LeishMANIAdb
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Mannosyl-oligosaccharide glucosidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mannosyl-oligosaccharide glucosidase
Gene product:
Mannosyl oligosaccharide glucosidase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IB45_LEIDO
TriTrypDb:
LdBPK_282350.1 * , LdCL_280028600 , LDHU3_28.3180
Length:
947

Annotations

LeishMANIAdb annotations

Mannosyl glucosidase, conserved ER resident enzyme. Only duplicated in T. rangeli, T.theileri and T. cruzi.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 10
GO:0016020 membrane 2 10
GO:0031090 organelle membrane 3 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A0A3Q8IB45
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB45

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 10
GO:0006486 protein glycosylation 4 10
GO:0006487 protein N-linked glycosylation 5 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0009311 oligosaccharide metabolic process 4 10
GO:0019538 protein metabolic process 3 10
GO:0036211 protein modification process 4 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043412 macromolecule modification 4 10
GO:0043413 macromolecule glycosylation 3 10
GO:0044238 primary metabolic process 2 10
GO:0070085 glycosylation 2 10
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 10
GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity 6 10
GO:0015926 glucosidase activity 5 10
GO:0016787 hydrolase activity 2 10
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 254 258 PF00656 0.280
CLV_C14_Caspase3-7 877 881 PF00656 0.302
CLV_NRD_NRD_1 310 312 PF00675 0.550
CLV_NRD_NRD_1 349 351 PF00675 0.567
CLV_NRD_NRD_1 381 383 PF00675 0.494
CLV_NRD_NRD_1 4 6 PF00675 0.456
CLV_NRD_NRD_1 615 617 PF00675 0.530
CLV_NRD_NRD_1 626 628 PF00675 0.516
CLV_NRD_NRD_1 657 659 PF00675 0.473
CLV_NRD_NRD_1 679 681 PF00675 0.538
CLV_NRD_NRD_1 8 10 PF00675 0.464
CLV_PCSK_FUR_1 2 6 PF00082 0.460
CLV_PCSK_KEX2_1 349 351 PF00082 0.606
CLV_PCSK_KEX2_1 35 37 PF00082 0.441
CLV_PCSK_KEX2_1 4 6 PF00082 0.456
CLV_PCSK_KEX2_1 655 657 PF00082 0.465
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.466
CLV_PCSK_PC1ET2_1 655 657 PF00082 0.502
CLV_PCSK_SKI1_1 132 136 PF00082 0.580
CLV_PCSK_SKI1_1 36 40 PF00082 0.428
CLV_PCSK_SKI1_1 43 47 PF00082 0.261
CLV_PCSK_SKI1_1 450 454 PF00082 0.482
CLV_PCSK_SKI1_1 465 469 PF00082 0.455
CLV_PCSK_SKI1_1 5 9 PF00082 0.458
CLV_PCSK_SKI1_1 554 558 PF00082 0.530
CLV_PCSK_SKI1_1 575 579 PF00082 0.491
CLV_PCSK_SKI1_1 583 587 PF00082 0.493
CLV_PCSK_SKI1_1 620 624 PF00082 0.553
CLV_PCSK_SKI1_1 648 652 PF00082 0.505
CLV_PCSK_SKI1_1 936 940 PF00082 0.515
DEG_APCC_DBOX_1 42 50 PF00400 0.502
DEG_APCC_DBOX_1 647 655 PF00400 0.302
DEG_APCC_DBOX_1 935 943 PF00400 0.331
DEG_MDM2_SWIB_1 214 222 PF02201 0.330
DEG_MDM2_SWIB_1 544 552 PF02201 0.267
DEG_Nend_UBRbox_1 1 4 PF02207 0.691
DOC_ANK_TNKS_1 266 273 PF00023 0.315
DOC_CDC14_PxL_1 537 545 PF14671 0.311
DOC_CDC14_PxL_1 55 63 PF14671 0.391
DOC_CKS1_1 367 372 PF01111 0.430
DOC_CKS1_1 65 70 PF01111 0.351
DOC_CYCLIN_RxL_1 930 944 PF00134 0.315
DOC_CYCLIN_yClb5_NLxxxL_5 70 79 PF00134 0.385
DOC_CYCLIN_yCln2_LP_2 56 62 PF00134 0.308
DOC_MAPK_DCC_7 130 139 PF00069 0.247
DOC_MAPK_gen_1 130 139 PF00069 0.247
DOC_MAPK_gen_1 199 209 PF00069 0.330
DOC_MAPK_gen_1 435 443 PF00069 0.365
DOC_MAPK_gen_1 447 455 PF00069 0.246
DOC_MAPK_gen_1 515 523 PF00069 0.267
DOC_MAPK_HePTP_8 129 141 PF00069 0.330
DOC_MAPK_MEF2A_6 132 141 PF00069 0.265
DOC_MAPK_MEF2A_6 199 207 PF00069 0.335
DOC_MAPK_MEF2A_6 447 455 PF00069 0.292
DOC_MAPK_RevD_3 336 350 PF00069 0.390
DOC_PP2B_LxvP_1 19 22 PF13499 0.711
DOC_PP2B_LxvP_1 249 252 PF13499 0.330
DOC_PP2B_LxvP_1 56 59 PF13499 0.308
DOC_PP4_FxxP_1 101 104 PF00568 0.404
DOC_PP4_FxxP_1 367 370 PF00568 0.425
DOC_PP4_FxxP_1 532 535 PF00568 0.267
DOC_USP7_MATH_1 128 132 PF00917 0.330
DOC_USP7_MATH_1 407 411 PF00917 0.591
DOC_USP7_MATH_1 844 848 PF00917 0.330
DOC_USP7_MATH_1 878 882 PF00917 0.267
DOC_USP7_MATH_1 934 938 PF00917 0.302
DOC_USP7_UBL2_3 35 39 PF12436 0.674
DOC_USP7_UBL2_3 550 554 PF12436 0.290
DOC_USP7_UBL2_3 655 659 PF12436 0.374
DOC_WW_Pin1_4 209 214 PF00397 0.265
DOC_WW_Pin1_4 227 232 PF00397 0.196
DOC_WW_Pin1_4 258 263 PF00397 0.330
DOC_WW_Pin1_4 285 290 PF00397 0.416
DOC_WW_Pin1_4 317 322 PF00397 0.402
DOC_WW_Pin1_4 366 371 PF00397 0.439
DOC_WW_Pin1_4 393 398 PF00397 0.413
DOC_WW_Pin1_4 583 588 PF00397 0.290
DOC_WW_Pin1_4 596 601 PF00397 0.290
DOC_WW_Pin1_4 629 634 PF00397 0.344
DOC_WW_Pin1_4 64 69 PF00397 0.426
DOC_WW_Pin1_4 790 795 PF00397 0.265
DOC_WW_Pin1_4 917 922 PF00397 0.302
LIG_14-3-3_CanoR_1 153 157 PF00244 0.333
LIG_14-3-3_CanoR_1 167 174 PF00244 0.352
LIG_14-3-3_CanoR_1 382 386 PF00244 0.388
LIG_14-3-3_CanoR_1 43 49 PF00244 0.551
LIG_14-3-3_CanoR_1 454 463 PF00244 0.309
LIG_14-3-3_CanoR_1 465 470 PF00244 0.324
LIG_14-3-3_CanoR_1 515 524 PF00244 0.285
LIG_14-3-3_CanoR_1 620 629 PF00244 0.324
LIG_14-3-3_CanoR_1 784 794 PF00244 0.296
LIG_Actin_WH2_2 122 137 PF00022 0.267
LIG_APCC_ABBA_1 281 286 PF00400 0.265
LIG_BIR_III_4 315 319 PF00653 0.461
LIG_BRCT_BRCA1_1 123 127 PF00533 0.330
LIG_BRCT_BRCA1_1 476 480 PF00533 0.330
LIG_BRCT_BRCA1_1 834 838 PF00533 0.330
LIG_eIF4E_1 48 54 PF01652 0.360
LIG_FHA_1 136 142 PF00498 0.330
LIG_FHA_1 278 284 PF00498 0.335
LIG_FHA_1 410 416 PF00498 0.530
LIG_FHA_1 425 431 PF00498 0.303
LIG_FHA_1 466 472 PF00498 0.346
LIG_FHA_1 567 573 PF00498 0.307
LIG_FHA_1 600 606 PF00498 0.257
LIG_FHA_1 668 674 PF00498 0.347
LIG_FHA_1 750 756 PF00498 0.365
LIG_FHA_1 817 823 PF00498 0.330
LIG_FHA_1 933 939 PF00498 0.291
LIG_FHA_2 23 29 PF00498 0.647
LIG_FHA_2 301 307 PF00498 0.369
LIG_FHA_2 318 324 PF00498 0.341
LIG_FHA_2 468 474 PF00498 0.315
LIG_Integrin_RGD_1 402 404 PF01839 0.610
LIG_LIR_Apic_2 366 370 PF02991 0.433
LIG_LIR_Apic_2 529 535 PF02991 0.302
LIG_LIR_Apic_2 717 722 PF02991 0.265
LIG_LIR_Apic_2 81 86 PF02991 0.426
LIG_LIR_Apic_2 98 104 PF02991 0.397
LIG_LIR_Gen_1 353 364 PF02991 0.417
LIG_LIR_Gen_1 461 471 PF02991 0.306
LIG_LIR_Gen_1 47 56 PF02991 0.400
LIG_LIR_Gen_1 482 492 PF02991 0.267
LIG_LIR_Gen_1 643 654 PF02991 0.229
LIG_LIR_Gen_1 735 743 PF02991 0.250
LIG_LIR_Gen_1 835 844 PF02991 0.265
LIG_LIR_Gen_1 896 906 PF02991 0.275
LIG_LIR_Nem_3 115 121 PF02991 0.265
LIG_LIR_Nem_3 257 263 PF02991 0.330
LIG_LIR_Nem_3 293 299 PF02991 0.357
LIG_LIR_Nem_3 353 359 PF02991 0.402
LIG_LIR_Nem_3 461 466 PF02991 0.317
LIG_LIR_Nem_3 47 51 PF02991 0.358
LIG_LIR_Nem_3 482 488 PF02991 0.259
LIG_LIR_Nem_3 643 649 PF02991 0.209
LIG_LIR_Nem_3 67 72 PF02991 0.336
LIG_LIR_Nem_3 735 740 PF02991 0.250
LIG_LIR_Nem_3 793 798 PF02991 0.302
LIG_LIR_Nem_3 835 841 PF02991 0.265
LIG_LIR_Nem_3 896 901 PF02991 0.251
LIG_LIR_Nem_3 913 919 PF02991 0.269
LIG_LIR_Nem_3 94 100 PF02991 0.331
LIG_LYPXL_S_1 801 805 PF13949 0.465
LIG_LYPXL_yS_3 802 805 PF13949 0.265
LIG_MYND_1 104 108 PF01753 0.356
LIG_NRBOX 45 51 PF00104 0.360
LIG_NRBOX 606 612 PF00104 0.330
LIG_NRBOX 938 944 PF00104 0.345
LIG_PDZ_Class_3 942 947 PF00595 0.296
LIG_Pex14_1 915 919 PF04695 0.330
LIG_Pex14_2 214 218 PF04695 0.306
LIG_Pex14_2 452 456 PF04695 0.355
LIG_Pex14_2 51 55 PF04695 0.386
LIG_Pex14_2 544 548 PF04695 0.262
LIG_RPA_C_Fungi 510 522 PF08784 0.360
LIG_SH2_CRK 65 69 PF00017 0.404
LIG_SH2_CRK 798 802 PF00017 0.344
LIG_SH2_CRK 898 902 PF00017 0.400
LIG_SH2_GRB2like 100 103 PF00017 0.460
LIG_SH2_GRB2like 798 801 PF00017 0.284
LIG_SH2_NCK_1 463 467 PF00017 0.400
LIG_SH2_NCK_1 592 596 PF00017 0.420
LIG_SH2_PTP2 858 861 PF00017 0.405
LIG_SH2_SRC 121 124 PF00017 0.308
LIG_SH2_SRC 485 488 PF00017 0.344
LIG_SH2_SRC 592 595 PF00017 0.360
LIG_SH2_SRC 875 878 PF00017 0.400
LIG_SH2_STAP1 144 148 PF00017 0.360
LIG_SH2_STAP1 191 195 PF00017 0.363
LIG_SH2_STAP1 385 389 PF00017 0.374
LIG_SH2_STAP1 463 467 PF00017 0.400
LIG_SH2_STAP1 781 785 PF00017 0.286
LIG_SH2_STAP1 798 802 PF00017 0.344
LIG_SH2_STAP1 97 101 PF00017 0.436
LIG_SH2_STAT5 158 161 PF00017 0.360
LIG_SH2_STAT5 358 361 PF00017 0.467
LIG_SH2_STAT5 48 51 PF00017 0.484
LIG_SH2_STAT5 485 488 PF00017 0.284
LIG_SH2_STAT5 635 638 PF00017 0.360
LIG_SH2_STAT5 65 68 PF00017 0.314
LIG_SH2_STAT5 795 798 PF00017 0.324
LIG_SH2_STAT5 83 86 PF00017 0.383
LIG_SH2_STAT5 858 861 PF00017 0.380
LIG_SH2_STAT5 875 878 PF00017 0.290
LIG_SH2_STAT5 898 901 PF00017 0.471
LIG_SH2_STAT5 97 100 PF00017 0.490
LIG_SH3_3 102 108 PF00018 0.429
LIG_SH3_3 160 166 PF00018 0.400
LIG_SH3_3 646 652 PF00018 0.227
LIG_SH3_3 684 690 PF00018 0.400
LIG_SUMO_SIM_anti_2 206 212 PF11976 0.400
LIG_SUMO_SIM_anti_2 519 526 PF11976 0.312
LIG_SUMO_SIM_anti_2 738 745 PF11976 0.400
LIG_SUMO_SIM_par_1 467 473 PF11976 0.312
LIG_TRAF2_1 25 28 PF00917 0.575
LIG_TRAF2_1 682 685 PF00917 0.407
LIG_UBA3_1 542 550 PF00899 0.343
LIG_UBA3_1 603 612 PF00899 0.400
LIG_UBA3_1 650 659 PF00899 0.360
LIG_UBA3_1 865 872 PF00899 0.348
LIG_WRPW_2 449 452 PF00400 0.391
LIG_WW_1 104 107 PF00397 0.465
MOD_CDK_SPxxK_3 258 265 PF00069 0.400
MOD_CDK_SPxxK_3 317 324 PF00069 0.499
MOD_CK1_1 354 360 PF00069 0.493
MOD_CK1_1 366 372 PF00069 0.475
MOD_CK1_1 384 390 PF00069 0.548
MOD_CK1_1 442 448 PF00069 0.497
MOD_CK1_1 599 605 PF00069 0.457
MOD_CK1_1 615 621 PF00069 0.464
MOD_CK1_1 788 794 PF00069 0.382
MOD_CK1_1 837 843 PF00069 0.284
MOD_CK2_1 22 28 PF00069 0.608
MOD_CK2_1 300 306 PF00069 0.483
MOD_CK2_1 317 323 PF00069 0.544
MOD_CK2_1 467 473 PF00069 0.437
MOD_CK2_1 711 717 PF00069 0.344
MOD_CK2_1 745 751 PF00069 0.298
MOD_CMANNOS 657 660 PF00535 0.284
MOD_DYRK1A_RPxSP_1 583 587 PF00069 0.344
MOD_GlcNHglycan 145 148 PF01048 0.400
MOD_GlcNHglycan 163 166 PF01048 0.467
MOD_GlcNHglycan 353 356 PF01048 0.407
MOD_GlcNHglycan 444 447 PF01048 0.368
MOD_GlcNHglycan 481 484 PF01048 0.340
MOD_GlcNHglycan 518 521 PF01048 0.306
MOD_GlcNHglycan 617 620 PF01048 0.404
MOD_GlcNHglycan 713 716 PF01048 0.335
MOD_GlcNHglycan 846 849 PF01048 0.471
MOD_GlcNHglycan 861 864 PF01048 0.284
MOD_GlcNHglycan 882 885 PF01048 0.414
MOD_GSK3_1 117 124 PF00069 0.400
MOD_GSK3_1 161 168 PF00069 0.438
MOD_GSK3_1 236 243 PF00069 0.417
MOD_GSK3_1 381 388 PF00069 0.545
MOD_GSK3_1 424 431 PF00069 0.391
MOD_GSK3_1 435 442 PF00069 0.289
MOD_GSK3_1 474 481 PF00069 0.380
MOD_GSK3_1 579 586 PF00069 0.390
MOD_GSK3_1 741 748 PF00069 0.308
MOD_GSK3_1 786 793 PF00069 0.393
MOD_GSK3_1 832 839 PF00069 0.443
MOD_GSK3_1 928 935 PF00069 0.348
MOD_LATS_1 223 229 PF00433 0.379
MOD_N-GLC_1 112 117 PF02516 0.355
MOD_N-GLC_1 456 461 PF02516 0.400
MOD_N-GLC_1 811 816 PF02516 0.227
MOD_NEK2_1 152 157 PF00069 0.360
MOD_NEK2_1 290 295 PF00069 0.531
MOD_NEK2_1 391 396 PF00069 0.466
MOD_NEK2_1 474 479 PF00069 0.404
MOD_NEK2_1 511 516 PF00069 0.444
MOD_NEK2_1 543 548 PF00069 0.326
MOD_NEK2_1 742 747 PF00069 0.344
MOD_NEK2_1 834 839 PF00069 0.326
MOD_NEK2_1 879 884 PF00069 0.384
MOD_NEK2_1 897 902 PF00069 0.226
MOD_NEK2_2 385 390 PF00069 0.463
MOD_NEK2_2 86 91 PF00069 0.309
MOD_PIKK_1 166 172 PF00454 0.360
MOD_PIKK_1 240 246 PF00454 0.448
MOD_PIKK_1 661 667 PF00454 0.284
MOD_PKA_2 152 158 PF00069 0.371
MOD_PKA_2 166 172 PF00069 0.253
MOD_PKA_2 381 387 PF00069 0.420
MOD_PKA_2 516 522 PF00069 0.400
MOD_PKA_2 615 621 PF00069 0.360
MOD_PKA_2 779 785 PF00069 0.320
MOD_PKA_2 844 850 PF00069 0.400
MOD_Plk_1 112 118 PF00069 0.284
MOD_Plk_1 17 23 PF00069 0.632
MOD_Plk_1 277 283 PF00069 0.383
MOD_Plk_1 385 391 PF00069 0.387
MOD_Plk_1 86 92 PF00069 0.413
MOD_Plk_2-3 759 765 PF00069 0.384
MOD_Plk_4 44 50 PF00069 0.439
MOD_Plk_4 556 562 PF00069 0.304
MOD_Plk_4 599 605 PF00069 0.284
MOD_Plk_4 694 700 PF00069 0.428
MOD_Plk_4 742 748 PF00069 0.319
MOD_ProDKin_1 209 215 PF00069 0.308
MOD_ProDKin_1 227 233 PF00069 0.212
MOD_ProDKin_1 258 264 PF00069 0.400
MOD_ProDKin_1 285 291 PF00069 0.521
MOD_ProDKin_1 317 323 PF00069 0.502
MOD_ProDKin_1 366 372 PF00069 0.560
MOD_ProDKin_1 393 399 PF00069 0.537
MOD_ProDKin_1 583 589 PF00069 0.344
MOD_ProDKin_1 596 602 PF00069 0.344
MOD_ProDKin_1 629 635 PF00069 0.420
MOD_ProDKin_1 64 70 PF00069 0.420
MOD_ProDKin_1 790 796 PF00069 0.308
MOD_ProDKin_1 917 923 PF00069 0.360
MOD_SUMO_rev_2 266 274 PF00179 0.382
MOD_SUMO_rev_2 503 511 PF00179 0.300
TRG_DiLeu_BaLyEn_6 3 8 PF01217 0.580
TRG_DiLeu_BaLyEn_6 538 543 PF01217 0.373
TRG_DiLeu_BaLyEn_6 56 61 PF01217 0.391
TRG_ENDOCYTIC_2 422 425 PF00928 0.413
TRG_ENDOCYTIC_2 463 466 PF00928 0.400
TRG_ENDOCYTIC_2 48 51 PF00928 0.397
TRG_ENDOCYTIC_2 485 488 PF00928 0.344
TRG_ENDOCYTIC_2 798 801 PF00928 0.284
TRG_ENDOCYTIC_2 802 805 PF00928 0.284
TRG_ENDOCYTIC_2 831 834 PF00928 0.347
TRG_ENDOCYTIC_2 898 901 PF00928 0.344
TRG_ENDOCYTIC_2 919 922 PF00928 0.344
TRG_ER_diArg_1 348 350 PF00400 0.500
TRG_ER_diArg_1 4 6 PF00400 0.577
TRG_ER_diArg_1 515 518 PF00400 0.360
TRG_ER_diArg_1 703 706 PF00400 0.284
TRG_ER_diArg_1 75 78 PF00400 0.419
TRG_NES_CRM1_1 461 473 PF08389 0.288
TRG_NLS_Bipartite_1 616 631 PF00514 0.400
TRG_NLS_MonoCore_2 626 631 PF00514 0.227
TRG_NLS_MonoExtC_3 654 659 PF00514 0.312
TRG_NLS_MonoExtN_4 652 659 PF00514 0.360
TRG_Pf-PMV_PEXEL_1 349 353 PF00026 0.522
TRG_Pf-PMV_PEXEL_1 460 464 PF00026 0.379
TRG_Pf-PMV_PEXEL_1 681 685 PF00026 0.360
TRG_Pf-PMV_PEXEL_1 825 830 PF00026 0.470

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEY5 Leptomonas seymouri 74% 100%
A0A0S4JC40 Bodo saltans 25% 100%
A0A1X0NS89 Trypanosomatidae 38% 100%
A0A3R7LQE3 Trypanosoma rangeli 40% 100%
A4HGS4 Leishmania braziliensis 86% 100%
A4I3U9 Leishmania infantum 99% 100%
E9B041 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q845 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS