DNA translocase FtsK

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB46_LEIDO

TriTrypDb:

LdBPK_190020.1 , LdCL_190005100 , LDHU3_19.0020

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IB46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	129	135	PF00400	0.586
DOC_CKS1_1	129	134	PF01111	0.522
DOC_CKS1_1	29	34	PF01111	0.600
DOC_USP7_MATH_1	171	175	PF00917	0.689
DOC_USP7_MATH_1	202	206	PF00917	0.662
DOC_USP7_MATH_1	54	58	PF00917	0.697
DOC_WW_Pin1_4	128	133	PF00397	0.520
DOC_WW_Pin1_4	15	20	PF00397	0.704
DOC_WW_Pin1_4	28	33	PF00397	0.731
LIG_14-3-3_CanoR_1	152	157	PF00244	0.676
LIG_14-3-3_CanoR_1	225	232	PF00244	0.608
LIG_14-3-3_CanoR_1	237	244	PF00244	0.571
LIG_14-3-3_CanoR_1	246	250	PF00244	0.678
LIG_14-3-3_CanoR_1	3	9	PF00244	0.610
LIG_14-3-3_CanoR_1	99	104	PF00244	0.621
LIG_BRCT_BRCA1_1	190	194	PF00533	0.677
LIG_FHA_1	144	150	PF00498	0.648
LIG_MAD2	99	107	PF02301	0.559
LIG_Pex14_2	222	226	PF04695	0.646
LIG_SH2_GRB2like	180	183	PF00017	0.575
LIG_SH2_STAT5	93	96	PF00017	0.493
LIG_SH3_1	30	36	PF00018	0.457
LIG_SH3_3	100	106	PF00018	0.545
LIG_SH3_3	126	132	PF00018	0.534
LIG_SH3_3	138	144	PF00018	0.554
LIG_SH3_3	26	32	PF00018	0.735
LIG_SH3_3	33	39	PF00018	0.732
LIG_SH3_3	48	54	PF00018	0.733
LIG_SH3_3	64	70	PF00018	0.683
LIG_SH3_3	76	82	PF00018	0.558
LIG_SH3_3	85	91	PF00018	0.621
LIG_SUMO_SIM_par_1	93	98	PF11976	0.494
LIG_TRAF2_1	57	60	PF00917	0.708
LIG_WW_3	105	109	PF00397	0.571
MOD_CDC14_SPxK_1	20	23	PF00782	0.621
MOD_CDK_SPxK_1	17	23	PF00069	0.618
MOD_CK1_1	155	161	PF00069	0.628
MOD_CK1_1	205	211	PF00069	0.690
MOD_CK1_1	248	254	PF00069	0.687
MOD_CK2_1	38	44	PF00069	0.628
MOD_CK2_1	54	60	PF00069	0.601
MOD_GlcNHglycan	122	125	PF01048	0.555
MOD_GlcNHglycan	173	176	PF01048	0.741
MOD_GlcNHglycan	207	210	PF01048	0.744
MOD_GlcNHglycan	233	236	PF01048	0.539
MOD_GlcNHglycan	239	242	PF01048	0.578
MOD_GSK3_1	128	135	PF00069	0.595
MOD_GSK3_1	148	155	PF00069	0.648
MOD_GSK3_1	24	31	PF00069	0.805
MOD_GSK3_1	38	45	PF00069	0.500
MOD_NEK2_1	194	199	PF00069	0.643
MOD_PIKK_1	107	113	PF00454	0.642
MOD_PIKK_1	173	179	PF00454	0.652
MOD_PIKK_1	194	200	PF00454	0.629
MOD_PIKK_1	24	30	PF00454	0.779
MOD_PIKK_1	245	251	PF00454	0.688
MOD_PIKK_1	38	44	PF00454	0.622
MOD_PK_1	99	105	PF00069	0.618
MOD_PKA_2	107	113	PF00069	0.634
MOD_PKA_2	215	221	PF00069	0.730
MOD_PKA_2	226	232	PF00069	0.511
MOD_PKA_2	245	251	PF00069	0.636
MOD_PKA_2	4	10	PF00069	0.678
MOD_Plk_2-3	55	61	PF00069	0.709
MOD_ProDKin_1	128	134	PF00069	0.522
MOD_ProDKin_1	15	21	PF00069	0.705
MOD_ProDKin_1	28	34	PF00069	0.726
TRG_ER_diArg_1	2	5	PF00400	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE1	Leptomonas seymouri	74%	68%
A0A1X0P6F6	Trypanosomatidae	38%	77%
A0A3R7JZB4	Trypanosoma rangeli	37%	76%
A4H9V9	Leishmania braziliensis	83%	98%
A4HY41	Leishmania infantum	99%	100%
E9ARV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDL9	Leishmania major	92%	100%
V5BBT3	Trypanosoma cruzi	34%	76%