Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB47_LEIDO

TriTrypDb:

LdBPK_211010.1 , LdCL_210015100 , LDHU3_21.1200

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IB47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB47

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0051087	protein-folding chaperone binding	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.703
CLV_C14_Caspase3-7	226	230	PF00656	0.656
CLV_NRD_NRD_1	132	134	PF00675	0.549
CLV_NRD_NRD_1	157	159	PF00675	0.338
CLV_NRD_NRD_1	186	188	PF00675	0.424
CLV_NRD_NRD_1	272	274	PF00675	0.358
CLV_NRD_NRD_1	285	287	PF00675	0.419
CLV_NRD_NRD_1	97	99	PF00675	0.517
CLV_PCSK_KEX2_1	132	134	PF00082	0.550
CLV_PCSK_KEX2_1	157	159	PF00082	0.338
CLV_PCSK_KEX2_1	185	187	PF00082	0.420
CLV_PCSK_KEX2_1	272	274	PF00082	0.342
CLV_PCSK_KEX2_1	285	287	PF00082	0.419
CLV_PCSK_KEX2_1	97	99	PF00082	0.534
CLV_PCSK_SKI1_1	157	161	PF00082	0.393
CLV_PCSK_SKI1_1	273	277	PF00082	0.379
DEG_Nend_Nbox_1	1	3	PF02207	0.464
DOC_ANK_TNKS_1	132	139	PF00023	0.618
DOC_MAPK_DCC_7	286	296	PF00069	0.617
DOC_PP4_FxxP_1	144	147	PF00568	0.607
DOC_USP7_MATH_1	110	114	PF00917	0.789
DOC_USP7_MATH_1	13	17	PF00917	0.515
DOC_USP7_MATH_1	147	151	PF00917	0.529
DOC_USP7_MATH_1	213	217	PF00917	0.701
DOC_USP7_MATH_1	25	29	PF00917	0.445
DOC_USP7_UBL2_3	270	274	PF12436	0.601
DOC_WW_Pin1_4	21	26	PF00397	0.506
DOC_WW_Pin1_4	285	290	PF00397	0.604
DOC_WW_Pin1_4	36	41	PF00397	0.494
LIG_14-3-3_CanoR_1	97	106	PF00244	0.745
LIG_BRCT_BRCA1_1	149	153	PF00533	0.571
LIG_FHA_1	250	256	PF00498	0.554
LIG_FHA_1	282	288	PF00498	0.590
LIG_FHA_1	75	81	PF00498	0.324
LIG_FHA_2	170	176	PF00498	0.662
LIG_LIR_Apic_2	141	147	PF02991	0.624
LIG_LIR_Gen_1	150	159	PF02991	0.549
LIG_LIR_Nem_3	149	155	PF02991	0.538
LIG_LIR_Nem_3	39	45	PF02991	0.497
LIG_MLH1_MIPbox_1	149	153	PF16413	0.571
LIG_Rb_LxCxE_1	118	137	PF01857	0.624
LIG_SH2_NCK_1	20	24	PF00017	0.500
LIG_SH2_NCK_1	65	69	PF00017	0.353
LIG_SH2_SRC	63	66	PF00017	0.409
LIG_SH2_STAP1	65	69	PF00017	0.353
LIG_SH2_STAT3	59	62	PF00017	0.443
LIG_SH2_STAT5	155	158	PF00017	0.592
LIG_SH2_STAT5	173	176	PF00017	0.570
LIG_SH2_STAT5	63	66	PF00017	0.409
LIG_SH3_1	286	292	PF00018	0.624
LIG_SH3_3	286	292	PF00018	0.619
LIG_SH3_3	34	40	PF00018	0.482
LIG_SH3_3	7	13	PF00018	0.485
LIG_UBA3_1	44	51	PF00899	0.493
MOD_CDK_SPxxK_3	36	43	PF00069	0.507
MOD_CK1_1	100	106	PF00069	0.672
MOD_CK1_1	16	22	PF00069	0.436
MOD_CK1_1	28	34	PF00069	0.474
MOD_CK1_1	4	10	PF00069	0.485
MOD_CK1_1	46	52	PF00069	0.489
MOD_CK2_1	169	175	PF00069	0.545
MOD_Cter_Amidation	95	98	PF01082	0.525
MOD_GlcNHglycan	112	115	PF01048	0.506
MOD_GlcNHglycan	14	18	PF01048	0.692
MOD_GlcNHglycan	149	152	PF01048	0.351
MOD_GlcNHglycan	219	222	PF01048	0.502
MOD_GlcNHglycan	229	232	PF01048	0.443
MOD_GlcNHglycan	33	36	PF01048	0.748
MOD_GlcNHglycan	4	7	PF01048	0.764
MOD_GlcNHglycan	66	69	PF01048	0.378
MOD_GlcNHglycan	99	102	PF01048	0.515
MOD_GSK3_1	1	8	PF00069	0.471
MOD_GSK3_1	147	154	PF00069	0.655
MOD_GSK3_1	169	176	PF00069	0.576
MOD_GSK3_1	21	28	PF00069	0.491
MOD_GSK3_1	213	220	PF00069	0.769
MOD_GSK3_1	281	288	PF00069	0.623
MOD_GSK3_1	46	53	PF00069	0.434
MOD_GSK3_1	72	79	PF00069	0.409
MOD_N-GLC_1	208	213	PF02516	0.504
MOD_NEK2_1	1	6	PF00069	0.532
MOD_NEK2_1	29	34	PF00069	0.579
MOD_NEK2_1	44	49	PF00069	0.383
MOD_NEK2_1	72	77	PF00069	0.377
MOD_PIKK_1	249	255	PF00454	0.511
MOD_PIKK_1	46	52	PF00454	0.509
MOD_PKA_1	97	103	PF00069	0.737
MOD_PKA_2	263	269	PF00069	0.690
MOD_PKA_2	97	103	PF00069	0.743
MOD_Plk_1	190	196	PF00069	0.597
MOD_Plk_4	169	175	PF00069	0.567
MOD_Plk_4	190	196	PF00069	0.654
MOD_Plk_4	76	82	PF00069	0.409
MOD_ProDKin_1	21	27	PF00069	0.505
MOD_ProDKin_1	285	291	PF00069	0.604
MOD_ProDKin_1	36	42	PF00069	0.490
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.575
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.463
TRG_ER_diArg_1	156	158	PF00400	0.540
TRG_ER_diArg_1	184	187	PF00400	0.627
TRG_ER_diArg_1	285	287	PF00400	0.619
TRG_ER_diArg_1	97	99	PF00400	0.708
TRG_NES_CRM1_1	253	267	PF08389	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P829	Leptomonas seymouri	39%	100%
A0A1X0NYB3	Trypanosomatidae	30%	75%
A4HBT9	Leishmania braziliensis	69%	99%
A4HZ86	Leishmania infantum	99%	100%
E9AV61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QCC0	Leishmania major	89%	100%