Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB49_LEIDO

TriTrypDb:

LdBPK_180860.1 , LdCL_180013700 , LDHU3_18.1110

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IB49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.849
CLV_C14_Caspase3-7	315	319	PF00656	0.542
CLV_C14_Caspase3-7	623	627	PF00656	0.727
CLV_C14_Caspase3-7	787	791	PF00656	0.792
CLV_NRD_NRD_1	201	203	PF00675	0.666
CLV_NRD_NRD_1	28	30	PF00675	0.583
CLV_NRD_NRD_1	293	295	PF00675	0.782
CLV_NRD_NRD_1	42	44	PF00675	0.594
CLV_NRD_NRD_1	422	424	PF00675	0.724
CLV_NRD_NRD_1	433	435	PF00675	0.589
CLV_NRD_NRD_1	458	460	PF00675	0.654
CLV_NRD_NRD_1	576	578	PF00675	0.692
CLV_NRD_NRD_1	821	823	PF00675	0.772
CLV_PCSK_FUR_1	420	424	PF00082	0.704
CLV_PCSK_KEX2_1	201	203	PF00082	0.666
CLV_PCSK_KEX2_1	293	295	PF00082	0.814
CLV_PCSK_KEX2_1	41	43	PF00082	0.633
CLV_PCSK_KEX2_1	422	424	PF00082	0.725
CLV_PCSK_KEX2_1	433	435	PF00082	0.595
CLV_PCSK_KEX2_1	458	460	PF00082	0.654
CLV_PCSK_KEX2_1	576	578	PF00082	0.692
CLV_PCSK_KEX2_1	821	823	PF00082	0.772
CLV_PCSK_PC7_1	454	460	PF00082	0.644
CLV_PCSK_SKI1_1	433	437	PF00082	0.589
DEG_APCC_DBOX_1	40	48	PF00400	0.615
DEG_APCC_DBOX_1	433	441	PF00400	0.591
DEG_SCF_FBW7_1	117	124	PF00400	0.815
DEG_SCF_TRCP1_1	676	682	PF00400	0.718
DEG_SPOP_SBC_1	229	233	PF00917	0.630
DEG_SPOP_SBC_1	680	684	PF00917	0.789
DEG_SPOP_SBC_1	856	860	PF00917	0.707
DEG_SPOP_SBC_1	87	91	PF00917	0.791
DOC_CKS1_1	346	351	PF01111	0.577
DOC_CKS1_1	403	408	PF01111	0.569
DOC_CYCLIN_RxL_1	661	672	PF00134	0.640
DOC_MAPK_DCC_7	202	212	PF00069	0.677
DOC_MAPK_gen_1	147	156	PF00069	0.636
DOC_MAPK_gen_1	401	410	PF00069	0.573
DOC_MAPK_gen_1	41	49	PF00069	0.642
DOC_MAPK_MEF2A_6	204	212	PF00069	0.642
DOC_MAPK_MEF2A_6	401	410	PF00069	0.548
DOC_PP2B_LxvP_1	211	214	PF13499	0.762
DOC_PP2B_LxvP_1	518	521	PF13499	0.676
DOC_USP7_MATH_1	162	166	PF00917	0.464
DOC_USP7_MATH_1	2	6	PF00917	0.738
DOC_USP7_MATH_1	200	204	PF00917	0.671
DOC_USP7_MATH_1	220	224	PF00917	0.457
DOC_USP7_MATH_1	230	234	PF00917	0.538
DOC_USP7_MATH_1	297	301	PF00917	0.784
DOC_USP7_MATH_1	543	547	PF00917	0.689
DOC_USP7_MATH_1	57	61	PF00917	0.667
DOC_USP7_MATH_1	768	772	PF00917	0.747
DOC_USP7_MATH_1	782	786	PF00917	0.675
DOC_USP7_MATH_1	827	831	PF00917	0.613
DOC_USP7_MATH_1	855	859	PF00917	0.710
DOC_USP7_MATH_1	87	91	PF00917	0.771
DOC_WW_Pin1_4	117	122	PF00397	0.743
DOC_WW_Pin1_4	301	306	PF00397	0.610
DOC_WW_Pin1_4	335	340	PF00397	0.741
DOC_WW_Pin1_4	345	350	PF00397	0.519
DOC_WW_Pin1_4	378	383	PF00397	0.635
DOC_WW_Pin1_4	402	407	PF00397	0.561
DOC_WW_Pin1_4	465	470	PF00397	0.628
DOC_WW_Pin1_4	535	540	PF00397	0.736
DOC_WW_Pin1_4	624	629	PF00397	0.765
DOC_WW_Pin1_4	752	757	PF00397	0.795
LIG_14-3-3_CanoR_1	113	121	PF00244	0.745
LIG_14-3-3_CanoR_1	128	138	PF00244	0.799
LIG_14-3-3_CanoR_1	147	156	PF00244	0.549
LIG_14-3-3_CanoR_1	285	292	PF00244	0.710
LIG_14-3-3_CanoR_1	3	7	PF00244	0.637
LIG_14-3-3_CanoR_1	449	453	PF00244	0.676
LIG_14-3-3_CanoR_1	664	669	PF00244	0.652
LIG_14-3-3_CanoR_1	821	827	PF00244	0.761
LIG_EVH1_2	121	125	PF00568	0.808
LIG_FHA_1	234	240	PF00498	0.620
LIG_FHA_1	287	293	PF00498	0.706
LIG_FHA_1	322	328	PF00498	0.607
LIG_FHA_1	398	404	PF00498	0.566
LIG_FHA_1	542	548	PF00498	0.634
LIG_FHA_1	668	674	PF00498	0.766
LIG_FHA_1	681	687	PF00498	0.557
LIG_FHA_1	699	705	PF00498	0.335
LIG_FHA_1	76	82	PF00498	0.777
LIG_FHA_1	805	811	PF00498	0.556
LIG_FHA_1	841	847	PF00498	0.730
LIG_FHA_2	16	22	PF00498	0.595
LIG_FHA_2	313	319	PF00498	0.626
LIG_FHA_2	345	351	PF00498	0.556
LIG_FHA_2	525	531	PF00498	0.692
LIG_FHA_2	621	627	PF00498	0.728
LIG_FHA_2	762	768	PF00498	0.722
LIG_FHA_2	8	14	PF00498	0.689
LIG_IBAR_NPY_1	309	311	PF08397	0.734
LIG_LIR_Gen_1	151	160	PF02991	0.660
LIG_LIR_Gen_1	17	26	PF02991	0.611
LIG_LIR_Gen_1	350	361	PF02991	0.558
LIG_LIR_Gen_1	801	811	PF02991	0.618
LIG_LIR_Nem_3	151	156	PF02991	0.655
LIG_LIR_Nem_3	172	176	PF02991	0.566
LIG_LIR_Nem_3	308	314	PF02991	0.650
LIG_LIR_Nem_3	350	356	PF02991	0.555
LIG_LIR_Nem_3	513	518	PF02991	0.587
LIG_LIR_Nem_3	801	806	PF02991	0.621
LIG_MYND_1	183	187	PF01753	0.730
LIG_PCNA_yPIPBox_3	568	577	PF02747	0.657
LIG_PCNA_yPIPBox_3	659	669	PF02747	0.642
LIG_PDZ_Class_1	865	870	PF00595	0.795
LIG_Pex14_2	169	173	PF04695	0.608
LIG_Pex14_2	698	702	PF04695	0.599
LIG_RPA_C_Fungi	144	156	PF08784	0.655
LIG_SH2_CRK	260	264	PF00017	0.638
LIG_SH2_NCK_1	314	318	PF00017	0.630
LIG_SH2_SRC	642	645	PF00017	0.766
LIG_SH2_STAP1	150	154	PF00017	0.633
LIG_SH2_STAT5	14	17	PF00017	0.608
LIG_SH2_STAT5	311	314	PF00017	0.654
LIG_SH2_STAT5	497	500	PF00017	0.593
LIG_SH2_STAT5	559	562	PF00017	0.655
LIG_SH2_STAT5	642	645	PF00017	0.552
LIG_SH2_STAT5	714	717	PF00017	0.676
LIG_SH3_2	135	140	PF14604	0.789
LIG_SH3_3	1	7	PF00018	0.815
LIG_SH3_3	132	138	PF00018	0.676
LIG_SH3_3	299	305	PF00018	0.766
LIG_SH3_3	343	349	PF00018	0.595
LIG_SH3_3	368	374	PF00018	0.743
LIG_SH3_3	400	406	PF00018	0.568
LIG_SH3_3	463	469	PF00018	0.609
LIG_SH3_3	518	524	PF00018	0.751
LIG_SH3_3	536	542	PF00018	0.513
LIG_SH3_3	707	713	PF00018	0.608
LIG_SUMO_SIM_anti_2	324	329	PF11976	0.541
LIG_SUMO_SIM_par_1	664	672	PF11976	0.604
LIG_SUMO_SIM_par_1	77	86	PF11976	0.780
LIG_WRC_WIRS_1	16	21	PF05994	0.587
MOD_CDC14_SPxK_1	538	541	PF00782	0.698
MOD_CDK_SPxK_1	535	541	PF00069	0.698
MOD_CDK_SPxxK_3	378	385	PF00069	0.716
MOD_CK1_1	103	109	PF00069	0.497
MOD_CK1_1	112	118	PF00069	0.738
MOD_CK1_1	126	132	PF00069	0.740
MOD_CK1_1	215	221	PF00069	0.700
MOD_CK1_1	231	237	PF00069	0.612
MOD_CK1_1	300	306	PF00069	0.717
MOD_CK1_1	338	344	PF00069	0.737
MOD_CK1_1	381	387	PF00069	0.634
MOD_CK1_1	465	471	PF00069	0.616
MOD_CK1_1	60	66	PF00069	0.691
MOD_CK1_1	611	617	PF00069	0.800
MOD_CK1_1	645	651	PF00069	0.627
MOD_CK1_1	667	673	PF00069	0.751
MOD_CK1_1	682	688	PF00069	0.561
MOD_CK1_1	71	77	PF00069	0.755
MOD_CK1_1	728	734	PF00069	0.685
MOD_CK1_1	785	791	PF00069	0.723
MOD_CK1_1	794	800	PF00069	0.685
MOD_CK1_1	83	89	PF00069	0.675
MOD_CK1_1	91	97	PF00069	0.550
MOD_CK2_1	344	350	PF00069	0.616
MOD_CK2_1	820	826	PF00069	0.755
MOD_CK2_1	87	93	PF00069	0.715
MOD_DYRK1A_RPxSP_1	301	305	PF00069	0.602
MOD_GlcNHglycan	102	105	PF01048	0.774
MOD_GlcNHglycan	125	128	PF01048	0.746
MOD_GlcNHglycan	150	153	PF01048	0.652
MOD_GlcNHglycan	160	163	PF01048	0.619
MOD_GlcNHglycan	164	167	PF01048	0.609
MOD_GlcNHglycan	214	217	PF01048	0.712
MOD_GlcNHglycan	330	333	PF01048	0.553
MOD_GlcNHglycan	375	378	PF01048	0.724
MOD_GlcNHglycan	426	429	PF01048	0.589
MOD_GlcNHglycan	473	476	PF01048	0.477
MOD_GlcNHglycan	491	494	PF01048	0.681
MOD_GlcNHglycan	560	563	PF01048	0.588
MOD_GlcNHglycan	59	62	PF01048	0.780
MOD_GlcNHglycan	608	611	PF01048	0.747
MOD_GlcNHglycan	613	616	PF01048	0.770
MOD_GlcNHglycan	644	647	PF01048	0.698
MOD_GlcNHglycan	676	679	PF01048	0.756
MOD_GlcNHglycan	686	689	PF01048	0.627
MOD_GlcNHglycan	70	73	PF01048	0.638
MOD_GlcNHglycan	780	783	PF01048	0.724
MOD_GlcNHglycan	784	787	PF01048	0.728
MOD_GlcNHglycan	800	803	PF01048	0.410
MOD_GlcNHglycan	817	820	PF01048	0.739
MOD_GlcNHglycan	829	832	PF01048	0.777
MOD_GlcNHglycan	97	100	PF01048	0.811
MOD_GSK3_1	100	107	PF00069	0.617
MOD_GSK3_1	108	115	PF00069	0.679
MOD_GSK3_1	117	124	PF00069	0.732
MOD_GSK3_1	126	133	PF00069	0.789
MOD_GSK3_1	158	165	PF00069	0.488
MOD_GSK3_1	221	228	PF00069	0.750
MOD_GSK3_1	229	236	PF00069	0.745
MOD_GSK3_1	276	283	PF00069	0.711
MOD_GSK3_1	297	304	PF00069	0.808
MOD_GSK3_1	341	348	PF00069	0.664
MOD_GSK3_1	369	376	PF00069	0.632
MOD_GSK3_1	489	496	PF00069	0.594
MOD_GSK3_1	524	531	PF00069	0.582
MOD_GSK3_1	541	548	PF00069	0.598
MOD_GSK3_1	56	63	PF00069	0.692
MOD_GSK3_1	604	611	PF00069	0.754
MOD_GSK3_1	616	623	PF00069	0.659
MOD_GSK3_1	680	687	PF00069	0.701
MOD_GSK3_1	71	78	PF00069	0.775
MOD_GSK3_1	736	743	PF00069	0.768
MOD_GSK3_1	778	785	PF00069	0.782
MOD_GSK3_1	794	801	PF00069	0.548
MOD_GSK3_1	82	89	PF00069	0.639
MOD_GSK3_1	91	98	PF00069	0.791
MOD_N-GLC_1	567	572	PF02516	0.707
MOD_NEK2_1	15	20	PF00069	0.618
MOD_NEK2_1	312	317	PF00069	0.693
MOD_NEK2_1	323	328	PF00069	0.472
MOD_NEK2_1	356	361	PF00069	0.574
MOD_NEK2_1	424	429	PF00069	0.702
MOD_NEK2_1	470	475	PF00069	0.616
MOD_NEK2_1	528	533	PF00069	0.713
MOD_NEK2_1	558	563	PF00069	0.584
MOD_NEK2_1	698	703	PF00069	0.602
MOD_NEK2_2	524	529	PF00069	0.726
MOD_PIKK_1	2	8	PF00454	0.728
MOD_PIKK_1	785	791	PF00454	0.793
MOD_PIKK_1	840	846	PF00454	0.800
MOD_PKA_1	422	428	PF00069	0.686
MOD_PKA_1	736	742	PF00069	0.801
MOD_PKA_2	112	118	PF00069	0.748
MOD_PKA_2	127	133	PF00069	0.552
MOD_PKA_2	148	154	PF00069	0.680
MOD_PKA_2	158	164	PF00069	0.593
MOD_PKA_2	2	8	PF00069	0.636
MOD_PKA_2	200	206	PF00069	0.658
MOD_PKA_2	284	290	PF00069	0.724
MOD_PKA_2	300	306	PF00069	0.645
MOD_PKA_2	422	428	PF00069	0.692
MOD_PKA_2	448	454	PF00069	0.672
MOD_PKA_2	815	821	PF00069	0.713
MOD_PKA_2	91	97	PF00069	0.620
MOD_PKB_1	420	428	PF00069	0.689
MOD_PKB_1	606	614	PF00069	0.710
MOD_Plk_1	567	573	PF00069	0.701
MOD_Plk_2-3	448	454	PF00069	0.620
MOD_Plk_4	181	187	PF00069	0.696
MOD_Plk_4	233	239	PF00069	0.584
MOD_Plk_4	323	329	PF00069	0.538
MOD_Plk_4	356	362	PF00069	0.563
MOD_Plk_4	462	468	PF00069	0.683
MOD_Plk_4	493	499	PF00069	0.557
MOD_Plk_4	768	774	PF00069	0.733
MOD_ProDKin_1	117	123	PF00069	0.742
MOD_ProDKin_1	301	307	PF00069	0.608
MOD_ProDKin_1	335	341	PF00069	0.735
MOD_ProDKin_1	345	351	PF00069	0.521
MOD_ProDKin_1	378	384	PF00069	0.627
MOD_ProDKin_1	402	408	PF00069	0.561
MOD_ProDKin_1	465	471	PF00069	0.629
MOD_ProDKin_1	535	541	PF00069	0.737
MOD_ProDKin_1	624	630	PF00069	0.762
MOD_ProDKin_1	752	758	PF00069	0.796
MOD_SUMO_rev_2	598	604	PF00179	0.805
TRG_DiLeu_BaEn_1	432	437	PF01217	0.672
TRG_DiLeu_BaEn_2	171	177	PF01217	0.609
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.493
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.647
TRG_DiLeu_BaLyEn_6	570	575	PF01217	0.657
TRG_ENDOCYTIC_2	641	644	PF00928	0.710
TRG_ENDOCYTIC_2	714	717	PF00928	0.676
TRG_ENDOCYTIC_2	724	727	PF00928	0.668
TRG_ER_diArg_1	147	150	PF00400	0.656
TRG_ER_diArg_1	156	159	PF00400	0.679
TRG_ER_diArg_1	201	204	PF00400	0.628
TRG_ER_diArg_1	292	294	PF00400	0.784
TRG_ER_diArg_1	41	43	PF00400	0.636
TRG_ER_diArg_1	420	423	PF00400	0.674
TRG_ER_diArg_1	433	435	PF00400	0.595
TRG_ER_diArg_1	458	460	PF00400	0.654
TRG_ER_diArg_1	575	577	PF00400	0.684
TRG_ER_diArg_1	744	747	PF00400	0.715
TRG_ER_diArg_1	820	822	PF00400	0.750
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	573	578	PF00026	0.686
TRG_PTS1	867	870	PF00515	0.725

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBC4	Leptomonas seymouri	50%	100%
A0A422P1W2	Trypanosoma rangeli	24%	100%
A4H9S5	Leishmania braziliensis	77%	100%
A4HXW0	Leishmania infantum	100%	100%
E9ARM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QDV6	Leishmania major	90%	100%