Rad51/AAA domain/KaiC/ATPase family associated with various cellular activities (AAA), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rad51, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB69_LEIDO

TriTrypDb:

LdBPK_110230.1 , LdCL_110007200 , LDHU3_11.0290

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IB69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB69

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	6
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	6
GO:0006974	DNA damage response	4	6
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	6
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	6
GO:0051716	cellular response to stimulus	2	6
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000730	DNA recombinase assembly	7	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0042148	strand invasion	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090735	DNA repair complex assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140299	small molecule sensor activity	1	7
GO:0140612	DNA damage sensor activity	2	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0140664	ATP-dependent DNA damage sensor activity	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0000150	DNA strand exchange activity	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.590
CLV_C14_Caspase3-7	222	226	PF00656	0.455
CLV_C14_Caspase3-7	231	235	PF00656	0.403
CLV_C14_Caspase3-7	242	246	PF00656	0.427
CLV_C14_Caspase3-7	4	8	PF00656	0.600
CLV_NRD_NRD_1	164	166	PF00675	0.289
CLV_NRD_NRD_1	20	22	PF00675	0.564
CLV_NRD_NRD_1	280	282	PF00675	0.274
CLV_PCSK_KEX2_1	164	166	PF00082	0.289
CLV_PCSK_KEX2_1	20	22	PF00082	0.564
CLV_PCSK_KEX2_1	280	282	PF00082	0.312
CLV_PCSK_KEX2_1	305	307	PF00082	0.290
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.259
CLV_PCSK_SKI1_1	390	394	PF00082	0.458
CLV_PCSK_SKI1_1	428	432	PF00082	0.516
DEG_APCC_DBOX_1	433	441	PF00400	0.426
DEG_COP1_1	508	518	PF00400	0.468
DEG_ODPH_VHL_1	492	504	PF01847	0.606
DEG_SCF_FBW7_2	29	35	PF00400	0.517
DEG_SPOP_SBC_1	140	144	PF00917	0.466
DOC_CKS1_1	29	34	PF01111	0.520
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.394
DOC_MAPK_gen_1	432	439	PF00069	0.543
DOC_PP1_RVXF_1	388	394	PF00149	0.420
DOC_PP1_RVXF_1	430	436	PF00149	0.473
DOC_PP2B_LxvP_1	146	149	PF13499	0.492
DOC_PP2B_LxvP_1	444	447	PF13499	0.414
DOC_PP2B_LxvP_1	454	457	PF13499	0.450
DOC_USP7_MATH_1	10	14	PF00917	0.586
DOC_USP7_MATH_1	130	134	PF00917	0.574
DOC_USP7_MATH_1	140	144	PF00917	0.518
DOC_USP7_MATH_1	211	215	PF00917	0.575
DOC_USP7_MATH_1	23	27	PF00917	0.484
DOC_USP7_MATH_1	355	359	PF00917	0.608
DOC_USP7_MATH_1	375	379	PF00917	0.470
DOC_USP7_MATH_1	413	417	PF00917	0.584
DOC_USP7_MATH_1	69	73	PF00917	0.732
DOC_WW_Pin1_4	109	114	PF00397	0.587
DOC_WW_Pin1_4	259	264	PF00397	0.506
DOC_WW_Pin1_4	28	33	PF00397	0.501
DOC_WW_Pin1_4	411	416	PF00397	0.623
DOC_WW_Pin1_4	439	444	PF00397	0.479
DOC_WW_Pin1_4	56	61	PF00397	0.523
DOC_WW_Pin1_4	88	93	PF00397	0.633
LIG_14-3-3_CanoR_1	165	175	PF00244	0.499
LIG_14-3-3_CanoR_1	280	284	PF00244	0.480
LIG_14-3-3_CanoR_1	331	341	PF00244	0.571
LIG_14-3-3_CanoR_1	39	45	PF00244	0.488
LIG_14-3-3_CanoR_1	455	461	PF00244	0.496
LIG_14-3-3_CanoR_1	51	61	PF00244	0.519
LIG_14-3-3_CanoR_1	64	71	PF00244	0.686
LIG_14-3-3_CanoR_1	97	105	PF00244	0.681
LIG_Actin_WH2_2	148	166	PF00022	0.459
LIG_Actin_WH2_2	389	405	PF00022	0.385
LIG_AP2alpha_2	508	510	PF02296	0.559
LIG_BIR_III_2	7	11	PF00653	0.613
LIG_BIR_III_4	123	127	PF00653	0.585
LIG_BIR_III_4	420	424	PF00653	0.533
LIG_BRCT_BRCA1_1	143	147	PF00533	0.451
LIG_BRCT_BRCA1_1	415	419	PF00533	0.595
LIG_CaM_IQ_9	298	314	PF13499	0.445
LIG_Clathr_ClatBox_1	269	273	PF01394	0.459
LIG_Clathr_ClatBox_1	504	508	PF01394	0.582
LIG_FHA_1	264	270	PF00498	0.480
LIG_FHA_1	4	10	PF00498	0.623
LIG_FHA_1	63	69	PF00498	0.599
LIG_FHA_2	197	203	PF00498	0.453
LIG_FHA_2	217	223	PF00498	0.404
LIG_FHA_2	494	500	PF00498	0.614
LIG_FHA_2	83	89	PF00498	0.683
LIG_LIR_Gen_1	511	520	PF02991	0.494
LIG_LIR_Nem_3	511	515	PF02991	0.510
LIG_LIR_Nem_3	517	521	PF02991	0.545
LIG_NRBOX	246	252	PF00104	0.459
LIG_PDZ_Class_2	516	521	PF00595	0.481
LIG_Pex14_1	356	360	PF04695	0.610
LIG_SH2_NCK_1	512	516	PF00017	0.479
LIG_SH2_STAP1	360	364	PF00017	0.536
LIG_SH2_STAT5	512	515	PF00017	0.445
LIG_SH3_1	412	418	PF00018	0.605
LIG_SH3_2	92	97	PF14604	0.555
LIG_SH3_3	367	373	PF00018	0.625
LIG_SH3_3	412	418	PF00018	0.605
LIG_SH3_3	464	470	PF00018	0.744
LIG_SH3_3	488	494	PF00018	0.611
LIG_SH3_3	89	95	PF00018	0.621
LIG_SUMO_SIM_anti_2	499	506	PF11976	0.592
LIG_SUMO_SIM_par_1	268	274	PF11976	0.459
LIG_SUMO_SIM_par_1	314	319	PF11976	0.459
LIG_SUMO_SIM_par_1	503	508	PF11976	0.589
LIG_TRAF2_1	220	223	PF00917	0.491
LIG_WRC_WIRS_1	515	520	PF05994	0.431
MOD_CDC14_SPxK_1	414	417	PF00782	0.589
MOD_CDC14_SPxK_1	94	97	PF00782	0.612
MOD_CDK_SPxK_1	411	417	PF00069	0.580
MOD_CDK_SPxK_1	91	97	PF00069	0.621
MOD_CK1_1	196	202	PF00069	0.366
MOD_CK1_1	262	268	PF00069	0.301
MOD_CK1_1	332	338	PF00069	0.612
MOD_CK1_1	358	364	PF00069	0.571
MOD_CK1_1	378	384	PF00069	0.580
MOD_CK1_1	485	491	PF00069	0.524
MOD_CK1_1	503	509	PF00069	0.440
MOD_CK2_1	216	222	PF00069	0.335
MOD_CK2_1	493	499	PF00069	0.772
MOD_CK2_1	82	88	PF00069	0.687
MOD_GlcNHglycan	119	122	PF01048	0.718
MOD_GlcNHglycan	128	131	PF01048	0.539
MOD_GlcNHglycan	132	135	PF01048	0.476
MOD_GlcNHglycan	207	210	PF01048	0.375
MOD_GlcNHglycan	213	216	PF01048	0.417
MOD_GlcNHglycan	24	28	PF01048	0.482
MOD_GlcNHglycan	258	262	PF01048	0.335
MOD_GlcNHglycan	364	367	PF01048	0.605
MOD_GlcNHglycan	407	410	PF01048	0.556
MOD_GlcNHglycan	487	490	PF01048	0.534
MOD_GlcNHglycan	71	74	PF01048	0.629
MOD_GSK3_1	115	122	PF00069	0.574
MOD_GSK3_1	126	133	PF00069	0.636
MOD_GSK3_1	147	154	PF00069	0.415
MOD_GSK3_1	174	181	PF00069	0.371
MOD_GSK3_1	207	214	PF00069	0.329
MOD_GSK3_1	224	231	PF00069	0.245
MOD_GSK3_1	259	266	PF00069	0.311
MOD_GSK3_1	296	303	PF00069	0.290
MOD_GSK3_1	330	337	PF00069	0.582
MOD_GSK3_1	358	365	PF00069	0.632
MOD_GSK3_1	375	382	PF00069	0.599
MOD_GSK3_1	456	463	PF00069	0.511
MOD_GSK3_1	510	517	PF00069	0.433
MOD_GSK3_1	52	59	PF00069	0.483
MOD_GSK3_1	79	86	PF00069	0.605
MOD_NEK2_1	1	6	PF00069	0.749
MOD_NEK2_1	104	109	PF00069	0.597
MOD_NEK2_1	117	122	PF00069	0.668
MOD_NEK2_1	279	284	PF00069	0.322
MOD_NEK2_1	297	302	PF00069	0.306
MOD_NEK2_1	316	321	PF00069	0.289
MOD_NEK2_1	329	334	PF00069	0.582
MOD_OFUCOSY	190	197	PF10250	0.255
MOD_PIKK_1	316	322	PF00454	0.283
MOD_PIKK_1	49	55	PF00454	0.504
MOD_PIKK_1	493	499	PF00454	0.611
MOD_PKA_2	126	132	PF00069	0.752
MOD_PKA_2	279	285	PF00069	0.321
MOD_PKA_2	330	336	PF00069	0.563
MOD_PKA_2	485	491	PF00069	0.479
MOD_PKA_2	63	69	PF00069	0.659
MOD_Plk_1	227	233	PF00069	0.236
MOD_Plk_1	23	29	PF00069	0.637
MOD_Plk_1	83	89	PF00069	0.683
MOD_Plk_2-3	228	234	PF00069	0.282
MOD_Plk_2-3	379	385	PF00069	0.542
MOD_Plk_4	228	234	PF00069	0.244
MOD_Plk_4	500	506	PF00069	0.630
MOD_Plk_4	514	520	PF00069	0.360
MOD_ProDKin_1	109	115	PF00069	0.590
MOD_ProDKin_1	259	265	PF00069	0.355
MOD_ProDKin_1	28	34	PF00069	0.508
MOD_ProDKin_1	411	417	PF00069	0.628
MOD_ProDKin_1	439	445	PF00069	0.480
MOD_ProDKin_1	56	62	PF00069	0.530
MOD_ProDKin_1	88	94	PF00069	0.630
MOD_SUMO_for_1	11	14	PF00179	0.594
TRG_DiLeu_BaEn_1	228	233	PF01217	0.236
TRG_DiLeu_BaEn_1	500	505	PF01217	0.592
TRG_DiLeu_BaEn_2	513	519	PF01217	0.426
TRG_ENDOCYTIC_2	512	515	PF00928	0.486
TRG_ER_diArg_1	163	165	PF00400	0.332
TRG_ER_diArg_1	20	22	PF00400	0.726
TRG_ER_diArg_1	279	281	PF00400	0.380
TRG_ER_diArg_1	431	434	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF4	Leptomonas seymouri	40%	100%
A4H9T5	Leishmania braziliensis	69%	100%
A4HUT5	Leishmania infantum	98%	99%
E9ANG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QH57	Leishmania major	90%	100%