Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain/Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylenetetrahydrofolate dehydrogenase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IB41_LEIDO

TriTrypDb:

LdBPK_220220.1 , LdCL_220008300 , LDHU3_22.0490

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IB41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB41

Function

Biological processes
Term	Name	Level	Count
GO:0006730	one-carbon metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0044237	cellular metabolic process	2	8
GO:0044281	small molecule metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	5	8
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	6	8
GO:0016491	oxidoreductase activity	2	8
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	8
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	8
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.649
CLV_C14_Caspase3-7	50	54	PF00656	0.384
CLV_NRD_NRD_1	273	275	PF00675	0.433
CLV_NRD_NRD_1	371	373	PF00675	0.365
CLV_NRD_NRD_1	38	40	PF00675	0.384
CLV_NRD_NRD_1	423	425	PF00675	0.547
CLV_NRD_NRD_1	62	64	PF00675	0.361
CLV_NRD_NRD_1	9	11	PF00675	0.717
CLV_PCSK_KEX2_1	273	275	PF00082	0.433
CLV_PCSK_KEX2_1	38	40	PF00082	0.349
CLV_PCSK_KEX2_1	423	425	PF00082	0.547
CLV_PCSK_KEX2_1	61	63	PF00082	0.347
CLV_PCSK_KEX2_1	9	11	PF00082	0.711
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.368
CLV_PCSK_SKI1_1	115	119	PF00082	0.301
CLV_PCSK_SKI1_1	193	197	PF00082	0.506
CLV_PCSK_SKI1_1	205	209	PF00082	0.307
DEG_APCC_DBOX_1	114	122	PF00400	0.301
DEG_APCC_DBOX_1	143	151	PF00400	0.660
DEG_APCC_DBOX_1	272	280	PF00400	0.453
DOC_CYCLIN_yCln2_LP_2	104	110	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.629
DOC_MAPK_gen_1	113	121	PF00069	0.361
DOC_MAPK_gen_1	273	281	PF00069	0.391
DOC_MAPK_gen_1	38	46	PF00069	0.376
DOC_MAPK_HePTP_8	36	48	PF00069	0.453
DOC_MAPK_JIP1_4	115	121	PF00069	0.326
DOC_MAPK_MEF2A_6	38	47	PF00069	0.317
DOC_MAPK_MEF2A_6	443	451	PF00069	0.713
DOC_PP1_RVXF_1	203	210	PF00149	0.361
DOC_PP2B_LxvP_1	104	107	PF13499	0.326
DOC_PP2B_LxvP_1	449	452	PF13499	0.692
DOC_USP7_MATH_1	152	156	PF00917	0.683
DOC_USP7_MATH_1	157	161	PF00917	0.401
DOC_USP7_MATH_1	177	181	PF00917	0.421
DOC_USP7_MATH_1	224	228	PF00917	0.726
DOC_USP7_MATH_1	240	244	PF00917	0.543
DOC_USP7_MATH_1	262	266	PF00917	0.741
DOC_WW_Pin1_4	238	243	PF00397	0.731
DOC_WW_Pin1_4	249	254	PF00397	0.744
DOC_WW_Pin1_4	392	397	PF00397	0.308
LIG_14-3-3_CanoR_1	146	151	PF00244	0.594
LIG_14-3-3_CanoR_1	263	272	PF00244	0.746
LIG_14-3-3_CanoR_1	29	37	PF00244	0.142
LIG_14-3-3_CanoR_1	308	313	PF00244	0.422
LIG_14-3-3_CanoR_1	88	94	PF00244	0.421
LIG_14-3-3_CanoR_1	9	17	PF00244	0.610
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_EVH1_1	106	110	PF00568	0.428
LIG_FHA_1	245	251	PF00498	0.755
LIG_FHA_1	289	295	PF00498	0.326
LIG_FHA_1	3	9	PF00498	0.699
LIG_FHA_1	32	38	PF00498	0.391
LIG_FHA_1	428	434	PF00498	0.582
LIG_LIR_Gen_1	206	216	PF02991	0.512
LIG_LIR_Gen_1	422	433	PF02991	0.570
LIG_LIR_Nem_3	206	212	PF02991	0.473
LIG_LIR_Nem_3	215	221	PF02991	0.615
LIG_LIR_Nem_3	422	428	PF02991	0.610
LIG_Pex14_2	335	339	PF04695	0.453
LIG_RPA_C_Fungi	5	17	PF08784	0.514
LIG_SH2_CRK	425	429	PF00017	0.606
LIG_SH2_GRB2like	57	60	PF00017	0.428
LIG_SH2_NCK_1	425	429	PF00017	0.609
LIG_SH2_SRC	57	60	PF00017	0.453
LIG_SH2_STAP1	429	433	PF00017	0.571
LIG_SH2_STAT5	211	214	PF00017	0.453
LIG_SH2_STAT5	429	432	PF00017	0.554
LIG_SH2_STAT5	57	60	PF00017	0.307
LIG_SH3_3	104	110	PF00018	0.428
LIG_SH3_3	230	236	PF00018	0.718
LIG_SH3_3	250	256	PF00018	0.433
LIG_SH3_3	284	290	PF00018	0.326
LIG_SUMO_SIM_par_1	44	50	PF11976	0.384
LIG_UBA3_1	118	125	PF00899	0.326
LIG_UBA3_1	408	413	PF00899	0.394
LIG_WW_3	270	274	PF00397	0.609
MOD_CDK_SPxxK_3	252	259	PF00069	0.668
MOD_CK1_1	155	161	PF00069	0.640
MOD_CK1_1	252	258	PF00069	0.765
MOD_CK1_1	264	270	PF00069	0.607
MOD_CK1_1	311	317	PF00069	0.453
MOD_CK1_1	4	10	PF00069	0.665
MOD_CK2_1	228	234	PF00069	0.775
MOD_CK2_1	251	257	PF00069	0.742
MOD_GlcNHglycan	12	15	PF01048	0.457
MOD_GlcNHglycan	154	157	PF01048	0.624
MOD_GlcNHglycan	17	20	PF01048	0.324
MOD_GlcNHglycan	179	182	PF01048	0.717
MOD_GlcNHglycan	183	186	PF01048	0.730
MOD_GlcNHglycan	229	233	PF01048	0.747
MOD_GlcNHglycan	244	247	PF01048	0.578
MOD_GlcNHglycan	264	267	PF01048	0.450
MOD_GlcNHglycan	369	372	PF01048	0.420
MOD_GlcNHglycan	385	388	PF01048	0.366
MOD_GlcNHglycan	77	80	PF01048	0.430
MOD_GSK3_1	142	149	PF00069	0.669
MOD_GSK3_1	151	158	PF00069	0.541
MOD_GSK3_1	177	184	PF00069	0.648
MOD_GSK3_1	203	210	PF00069	0.446
MOD_GSK3_1	224	231	PF00069	0.697
MOD_GSK3_1	234	241	PF00069	0.602
MOD_GSK3_1	261	268	PF00069	0.706
MOD_GSK3_1	297	304	PF00069	0.444
MOD_GSK3_1	4	11	PF00069	0.695
MOD_N-GLC_1	281	286	PF02516	0.326
MOD_NEK2_1	1	6	PF00069	0.668
MOD_NEK2_1	244	249	PF00069	0.728
MOD_NEK2_1	301	306	PF00069	0.351
MOD_NEK2_1	335	340	PF00069	0.428
MOD_NEK2_1	402	407	PF00069	0.349
MOD_NEK2_1	77	82	PF00069	0.453
MOD_NEK2_1	8	13	PF00069	0.585
MOD_NEK2_1	86	91	PF00069	0.313
MOD_PIKK_1	265	271	PF00454	0.739
MOD_PKA_2	262	268	PF00069	0.767
MOD_PKA_2	30	36	PF00069	0.442
MOD_PKA_2	8	14	PF00069	0.641
MOD_PKB_1	144	152	PF00069	0.591
MOD_PKB_1	27	35	PF00069	0.375
MOD_Plk_1	228	234	PF00069	0.779
MOD_Plk_1	281	287	PF00069	0.326
MOD_Plk_1	335	341	PF00069	0.428
MOD_Plk_4	146	152	PF00069	0.661
MOD_Plk_4	157	163	PF00069	0.663
MOD_Plk_4	32	38	PF00069	0.457
MOD_ProDKin_1	238	244	PF00069	0.733
MOD_ProDKin_1	249	255	PF00069	0.744
MOD_ProDKin_1	392	398	PF00069	0.308
MOD_SUMO_rev_2	252	261	PF00179	0.674
TRG_DiLeu_BaEn_2	191	197	PF01217	0.431
TRG_ENDOCYTIC_2	425	428	PF00928	0.621
TRG_ENDOCYTIC_2	429	432	PF00928	0.567
TRG_ER_diArg_1	112	115	PF00400	0.349
TRG_ER_diArg_1	144	147	PF00400	0.582
TRG_ER_diArg_1	186	189	PF00400	0.661
TRG_ER_diArg_1	26	29	PF00400	0.346
TRG_ER_diArg_1	272	274	PF00400	0.654
TRG_ER_diArg_1	37	39	PF00400	0.320
TRG_ER_diArg_1	423	425	PF00400	0.497
TRG_ER_diArg_1	8	10	PF00400	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAR1	Leptomonas seymouri	55%	88%
A0A1X0NT48	Trypanosomatidae	43%	100%
A0A422NSL2	Trypanosoma rangeli	41%	100%
A4HZR2	Leishmania infantum	99%	100%
E9AVL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BK74	Trypanosoma cruzi	40%	100%