRD_NRD_1	406	408	PF00675	0.295
CLV_NRD_NRD_1	480	482	PF00675	0.561
CLV_NRD_NRD_1	729	731	PF00675	0.437
CLV_NRD_NRD_1	76	78	PF00675	0.421
CLV_PCSK_KEX2_1	181	183	PF00082	0.332
CLV_PCSK_KEX2_1	264	266	PF00082	0.222
CLV_PCSK_KEX2_1	388	390	PF00082	0.212
CLV_PCSK_KEX2_1	406	408	PF00082	0.212
CLV_PCSK_KEX2_1	729	731	PF00082	0.441
CLV_PCSK_KEX2_1	748	750	PF00082	0.384
CLV_PCSK_KEX2_1	76	78	PF00082	0.421
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.278
CLV_PCSK_PC1ET2_1	748	750	PF00082	0.517
CLV_PCSK_PC7_1	384	390	PF00082	0.260
CLV_PCSK_SKI1_1	104	108	PF00082	0.479
CLV_PCSK_SKI1_1	136	140	PF00082	0.325
CLV_PCSK_SKI1_1	145	149	PF00082	0.307
CLV_PCSK_SKI1_1	157	161	PF00082	0.315
CLV_PCSK_SKI1_1	456	460	PF00082	0.237
CLV_PCSK_SKI1_1	757	761	PF00082	0.462
DEG_SCF_TRCP1_1	625	631	PF00400	0.583
DEG_SPOP_SBC_1	210	214	PF00917	0.469
DEG_SPOP_SBC_1	324	328	PF00917	0.675
DEG_SPOP_SBC_1	332	336	PF00917	0.751
DEG_SPOP_SBC_1	359	363	PF00917	0.643
DEG_SPOP_SBC_1	563	567	PF00917	0.543
DOC_CKS1_1	273	278	PF01111	0.422
DOC_CKS1_1	558	563	PF01111	0.706
DOC_CYCLIN_yCln2_LP_2	437	443	PF00134	0.478
DOC_MAPK_FxFP_2	100	103	PF00069	0.295
DOC_MAPK_gen_1	406	413	PF00069	0.510
DOC_MAPK_gen_1	746	754	PF00069	0.480
DOC_MAPK_MEF2A_6	406	415	PF00069	0.476
DOC_MAPK_MEF2A_6	432	441	PF00069	0.515
DOC_MAPK_MEF2A_6	456	465	PF00069	0.418
DOC_MAPK_NFAT4_5	456	464	PF00069	0.412
DOC_PP1_RVXF_1	219	226	PF00149	0.562
DOC_PP2B_LxvP_1	437	440	PF13499	0.478
DOC_PP4_FxxP_1	100	103	PF00568	0.295
DOC_USP7_MATH_1	138	142	PF00917	0.541
DOC_USP7_MATH_1	167	171	PF00917	0.460
DOC_USP7_MATH_1	18	22	PF00917	0.748
DOC_USP7_MATH_1	188	192	PF00917	0.515
DOC_USP7_MATH_1	193	197	PF00917	0.523
DOC_USP7_MATH_1	203	207	PF00917	0.354
DOC_USP7_MATH_1	208	212	PF00917	0.387
DOC_USP7_MATH_1	233	237	PF00917	0.407
DOC_USP7_MATH_1	304	308	PF00917	0.599
DOC_USP7_MATH_1	333	337	PF00917	0.737
DOC_USP7_MATH_1	352	356	PF00917	0.608
DOC_USP7_MATH_1	359	363	PF00917	0.574
DOC_USP7_MATH_1	503	507	PF00917	0.660
DOC_USP7_MATH_1	563	567	PF00917	0.672
DOC_USP7_MATH_1	612	616	PF00917	0.715
DOC_USP7_MATH_1	623	627	PF00917	0.661
DOC_USP7_MATH_1	643	647	PF00917	0.753
DOC_USP7_MATH_2	426	432	PF00917	0.428
DOC_USP7_UBL2_3	667	671	PF12436	0.522
DOC_USP7_UBL2_3	727	731	PF12436	0.547
DOC_WW_Pin1_4	189	194	PF00397	0.535
DOC_WW_Pin1_4	211	216	PF00397	0.349
DOC_WW_Pin1_4	272	277	PF00397	0.419
DOC_WW_Pin1_4	287	292	PF00397	0.498
DOC_WW_Pin1_4	319	324	PF00397	0.672
DOC_WW_Pin1_4	355	360	PF00397	0.617
DOC_WW_Pin1_4	40	45	PF00397	0.450
DOC_WW_Pin1_4	413	418	PF00397	0.460
DOC_WW_Pin1_4	510	515	PF00397	0.742
DOC_WW_Pin1_4	516	521	PF00397	0.691
DOC_WW_Pin1_4	536	541	PF00397	0.682
DOC_WW_Pin1_4	545	550	PF00397	0.606
DOC_WW_Pin1_4	557	562	PF00397	0.631
LIG_14-3-3_CanoR_1	303	309	PF00244	0.711
LIG_14-3-3_CanoR_1	360	365	PF00244	0.551
LIG_14-3-3_CanoR_1	384	392	PF00244	0.515
LIG_14-3-3_CanoR_1	456	462	PF00244	0.458
LIG_14-3-3_CanoR_1	481	485	PF00244	0.606
LIG_APCC_ABBAyCdc20_2	55	61	PF00400	0.524
LIG_BIR_III_4	166	170	PF00653	0.428
LIG_BRCT_BRCA1_1	235	239	PF00533	0.412
LIG_BRCT_BRCA1_1	257	261	PF00533	0.478
LIG_BRCT_BRCA1_1	96	100	PF00533	0.361
LIG_CtBP_PxDLS_1	44	48	PF00389	0.445
LIG_deltaCOP1_diTrp_1	379	383	PF00928	0.412
LIG_EH1_1	577	585	PF00400	0.461
LIG_FHA_1	192	198	PF00498	0.397
LIG_FHA_1	227	233	PF00498	0.419
LIG_FHA_1	359	365	PF00498	0.566
LIG_FHA_1	458	464	PF00498	0.415
LIG_FHA_1	596	602	PF00498	0.581
LIG_FHA_1	646	652	PF00498	0.571
LIG_FHA_1	670	676	PF00498	0.582
LIG_FHA_2	156	162	PF00498	0.461
LIG_FHA_2	41	47	PF00498	0.436
LIG_FHA_2	440	446	PF00498	0.468
LIG_FHA_2	521	527	PF00498	0.570
LIG_FHA_2	542	548	PF00498	0.629
LIG_FHA_2	600	606	PF00498	0.553
LIG_FHA_2	655	661	PF00498	0.558
LIG_FHA_2	73	79	PF00498	0.419
LIG_LIR_Apic_2	170	175	PF02991	0.412
LIG_LIR_Apic_2	97	103	PF02991	0.326
LIG_LIR_Gen_1	236	247	PF02991	0.436
LIG_LIR_Gen_1	56	67	PF02991	0.389
LIG_LIR_Gen_1	95	106	PF02991	0.340
LIG_LIR_Nem_3	184	189	PF02991	0.528
LIG_LIR_Nem_3	236	242	PF02991	0.435
LIG_LIR_Nem_3	305	311	PF02991	0.512
LIG_LIR_Nem_3	401	405	PF02991	0.415
LIG_LIR_Nem_3	431	436	PF02991	0.484
LIG_LIR_Nem_3	56	62	PF02991	0.379
LIG_LIR_Nem_3	95	101	PF02991	0.360
LIG_PCNA_yPIPBox_3	577	591	PF02747	0.505
LIG_Pex14_2	96	100	PF04695	0.368
LIG_RPA_C_Fungi	589	601	PF08784	0.558
LIG_RPA_C_Fungi	704	716	PF08784	0.471
LIG_SH2_CRK	186	190	PF00017	0.509
LIG_SH2_SRC	186	189	PF00017	0.429
LIG_SH2_STAT3	82	85	PF00017	0.429
LIG_SH2_STAT5	367	370	PF00017	0.340
LIG_SH2_STAT5	758	761	PF00017	0.554
LIG_SH2_STAT5	82	85	PF00017	0.441
LIG_SH3_3	221	227	PF00018	0.297
LIG_SH3_3	293	299	PF00018	0.567
LIG_SH3_3	351	357	PF00018	0.622
LIG_SH3_3	387	393	PF00018	0.306
LIG_SH3_3	462	468	PF00018	0.247
LIG_SH3_3	505	511	PF00018	0.645
LIG_SH3_3	512	518	PF00018	0.619
LIG_SH3_3	550	556	PF00018	0.647
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.315
LIG_SUMO_SIM_par_1	107	113	PF11976	0.324
LIG_SUMO_SIM_par_1	173	179	PF11976	0.250
LIG_SUMO_SIM_par_1	228	234	PF11976	0.368
LIG_SUMO_SIM_par_1	268	275	PF11976	0.394
LIG_SUMO_SIM_par_1	457	462	PF11976	0.340
LIG_TRAF2_1	43	46	PF00917	0.434
LIG_TRAF2_1	442	445	PF00917	0.312
LIG_TRAF2_1	653	656	PF00917	0.631
LIG_TRAF2_1	657	660	PF00917	0.641
LIG_TRAF2_1	708	711	PF00917	0.493
LIG_TRAF2_1	717	720	PF00917	0.436
LIG_WRC_WIRS_1	156	161	PF05994	0.282
LIG_WW_2	468	471	PF00397	0.607
MOD_CDC14_SPxK_1	548	551	PF00782	0.700
MOD_CDK_SPK_2	355	360	PF00069	0.556
MOD_CDK_SPxK_1	545	551	PF00069	0.592
MOD_CK1_1	132	138	PF00069	0.488
MOD_CK1_1	191	197	PF00069	0.477
MOD_CK1_1	206	212	PF00069	0.649
MOD_CK1_1	213	219	PF00069	0.392
MOD_CK1_1	269	275	PF00069	0.292
MOD_CK1_1	314	320	PF00069	0.606
MOD_CK1_1	326	332	PF00069	0.620
MOD_CK1_1	335	341	PF00069	0.675
MOD_CK1_1	355	361	PF00069	0.646
MOD_CK1_1	506	512	PF00069	0.567
MOD_CK1_1	539	545	PF00069	0.683
MOD_CK1_1	621	627	PF00069	0.779
MOD_CK1_1	628	634	PF00069	0.699
MOD_CK2_1	117	123	PF00069	0.514
MOD_CK2_1	155	161	PF00069	0.329
MOD_CK2_1	167	173	PF00069	0.350
MOD_CK2_1	40	46	PF00069	0.430
MOD_CK2_1	428	434	PF00069	0.369
MOD_CK2_1	439	445	PF00069	0.249
MOD_CK2_1	520	526	PF00069	0.624
MOD_CK2_1	541	547	PF00069	0.688
MOD_CK2_1	564	570	PF00069	0.651
MOD_CK2_1	623	629	PF00069	0.733
MOD_CK2_1	654	660	PF00069	0.571
MOD_CK2_1	72	78	PF00069	0.422
MOD_DYRK1A_RPxSP_1	545	549	PF00069	0.735
MOD_GlcNHglycan	119	122	PF01048	0.538
MOD_GlcNHglycan	130	134	PF01048	0.573
MOD_GlcNHglycan	14	17	PF01048	0.688
MOD_GlcNHglycan	141	144	PF01048	0.372
MOD_GlcNHglycan	208	211	PF01048	0.621
MOD_GlcNHglycan	21	24	PF01048	0.710
MOD_GlcNHglycan	252	255	PF01048	0.311
MOD_GlcNHglycan	27	30	PF01048	0.698
MOD_GlcNHglycan	318	321	PF01048	0.638
MOD_GlcNHglycan	328	331	PF01048	0.579
MOD_GlcNHglycan	335	338	PF01048	0.620
MOD_GlcNHglycan	354	357	PF01048	0.641
MOD_GlcNHglycan	475	478	PF01048	0.535
MOD_GlcNHglycan	566	569	PF01048	0.706
MOD_GlcNHglycan	613	617	PF01048	0.595
MOD_GlcNHglycan	620	623	PF01048	0.545
MOD_GlcNHglycan	625	628	PF01048	0.605
MOD_GlcNHglycan	629	633	PF01048	0.584
MOD_GlcNHglycan	645	648	PF01048	0.688
MOD_GSK3_1	134	141	PF00069	0.213
MOD_GSK3_1	157	164	PF00069	0.282
MOD_GSK3_1	189	196	PF00069	0.490
MOD_GSK3_1	206	213	PF00069	0.612
MOD_GSK3_1	265	272	PF00069	0.309
MOD_GSK3_1	277	284	PF00069	0.350
MOD_GSK3_1	319	326	PF00069	0.631
MOD_GSK3_1	331	338	PF00069	0.602
MOD_GSK3_1	355	362	PF00069	0.595
MOD_GSK3_1	367	374	PF00069	0.278
MOD_GSK3_1	424	431	PF00069	0.308
MOD_GSK3_1	497	504	PF00069	0.684
MOD_GSK3_1	506	513	PF00069	0.635
MOD_GSK3_1	516	523	PF00069	0.523
MOD_GSK3_1	541	548	PF00069	0.661
MOD_GSK3_1	595	602	PF00069	0.495
MOD_GSK3_1	621	628	PF00069	0.575
MOD_GSK3_1	748	755	PF00069	0.556
MOD_N-GLC_1	277	282	PF02516	0.247
MOD_N-GLC_1	6	11	PF02516	0.532
MOD_N-GLC_2	149	151	PF02516	0.247
MOD_NEK2_1	129	134	PF00069	0.624
MOD_NEK2_1	139	144	PF00069	0.416
MOD_NEK2_1	277	282	PF00069	0.411
MOD_NEK2_1	452	457	PF00069	0.356
MOD_NEK2_1	459	464	PF00069	0.320
MOD_NEK2_1	480	485	PF00069	0.556
MOD_NEK2_1	564	569	PF00069	0.513
MOD_PIKK_1	176	182	PF00454	0.340
MOD_PIKK_1	335	341	PF00454	0.582
MOD_PIKK_1	497	503	PF00454	0.775
MOD_PIKK_1	506	512	PF00454	0.722
MOD_PIKK_1	655	661	PF00454	0.719
MOD_PKA_1	748	754	PF00069	0.543
MOD_PKA_2	167	173	PF00069	0.390
MOD_PKA_2	234	240	PF00069	0.282
MOD_PKA_2	281	287	PF00069	0.419
MOD_PKA_2	302	308	PF00069	0.593
MOD_PKA_2	359	365	PF00069	0.548
MOD_PKA_2	371	377	PF00069	0.302
MOD_PKA_2	383	389	PF00069	0.376
MOD_PKA_2	480	486	PF00069	0.577
MOD_PKA_2	748	754	PF00069	0.473
MOD_PKB_1	10	18	PF00069	0.551
MOD_Plk_1	277	283	PF00069	0.247
MOD_Plk_1	94	100	PF00069	0.376
MOD_Plk_4	266	272	PF00069	0.315
MOD_ProDKin_1	189	195	PF00069	0.527
MOD_ProDKin_1	211	217	PF00069	0.349
MOD_ProDKin_1	272	278	PF00069	0.258
MOD_ProDKin_1	287	293	PF00069	0.491
MOD_ProDKin_1	319	325	PF00069	0.668
MOD_ProDKin_1	355	361	PF00069	0.615
MOD_ProDKin_1	40	46	PF00069	0.445
MOD_ProDKin_1	413	419	PF00069	0.315
MOD_ProDKin_1	510	516	PF00069	0.746
MOD_ProDKin_1	536	542	PF00069	0.683
MOD_ProDKin_1	545	551	PF00069	0.609
MOD_ProDKin_1	557	563	PF00069	0.634
MOD_SUMO_rev_2	120	127	PF00179	0.565
TRG_DiLeu_BaEn_2	659	665	PF01217	0.602
TRG_DiLeu_BaEn_4	78	84	PF01217	0.428
TRG_ENDOCYTIC_2	186	189	PF00928	0.505
TRG_ENDOCYTIC_2	433	436	PF00928	0.340
TRG_ER_diArg_1	181	183	PF00400	0.391
TRG_ER_diArg_1	263	265	PF00400	0.262
TRG_ER_diArg_1	405	407	PF00400	0.358
TRG_ER_diArg_1	688	691	PF00400	0.448
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3H0	Leptomonas seymouri	52%	95%
A0A0S4JRA4	Bodo saltans	33%	100%
A0A1X0P812	Trypanosomatidae	35%	100%
A0A3R7N1E2	Trypanosoma rangeli	38%	100%
A4H9N3	Leishmania braziliensis	75%	99%
A4HXZ7	Leishmania infantum	98%	100%
D0A5A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ARR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q0E9G3	Drosophila melanogaster	22%	91%
Q4QDR8	Leishmania major	89%	100%
V5AZ63	Trypanosoma cruzi	39%	100%