BAG domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB32_LEIDO

TriTrypDb:

LdBPK_220020.1 , LdCL_220006300 , LDHU3_22.0210

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IB32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB32

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0051087	protein-folding chaperone binding	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.635
CLV_C14_Caspase3-7	444	448	PF00656	0.470
CLV_NRD_NRD_1	129	131	PF00675	0.673
CLV_NRD_NRD_1	296	298	PF00675	0.630
CLV_NRD_NRD_1	406	408	PF00675	0.274
CLV_NRD_NRD_1	434	436	PF00675	0.268
CLV_PCSK_FUR_1	432	436	PF00082	0.242
CLV_PCSK_KEX2_1	162	164	PF00082	0.735
CLV_PCSK_KEX2_1	295	297	PF00082	0.730
CLV_PCSK_KEX2_1	434	436	PF00082	0.242
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.735
CLV_PCSK_SKI1_1	192	196	PF00082	0.634
CLV_PCSK_SKI1_1	37	41	PF00082	0.396
CLV_PCSK_SKI1_1	416	420	PF00082	0.267
CLV_PCSK_SKI1_1	440	444	PF00082	0.273
CLV_Separin_Metazoa	413	417	PF03568	0.448
DEG_APCC_DBOX_1	345	353	PF00400	0.351
DEG_SCF_FBW7_1	74	81	PF00400	0.401
DOC_CKS1_1	75	80	PF01111	0.488
DOC_CYCLIN_RxL_1	413	422	PF00134	0.448
DOC_MAPK_gen_1	16	25	PF00069	0.439
DOC_MAPK_gen_1	295	302	PF00069	0.618
DOC_MAPK_MEF2A_6	19	27	PF00069	0.439
DOC_MAPK_MEF2A_6	295	302	PF00069	0.580
DOC_PP1_RVXF_1	414	420	PF00149	0.448
DOC_PP2B_LxvP_1	25	28	PF13499	0.424
DOC_USP7_MATH_1	120	124	PF00917	0.701
DOC_USP7_MATH_1	161	165	PF00917	0.592
DOC_USP7_MATH_1	172	176	PF00917	0.605
DOC_USP7_MATH_1	246	250	PF00917	0.678
DOC_USP7_MATH_1	254	258	PF00917	0.714
DOC_USP7_MATH_1	259	263	PF00917	0.729
DOC_USP7_MATH_1	69	73	PF00917	0.398
DOC_USP7_UBL2_3	169	173	PF12436	0.691
DOC_USP7_UBL2_3	436	440	PF12436	0.516
DOC_WW_Pin1_4	116	121	PF00397	0.569
DOC_WW_Pin1_4	147	152	PF00397	0.646
DOC_WW_Pin1_4	207	212	PF00397	0.692
DOC_WW_Pin1_4	223	228	PF00397	0.534
DOC_WW_Pin1_4	240	245	PF00397	0.695
DOC_WW_Pin1_4	267	272	PF00397	0.807
DOC_WW_Pin1_4	350	355	PF00397	0.460
DOC_WW_Pin1_4	397	402	PF00397	0.348
DOC_WW_Pin1_4	74	79	PF00397	0.485
LIG_14-3-3_CanoR_1	130	139	PF00244	0.602
LIG_14-3-3_CanoR_1	163	168	PF00244	0.717
LIG_14-3-3_CanoR_1	171	179	PF00244	0.638
LIG_14-3-3_CanoR_1	297	303	PF00244	0.458
LIG_14-3-3_CanoR_1	85	89	PF00244	0.655
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BIR_III_4	447	451	PF00653	0.463
LIG_eIF4E_1	68	74	PF01652	0.490
LIG_FHA_1	113	119	PF00498	0.609
LIG_FHA_1	163	169	PF00498	0.826
LIG_FHA_1	20	26	PF00498	0.434
LIG_FHA_1	28	34	PF00498	0.394
LIG_FHA_1	419	425	PF00498	0.448
LIG_FHA_1	48	54	PF00498	0.267
LIG_FHA_2	122	128	PF00498	0.636
LIG_FHA_2	16	22	PF00498	0.554
LIG_FHA_2	381	387	PF00498	0.395
LIG_FHA_2	75	81	PF00498	0.449
LIG_GBD_Chelix_1	32	40	PF00786	0.445
LIG_LIR_Nem_3	67	73	PF02991	0.448
LIG_MYND_1	335	339	PF01753	0.485
LIG_SH2_CRK	54	58	PF00017	0.426
LIG_SH2_NCK_1	141	145	PF00017	0.622
LIG_SH2_NCK_1	376	380	PF00017	0.385
LIG_SH2_STAP1	141	145	PF00017	0.622
LIG_SH2_STAP1	411	415	PF00017	0.448
LIG_SH2_STAT3	4	7	PF00017	0.560
LIG_SH2_STAT5	141	144	PF00017	0.566
LIG_SH2_STAT5	64	67	PF00017	0.422
LIG_SH3_3	208	214	PF00018	0.677
LIG_SH3_3	265	271	PF00018	0.623
LIG_SH3_3	87	93	PF00018	0.695
LIG_SH3_4	338	345	PF00018	0.409
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.431
LIG_SUMO_SIM_anti_2	389	395	PF11976	0.449
LIG_SUMO_SIM_par_1	348	353	PF11976	0.310
LIG_SUMO_SIM_par_1	383	390	PF11976	0.344
LIG_TRAF2_2	261	266	PF00917	0.631
LIG_TYR_ITIM	52	57	PF00017	0.471
LIG_WRC_WIRS_1	36	41	PF05994	0.420
LIG_WW_3	88	92	PF00397	0.653
MOD_CDK_SPK_2	267	272	PF00069	0.802
MOD_CDK_SPK_2	350	355	PF00069	0.365
MOD_CDK_SPxxK_3	350	357	PF00069	0.435
MOD_CK1_1	112	118	PF00069	0.786
MOD_CK1_1	181	187	PF00069	0.706
MOD_CK1_1	262	268	PF00069	0.714
MOD_CK1_1	270	276	PF00069	0.729
MOD_CK1_1	321	327	PF00069	0.480
MOD_CK1_1	400	406	PF00069	0.516
MOD_CK2_1	147	153	PF00069	0.664
MOD_CK2_1	15	21	PF00069	0.470
MOD_CK2_1	3	9	PF00069	0.599
MOD_CK2_1	380	386	PF00069	0.381
MOD_GlcNHglycan	124	127	PF01048	0.632
MOD_GlcNHglycan	142	145	PF01048	0.504
MOD_GlcNHglycan	174	177	PF01048	0.700
MOD_GlcNHglycan	218	221	PF01048	0.673
MOD_GlcNHglycan	230	233	PF01048	0.621
MOD_GlcNHglycan	283	286	PF01048	0.715
MOD_GSK3_1	108	115	PF00069	0.707
MOD_GSK3_1	116	123	PF00069	0.689
MOD_GSK3_1	15	22	PF00069	0.512
MOD_GSK3_1	180	187	PF00069	0.677
MOD_GSK3_1	197	204	PF00069	0.619
MOD_GSK3_1	246	253	PF00069	0.623
MOD_GSK3_1	270	277	PF00069	0.603
MOD_GSK3_1	74	81	PF00069	0.541
MOD_N-GLC_1	250	255	PF02516	0.619
MOD_NEK2_1	109	114	PF00069	0.554
MOD_PIKK_1	186	192	PF00454	0.631
MOD_PIKK_1	246	252	PF00454	0.702
MOD_PIKK_1	259	265	PF00454	0.566
MOD_PIKK_1	3	9	PF00454	0.489
MOD_PIKK_1	80	86	PF00454	0.646
MOD_PK_1	348	354	PF00069	0.317
MOD_PKA_1	162	168	PF00069	0.693
MOD_PKA_2	112	118	PF00069	0.790
MOD_PKA_2	129	135	PF00069	0.519
MOD_PKA_2	15	21	PF00069	0.490
MOD_PKA_2	162	168	PF00069	0.797
MOD_PKA_2	84	90	PF00069	0.589
MOD_Plk_1	319	325	PF00069	0.371
MOD_Plk_1	60	66	PF00069	0.415
MOD_Plk_2-3	380	386	PF00069	0.402
MOD_Plk_4	163	169	PF00069	0.599
MOD_Plk_4	60	66	PF00069	0.417
MOD_Plk_4	69	75	PF00069	0.375
MOD_ProDKin_1	116	122	PF00069	0.570
MOD_ProDKin_1	147	153	PF00069	0.650
MOD_ProDKin_1	207	213	PF00069	0.688
MOD_ProDKin_1	223	229	PF00069	0.530
MOD_ProDKin_1	240	246	PF00069	0.690
MOD_ProDKin_1	267	273	PF00069	0.807
MOD_ProDKin_1	350	356	PF00069	0.454
MOD_ProDKin_1	397	403	PF00069	0.348
MOD_ProDKin_1	74	80	PF00069	0.496
MOD_SUMO_rev_2	447	456	PF00179	0.637
TRG_DiLeu_BaEn_1	380	385	PF01217	0.434
TRG_DiLeu_BaEn_2	34	40	PF01217	0.449
TRG_DiLeu_BaEn_3	412	418	PF01217	0.448
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.482
TRG_ENDOCYTIC_2	411	414	PF00928	0.448
TRG_ENDOCYTIC_2	54	57	PF00928	0.426
TRG_ER_diArg_1	295	297	PF00400	0.643
TRG_ER_diArg_1	431	434	PF00400	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G1	Leptomonas seymouri	50%	96%
A4HC67	Leishmania braziliensis	69%	100%
A4HZP2	Leishmania infantum	100%	100%
C9ZSD2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AVJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QBY1	Leishmania major	91%	100%
V5BK86	Trypanosoma cruzi	33%	98%