Chaperone protein DNAj, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB64_LEIDO

TriTrypDb:

LdBPK_181650.1 , LdCL_180021800 , LDHU3_18.2110

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IB64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.526
CLV_NRD_NRD_1	192	194	PF00675	0.422
CLV_NRD_NRD_1	207	209	PF00675	0.361
CLV_NRD_NRD_1	62	64	PF00675	0.701
CLV_NRD_NRD_1	66	68	PF00675	0.675
CLV_PCSK_KEX2_1	111	113	PF00082	0.526
CLV_PCSK_KEX2_1	192	194	PF00082	0.422
CLV_PCSK_KEX2_1	207	209	PF00082	0.361
CLV_PCSK_KEX2_1	61	63	PF00082	0.709
CLV_PCSK_KEX2_1	66	68	PF00082	0.670
CLV_PCSK_PC7_1	62	68	PF00082	0.687
CLV_PCSK_SKI1_1	192	196	PF00082	0.438
CLV_PCSK_SKI1_1	207	211	PF00082	0.283
CLV_PCSK_SKI1_1	357	361	PF00082	0.451
CLV_PCSK_SKI1_1	471	475	PF00082	0.494
DEG_SCF_FBW7_1	487	494	PF00400	0.598
DEG_SPOP_SBC_1	302	306	PF00917	0.300
DEG_SPOP_SBC_1	491	495	PF00917	0.617
DOC_CKS1_1	335	340	PF01111	0.443
DOC_CYCLIN_RxL_1	279	289	PF00134	0.466
DOC_CYCLIN_RxL_1	518	528	PF00134	0.298
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.646
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.400
DOC_MAPK_gen_1	108	116	PF00069	0.507
DOC_MAPK_gen_1	207	214	PF00069	0.447
DOC_MAPK_gen_1	535	543	PF00069	0.326
DOC_MAPK_MEF2A_6	259	268	PF00069	0.346
DOC_MAPK_MEF2A_6	430	437	PF00069	0.364
DOC_MAPK_NFAT4_5	430	438	PF00069	0.363
DOC_PP2B_LxvP_1	523	526	PF13499	0.264
DOC_USP7_MATH_1	186	190	PF00917	0.325
DOC_USP7_MATH_1	244	248	PF00917	0.445
DOC_USP7_MATH_1	297	301	PF00917	0.395
DOC_USP7_MATH_1	37	41	PF00917	0.665
DOC_USP7_MATH_1	480	484	PF00917	0.546
DOC_USP7_MATH_1	97	101	PF00917	0.669
DOC_USP7_UBL2_3	496	500	PF12436	0.628
DOC_WW_Pin1_4	164	169	PF00397	0.569
DOC_WW_Pin1_4	224	229	PF00397	0.403
DOC_WW_Pin1_4	334	339	PF00397	0.432
DOC_WW_Pin1_4	487	492	PF00397	0.723
DOC_WW_Pin1_4	495	500	PF00397	0.735
DOC_WW_Pin1_4	95	100	PF00397	0.677
LIG_14-3-3_CanoR_1	156	162	PF00244	0.390
LIG_14-3-3_CanoR_1	211	219	PF00244	0.379
LIG_14-3-3_CanoR_1	282	287	PF00244	0.474
LIG_14-3-3_CanoR_1	301	311	PF00244	0.214
LIG_14-3-3_CanoR_1	419	424	PF00244	0.481
LIG_14-3-3_CanoR_1	430	434	PF00244	0.355
LIG_14-3-3_CanoR_1	446	452	PF00244	0.304
LIG_14-3-3_CanoR_1	513	517	PF00244	0.590
LIG_14-3-3_CanoR_1	549	558	PF00244	0.403
LIG_APCC_ABBA_1	226	231	PF00400	0.444
LIG_APCC_ABBAyCdc20_2	393	399	PF00400	0.438
LIG_BH_BH3_1	73	89	PF00452	0.515
LIG_BRCT_BRCA1_1	314	318	PF00533	0.361
LIG_Clathr_ClatBox_1	283	287	PF01394	0.363
LIG_FHA_1	11	17	PF00498	0.498
LIG_FHA_1	165	171	PF00498	0.486
LIG_FHA_1	189	195	PF00498	0.492
LIG_FHA_1	320	326	PF00498	0.554
LIG_FHA_1	378	384	PF00498	0.405
LIG_FHA_1	422	428	PF00498	0.441
LIG_FHA_1	446	452	PF00498	0.320
LIG_FHA_1	520	526	PF00498	0.397
LIG_FHA_2	303	309	PF00498	0.536
LIG_FHA_2	44	50	PF00498	0.585
LIG_FHA_2	492	498	PF00498	0.776
LIG_FHA_2	81	87	PF00498	0.635
LIG_LIR_Gen_1	151	162	PF02991	0.355
LIG_LIR_Gen_1	246	254	PF02991	0.461
LIG_LIR_Gen_1	315	325	PF02991	0.383
LIG_LIR_Gen_1	358	366	PF02991	0.541
LIG_LIR_Gen_1	409	416	PF02991	0.410
LIG_LIR_Gen_1	71	81	PF02991	0.590
LIG_LIR_Nem_3	151	157	PF02991	0.336
LIG_LIR_Nem_3	246	251	PF02991	0.377
LIG_LIR_Nem_3	315	321	PF02991	0.388
LIG_LIR_Nem_3	343	349	PF02991	0.500
LIG_LIR_Nem_3	358	363	PF02991	0.502
LIG_LIR_Nem_3	409	414	PF02991	0.411
LIG_LIR_Nem_3	517	523	PF02991	0.355
LIG_LIR_Nem_3	537	541	PF02991	0.284
LIG_LIR_Nem_3	562	568	PF02991	0.264
LIG_LIR_Nem_3	71	77	PF02991	0.488
LIG_NRBOX	326	332	PF00104	0.462
LIG_Pex14_1	314	318	PF04695	0.432
LIG_Rb_LxCxE_1	258	277	PF01857	0.276
LIG_SH2_CRK	248	252	PF00017	0.285
LIG_SH2_CRK	520	524	PF00017	0.331
LIG_SH2_CRK	538	542	PF00017	0.281
LIG_SH2_GRB2like	248	251	PF00017	0.447
LIG_SH2_NCK_1	147	151	PF00017	0.336
LIG_SH2_SRC	572	575	PF00017	0.326
LIG_SH2_STAP1	248	252	PF00017	0.405
LIG_SH2_STAP1	257	261	PF00017	0.413
LIG_SH2_STAP1	423	427	PF00017	0.433
LIG_SH2_STAP1	572	576	PF00017	0.264
LIG_SH2_STAT3	295	298	PF00017	0.402
LIG_SH2_STAT5	248	251	PF00017	0.399
LIG_SH2_STAT5	252	255	PF00017	0.425
LIG_SH2_STAT5	303	306	PF00017	0.306
LIG_SH2_STAT5	423	426	PF00017	0.476
LIG_SH3_3	383	389	PF00018	0.481
LIG_SUMO_SIM_anti_2	262	269	PF11976	0.352
LIG_SUMO_SIM_anti_2	432	438	PF11976	0.333
LIG_SUMO_SIM_par_1	193	198	PF11976	0.508
LIG_SUMO_SIM_par_1	282	287	PF11976	0.359
LIG_TRAF2_1	571	574	PF00917	0.397
LIG_TYR_ITIM	518	523	PF00017	0.397
MOD_CDC14_SPxK_1	227	230	PF00782	0.421
MOD_CDK_SPK_2	495	500	PF00069	0.631
MOD_CDK_SPxK_1	224	230	PF00069	0.409
MOD_CDK_SPxxK_3	334	341	PF00069	0.442
MOD_CDK_SPxxK_3	495	502	PF00069	0.587
MOD_CK1_1	320	326	PF00069	0.458
MOD_CK1_1	495	501	PF00069	0.735
MOD_CK1_1	512	518	PF00069	0.527
MOD_CK2_1	112	118	PF00069	0.482
MOD_CK2_1	302	308	PF00069	0.549
MOD_CK2_1	419	425	PF00069	0.443
MOD_CK2_1	491	497	PF00069	0.753
MOD_GlcNHglycan	158	161	PF01048	0.466
MOD_GlcNHglycan	204	207	PF01048	0.523
MOD_GlcNHglycan	527	530	PF01048	0.358
MOD_GlcNHglycan	551	554	PF01048	0.377
MOD_GlcNHglycan	577	580	PF01048	0.516
MOD_GSK3_1	282	289	PF00069	0.318
MOD_GSK3_1	297	304	PF00069	0.356
MOD_GSK3_1	39	46	PF00069	0.712
MOD_GSK3_1	421	428	PF00069	0.509
MOD_GSK3_1	486	493	PF00069	0.708
MOD_GSK3_1	521	528	PF00069	0.476
MOD_GSK3_1	557	564	PF00069	0.329
MOD_LATS_1	519	525	PF00433	0.368
MOD_N-GLC_2	185	187	PF02516	0.299
MOD_NEK2_1	155	160	PF00069	0.539
MOD_NEK2_1	286	291	PF00069	0.557
MOD_NEK2_1	414	419	PF00069	0.416
MOD_NEK2_1	429	434	PF00069	0.372
MOD_NEK2_1	50	55	PF00069	0.550
MOD_NEK2_2	314	319	PF00069	0.440
MOD_NEK2_2	561	566	PF00069	0.326
MOD_PIKK_1	10	16	PF00454	0.494
MOD_PIKK_1	212	218	PF00454	0.381
MOD_PIKK_1	37	43	PF00454	0.693
MOD_PIKK_1	377	383	PF00454	0.540
MOD_PK_1	112	118	PF00069	0.455
MOD_PKA_1	207	213	PF00069	0.280
MOD_PKA_2	155	161	PF00069	0.426
MOD_PKA_2	207	213	PF00069	0.411
MOD_PKA_2	429	435	PF00069	0.442
MOD_PKA_2	445	451	PF00069	0.254
MOD_PKA_2	512	518	PF00069	0.483
MOD_PKB_1	299	307	PF00069	0.306
MOD_Plk_1	112	118	PF00069	0.482
MOD_Plk_1	425	431	PF00069	0.462
MOD_Plk_1	454	460	PF00069	0.395
MOD_Plk_1	561	567	PF00069	0.326
MOD_Plk_4	320	326	PF00069	0.382
MOD_Plk_4	374	380	PF00069	0.509
MOD_Plk_4	406	412	PF00069	0.548
MOD_Plk_4	429	435	PF00069	0.404
MOD_ProDKin_1	164	170	PF00069	0.559
MOD_ProDKin_1	224	230	PF00069	0.409
MOD_ProDKin_1	334	340	PF00069	0.434
MOD_ProDKin_1	487	493	PF00069	0.727
MOD_ProDKin_1	495	501	PF00069	0.734
MOD_ProDKin_1	95	101	PF00069	0.679
MOD_SUMO_rev_2	133	138	PF00179	0.393
MOD_SUMO_rev_2	528	537	PF00179	0.323
TRG_AP2beta_CARGO_1	358	367	PF09066	0.321
TRG_DiLeu_BaEn_1	456	461	PF01217	0.413
TRG_DiLeu_BaEn_1	64	69	PF01217	0.602
TRG_DiLeu_BaEn_2	373	379	PF01217	0.386
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.439
TRG_ENDOCYTIC_2	248	251	PF00928	0.364
TRG_ENDOCYTIC_2	411	414	PF00928	0.326
TRG_ENDOCYTIC_2	520	523	PF00928	0.264
TRG_ENDOCYTIC_2	538	541	PF00928	0.264
TRG_ENDOCYTIC_2	572	575	PF00928	0.264
TRG_ER_diArg_1	192	194	PF00400	0.422
TRG_ER_diArg_1	207	209	PF00400	0.400
TRG_ER_diArg_1	400	403	PF00400	0.338
TRG_ER_diArg_1	60	63	PF00400	0.629
TRG_ER_diArg_1	65	67	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HST8	Leptomonas seymouri	45%	99%
A0A1X0P804	Trypanosomatidae	26%	97%
A0A3R7KJ25	Trypanosoma rangeli	27%	94%
A4HY36	Leishmania infantum	99%	100%
D0A549	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QDM3	Leishmania major	92%	100%
V5B4A5	Trypanosoma cruzi	27%	100%