LeishMANIAdb
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Cysteine peptidase, Clan CA, family C2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cysteine peptidase, Clan CA, family C2, putative
Gene product:
cysteine peptidase, Clan CA, family C2, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IB60_LEIDO
TriTrypDb:
LdBPK_181070.1 , LdCL_180015900 , LDHU3_18.1370
Length:
763

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005929 cilium 4 8
GO:0042995 cell projection 2 8
GO:0043226 organelle 2 8
GO:0043227 membrane-bounded organelle 3 8
GO:0110165 cellular anatomical entity 1 8
GO:0120025 plasma membrane bounded cell projection 3 8
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A0A3Q8IB60
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB60

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0019538 protein metabolic process 3 10
GO:0043170 macromolecule metabolic process 3 10
GO:0044238 primary metabolic process 2 10
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004175 endopeptidase activity 4 10
GO:0004197 cysteine-type endopeptidase activity 5 10
GO:0004198 calcium-dependent cysteine-type endopeptidase activity 6 10
GO:0008233 peptidase activity 3 10
GO:0008234 cysteine-type peptidase activity 4 10
GO:0016787 hydrolase activity 2 10
GO:0140096 catalytic activity, acting on a protein 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 537 541 PF00656 0.490
CLV_C14_Caspase3-7 615 619 PF00656 0.375
CLV_C14_Caspase3-7 689 693 PF00656 0.417
CLV_NRD_NRD_1 43 45 PF00675 0.463
CLV_NRD_NRD_1 562 564 PF00675 0.333
CLV_PCSK_KEX2_1 276 278 PF00082 0.286
CLV_PCSK_KEX2_1 562 564 PF00082 0.332
CLV_PCSK_KEX2_1 642 644 PF00082 0.457
CLV_PCSK_PC1ET2_1 276 278 PF00082 0.224
CLV_PCSK_PC1ET2_1 642 644 PF00082 0.457
CLV_PCSK_SKI1_1 164 168 PF00082 0.441
CLV_PCSK_SKI1_1 442 446 PF00082 0.324
CLV_PCSK_SKI1_1 477 481 PF00082 0.318
CLV_PCSK_SKI1_1 48 52 PF00082 0.457
CLV_PCSK_SKI1_1 76 80 PF00082 0.459
DEG_APCC_DBOX_1 47 55 PF00400 0.386
DEG_MDM2_SWIB_1 631 638 PF02201 0.399
DOC_MAPK_gen_1 44 53 PF00069 0.517
DOC_MAPK_gen_1 522 531 PF00069 0.416
DOC_MAPK_MEF2A_6 524 533 PF00069 0.401
DOC_PIKK_1 55 63 PF02985 0.454
DOC_PP1_RVXF_1 460 466 PF00149 0.503
DOC_PP4_FxxP_1 212 215 PF00568 0.556
DOC_PP4_FxxP_1 723 726 PF00568 0.413
DOC_USP7_MATH_1 229 233 PF00917 0.615
DOC_USP7_MATH_1 394 398 PF00917 0.511
DOC_USP7_MATH_1 436 440 PF00917 0.458
DOC_USP7_MATH_1 501 505 PF00917 0.389
DOC_USP7_MATH_1 718 722 PF00917 0.395
DOC_USP7_UBL2_3 331 335 PF12436 0.440
DOC_WW_Pin1_4 243 248 PF00397 0.510
DOC_WW_Pin1_4 290 295 PF00397 0.468
DOC_WW_Pin1_4 319 324 PF00397 0.569
DOC_WW_Pin1_4 670 675 PF00397 0.568
LIG_14-3-3_CanoR_1 368 378 PF00244 0.478
LIG_14-3-3_CanoR_1 379 388 PF00244 0.497
LIG_14-3-3_CanoR_1 524 533 PF00244 0.376
LIG_14-3-3_CanoR_1 594 600 PF00244 0.419
LIG_14-3-3_CanoR_1 602 608 PF00244 0.499
LIG_14-3-3_CanoR_1 610 615 PF00244 0.554
LIG_14-3-3_CanoR_1 643 651 PF00244 0.438
LIG_14-3-3_CanoR_1 653 657 PF00244 0.394
LIG_14-3-3_CanoR_1 704 708 PF00244 0.477
LIG_14-3-3_CterR_2 759 763 PF00244 0.525
LIG_APCC_ABBA_1 295 300 PF00400 0.548
LIG_APCC_ABBA_1 482 487 PF00400 0.448
LIG_BRCT_BRCA1_1 320 324 PF00533 0.468
LIG_BRCT_BRCA1_1 371 375 PF00533 0.524
LIG_BRCT_BRCA1_1 574 578 PF00533 0.446
LIG_BRCT_BRCA1_1 583 587 PF00533 0.428
LIG_BRCT_BRCA1_1 627 631 PF00533 0.523
LIG_BRCT_BRCA1_1 672 676 PF00533 0.572
LIG_CaM_IQ_9 21 36 PF13499 0.417
LIG_EH1_1 127 135 PF00400 0.409
LIG_FHA_1 177 183 PF00498 0.518
LIG_FHA_1 217 223 PF00498 0.394
LIG_FHA_1 453 459 PF00498 0.496
LIG_FHA_1 590 596 PF00498 0.447
LIG_FHA_1 657 663 PF00498 0.466
LIG_FHA_1 704 710 PF00498 0.458
LIG_FHA_1 752 758 PF00498 0.434
LIG_FHA_2 194 200 PF00498 0.593
LIG_FHA_2 357 363 PF00498 0.573
LIG_FHA_2 371 377 PF00498 0.422
LIG_FHA_2 394 400 PF00498 0.484
LIG_FHA_2 465 471 PF00498 0.482
LIG_FHA_2 492 498 PF00498 0.417
LIG_FHA_2 684 690 PF00498 0.574
LIG_FHA_2 698 704 PF00498 0.426
LIG_KLC1_Yacidic_2 296 300 PF13176 0.458
LIG_LIR_Apic_2 210 215 PF02991 0.577
LIG_LIR_Apic_2 720 726 PF02991 0.422
LIG_LIR_Gen_1 196 205 PF02991 0.461
LIG_LIR_Gen_1 225 233 PF02991 0.347
LIG_LIR_Gen_1 264 274 PF02991 0.458
LIG_LIR_Gen_1 322 333 PF02991 0.500
LIG_LIR_Gen_1 372 381 PF02991 0.506
LIG_LIR_Gen_1 467 475 PF02991 0.533
LIG_LIR_Gen_1 476 485 PF02991 0.492
LIG_LIR_Gen_1 584 595 PF02991 0.441
LIG_LIR_Gen_1 6 16 PF02991 0.486
LIG_LIR_Gen_1 632 641 PF02991 0.583
LIG_LIR_LC3C_4 272 275 PF02991 0.458
LIG_LIR_Nem_3 196 201 PF02991 0.496
LIG_LIR_Nem_3 221 227 PF02991 0.373
LIG_LIR_Nem_3 264 269 PF02991 0.578
LIG_LIR_Nem_3 322 328 PF02991 0.460
LIG_LIR_Nem_3 372 378 PF02991 0.462
LIG_LIR_Nem_3 449 453 PF02991 0.538
LIG_LIR_Nem_3 467 471 PF02991 0.483
LIG_LIR_Nem_3 474 478 PF02991 0.450
LIG_LIR_Nem_3 584 590 PF02991 0.433
LIG_LIR_Nem_3 6 12 PF02991 0.362
LIG_LIR_Nem_3 632 638 PF02991 0.574
LIG_LIR_Nem_3 720 725 PF02991 0.316
LIG_LRP6_Inhibitor_1 100 106 PF00058 0.365
LIG_MLH1_MIPbox_1 583 587 PF16413 0.428
LIG_PCNA_yPIPBox_3 106 119 PF02747 0.399
LIG_Pex14_1 635 639 PF04695 0.398
LIG_Pex14_2 371 375 PF04695 0.531
LIG_Pex14_2 471 475 PF04695 0.550
LIG_Pex14_2 479 483 PF04695 0.478
LIG_Pex14_2 631 635 PF04695 0.383
LIG_PTB_Apo_2 511 518 PF02174 0.326
LIG_SH2_CRK 198 202 PF00017 0.474
LIG_SH2_CRK 227 231 PF00017 0.380
LIG_SH2_CRK 266 270 PF00017 0.524
LIG_SH2_CRK 325 329 PF00017 0.502
LIG_SH2_CRK 340 344 PF00017 0.377
LIG_SH2_CRK 414 418 PF00017 0.477
LIG_SH2_CRK 429 433 PF00017 0.457
LIG_SH2_GRB2like 250 253 PF00017 0.324
LIG_SH2_NCK_1 198 202 PF00017 0.486
LIG_SH2_PTP2 9 12 PF00017 0.379
LIG_SH2_STAP1 198 202 PF00017 0.496
LIG_SH2_STAP1 325 329 PF00017 0.588
LIG_SH2_STAP1 429 433 PF00017 0.449
LIG_SH2_STAP1 446 450 PF00017 0.564
LIG_SH2_STAP1 737 741 PF00017 0.369
LIG_SH2_STAT3 251 254 PF00017 0.411
LIG_SH2_STAT5 128 131 PF00017 0.473
LIG_SH2_STAT5 227 230 PF00017 0.439
LIG_SH2_STAT5 284 287 PF00017 0.504
LIG_SH2_STAT5 298 301 PF00017 0.524
LIG_SH2_STAT5 342 345 PF00017 0.552
LIG_SH2_STAT5 41 44 PF00017 0.432
LIG_SH2_STAT5 727 730 PF00017 0.441
LIG_SH2_STAT5 9 12 PF00017 0.417
LIG_SH3_3 241 247 PF00018 0.438
LIG_SH3_3 432 438 PF00018 0.578
LIG_SH3_3 671 677 PF00018 0.533
LIG_SUMO_SIM_anti_2 131 138 PF11976 0.401
LIG_SUMO_SIM_anti_2 350 356 PF11976 0.523
LIG_SUMO_SIM_anti_2 659 664 PF11976 0.455
LIG_SUMO_SIM_anti_2 686 692 PF11976 0.571
LIG_SUMO_SIM_par_1 131 138 PF11976 0.513
LIG_SUMO_SIM_par_1 261 267 PF11976 0.467
LIG_SUMO_SIM_par_1 529 534 PF11976 0.335
LIG_SUMO_SIM_par_1 661 667 PF11976 0.359
LIG_TRAF2_1 232 235 PF00917 0.551
LIG_TRAF2_1 397 400 PF00917 0.458
LIG_TRAF2_1 402 405 PF00917 0.433
LIG_TRAF2_1 700 703 PF00917 0.448
LIG_TRFH_1 587 591 PF08558 0.463
LIG_TRFH_1 722 726 PF08558 0.381
LIG_TYR_ITIM 412 417 PF00017 0.511
LIG_TYR_ITSM 194 201 PF00017 0.487
LIG_WRC_WIRS_1 191 196 PF05994 0.378
LIG_WRC_WIRS_1 230 235 PF05994 0.442
LIG_WRC_WIRS_1 709 714 PF05994 0.515
MOD_CK1_1 146 152 PF00069 0.611
MOD_CK1_1 185 191 PF00069 0.545
MOD_CK1_1 193 199 PF00069 0.560
MOD_CK1_1 200 206 PF00069 0.597
MOD_CK1_1 319 325 PF00069 0.510
MOD_CK1_1 367 373 PF00069 0.514
MOD_CK1_1 506 512 PF00069 0.404
MOD_CK1_1 534 540 PF00069 0.425
MOD_CK1_1 629 635 PF00069 0.454
MOD_CK1_1 667 673 PF00069 0.469
MOD_CK1_1 751 757 PF00069 0.402
MOD_CK1_1 8 14 PF00069 0.384
MOD_CK1_1 85 91 PF00069 0.381
MOD_CK2_1 229 235 PF00069 0.514
MOD_CK2_1 290 296 PF00069 0.511
MOD_CK2_1 356 362 PF00069 0.573
MOD_CK2_1 393 399 PF00069 0.485
MOD_CK2_1 491 497 PF00069 0.427
MOD_CK2_1 609 615 PF00069 0.392
MOD_CK2_1 697 703 PF00069 0.523
MOD_Cter_Amidation 169 172 PF01082 0.484
MOD_GlcNHglycan 159 162 PF01048 0.527
MOD_GlcNHglycan 36 40 PF01048 0.476
MOD_GlcNHglycan 404 408 PF01048 0.321
MOD_GlcNHglycan 505 508 PF01048 0.507
MOD_GlcNHglycan 526 529 PF01048 0.396
MOD_GlcNHglycan 533 536 PF01048 0.490
MOD_GlcNHglycan 98 101 PF01048 0.380
MOD_GSK3_1 1 8 PF00069 0.464
MOD_GSK3_1 110 117 PF00069 0.502
MOD_GSK3_1 120 127 PF00069 0.399
MOD_GSK3_1 143 150 PF00069 0.575
MOD_GSK3_1 176 183 PF00069 0.571
MOD_GSK3_1 190 197 PF00069 0.622
MOD_GSK3_1 218 225 PF00069 0.538
MOD_GSK3_1 353 360 PF00069 0.538
MOD_GSK3_1 366 373 PF00069 0.574
MOD_GSK3_1 399 406 PF00069 0.482
MOD_GSK3_1 487 494 PF00069 0.422
MOD_GSK3_1 499 506 PF00069 0.419
MOD_GSK3_1 529 536 PF00069 0.463
MOD_GSK3_1 598 605 PF00069 0.424
MOD_GSK3_1 625 632 PF00069 0.504
MOD_GSK3_1 652 659 PF00069 0.449
MOD_GSK3_1 708 715 PF00069 0.466
MOD_GSK3_1 743 750 PF00069 0.545
MOD_GSK3_1 78 85 PF00069 0.433
MOD_N-GLC_1 157 162 PF02516 0.514
MOD_N-GLC_1 524 529 PF02516 0.517
MOD_N-GLC_2 255 257 PF02516 0.391
MOD_N-GLC_2 318 320 PF02516 0.311
MOD_N-GLC_2 565 567 PF02516 0.387
MOD_NEK2_1 120 125 PF00069 0.352
MOD_NEK2_1 147 152 PF00069 0.609
MOD_NEK2_1 176 181 PF00069 0.567
MOD_NEK2_1 182 187 PF00069 0.501
MOD_NEK2_1 238 243 PF00069 0.524
MOD_NEK2_1 24 29 PF00069 0.444
MOD_NEK2_1 269 274 PF00069 0.545
MOD_NEK2_1 35 40 PF00069 0.380
MOD_NEK2_1 366 371 PF00069 0.511
MOD_NEK2_1 403 408 PF00069 0.484
MOD_NEK2_1 533 538 PF00069 0.528
MOD_NEK2_1 595 600 PF00069 0.315
MOD_NEK2_1 626 631 PF00069 0.428
MOD_NEK2_1 664 669 PF00069 0.519
MOD_NEK2_1 712 717 PF00069 0.404
MOD_NEK2_1 747 752 PF00069 0.445
MOD_NEK2_1 758 763 PF00069 0.594
MOD_NEK2_1 78 83 PF00069 0.443
MOD_NEK2_2 218 223 PF00069 0.435
MOD_NEK2_2 718 723 PF00069 0.492
MOD_NEK2_2 737 742 PF00069 0.196
MOD_PIKK_1 506 512 PF00454 0.393
MOD_PIKK_1 664 670 PF00454 0.349
MOD_PIKK_1 697 703 PF00454 0.446
MOD_PIKK_1 745 751 PF00454 0.407
MOD_PK_1 610 616 PF00069 0.369
MOD_PK_1 684 690 PF00069 0.508
MOD_PK_1 753 759 PF00069 0.415
MOD_PKA_1 642 648 PF00069 0.401
MOD_PKA_2 120 126 PF00069 0.380
MOD_PKA_2 222 228 PF00069 0.398
MOD_PKA_2 367 373 PF00069 0.440
MOD_PKA_2 394 400 PF00069 0.424
MOD_PKA_2 523 529 PF00069 0.320
MOD_PKA_2 609 615 PF00069 0.458
MOD_PKA_2 642 648 PF00069 0.446
MOD_PKA_2 652 658 PF00069 0.421
MOD_PKA_2 703 709 PF00069 0.373
MOD_PKB_1 608 616 PF00069 0.362
MOD_Plk_1 157 163 PF00069 0.520
MOD_Plk_1 203 209 PF00069 0.481
MOD_Plk_1 344 350 PF00069 0.521
MOD_Plk_1 399 405 PF00069 0.552
MOD_Plk_1 5 11 PF00069 0.581
MOD_Plk_1 524 530 PF00069 0.449
MOD_Plk_1 539 545 PF00069 0.505
MOD_Plk_1 702 708 PF00069 0.384
MOD_Plk_1 737 743 PF00069 0.419
MOD_Plk_2-3 399 405 PF00069 0.511
MOD_Plk_4 114 120 PF00069 0.416
MOD_Plk_4 124 130 PF00069 0.365
MOD_Plk_4 190 196 PF00069 0.546
MOD_Plk_4 197 203 PF00069 0.494
MOD_Plk_4 261 267 PF00069 0.567
MOD_Plk_4 269 275 PF00069 0.526
MOD_Plk_4 310 316 PF00069 0.561
MOD_Plk_4 5 11 PF00069 0.452
MOD_Plk_4 513 519 PF00069 0.389
MOD_Plk_4 581 587 PF00069 0.442
MOD_Plk_4 634 640 PF00069 0.419
MOD_Plk_4 658 664 PF00069 0.413
MOD_Plk_4 708 714 PF00069 0.423
MOD_Plk_4 718 724 PF00069 0.343
MOD_Plk_4 737 743 PF00069 0.198
MOD_Plk_4 753 759 PF00069 0.271
MOD_Plk_4 78 84 PF00069 0.356
MOD_ProDKin_1 243 249 PF00069 0.515
MOD_ProDKin_1 290 296 PF00069 0.468
MOD_ProDKin_1 319 325 PF00069 0.569
MOD_ProDKin_1 670 676 PF00069 0.561
MOD_SUMO_rev_2 486 495 PF00179 0.500
MOD_SUMO_rev_2 73 78 PF00179 0.395
TRG_DiLeu_BaEn_1 111 116 PF01217 0.461
TRG_DiLeu_BaEn_1 476 481 PF01217 0.523
TRG_DiLeu_BaEn_1 720 725 PF01217 0.413
TRG_DiLeu_BaEn_1 73 78 PF01217 0.436
TRG_DiLeu_BaEn_4 73 79 PF01217 0.359
TRG_ENDOCYTIC_2 198 201 PF00928 0.492
TRG_ENDOCYTIC_2 227 230 PF00928 0.482
TRG_ENDOCYTIC_2 266 269 PF00928 0.492
TRG_ENDOCYTIC_2 325 328 PF00928 0.502
TRG_ENDOCYTIC_2 340 343 PF00928 0.377
TRG_ENDOCYTIC_2 414 417 PF00928 0.499
TRG_ENDOCYTIC_2 429 432 PF00928 0.457
TRG_ENDOCYTIC_2 9 12 PF00928 0.354
TRG_ER_diArg_1 561 563 PF00400 0.358
TRG_ER_diArg_1 607 610 PF00400 0.378
TRG_NES_CRM1_1 254 267 PF08389 0.227
TRG_Pf-PMV_PEXEL_1 106 111 PF00026 0.489
TRG_Pf-PMV_PEXEL_1 22 26 PF00026 0.470
TRG_Pf-PMV_PEXEL_1 341 345 PF00026 0.324
TRG_Pf-PMV_PEXEL_1 379 383 PF00026 0.263
TRG_Pf-PMV_PEXEL_1 76 80 PF00026 0.403

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF13 Leptomonas seymouri 48% 100%
A0A1X0P7A0 Trypanosomatidae 25% 100%
A0A3R7KWU1 Trypanosoma rangeli 27% 100%
A4H9L6 Leishmania braziliensis 72% 100%
A4HXY0 Leishmania infantum 100% 100%
D0A5C8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9ARP3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QDT6 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS