Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB33_LEIDO

TriTrypDb:

LdBPK_231370.1 , LdCL_230020800 , LDHU3_23.1820

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005814	centriole	5	2
GO:0005874	microtubule	6	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IB33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB33

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0030030	cell projection organization	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.601
CLV_C14_Caspase3-7	253	257	PF00656	0.620
CLV_C14_Caspase3-7	31	35	PF00656	0.708
CLV_C14_Caspase3-7	474	478	PF00656	0.551
CLV_NRD_NRD_1	103	105	PF00675	0.602
CLV_NRD_NRD_1	193	195	PF00675	0.630
CLV_NRD_NRD_1	268	270	PF00675	0.608
CLV_NRD_NRD_1	382	384	PF00675	0.563
CLV_NRD_NRD_1	6	8	PF00675	0.594
CLV_PCSK_FUR_1	134	138	PF00082	0.446
CLV_PCSK_FUR_1	380	384	PF00082	0.467
CLV_PCSK_KEX2_1	136	138	PF00082	0.546
CLV_PCSK_KEX2_1	192	194	PF00082	0.632
CLV_PCSK_KEX2_1	343	345	PF00082	0.631
CLV_PCSK_KEX2_1	380	382	PF00082	0.599
CLV_PCSK_KEX2_1	55	57	PF00082	0.714
CLV_PCSK_KEX2_1	580	582	PF00082	0.594
CLV_PCSK_KEX2_1	6	8	PF00082	0.629
CLV_PCSK_KEX2_1	606	608	PF00082	0.604
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.449
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.644
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.631
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.714
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.497
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.604
CLV_PCSK_SKI1_1	129	133	PF00082	0.543
CLV_PCSK_SKI1_1	194	198	PF00082	0.586
CLV_PCSK_SKI1_1	333	337	PF00082	0.571
CLV_PCSK_SKI1_1	415	419	PF00082	0.737
CLV_PCSK_SKI1_1	468	472	PF00082	0.485
DEG_APCC_DBOX_1	5	13	PF00400	0.537
DEG_Nend_Nbox_1	1	3	PF02207	0.563
DOC_CYCLIN_RxL_1	327	340	PF00134	0.572
DOC_MAPK_gen_1	192	199	PF00069	0.581
DOC_MAPK_gen_1	320	330	PF00069	0.578
DOC_MAPK_gen_1	588	598	PF00069	0.515
DOC_MAPK_gen_1	606	612	PF00069	0.378
DOC_MAPK_MEF2A_6	6	13	PF00069	0.619
DOC_PP1_RVXF_1	555	561	PF00149	0.528
DOC_PP2B_LxvP_1	371	374	PF13499	0.710
DOC_SPAK_OSR1_1	607	611	PF12202	0.594
DOC_USP7_MATH_1	147	151	PF00917	0.582
DOC_USP7_MATH_1	16	20	PF00917	0.777
DOC_USP7_MATH_1	160	164	PF00917	0.499
DOC_USP7_MATH_1	168	172	PF00917	0.483
DOC_USP7_MATH_1	22	26	PF00917	0.743
DOC_USP7_MATH_1	257	261	PF00917	0.569
DOC_USP7_MATH_1	40	44	PF00917	0.769
DOC_USP7_MATH_1	401	405	PF00917	0.709
DOC_USP7_MATH_1	406	410	PF00917	0.760
DOC_USP7_MATH_1	440	444	PF00917	0.544
DOC_USP7_UBL2_3	568	572	PF12436	0.624
DOC_WW_Pin1_4	14	19	PF00397	0.765
DOC_WW_Pin1_4	209	214	PF00397	0.710
LIG_14-3-3_CanoR_1	10	16	PF00244	0.785
LIG_14-3-3_CanoR_1	162	166	PF00244	0.489
LIG_14-3-3_CanoR_1	359	367	PF00244	0.560
LIG_14-3-3_CanoR_1	382	388	PF00244	0.611
LIG_14-3-3_CanoR_1	468	473	PF00244	0.630
LIG_14-3-3_CanoR_1	56	62	PF00244	0.703
LIG_Actin_WH2_2	42	57	PF00022	0.585
LIG_FAT_LD_1	612	620	PF03623	0.462
LIG_FHA_1	18	24	PF00498	0.725
LIG_FHA_1	210	216	PF00498	0.717
LIG_FHA_1	351	357	PF00498	0.531
LIG_FHA_1	571	577	PF00498	0.572
LIG_FHA_1	592	598	PF00498	0.557
LIG_FHA_2	165	171	PF00498	0.647
LIG_FHA_2	184	190	PF00498	0.573
LIG_FHA_2	261	267	PF00498	0.580
LIG_FHA_2	361	367	PF00498	0.627
LIG_LIR_Gen_1	139	147	PF02991	0.588
LIG_LIR_Nem_3	133	138	PF02991	0.615
LIG_LIR_Nem_3	139	145	PF02991	0.582
LIG_MAD2	10	18	PF02301	0.587
LIG_NRBOX	611	617	PF00104	0.462
LIG_PCNA_yPIPBox_3	606	616	PF02747	0.592
LIG_PTB_Apo_2	85	92	PF02174	0.613
LIG_SH2_STAP1	547	551	PF00017	0.639
LIG_SH2_STAT5	565	568	PF00017	0.513
LIG_SH2_STAT5	90	93	PF00017	0.680
LIG_SH3_4	432	439	PF00018	0.796
LIG_SUMO_SIM_anti_2	222	229	PF11976	0.704
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.718
LIG_SUMO_SIM_par_1	28	35	PF11976	0.718
LIG_SUMO_SIM_par_1	550	556	PF11976	0.610
LIG_TRAF2_1	345	348	PF00917	0.637
LIG_UBA3_1	29	38	PF00899	0.715
LIG_UBA3_1	576	580	PF00899	0.580
MOD_CK1_1	164	170	PF00069	0.512
MOD_CK1_1	17	23	PF00069	0.675
MOD_CK1_1	260	266	PF00069	0.532
MOD_CK1_1	285	291	PF00069	0.599
MOD_CK1_1	41	47	PF00069	0.668
MOD_CK1_1	515	521	PF00069	0.617
MOD_CK1_1	524	530	PF00069	0.555
MOD_CK1_1	533	539	PF00069	0.368
MOD_CK1_1	72	78	PF00069	0.678
MOD_CK1_1	89	95	PF00069	0.499
MOD_CK2_1	183	189	PF00069	0.579
MOD_CK2_1	22	28	PF00069	0.758
MOD_CK2_1	260	266	PF00069	0.579
MOD_CK2_1	300	306	PF00069	0.548
MOD_CK2_1	360	366	PF00069	0.626
MOD_CK2_1	382	388	PF00069	0.616
MOD_CK2_1	450	456	PF00069	0.566
MOD_CK2_1	507	513	PF00069	0.625
MOD_GlcNHglycan	153	156	PF01048	0.607
MOD_GlcNHglycan	170	173	PF01048	0.539
MOD_GlcNHglycan	217	220	PF01048	0.774
MOD_GlcNHglycan	294	297	PF01048	0.528
MOD_GlcNHglycan	314	317	PF01048	0.673
MOD_GlcNHglycan	40	43	PF01048	0.588
MOD_GlcNHglycan	408	411	PF01048	0.697
MOD_GlcNHglycan	48	52	PF01048	0.697
MOD_GlcNHglycan	502	505	PF01048	0.617
MOD_GlcNHglycan	63	66	PF01048	0.525
MOD_GlcNHglycan	71	74	PF01048	0.783
MOD_GlcNHglycan	92	95	PF01048	0.544
MOD_GSK3_1	147	154	PF00069	0.542
MOD_GSK3_1	160	167	PF00069	0.521
MOD_GSK3_1	183	190	PF00069	0.654
MOD_GSK3_1	205	212	PF00069	0.680
MOD_GSK3_1	215	222	PF00069	0.575
MOD_GSK3_1	246	253	PF00069	0.592
MOD_GSK3_1	260	267	PF00069	0.356
MOD_GSK3_1	40	47	PF00069	0.757
MOD_GSK3_1	446	453	PF00069	0.590
MOD_GSK3_1	471	478	PF00069	0.568
MOD_GSK3_1	86	93	PF00069	0.772
MOD_N-GLC_1	120	125	PF02516	0.571
MOD_N-GLC_1	168	173	PF02516	0.660
MOD_N-GLC_1	38	43	PF02516	0.758
MOD_N-GLC_1	427	432	PF02516	0.607
MOD_N-GLC_1	468	473	PF02516	0.525
MOD_NEK2_1	151	156	PF00069	0.580
MOD_NEK2_1	205	210	PF00069	0.736
MOD_NEK2_1	241	246	PF00069	0.611
MOD_NEK2_1	307	312	PF00069	0.571
MOD_NEK2_1	446	451	PF00069	0.588
MOD_NEK2_1	512	517	PF00069	0.639
MOD_NEK2_1	86	91	PF00069	0.615
MOD_NEK2_2	161	166	PF00069	0.488
MOD_PIKK_1	106	112	PF00454	0.578
MOD_PIKK_1	241	247	PF00454	0.561
MOD_PIKK_1	285	291	PF00454	0.568
MOD_PIKK_1	515	521	PF00454	0.636
MOD_PIKK_1	600	606	PF00454	0.602
MOD_PK_1	246	252	PF00069	0.640
MOD_PK_1	300	306	PF00069	0.548
MOD_PK_1	475	481	PF00069	0.633
MOD_PKA_1	269	275	PF00069	0.621
MOD_PKA_1	300	306	PF00069	0.548
MOD_PKA_1	382	388	PF00069	0.616
MOD_PKA_1	55	61	PF00069	0.710
MOD_PKA_2	161	167	PF00069	0.488
MOD_PKA_2	241	247	PF00069	0.655
MOD_PKA_2	382	388	PF00069	0.616
MOD_PKA_2	530	536	PF00069	0.606
MOD_PKA_2	55	61	PF00069	0.716
MOD_PKB_1	380	388	PF00069	0.553
MOD_Plk_1	120	126	PF00069	0.571
MOD_Plk_1	260	266	PF00069	0.651
MOD_Plk_1	446	452	PF00069	0.651
MOD_Plk_1	468	474	PF00069	0.525
MOD_Plk_1	507	513	PF00069	0.613
MOD_Plk_1	547	553	PF00069	0.613
MOD_Plk_1	86	92	PF00069	0.704
MOD_Plk_4	120	126	PF00069	0.571
MOD_Plk_4	147	153	PF00069	0.568
MOD_Plk_4	211	217	PF00069	0.719
MOD_Plk_4	450	456	PF00069	0.578
MOD_Plk_4	547	553	PF00069	0.630
MOD_Plk_4	617	623	PF00069	0.592
MOD_Plk_4	86	92	PF00069	0.704
MOD_ProDKin_1	14	20	PF00069	0.766
MOD_ProDKin_1	209	215	PF00069	0.713
MOD_SUMO_rev_2	122	131	PF00179	0.553
MOD_SUMO_rev_2	141	150	PF00179	0.355
MOD_SUMO_rev_2	266	272	PF00179	0.597
MOD_SUMO_rev_2	347	356	PF00179	0.641
MOD_SUMO_rev_2	484	492	PF00179	0.626
MOD_SUMO_rev_2	569	573	PF00179	0.577
MOD_SUMO_rev_2	575	582	PF00179	0.540
MOD_SUMO_rev_2	584	589	PF00179	0.486
MOD_SUMO_rev_2	595	603	PF00179	0.318
TRG_DiLeu_BaEn_1	592	597	PF01217	0.626
TRG_DiLeu_BaEn_2	555	561	PF01217	0.528
TRG_DiLeu_BaEn_4	507	513	PF01217	0.602
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.566
TRG_ER_diArg_1	327	330	PF00400	0.568
TRG_ER_diArg_1	367	370	PF00400	0.679
TRG_ER_diArg_1	380	383	PF00400	0.536
TRG_ER_diArg_1	5	7	PF00400	0.596
TRG_NES_CRM1_1	578	590	PF08389	0.523
TRG_NLS_MonoExtN_4	6	11	PF00514	0.618
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A422NPG5	Trypanosoma rangeli	25%	83%
A4HCY4	Leishmania braziliensis	80%	100%
A4I0G9	Leishmania infantum	100%	100%
C9ZV65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	72%
E9AWD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QB41	Leishmania major	93%	100%