TKL protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

TKL protein kinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB65_LEIDO

TriTrypDb:

LdBPK_282640.1 , LdCL_280031500 , LDHU3_28.3570

Length:

804

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3Q8IB65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.493
CLV_NRD_NRD_1	728	730	PF00675	0.624
CLV_NRD_NRD_1	794	796	PF00675	0.404
CLV_PCSK_KEX2_1	794	796	PF00082	0.400
CLV_PCSK_SKI1_1	208	212	PF00082	0.682
CLV_PCSK_SKI1_1	313	317	PF00082	0.619
CLV_PCSK_SKI1_1	450	454	PF00082	0.599
CLV_PCSK_SKI1_1	550	554	PF00082	0.581
CLV_PCSK_SKI1_1	570	574	PF00082	0.615
CLV_PCSK_SKI1_1	767	771	PF00082	0.487
CLV_PCSK_SKI1_1	92	96	PF00082	0.591
DEG_APCC_DBOX_1	506	514	PF00400	0.420
DEG_COP1_1	407	417	PF00400	0.392
DEG_SPOP_SBC_1	199	203	PF00917	0.503
DEG_SPOP_SBC_1	709	713	PF00917	0.571
DOC_CDC14_PxL_1	21	29	PF14671	0.446
DOC_CDC14_PxL_1	85	93	PF14671	0.434
DOC_CKS1_1	417	422	PF01111	0.433
DOC_CKS1_1	536	541	PF01111	0.433
DOC_CKS1_1	745	750	PF01111	0.450
DOC_CYCLIN_RxL_1	764	772	PF00134	0.332
DOC_CYCLIN_RxL_1	89	98	PF00134	0.407
DOC_MAPK_gen_1	507	515	PF00069	0.417
DOC_MAPK_MEF2A_6	22	31	PF00069	0.570
DOC_MAPK_MEF2A_6	241	250	PF00069	0.457
DOC_MAPK_MEF2A_6	313	322	PF00069	0.341
DOC_MAPK_MEF2A_6	507	515	PF00069	0.355
DOC_MAPK_NFAT4_5	313	321	PF00069	0.417
DOC_PP2B_LxvP_1	355	358	PF13499	0.484
DOC_PP2B_LxvP_1	488	491	PF13499	0.349
DOC_PP2B_LxvP_1	513	516	PF13499	0.320
DOC_PP2B_LxvP_1	86	89	PF13499	0.438
DOC_PP4_FxxP_1	240	243	PF00568	0.502
DOC_USP7_MATH_1	112	116	PF00917	0.407
DOC_USP7_MATH_1	154	158	PF00917	0.488
DOC_USP7_MATH_1	200	204	PF00917	0.509
DOC_USP7_MATH_1	222	226	PF00917	0.540
DOC_USP7_MATH_1	358	362	PF00917	0.447
DOC_USP7_MATH_1	402	406	PF00917	0.477
DOC_USP7_MATH_1	482	486	PF00917	0.528
DOC_USP7_MATH_1	544	548	PF00917	0.393
DOC_USP7_MATH_1	623	627	PF00917	0.460
DOC_USP7_UBL2_3	550	554	PF12436	0.478
DOC_WW_Pin1_4	11	16	PF00397	0.680
DOC_WW_Pin1_4	416	421	PF00397	0.449
DOC_WW_Pin1_4	535	540	PF00397	0.389
DOC_WW_Pin1_4	570	575	PF00397	0.413
DOC_WW_Pin1_4	71	76	PF00397	0.422
DOC_WW_Pin1_4	744	749	PF00397	0.399
DOC_WW_Pin1_4	799	804	PF00397	0.712
LIG_14-3-3_CanoR_1	103	111	PF00244	0.331
LIG_14-3-3_CanoR_1	123	129	PF00244	0.479
LIG_14-3-3_CanoR_1	132	140	PF00244	0.487
LIG_14-3-3_CanoR_1	141	150	PF00244	0.359
LIG_14-3-3_CanoR_1	450	455	PF00244	0.432
LIG_14-3-3_CanoR_1	701	709	PF00244	0.470
LIG_14-3-3_CanoR_1	92	97	PF00244	0.338
LIG_Actin_WH2_2	686	703	PF00022	0.442
LIG_Actin_WH2_2	774	791	PF00022	0.464
LIG_BRCT_BRCA1_1	236	240	PF00533	0.512
LIG_BRCT_BRCA1_1	65	69	PF00533	0.396
LIG_Clathr_ClatBox_1	683	687	PF01394	0.404
LIG_deltaCOP1_diTrp_1	467	474	PF00928	0.440
LIG_eIF4E_1	298	304	PF01652	0.432
LIG_eIF4E_1	493	499	PF01652	0.426
LIG_eIF4E_1	505	511	PF01652	0.410
LIG_EVH1_1	86	90	PF00568	0.399
LIG_FHA_1	103	109	PF00498	0.374
LIG_FHA_1	144	150	PF00498	0.479
LIG_FHA_1	225	231	PF00498	0.511
LIG_FHA_1	377	383	PF00498	0.423
LIG_FHA_1	409	415	PF00498	0.527
LIG_FHA_1	601	607	PF00498	0.507
LIG_FHA_1	695	701	PF00498	0.362
LIG_FHA_1	704	710	PF00498	0.482
LIG_FHA_1	72	78	PF00498	0.415
LIG_FHA_1	763	769	PF00498	0.446
LIG_FHA_1	81	87	PF00498	0.399
LIG_FHA_2	156	162	PF00498	0.531
LIG_FHA_2	379	385	PF00498	0.343
LIG_FHA_2	405	411	PF00498	0.464
LIG_FHA_2	536	542	PF00498	0.397
LIG_FHA_2	605	611	PF00498	0.492
LIG_FHA_2	651	657	PF00498	0.417
LIG_FHA_2	665	671	PF00498	0.311
LIG_FHA_2	710	716	PF00498	0.536
LIG_FHA_2	745	751	PF00498	0.453
LIG_FHA_2	93	99	PF00498	0.433
LIG_GBD_Chelix_1	770	778	PF00786	0.443
LIG_HCF-1_HBM_1	342	345	PF13415	0.403
LIG_LIR_Apic_2	237	243	PF02991	0.511
LIG_LIR_Apic_2	734	738	PF02991	0.413
LIG_LIR_Apic_2	799	803	PF02991	0.706
LIG_LIR_Gen_1	419	429	PF02991	0.352
LIG_LIR_Gen_1	653	659	PF02991	0.448
LIG_LIR_Gen_1	661	669	PF02991	0.380
LIG_LIR_Gen_1	687	698	PF02991	0.348
LIG_LIR_LC3C_4	28	31	PF02991	0.289
LIG_LIR_Nem_3	209	214	PF02991	0.459
LIG_LIR_Nem_3	419	424	PF02991	0.320
LIG_LIR_Nem_3	465	471	PF02991	0.408
LIG_LIR_Nem_3	485	489	PF02991	0.235
LIG_LIR_Nem_3	517	522	PF02991	0.346
LIG_LIR_Nem_3	573	579	PF02991	0.354
LIG_LIR_Nem_3	653	657	PF02991	0.446
LIG_LIR_Nem_3	661	666	PF02991	0.429
LIG_LIR_Nem_3	687	693	PF02991	0.363
LIG_LIR_Nem_3	731	735	PF02991	0.423
LIG_LIR_Nem_3	763	769	PF02991	0.371
LIG_MLH1_MIPbox_1	65	69	PF16413	0.421
LIG_NRBOX	34	40	PF00104	0.407
LIG_PDZ_Class_1	799	804	PF00595	0.712
LIG_Pex14_1	294	298	PF04695	0.438
LIG_Pex14_2	107	111	PF04695	0.368
LIG_Pex14_2	211	215	PF04695	0.459
LIG_PTAP_UEV_1	493	498	PF05743	0.424
LIG_SH2_CRK	421	425	PF00017	0.345
LIG_SH2_CRK	766	770	PF00017	0.294
LIG_SH2_GRB2like	619	622	PF00017	0.392
LIG_SH2_SRC	619	622	PF00017	0.453
LIG_SH2_SRC	85	88	PF00017	0.417
LIG_SH2_STAP1	129	133	PF00017	0.499
LIG_SH2_STAP1	345	349	PF00017	0.404
LIG_SH2_STAP1	595	599	PF00017	0.529
LIG_SH2_STAT5	298	301	PF00017	0.424
LIG_SH2_STAT5	454	457	PF00017	0.421
LIG_SH2_STAT5	629	632	PF00017	0.363
LIG_SH2_STAT5	68	71	PF00017	0.385
LIG_SH2_STAT5	692	695	PF00017	0.340
LIG_SH2_STAT5	696	699	PF00017	0.311
LIG_SH2_STAT5	735	738	PF00017	0.423
LIG_SH2_STAT5	760	763	PF00017	0.371
LIG_SH2_STAT5	85	88	PF00017	0.392
LIG_SH3_2	87	92	PF14604	0.394
LIG_SH3_3	240	246	PF00018	0.470
LIG_SH3_3	289	295	PF00018	0.470
LIG_SH3_3	411	417	PF00018	0.521
LIG_SH3_3	423	429	PF00018	0.339
LIG_SH3_3	488	494	PF00018	0.370
LIG_SH3_3	496	502	PF00018	0.377
LIG_SH3_3	533	539	PF00018	0.358
LIG_SH3_3	81	87	PF00018	0.467
LIG_SUMO_SIM_anti_2	179	184	PF11976	0.383
LIG_SUMO_SIM_anti_2	274	281	PF11976	0.350
LIG_SUMO_SIM_anti_2	28	33	PF11976	0.467
LIG_SUMO_SIM_anti_2	361	367	PF11976	0.430
LIG_SUMO_SIM_par_1	274	281	PF11976	0.361
LIG_SUMO_SIM_par_1	28	33	PF11976	0.469
LIG_SUMO_SIM_par_1	459	465	PF11976	0.416
LIG_SUMO_SIM_par_1	520	526	PF11976	0.335
LIG_SUMO_SIM_par_1	767	772	PF11976	0.288
LIG_SUMO_SIM_par_1	92	98	PF11976	0.408
LIG_TYR_ITSM	417	424	PF00017	0.424
LIG_WW_1	295	298	PF00397	0.447
MOD_CDK_SPK_2	11	16	PF00069	0.655
MOD_CDK_SPxxK_3	744	751	PF00069	0.449
MOD_CK1_1	115	121	PF00069	0.385
MOD_CK1_1	128	134	PF00069	0.482
MOD_CK1_1	155	161	PF00069	0.535
MOD_CK1_1	187	193	PF00069	0.405
MOD_CK1_1	198	204	PF00069	0.454
MOD_CK1_1	206	212	PF00069	0.360
MOD_CK1_1	225	231	PF00069	0.386
MOD_CK1_1	234	240	PF00069	0.473
MOD_CK1_1	281	287	PF00069	0.482
MOD_CK1_1	308	314	PF00069	0.414
MOD_CK1_1	353	359	PF00069	0.466
MOD_CK1_1	404	410	PF00069	0.455
MOD_CK1_1	433	439	PF00069	0.467
MOD_CK1_1	444	450	PF00069	0.401
MOD_CK1_1	492	498	PF00069	0.345
MOD_CK1_1	556	562	PF00069	0.525
MOD_CK1_1	597	603	PF00069	0.509
MOD_CK1_1	634	640	PF00069	0.468
MOD_CK1_1	718	724	PF00069	0.539
MOD_CK2_1	206	212	PF00069	0.492
MOD_CK2_1	443	449	PF00069	0.476
MOD_CK2_1	664	670	PF00069	0.456
MOD_CK2_1	704	710	PF00069	0.551
MOD_CK2_1	716	722	PF00069	0.465
MOD_GlcNHglycan	154	157	PF01048	0.721
MOD_GlcNHglycan	167	170	PF01048	0.563
MOD_GlcNHglycan	2	5	PF01048	0.578
MOD_GlcNHglycan	208	211	PF01048	0.684
MOD_GlcNHglycan	352	355	PF01048	0.632
MOD_GlcNHglycan	432	435	PF01048	0.668
MOD_GlcNHglycan	443	446	PF01048	0.685
MOD_GlcNHglycan	494	497	PF01048	0.596
MOD_GlcNHglycan	529	532	PF01048	0.699
MOD_GlcNHglycan	541	545	PF01048	0.564
MOD_GlcNHglycan	546	549	PF01048	0.523
MOD_GlcNHglycan	613	616	PF01048	0.642
MOD_GlcNHglycan	631	634	PF01048	0.489
MOD_GSK3_1	102	109	PF00069	0.423
MOD_GSK3_1	128	135	PF00069	0.462
MOD_GSK3_1	150	157	PF00069	0.448
MOD_GSK3_1	194	201	PF00069	0.441
MOD_GSK3_1	202	209	PF00069	0.474
MOD_GSK3_1	222	229	PF00069	0.311
MOD_GSK3_1	230	237	PF00069	0.494
MOD_GSK3_1	280	287	PF00069	0.405
MOD_GSK3_1	400	407	PF00069	0.453
MOD_GSK3_1	433	440	PF00069	0.446
MOD_GSK3_1	452	459	PF00069	0.281
MOD_GSK3_1	478	485	PF00069	0.489
MOD_GSK3_1	523	530	PF00069	0.403
MOD_GSK3_1	531	538	PF00069	0.357
MOD_GSK3_1	540	547	PF00069	0.267
MOD_GSK3_1	553	560	PF00069	0.467
MOD_GSK3_1	593	600	PF00069	0.447
MOD_GSK3_1	625	632	PF00069	0.448
MOD_GSK3_1	64	71	PF00069	0.390
MOD_GSK3_1	646	653	PF00069	0.417
MOD_GSK3_1	658	665	PF00069	0.396
MOD_GSK3_1	700	707	PF00069	0.448
MOD_LATS_1	591	597	PF00433	0.491
MOD_N-GLC_1	112	117	PF02516	0.581
MOD_N-GLC_1	187	192	PF02516	0.598
MOD_N-GLC_1	194	199	PF02516	0.575
MOD_N-GLC_1	284	289	PF02516	0.717
MOD_N-GLC_1	308	313	PF02516	0.642
MOD_N-GLC_1	400	405	PF02516	0.650
MOD_N-GLC_1	715	720	PF02516	0.734
MOD_N-GLC_1	79	84	PF02516	0.690
MOD_NEK2_1	107	112	PF00069	0.378
MOD_NEK2_1	194	199	PF00069	0.421
MOD_NEK2_1	280	285	PF00069	0.430
MOD_NEK2_1	288	293	PF00069	0.502
MOD_NEK2_1	350	355	PF00069	0.375
MOD_NEK2_1	393	398	PF00069	0.372
MOD_NEK2_1	452	457	PF00069	0.422
MOD_NEK2_1	522	527	PF00069	0.335
MOD_NEK2_1	540	545	PF00069	0.325
MOD_NEK2_1	558	563	PF00069	0.373
MOD_NEK2_1	575	580	PF00069	0.388
MOD_NEK2_1	611	616	PF00069	0.396
MOD_NEK2_1	631	636	PF00069	0.378
MOD_NEK2_1	669	674	PF00069	0.386
MOD_NEK2_1	686	691	PF00069	0.295
MOD_NEK2_1	69	74	PF00069	0.475
MOD_NEK2_1	700	705	PF00069	0.334
MOD_NEK2_1	723	728	PF00069	0.468
MOD_NEK2_1	769	774	PF00069	0.384
MOD_PIKK_1	308	314	PF00454	0.472
MOD_PIKK_1	337	343	PF00454	0.439
MOD_PIKK_1	348	354	PF00454	0.401
MOD_PIKK_1	664	670	PF00454	0.359
MOD_PIKK_1	677	683	PF00454	0.370
MOD_PIKK_1	700	706	PF00454	0.455
MOD_PKA_2	102	108	PF00069	0.378
MOD_PKA_2	122	128	PF00069	0.443
MOD_PKA_2	281	287	PF00069	0.458
MOD_PKA_2	337	343	PF00069	0.391
MOD_PKA_2	430	436	PF00069	0.475
MOD_PKA_2	700	706	PF00069	0.459
MOD_Plk_1	112	118	PF00069	0.410
MOD_Plk_1	194	200	PF00069	0.419
MOD_Plk_1	234	240	PF00069	0.487
MOD_Plk_1	284	290	PF00069	0.531
MOD_Plk_1	686	692	PF00069	0.396
MOD_Plk_1	694	700	PF00069	0.335
MOD_Plk_1	715	721	PF00069	0.529
MOD_Plk_1	753	759	PF00069	0.365
MOD_Plk_2-3	378	384	PF00069	0.427
MOD_Plk_4	115	121	PF00069	0.365
MOD_Plk_4	187	193	PF00069	0.373
MOD_Plk_4	25	31	PF00069	0.469
MOD_Plk_4	359	365	PF00069	0.442
MOD_Plk_4	64	70	PF00069	0.413
MOD_Plk_4	731	737	PF00069	0.423
MOD_Plk_4	80	86	PF00069	0.459
MOD_Plk_4	92	98	PF00069	0.284
MOD_ProDKin_1	11	17	PF00069	0.680
MOD_ProDKin_1	416	422	PF00069	0.443
MOD_ProDKin_1	535	541	PF00069	0.391
MOD_ProDKin_1	570	576	PF00069	0.412
MOD_ProDKin_1	71	77	PF00069	0.423
MOD_ProDKin_1	744	750	PF00069	0.405
MOD_SUMO_rev_2	157	167	PF00179	0.502
MOD_SUMO_rev_2	710	719	PF00179	0.530
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.721
TRG_ENDOCYTIC_2	421	424	PF00928	0.323
TRG_ENDOCYTIC_2	766	769	PF00928	0.376
TRG_ER_diArg_1	793	795	PF00400	0.644
TRG_NES_CRM1_1	173	185	PF08389	0.431
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A4	Leptomonas seymouri	55%	100%
A0A0S4JR51	Bodo saltans	25%	100%
A0A1X0NQP9	Trypanosomatidae	27%	100%
A0A3R7KTE0	Trypanosoma rangeli	30%	100%
A4I3X7	Leishmania infantum	100%	100%
D0A945	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B067	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q818	Leishmania major	93%	100%
V5DCU8	Trypanosoma cruzi	29%	100%