Peroxisomal biogenesis factor 11 (PEX11) family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal membrane like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IB71_LEIDO

TriTrypDb:

LdBPK_240140.1 , LdCL_240006300 , LDHU3_24.0160

Length:

220

Annotations

Annotations by Jardim et al.

Glycosome membrane, Peroxin 11 Glycosomal membrane like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IB71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB71

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016559	peroxisome fission	6	11
GO:0048285	organelle fission	5	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.408
CLV_PCSK_KEX2_1	146	148	PF00082	0.378
CLV_PCSK_KEX2_1	72	74	PF00082	0.341
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.411
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.334
CLV_PCSK_SKI1_1	120	124	PF00082	0.577
CLV_PCSK_SKI1_1	19	23	PF00082	0.285
CLV_PCSK_SKI1_1	78	82	PF00082	0.306
CLV_PCSK_SKI1_1	85	89	PF00082	0.324
DEG_APCC_DBOX_1	77	85	PF00400	0.534
DOC_CYCLIN_RxL_1	82	89	PF00134	0.408
DOC_MAPK_gen_1	146	154	PF00069	0.560
DOC_PP1_RVXF_1	53	60	PF00149	0.496
DOC_PP1_RVXF_1	76	83	PF00149	0.507
DOC_PP4_FxxP_1	104	107	PF00568	0.245
DOC_USP7_MATH_1	13	17	PF00917	0.520
DOC_USP7_MATH_1	198	202	PF00917	0.597
DOC_USP7_MATH_1	45	49	PF00917	0.506
DOC_WW_Pin1_4	106	111	PF00397	0.334
LIG_14-3-3_CanoR_1	55	60	PF00244	0.469
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_FHA_1	168	174	PF00498	0.508
LIG_GBD_Chelix_1	3	11	PF00786	0.267
LIG_Integrin_RGD_1	147	149	PF01839	0.347
LIG_LIR_Gen_1	134	144	PF02991	0.267
LIG_LIR_Gen_1	89	100	PF02991	0.408
LIG_LIR_Nem_3	134	139	PF02991	0.340
LIG_LIR_Nem_3	89	95	PF02991	0.409
LIG_Pex14_2	100	104	PF04695	0.334
LIG_Pex14_2	88	92	PF04695	0.408
LIG_PTB_Apo_2	34	41	PF02174	0.445
LIG_PTB_Apo_2	94	101	PF02174	0.408
LIG_Rb_pABgroove_1	82	90	PF01858	0.418
LIG_REV1ctd_RIR_1	25	33	PF16727	0.533
LIG_SH2_CRK	136	140	PF00017	0.381
LIG_SH2_CRK	35	39	PF00017	0.565
LIG_SH2_STAP1	127	131	PF00017	0.457
LIG_SH2_STAT5	117	120	PF00017	0.282
LIG_SH3_2	142	147	PF14604	0.618
LIG_SH3_3	104	110	PF00018	0.326
LIG_SH3_3	136	142	PF00018	0.414
LIG_SUMO_SIM_par_1	131	137	PF11976	0.328
LIG_UBA3_1	56	65	PF00899	0.493
MOD_CK1_1	113	119	PF00069	0.329
MOD_CK1_1	58	64	PF00069	0.507
MOD_GlcNHglycan	162	165	PF01048	0.361
MOD_GlcNHglycan	184	187	PF01048	0.320
MOD_GlcNHglycan	200	203	PF01048	0.366
MOD_GSK3_1	106	113	PF00069	0.276
MOD_GSK3_1	198	205	PF00069	0.605
MOD_N-GLC_2	157	159	PF02516	0.316
MOD_N-GLC_2	167	169	PF02516	0.350
MOD_NEK2_1	152	157	PF00069	0.574
MOD_NEK2_1	40	45	PF00069	0.438
MOD_PIKK_1	110	116	PF00454	0.301
MOD_Plk_4	113	119	PF00069	0.319
MOD_Plk_4	55	61	PF00069	0.485
MOD_Plk_4	6	12	PF00069	0.534
MOD_ProDKin_1	106	112	PF00069	0.334
TRG_ENDOCYTIC_2	136	139	PF00928	0.395
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ6	Leptomonas seymouri	74%	100%
A0A1X0NJI5	Trypanosomatidae	33%	100%
A0A1X0NR15	Trypanosomatidae	31%	100%
A0A422P470	Trypanosoma rangeli	31%	100%
A4HD72	Leishmania braziliensis	86%	100%
A4HGT0	Leishmania braziliensis	25%	100%
D0A924	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AH26	Leishmania infantum	100%	100%
E9AWK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QAW6	Leishmania major	95%	100%
V5BEE7	Trypanosoma cruzi	29%	100%