Meckel syndrome type 1 protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Meckel syndrome type 1 protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB52_LEIDO

TriTrypDb:

LdBPK_231750.1 , LdCL_230024600 , LDHU3_23.2320

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0032991	protein-containing complex	1	1
GO:0036038	MKS complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IB52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB52

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0030030	cell projection organization	4	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0006996	organelle organization	4	1
GO:0022607	cellular component assembly	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.684
CLV_NRD_NRD_1	156	158	PF00675	0.603
CLV_NRD_NRD_1	355	357	PF00675	0.584
CLV_NRD_NRD_1	394	396	PF00675	0.616
CLV_NRD_NRD_1	70	72	PF00675	0.601
CLV_PCSK_FUR_1	392	396	PF00082	0.620
CLV_PCSK_KEX2_1	156	158	PF00082	0.603
CLV_PCSK_KEX2_1	355	357	PF00082	0.584
CLV_PCSK_KEX2_1	392	394	PF00082	0.633
CLV_PCSK_KEX2_1	445	447	PF00082	0.683
CLV_PCSK_KEX2_1	70	72	PF00082	0.617
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.683
CLV_PCSK_SKI1_1	163	167	PF00082	0.507
CLV_PCSK_SKI1_1	19	23	PF00082	0.567
CLV_PCSK_SKI1_1	355	359	PF00082	0.593
CLV_PCSK_SKI1_1	63	67	PF00082	0.542
DEG_APCC_DBOX_1	14	22	PF00400	0.450
DEG_APCC_DBOX_1	354	362	PF00400	0.631
DEG_Nend_UBRbox_3	1	3	PF02207	0.635
DEG_SPOP_SBC_1	384	388	PF00917	0.696
DEG_SPOP_SBC_1	496	500	PF00917	0.547
DOC_ANK_TNKS_1	176	183	PF00023	0.524
DOC_CDC14_PxL_1	99	107	PF14671	0.560
DOC_CKS1_1	586	591	PF01111	0.416
DOC_CYCLIN_RxL_1	13	24	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	438	444	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	565	571	PF00134	0.547
DOC_MAPK_gen_1	11	18	PF00069	0.469
DOC_PP1_RVXF_1	17	24	PF00149	0.370
DOC_PP2B_LxvP_1	146	149	PF13499	0.609
DOC_PP2B_LxvP_1	565	568	PF13499	0.547
DOC_PP4_FxxP_1	120	123	PF00568	0.378
DOC_PP4_FxxP_1	531	534	PF00568	0.471
DOC_PP4_FxxP_1	539	542	PF00568	0.471
DOC_USP7_MATH_1	142	146	PF00917	0.696
DOC_USP7_MATH_1	207	211	PF00917	0.730
DOC_USP7_MATH_1	215	219	PF00917	0.765
DOC_USP7_MATH_1	233	237	PF00917	0.687
DOC_USP7_MATH_1	265	269	PF00917	0.547
DOC_USP7_MATH_1	330	334	PF00917	0.517
DOC_USP7_MATH_1	380	384	PF00917	0.671
DOC_USP7_MATH_1	385	389	PF00917	0.640
DOC_USP7_MATH_1	452	456	PF00917	0.560
DOC_USP7_MATH_1	496	500	PF00917	0.527
DOC_USP7_MATH_1	513	517	PF00917	0.422
DOC_USP7_MATH_1	543	547	PF00917	0.547
DOC_USP7_MATH_1	572	576	PF00917	0.547
DOC_USP7_MATH_2	55	61	PF00917	0.507
DOC_WW_Pin1_4	138	143	PF00397	0.667
DOC_WW_Pin1_4	182	187	PF00397	0.788
DOC_WW_Pin1_4	219	224	PF00397	0.643
DOC_WW_Pin1_4	437	442	PF00397	0.639
DOC_WW_Pin1_4	485	490	PF00397	0.579
DOC_WW_Pin1_4	51	56	PF00397	0.387
DOC_WW_Pin1_4	544	549	PF00397	0.514
DOC_WW_Pin1_4	577	582	PF00397	0.514
DOC_WW_Pin1_4	585	590	PF00397	0.514
LIG_14-3-3_CanoR_1	19	24	PF00244	0.477
LIG_14-3-3_CanoR_1	249	255	PF00244	0.442
LIG_14-3-3_CanoR_1	286	290	PF00244	0.438
LIG_14-3-3_CanoR_1	430	435	PF00244	0.691
LIG_14-3-3_CanoR_1	446	452	PF00244	0.632
LIG_14-3-3_CanoR_1	602	606	PF00244	0.547
LIG_14-3-3_CanoR_1	87	92	PF00244	0.661
LIG_Actin_WH2_2	344	361	PF00022	0.629
LIG_APCC_ABBA_1	59	64	PF00400	0.477
LIG_APCC_ABBAyCdc20_2	631	637	PF00400	0.514
LIG_Clathr_ClatBox_1	524	528	PF01394	0.547
LIG_deltaCOP1_diTrp_1	472	476	PF00928	0.547
LIG_DLG_GKlike_1	430	438	PF00625	0.690
LIG_FHA_1	20	26	PF00498	0.422
LIG_FHA_1	245	251	PF00498	0.500
LIG_FHA_1	272	278	PF00498	0.439
LIG_FHA_1	282	288	PF00498	0.368
LIG_FHA_1	472	478	PF00498	0.483
LIG_FHA_1	56	62	PF00498	0.557
LIG_FHA_1	560	566	PF00498	0.455
LIG_FHA_1	639	645	PF00498	0.508
LIG_FHA_2	594	600	PF00498	0.487
LIG_LIR_Apic_2	528	534	PF02991	0.474
LIG_LIR_Apic_2	536	542	PF02991	0.466
LIG_LIR_Gen_1	341	351	PF02991	0.710
LIG_LIR_Gen_1	455	464	PF02991	0.434
LIG_LIR_Gen_1	472	481	PF02991	0.446
LIG_LIR_Gen_1	503	513	PF02991	0.422
LIG_LIR_Nem_3	341	346	PF02991	0.717
LIG_LIR_Nem_3	455	461	PF02991	0.434
LIG_LIR_Nem_3	472	476	PF02991	0.446
LIG_LIR_Nem_3	503	509	PF02991	0.442
LIG_LIR_Nem_3	60	65	PF02991	0.486
LIG_NBox_RRM_1	23	33	PF00076	0.482
LIG_PCNA_TLS_4	122	129	PF02747	0.514
LIG_Pex14_2	531	535	PF04695	0.471
LIG_PTB_Apo_2	529	536	PF02174	0.493
LIG_REV1ctd_RIR_1	116	122	PF16727	0.379
LIG_REV1ctd_RIR_1	260	266	PF16727	0.518
LIG_SH2_CRK	28	32	PF00017	0.452
LIG_SH2_CRK	571	575	PF00017	0.514
LIG_SH2_NCK_1	571	575	PF00017	0.514
LIG_SH2_SRC	635	638	PF00017	0.514
LIG_SH2_STAP1	283	287	PF00017	0.364
LIG_SH2_STAP1	635	639	PF00017	0.514
LIG_SH2_STAT5	261	264	PF00017	0.582
LIG_SH2_STAT5	281	284	PF00017	0.243
LIG_SH3_2	545	550	PF14604	0.514
LIG_SH3_3	134	140	PF00018	0.595
LIG_SH3_3	399	405	PF00018	0.571
LIG_SH3_3	49	55	PF00018	0.446
LIG_SH3_3	539	545	PF00018	0.506
LIG_SH3_3	571	577	PF00018	0.514
LIG_SH3_3	583	589	PF00018	0.514
LIG_SUMO_SIM_par_1	522	528	PF11976	0.514
LIG_TYR_ITIM	569	574	PF00017	0.514
LIG_WRC_WIRS_1	282	287	PF05994	0.365
MOD_CDC14_SPxK_1	547	550	PF00782	0.514
MOD_CDK_SPxK_1	544	550	PF00069	0.514
MOD_CK1_1	222	228	PF00069	0.683
MOD_CK1_1	383	389	PF00069	0.700
MOD_CK1_1	425	431	PF00069	0.706
MOD_CK1_1	447	453	PF00069	0.525
MOD_CK1_1	498	504	PF00069	0.485
MOD_CK1_1	638	644	PF00069	0.521
MOD_CK1_1	80	86	PF00069	0.719
MOD_CK2_1	242	248	PF00069	0.492
MOD_CK2_1	335	341	PF00069	0.703
MOD_CK2_1	383	389	PF00069	0.668
MOD_CK2_1	51	57	PF00069	0.388
MOD_CK2_1	593	599	PF00069	0.487
MOD_CK2_1	66	72	PF00069	0.608
MOD_GlcNHglycan	217	220	PF01048	0.768
MOD_GlcNHglycan	224	227	PF01048	0.690
MOD_GlcNHglycan	244	247	PF01048	0.405
MOD_GlcNHglycan	406	409	PF01048	0.680
MOD_GlcNHglycan	446	449	PF01048	0.618
MOD_GlcNHglycan	81	85	PF01048	0.714
MOD_GlcNHglycan	89	92	PF01048	0.550
MOD_GSK3_1	138	145	PF00069	0.700
MOD_GSK3_1	213	220	PF00069	0.686
MOD_GSK3_1	240	247	PF00069	0.468
MOD_GSK3_1	261	268	PF00069	0.432
MOD_GSK3_1	281	288	PF00069	0.371
MOD_GSK3_1	380	387	PF00069	0.659
MOD_GSK3_1	418	425	PF00069	0.780
MOD_GSK3_1	494	501	PF00069	0.481
MOD_GSK3_1	51	58	PF00069	0.561
MOD_GSK3_1	638	645	PF00069	0.514
MOD_GSK3_1	73	80	PF00069	0.633
MOD_GSK3_1	87	94	PF00069	0.513
MOD_N-GLC_1	330	335	PF02516	0.497
MOD_N-GLC_1	97	102	PF02516	0.506
MOD_N-GLC_2	162	164	PF02516	0.547
MOD_NEK2_1	118	123	PF00069	0.392
MOD_NEK2_1	21	26	PF00069	0.293
MOD_NEK2_1	285	290	PF00069	0.398
MOD_NEK2_1	335	340	PF00069	0.637
MOD_NEK2_1	422	427	PF00069	0.631
MOD_NEK2_1	444	449	PF00069	0.563
MOD_NEK2_1	535	540	PF00069	0.503
MOD_NEK2_1	551	556	PF00069	0.519
MOD_NEK2_1	6	11	PF00069	0.546
MOD_NEK2_1	600	605	PF00069	0.471
MOD_NEK2_1	642	647	PF00069	0.520
MOD_NEK2_2	207	212	PF00069	0.610
MOD_NEK2_2	281	286	PF00069	0.479
MOD_NEK2_2	471	476	PF00069	0.484
MOD_NEK2_2	513	518	PF00069	0.422
MOD_PIKK_1	425	431	PF00454	0.706
MOD_PIKK_1	507	513	PF00454	0.471
MOD_PIKK_1	6	12	PF00454	0.510
MOD_PKA_2	110	116	PF00069	0.545
MOD_PKA_2	121	127	PF00069	0.425
MOD_PKA_2	285	291	PF00069	0.491
MOD_PKA_2	415	421	PF00069	0.732
MOD_PKA_2	452	458	PF00069	0.505
MOD_PKA_2	601	607	PF00069	0.543
MOD_Plk_1	233	239	PF00069	0.606
MOD_Plk_1	240	246	PF00069	0.596
MOD_Plk_1	42	48	PF00069	0.465
MOD_Plk_1	471	477	PF00069	0.483
MOD_Plk_1	535	541	PF00069	0.471
MOD_Plk_1	63	69	PF00069	0.514
MOD_Plk_1	97	103	PF00069	0.493
MOD_Plk_4	142	148	PF00069	0.613
MOD_Plk_4	271	277	PF00069	0.439
MOD_Plk_4	513	519	PF00069	0.515
MOD_Plk_4	57	63	PF00069	0.511
MOD_Plk_4	601	607	PF00069	0.506
MOD_Plk_4	91	97	PF00069	0.561
MOD_ProDKin_1	138	144	PF00069	0.667
MOD_ProDKin_1	182	188	PF00069	0.793
MOD_ProDKin_1	219	225	PF00069	0.643
MOD_ProDKin_1	437	443	PF00069	0.640
MOD_ProDKin_1	485	491	PF00069	0.579
MOD_ProDKin_1	51	57	PF00069	0.388
MOD_ProDKin_1	544	550	PF00069	0.514
MOD_ProDKin_1	577	583	PF00069	0.514
MOD_ProDKin_1	585	591	PF00069	0.514
MOD_SUMO_rev_2	34	38	PF00179	0.508
MOD_SUMO_rev_2	43	53	PF00179	0.377
TRG_DiLeu_BaEn_1	520	525	PF01217	0.547
TRG_DiLeu_BaEn_2	471	477	PF01217	0.514
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.522
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.547
TRG_ENDOCYTIC_2	28	31	PF00928	0.442
TRG_ENDOCYTIC_2	343	346	PF00928	0.640
TRG_ENDOCYTIC_2	458	461	PF00928	0.514
TRG_ENDOCYTIC_2	506	509	PF00928	0.541
TRG_ENDOCYTIC_2	571	574	PF00928	0.476
TRG_ENDOCYTIC_2	62	65	PF00928	0.483
TRG_ER_diArg_1	12	15	PF00400	0.464
TRG_ER_diArg_1	176	179	PF00400	0.580
TRG_ER_diArg_1	355	357	PF00400	0.584
TRG_ER_diArg_1	392	395	PF00400	0.623
TRG_NES_CRM1_1	522	536	PF08389	0.588
TRG_Pf-PMV_PEXEL_1	355	360	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B5	Leptomonas seymouri	53%	100%
A0A0S4IRB4	Bodo saltans	27%	82%
A4I0K7	Leishmania infantum	100%	100%
E9AWG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QB03	Leishmania major	90%	100%