Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB53_LEIDO

TriTrypDb:

LdBPK_181370.1 , LdCL_180019000 , LDHU3_18.1750

Length:

258

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IB53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.585
CLV_NRD_NRD_1	182	184	PF00675	0.651
CLV_NRD_NRD_1	40	42	PF00675	0.460
CLV_NRD_NRD_1	79	81	PF00675	0.328
CLV_PCSK_KEX2_1	182	184	PF00082	0.556
CLV_PCSK_KEX2_1	35	37	PF00082	0.432
CLV_PCSK_KEX2_1	39	41	PF00082	0.457
CLV_PCSK_KEX2_1	79	81	PF00082	0.328
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.393
CLV_PCSK_PC7_1	36	42	PF00082	0.448
CLV_PCSK_SKI1_1	74	78	PF00082	0.339
DEG_Nend_UBRbox_3	1	3	PF02207	0.611
DOC_MAPK_gen_1	35	46	PF00069	0.649
DOC_MAPK_gen_1	79	87	PF00069	0.566
DOC_MAPK_MEF2A_6	39	48	PF00069	0.689
DOC_MAPK_MEF2A_6	86	95	PF00069	0.486
DOC_PP1_RVXF_1	77	84	PF00149	0.560
DOC_PP2B_LxvP_1	69	72	PF13499	0.565
DOC_USP7_UBL2_3	9	13	PF12436	0.652
DOC_WW_Pin1_4	115	120	PF00397	0.334
DOC_WW_Pin1_4	185	190	PF00397	0.351
LIG_14-3-3_CanoR_1	133	140	PF00244	0.275
LIG_14-3-3_CanoR_1	252	258	PF00244	0.641
LIG_14-3-3_CanoR_1	59	66	PF00244	0.619
LIG_14-3-3_CanoR_1	74	83	PF00244	0.527
LIG_Clathr_ClatBox_1	4	8	PF01394	0.600
LIG_FHA_1	43	49	PF00498	0.626
LIG_LIR_Gen_1	124	132	PF02991	0.307
LIG_LIR_Gen_1	191	200	PF02991	0.281
LIG_LIR_Gen_1	239	249	PF02991	0.666
LIG_LIR_Gen_1	63	73	PF02991	0.570
LIG_LIR_Nem_3	191	196	PF02991	0.321
LIG_LIR_Nem_3	63	69	PF02991	0.528
LIG_PDZ_Class_1	253	258	PF00595	0.641
LIG_SH2_CRK	66	70	PF00017	0.561
LIG_SH2_NCK_1	134	138	PF00017	0.315
LIG_SH2_STAP1	125	129	PF00017	0.358
LIG_SH2_STAP1	134	138	PF00017	0.279
LIG_SH2_STAP1	66	70	PF00017	0.554
LIG_SH2_STAT5	107	110	PF00017	0.443
LIG_SH2_STAT5	195	198	PF00017	0.332
LIG_SH2_STAT5	6	9	PF00017	0.607
LIG_SH3_1	183	189	PF00018	0.356
LIG_SH3_3	183	189	PF00018	0.410
LIG_SUMO_SIM_anti_2	97	103	PF11976	0.407
LIG_SUMO_SIM_par_1	100	106	PF11976	0.405
LIG_SUMO_SIM_par_1	218	226	PF11976	0.620
LIG_SUMO_SIM_par_1	91	97	PF11976	0.330
LIG_TRAF2_1	189	192	PF00917	0.389
LIG_TRAF2_1	234	237	PF00917	0.616
LIG_TYR_ITIM	198	203	PF00017	0.306
LIG_UBA3_1	26	35	PF00899	0.572
LIG_UBA3_1	4	9	PF00899	0.621
LIG_ULM_U2AF65_1	79	84	PF00076	0.532
MOD_CK1_1	231	237	PF00069	0.622
MOD_CK2_1	185	191	PF00069	0.380
MOD_CK2_1	231	237	PF00069	0.667
MOD_GlcNHglycan	230	233	PF01048	0.524
MOD_GSK3_1	42	49	PF00069	0.612
MOD_PIKK_1	250	256	PF00454	0.657
MOD_PKA_1	35	41	PF00069	0.603
MOD_PKA_2	132	138	PF00069	0.270
MOD_PKA_2	35	41	PF00069	0.697
MOD_Plk_4	103	109	PF00069	0.410
MOD_ProDKin_1	115	121	PF00069	0.328
MOD_ProDKin_1	185	191	PF00069	0.352
MOD_SUMO_for_1	145	148	PF00179	0.358
TRG_DiLeu_BaEn_3	236	242	PF01217	0.631
TRG_DiLeu_BaEn_4	191	197	PF01217	0.340
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.590
TRG_ENDOCYTIC_2	125	128	PF00928	0.350
TRG_ENDOCYTIC_2	134	137	PF00928	0.270
TRG_ENDOCYTIC_2	195	198	PF00928	0.325
TRG_ENDOCYTIC_2	200	203	PF00928	0.301
TRG_ENDOCYTIC_2	66	69	PF00928	0.525
TRG_ENDOCYTIC_2	70	73	PF00928	0.606
TRG_ER_diArg_1	181	183	PF00400	0.332
TRG_ER_diArg_1	39	41	PF00400	0.638
TRG_ER_diArg_1	79	82	PF00400	0.521
TRG_NES_CRM1_1	152	165	PF08389	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JNI9	Bodo saltans	31%	72%
A0A1X0P730	Trypanosomatidae	46%	73%
A4H9P2	Leishmania braziliensis	80%	100%
A4HY09	Leishmania infantum	100%	100%
D0A587	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	74%
E9ARS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QDQ0	Leishmania major	96%	100%
V5BEH9	Trypanosoma cruzi	45%	91%