Protein DPCD

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein DPCD

Gene product:

DPCD protein family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB35_LEIDO

TriTrypDb:

LdBPK_282180.1 , LdCL_280026900 , LDHU3_28.2960

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IB35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.270
CLV_NRD_NRD_1	126	128	PF00675	0.353
CLV_NRD_NRD_1	13	15	PF00675	0.249
CLV_NRD_NRD_1	176	178	PF00675	0.391
CLV_NRD_NRD_1	40	42	PF00675	0.276
CLV_NRD_NRD_1	43	45	PF00675	0.276
CLV_PCSK_FUR_1	41	45	PF00082	0.299
CLV_PCSK_KEX2_1	131	133	PF00082	0.232
CLV_PCSK_KEX2_1	186	188	PF00082	0.433
CLV_PCSK_KEX2_1	42	44	PF00082	0.329
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.232
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.474
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.329
CLV_PCSK_PC7_1	127	133	PF00082	0.353
CLV_PCSK_SKI1_1	102	106	PF00082	0.229
CLV_PCSK_SKI1_1	128	132	PF00082	0.239
CLV_PCSK_SKI1_1	15	19	PF00082	0.255
CLV_PCSK_SKI1_1	46	50	PF00082	0.314
DEG_Nend_Nbox_1	1	3	PF02207	0.527
DOC_CYCLIN_yClb5_NLxxxL_5	66	72	PF00134	0.279
DOC_MAPK_gen_1	127	135	PF00069	0.239
DOC_PP2B_LxvP_1	133	136	PF13499	0.274
DOC_USP7_MATH_1	144	148	PF00917	0.342
DOC_USP7_MATH_1	5	9	PF00917	0.255
DOC_USP7_MATH_1	74	78	PF00917	0.412
DOC_WW_Pin1_4	189	194	PF00397	0.497
DOC_WW_Pin1_4	76	81	PF00397	0.301
LIG_14-3-3_CanoR_1	180	184	PF00244	0.391
LIG_FHA_1	156	162	PF00498	0.239
LIG_FHA_1	33	39	PF00498	0.239
LIG_Integrin_RGD_1	11	13	PF01839	0.320
LIG_LIR_Gen_1	29	39	PF02991	0.239
LIG_LIR_Nem_3	29	34	PF02991	0.239
LIG_PTB_Apo_2	94	101	PF02174	0.239
LIG_PTB_Phospho_1	94	100	PF10480	0.239
LIG_SH2_CRK	163	167	PF00017	0.274
LIG_SH2_CRK	31	35	PF00017	0.255
LIG_SH2_NCK_1	31	35	PF00017	0.255
LIG_SH2_STAT3	152	155	PF00017	0.274
LIG_SH2_STAT5	129	132	PF00017	0.239
LIG_SH2_STAT5	91	94	PF00017	0.299
LIG_SUMO_SIM_par_1	165	171	PF11976	0.370
MOD_CDK_SPxxK_3	189	196	PF00069	0.504
MOD_CK1_1	168	174	PF00069	0.310
MOD_CK1_1	182	188	PF00069	0.385
MOD_CK1_1	19	25	PF00069	0.350
MOD_CK1_1	53	59	PF00069	0.408
MOD_CK1_1	76	82	PF00069	0.320
MOD_GlcNHglycan	146	149	PF01048	0.356
MOD_GlcNHglycan	75	79	PF01048	0.299
MOD_GSK3_1	144	151	PF00069	0.342
MOD_GSK3_1	15	22	PF00069	0.350
MOD_GSK3_1	58	65	PF00069	0.317
MOD_PK_1	165	171	PF00069	0.299
MOD_PKA_1	42	48	PF00069	0.337
MOD_PKA_2	122	128	PF00069	0.239
MOD_PKA_2	179	185	PF00069	0.341
MOD_PKA_2	42	48	PF00069	0.311
MOD_Plk_1	53	59	PF00069	0.320
MOD_Plk_4	155	161	PF00069	0.258
MOD_Plk_4	165	171	PF00069	0.255
MOD_Plk_4	34	40	PF00069	0.270
MOD_Plk_4	5	11	PF00069	0.239
MOD_Plk_4	87	93	PF00069	0.383
MOD_ProDKin_1	189	195	PF00069	0.500
MOD_ProDKin_1	76	82	PF00069	0.301
MOD_SUMO_rev_2	7	17	PF00179	0.348
TRG_ENDOCYTIC_2	31	34	PF00928	0.255
TRG_ER_diArg_1	140	143	PF00400	0.301
TRG_ER_diArg_1	40	43	PF00400	0.279
TRG_ER_diArg_1	93	96	PF00400	0.255
TRG_NLS_MonoCore_2	40	45	PF00514	0.332
TRG_NLS_MonoExtC_3	41	46	PF00514	0.307
TRG_NLS_MonoExtN_4	41	46	PF00514	0.329
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q2	Leptomonas seymouri	82%	100%
A0A0S4J9I2	Bodo saltans	58%	90%
A0A1X0NSA8	Trypanosomatidae	68%	99%
A0A3R7N9M0	Trypanosoma rangeli	64%	97%
A4HGQ8	Leishmania braziliensis	90%	100%
A4I3T2	Leishmania infantum	100%	100%
A4IHF8	Xenopus tropicalis	38%	98%
A5D8N2	Xenopus laevis	38%	98%
D0A875	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	98%
E9B024	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q0P448	Danio rerio	41%	99%
Q24K21	Bos taurus	44%	98%
Q4Q862	Leishmania major	97%	100%
Q6AYM4	Rattus norvegicus	44%	98%
Q8BPA8	Mus musculus	44%	98%
Q9BVM2	Homo sapiens	44%	98%
V5BC63	Trypanosoma cruzi	64%	97%