Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB66_LEIDO

TriTrypDb:

LdBPK_211370.1 , LdCL_210019200 , LDHU3_21.1620

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	6
GO:0016020	membrane	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0000139	Golgi membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0031984	organelle subcompartment	2	1
GO:0031985	Golgi cisterna	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

A0A3Q8IB66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB66

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0007030	Golgi organization	5	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0000301	retrograde transport, vesicle recycling within Golgi	7	1
GO:0006810	transport	3	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.758
CLV_C14_Caspase3-7	507	511	PF00656	0.687
CLV_C14_Caspase3-7	538	542	PF00656	0.771
CLV_C14_Caspase3-7	568	572	PF00656	0.680
CLV_NRD_NRD_1	381	383	PF00675	0.541
CLV_NRD_NRD_1	392	394	PF00675	0.526
CLV_NRD_NRD_1	544	546	PF00675	0.554
CLV_PCSK_KEX2_1	381	383	PF00082	0.541
CLV_PCSK_KEX2_1	392	394	PF00082	0.526
CLV_PCSK_KEX2_1	543	545	PF00082	0.536
CLV_PCSK_PC7_1	377	383	PF00082	0.535
CLV_PCSK_SKI1_1	235	239	PF00082	0.465
CLV_PCSK_SKI1_1	377	381	PF00082	0.461
CLV_PCSK_SKI1_1	449	453	PF00082	0.533
CLV_PCSK_SKI1_1	579	583	PF00082	0.472
CLV_PCSK_SKI1_1	589	593	PF00082	0.301
CLV_Separin_Metazoa	389	393	PF03568	0.710
DEG_APCC_DBOX_1	376	384	PF00400	0.695
DEG_APCC_DBOX_1	428	436	PF00400	0.654
DEG_Nend_Nbox_1	1	3	PF02207	0.722
DEG_SPOP_SBC_1	88	92	PF00917	0.769
DOC_CYCLIN_yClb5_NLxxxL_5	435	444	PF00134	0.669
DOC_MAPK_gen_1	344	352	PF00069	0.740
DOC_MAPK_gen_1	427	435	PF00069	0.662
DOC_MAPK_gen_1	543	552	PF00069	0.723
DOC_MAPK_MEF2A_6	346	354	PF00069	0.703
DOC_MIT_MIM_1	305	313	PF04212	0.743
DOC_PP2B_LxvP_1	124	127	PF13499	0.752
DOC_PP4_FxxP_1	492	495	PF00568	0.831
DOC_USP7_MATH_1	167	171	PF00917	0.765
DOC_USP7_MATH_1	179	183	PF00917	0.746
DOC_USP7_MATH_1	285	289	PF00917	0.801
DOC_USP7_MATH_1	397	401	PF00917	0.749
DOC_USP7_MATH_1	496	500	PF00917	0.838
DOC_USP7_MATH_1	536	540	PF00917	0.838
DOC_USP7_MATH_1	565	569	PF00917	0.716
DOC_USP7_MATH_1	623	627	PF00917	0.456
DOC_USP7_MATH_1	87	91	PF00917	0.825
DOC_WW_Pin1_4	188	193	PF00397	0.720
DOC_WW_Pin1_4	393	398	PF00397	0.742
DOC_WW_Pin1_4	532	537	PF00397	0.782
DOC_WW_Pin1_4	97	102	PF00397	0.756
LIG_14-3-3_CanoR_1	134	142	PF00244	0.768
LIG_14-3-3_CanoR_1	287	293	PF00244	0.754
LIG_14-3-3_CanoR_1	381	391	PF00244	0.693
LIG_14-3-3_CanoR_1	40	47	PF00244	0.775
LIG_14-3-3_CanoR_1	488	492	PF00244	0.822
LIG_14-3-3_CanoR_1	49	54	PF00244	0.765
LIG_14-3-3_CanoR_1	505	514	PF00244	0.668
LIG_14-3-3_CanoR_1	579	588	PF00244	0.670
LIG_APCC_ABBA_1	259	264	PF00400	0.729
LIG_BIR_III_2	409	413	PF00653	0.653
LIG_BRCT_BRCA1_1	488	492	PF00533	0.833
LIG_BRCT_BRCA1_1	91	95	PF00533	0.780
LIG_CaM_IQ_9	338	353	PF13499	0.656
LIG_EH_1	163	167	PF12763	0.668
LIG_EVH1_1	492	496	PF00568	0.837
LIG_FHA_1	14	20	PF00498	0.777
LIG_FHA_1	333	339	PF00498	0.683
LIG_FHA_1	48	54	PF00498	0.752
LIG_FHA_1	608	614	PF00498	0.513
LIG_FHA_2	320	326	PF00498	0.589
LIG_FHA_2	383	389	PF00498	0.689
LIG_FHA_2	532	538	PF00498	0.772
LIG_GBD_Chelix_1	603	611	PF00786	0.510
LIG_Integrin_isoDGR_2	486	488	PF01839	0.472
LIG_LIR_Apic_2	489	495	PF02991	0.833
LIG_MYND_1	59	63	PF01753	0.798
LIG_PDZ_Class_3	624	629	PF00595	0.524
LIG_SH2_PTP2	595	598	PF00017	0.411
LIG_SH2_STAT5	595	598	PF00017	0.411
LIG_SH3_2	60	65	PF14604	0.806
LIG_SH3_3	490	496	PF00018	0.820
LIG_SH3_3	54	60	PF00018	0.798
LIG_SH3_3	616	622	PF00018	0.571
LIG_SUMO_SIM_par_1	122	128	PF11976	0.826
LIG_SUMO_SIM_par_1	562	569	PF11976	0.652
LIG_SUMO_SIM_par_1	609	616	PF11976	0.682
LIG_TRAF2_1	23	26	PF00917	0.664
LIG_TRAF2_1	612	615	PF00917	0.506
LIG_TRAF2_2	293	298	PF00917	0.798
LIG_WRC_WIRS_1	130	135	PF05994	0.730
LIG_WRC_WIRS_1	570	575	PF05994	0.609
MOD_CK1_1	125	131	PF00069	0.777
MOD_CK1_1	170	176	PF00069	0.670
MOD_CK1_1	288	294	PF00069	0.673
MOD_CK1_1	319	325	PF00069	0.675
MOD_CK1_1	395	401	PF00069	0.703
MOD_CK1_1	45	51	PF00069	0.709
MOD_CK1_1	569	575	PF00069	0.633
MOD_CK2_1	194	200	PF00069	0.691
MOD_CK2_1	286	292	PF00069	0.738
MOD_CK2_1	319	325	PF00069	0.541
MOD_CK2_1	531	537	PF00069	0.716
MOD_GlcNHglycan	102	105	PF01048	0.651
MOD_GlcNHglycan	107	110	PF01048	0.670
MOD_GlcNHglycan	159	162	PF01048	0.602
MOD_GlcNHglycan	182	185	PF01048	0.704
MOD_GlcNHglycan	288	291	PF01048	0.624
MOD_GlcNHglycan	377	380	PF01048	0.630
MOD_GlcNHglycan	399	402	PF01048	0.663
MOD_GlcNHglycan	44	47	PF01048	0.744
MOD_GlcNHglycan	478	481	PF01048	0.669
MOD_GlcNHglycan	507	510	PF01048	0.693
MOD_GlcNHglycan	517	520	PF01048	0.700
MOD_GlcNHglycan	537	541	PF01048	0.791
MOD_GlcNHglycan	614	618	PF01048	0.647
MOD_GlcNHglycan	68	71	PF01048	0.758
MOD_GSK3_1	100	107	PF00069	0.716
MOD_GSK3_1	125	132	PF00069	0.685
MOD_GSK3_1	167	174	PF00069	0.751
MOD_GSK3_1	392	399	PF00069	0.628
MOD_GSK3_1	41	48	PF00069	0.693
MOD_GSK3_1	431	438	PF00069	0.563
MOD_GSK3_1	528	535	PF00069	0.739
MOD_GSK3_1	565	572	PF00069	0.534
MOD_N-GLC_1	194	199	PF02516	0.598
MOD_NEK2_1	105	110	PF00069	0.799
MOD_NEK2_1	157	162	PF00069	0.737
MOD_NEK2_1	171	176	PF00069	0.615
MOD_NEK2_1	435	440	PF00069	0.537
MOD_NEK2_1	476	481	PF00069	0.667
MOD_NEK2_1	613	618	PF00069	0.641
MOD_NEK2_2	487	492	PF00069	0.691
MOD_PIKK_1	134	140	PF00454	0.723
MOD_PIKK_1	171	177	PF00454	0.765
MOD_PIKK_1	263	269	PF00454	0.669
MOD_PIKK_1	382	388	PF00454	0.611
MOD_PIKK_1	579	585	PF00454	0.556
MOD_PKA_1	392	398	PF00069	0.699
MOD_PKA_2	133	139	PF00069	0.724
MOD_PKA_2	245	251	PF00069	0.626
MOD_PKA_2	286	292	PF00069	0.699
MOD_PKA_2	362	368	PF00069	0.675
MOD_PKA_2	392	398	PF00069	0.685
MOD_PKA_2	476	482	PF00069	0.766
MOD_PKA_2	48	54	PF00069	0.735
MOD_PKA_2	487	493	PF00069	0.609
MOD_PKA_2	504	510	PF00069	0.516
MOD_Plk_1	194	200	PF00069	0.614
MOD_Plk_1	215	221	PF00069	0.670
MOD_Plk_2-3	13	19	PF00069	0.631
MOD_Plk_4	167	173	PF00069	0.752
MOD_Plk_4	487	493	PF00069	0.730
MOD_ProDKin_1	188	194	PF00069	0.651
MOD_ProDKin_1	393	399	PF00069	0.691
MOD_ProDKin_1	532	538	PF00069	0.743
MOD_ProDKin_1	97	103	PF00069	0.706
MOD_SUMO_rev_2	10	16	PF00179	0.621
MOD_SUMO_rev_2	271	280	PF00179	0.611
MOD_SUMO_rev_2	450	456	PF00179	0.579
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.563
TRG_ENDOCYTIC_2	458	461	PF00928	0.580
TRG_ENDOCYTIC_2	595	598	PF00928	0.390
TRG_ER_diArg_1	380	382	PF00400	0.680
TRG_ER_diArg_1	391	393	PF00400	0.545
TRG_ER_diArg_1	543	545	PF00400	0.719
TRG_ER_diArg_1	81	84	PF00400	0.758
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	381	386	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL5	Leptomonas seymouri	41%	94%
A4HBX1	Leishmania braziliensis	73%	100%
A4HZ89	Leishmania infantum	100%	100%
E9AV97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QC83	Leishmania major	91%	99%