Protein_kinase_A_catalytic_subunit/GeneDB:LmjF.18.1080

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase A catalytic subunit 3

Species:

Leishmania donovani

UniProt:

A0A3Q8IB30_LEIDO

TriTrypDb:

LdBPK_181090.1 , LdCL_180016100 , LDHU3_18.1390

Length:

332

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Annotations by Jardim et al.

Protein kinase, kinase A catalytic subunit PKAC1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005952	cAMP-dependent protein kinase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Phosphorylation

Promastigote: 169

Expansion

Sequence features

A0A3Q8IB30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB30

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	16
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016310	phosphorylation	5	16
GO:0019538	protein metabolic process	3	16
GO:0036211	protein modification process	4	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043412	macromolecule modification	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0004672	protein kinase activity	3	16
GO:0004674	protein serine/threonine kinase activity	4	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016301	kinase activity	4	16
GO:0016740	transferase activity	2	16
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	16
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140096	catalytic activity, acting on a protein	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0004690	cyclic nucleotide-dependent protein kinase activity	5	2
GO:0004691	cAMP-dependent protein kinase activity	6	2
GO:0004679	AMP-activated protein kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.321
CLV_PCSK_KEX2_1	161	163	PF00082	0.312
CLV_PCSK_KEX2_1	251	253	PF00082	0.280
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.324
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.280
CLV_PCSK_SKI1_1	137	141	PF00082	0.275
CLV_PCSK_SKI1_1	161	165	PF00082	0.296
CLV_PCSK_SKI1_1	166	170	PF00082	0.282
CLV_PCSK_SKI1_1	226	230	PF00082	0.376
CLV_PCSK_SKI1_1	242	246	PF00082	0.167
CLV_PCSK_SKI1_1	30	34	PF00082	0.334
CLV_PCSK_SKI1_1	311	315	PF00082	0.517
CLV_PCSK_SKI1_1	44	48	PF00082	0.228
CLV_Separin_Metazoa	50	54	PF03568	0.324
DEG_Nend_Nbox_1	1	3	PF02207	0.522
DOC_CYCLIN_RxL_1	236	248	PF00134	0.290
DOC_MAPK_DCC_7	280	288	PF00069	0.383
DOC_MAPK_gen_1	137	146	PF00069	0.280
DOC_MAPK_gen_1	280	288	PF00069	0.449
DOC_MAPK_gen_1	85	92	PF00069	0.357
DOC_MAPK_MEF2A_6	85	92	PF00069	0.328
DOC_PP1_RVXF_1	187	194	PF00149	0.290
DOC_PP1_RVXF_1	224	230	PF00149	0.311
DOC_USP7_MATH_1	306	310	PF00917	0.613
DOC_USP7_MATH_1	5	9	PF00917	0.431
DOC_USP7_MATH_1	62	66	PF00917	0.355
DOC_USP7_UBL2_3	185	189	PF12436	0.324
DOC_USP7_UBL2_3	217	221	PF12436	0.339
DOC_USP7_UBL2_3	44	48	PF12436	0.289
DOC_WW_Pin1_4	170	175	PF00397	0.280
DOC_WW_Pin1_4	211	216	PF00397	0.280
DOC_WW_Pin1_4	302	307	PF00397	0.468
DOC_WW_Pin1_4	311	316	PF00397	0.289
LIG_14-3-3_CanoR_1	11	17	PF00244	0.516
LIG_14-3-3_CanoR_1	162	170	PF00244	0.287
LIG_Actin_WH2_2	89	107	PF00022	0.290
LIG_APCC_ABBAyCdc20_2	132	138	PF00400	0.324
LIG_Clathr_ClatBox_1	244	248	PF01394	0.339
LIG_FHA_1	165	171	PF00498	0.289
LIG_FHA_1	248	254	PF00498	0.290
LIG_FHA_1	258	264	PF00498	0.290
LIG_FHA_2	1	7	PF00498	0.447
LIG_GBD_Chelix_1	75	83	PF00786	0.374
LIG_LIR_Apic_2	173	179	PF02991	0.278
LIG_LIR_Gen_1	271	282	PF02991	0.416
LIG_LIR_Gen_1	319	329	PF02991	0.509
LIG_LIR_Gen_1	37	46	PF02991	0.339
LIG_LIR_Gen_1	99	107	PF02991	0.314
LIG_LIR_Nem_3	133	139	PF02991	0.323
LIG_LIR_Nem_3	192	196	PF02991	0.319
LIG_LIR_Nem_3	23	29	PF02991	0.280
LIG_LIR_Nem_3	271	277	PF02991	0.407
LIG_LIR_Nem_3	296	302	PF02991	0.399
LIG_LIR_Nem_3	319	324	PF02991	0.376
LIG_LIR_Nem_3	37	43	PF02991	0.280
LIG_LIR_Nem_3	99	104	PF02991	0.312
LIG_NRBOX	195	201	PF00104	0.324
LIG_NRBOX	87	93	PF00104	0.324
LIG_PTB_Apo_2	262	269	PF02174	0.350
LIG_PTB_Apo_2	323	330	PF02174	0.552
LIG_PTB_Phospho_1	262	268	PF10480	0.350
LIG_PTB_Phospho_1	323	329	PF10480	0.555
LIG_SH2_CRK	40	44	PF00017	0.355
LIG_SH2_PTP2	89	92	PF00017	0.355
LIG_SH2_STAP1	201	205	PF00017	0.290
LIG_SH2_STAP1	219	223	PF00017	0.102
LIG_SH2_STAT5	118	121	PF00017	0.331
LIG_SH2_STAT5	128	131	PF00017	0.226
LIG_SH2_STAT5	176	179	PF00017	0.281
LIG_SH2_STAT5	268	271	PF00017	0.396
LIG_SH2_STAT5	298	301	PF00017	0.452
LIG_SH2_STAT5	329	332	PF00017	0.524
LIG_SH2_STAT5	89	92	PF00017	0.280
LIG_SH2_STAT5	94	97	PF00017	0.280
LIG_SH3_3	202	208	PF00018	0.319
LIG_SH3_3	224	230	PF00018	0.373
LIG_SH3_3	300	306	PF00018	0.465
LIG_SUMO_SIM_par_1	243	248	PF11976	0.339
LIG_TYR_ITIM	134	139	PF00017	0.280
LIG_TYR_ITIM	199	204	PF00017	0.290
LIG_UBA3_1	100	109	PF00899	0.324
LIG_UBA3_1	244	251	PF00899	0.339
LIG_UBA3_1	51	55	PF00899	0.288
MOD_CDC14_SPxK_1	214	217	PF00782	0.324
MOD_CDK_SPxK_1	211	217	PF00069	0.280
MOD_CK1_1	309	315	PF00069	0.515
MOD_CK2_1	10	16	PF00069	0.402
MOD_GSK3_1	166	173	PF00069	0.278
MOD_GSK3_1	243	250	PF00069	0.374
MOD_GSK3_1	302	309	PF00069	0.572
MOD_N-GLC_1	130	135	PF02516	0.409
MOD_N-GLC_1	257	262	PF02516	0.316
MOD_N-GLC_2	323	325	PF02516	0.521
MOD_NEK2_1	17	22	PF00069	0.290
MOD_NEK2_1	74	79	PF00069	0.345
MOD_NEK2_2	306	311	PF00069	0.391
MOD_PKA_1	161	167	PF00069	0.344
MOD_PKA_2	10	16	PF00069	0.510
MOD_PKA_2	161	167	PF00069	0.344
MOD_PKA_2	17	23	PF00069	0.401
MOD_Plk_1	130	136	PF00069	0.316
MOD_Plk_1	164	170	PF00069	0.280
MOD_Plk_1	62	68	PF00069	0.324
MOD_Plk_4	130	136	PF00069	0.409
MOD_Plk_4	62	68	PF00069	0.324
MOD_Plk_4	74	80	PF00069	0.324
MOD_ProDKin_1	170	176	PF00069	0.280
MOD_ProDKin_1	211	217	PF00069	0.280
MOD_ProDKin_1	302	308	PF00069	0.472
MOD_ProDKin_1	311	317	PF00069	0.282
MOD_SUMO_for_1	139	142	PF00179	0.280
TRG_ENDOCYTIC_2	136	139	PF00928	0.280
TRG_ENDOCYTIC_2	201	204	PF00928	0.280
TRG_ENDOCYTIC_2	207	210	PF00928	0.269
TRG_ENDOCYTIC_2	219	222	PF00928	0.102
TRG_ENDOCYTIC_2	40	43	PF00928	0.280
TRG_ENDOCYTIC_2	89	92	PF00928	0.285
TRG_ER_diArg_1	28	31	PF00400	0.280
TRG_Pf-PMV_PEXEL_1	137	142	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N5	Leptomonas seymouri	29%	77%
A0A0N0P3Q8	Leptomonas seymouri	31%	93%
A0A0N0P4J7	Leptomonas seymouri	29%	75%
A0A0N0P787	Leptomonas seymouri	31%	86%
A0A0N0P8H5	Leptomonas seymouri	86%	100%
A0A0N1HWQ2	Leptomonas seymouri	33%	100%
A0A0N1I6T8	Leptomonas seymouri	32%	100%
A0A0N1IIF9	Leptomonas seymouri	35%	100%
A0A0N1IM47	Leptomonas seymouri	29%	90%
A0A0N1PC31	Leptomonas seymouri	31%	85%
A0A0N1PD05	Leptomonas seymouri	28%	74%
A0A0N1PDW7	Leptomonas seymouri	31%	84%
A0A0S4IKH2	Bodo saltans	33%	67%
A0A0S4IMB7	Bodo saltans	30%	75%
A0A0S4IRU8	Bodo saltans	32%	77%
A0A0S4IRZ7	Bodo saltans	28%	67%
A0A0S4IX86	Bodo saltans	29%	77%
A0A0S4IZY3	Bodo saltans	63%	99%
A0A0S4J3Y5	Bodo saltans	31%	77%
A0A0S4J4B3	Bodo saltans	32%	74%
A0A0S4J4X4	Bodo saltans	36%	100%
A0A0S4J6L4	Bodo saltans	31%	87%
A0A0S4J7K4	Bodo saltans	29%	68%
A0A0S4JBR3	Bodo saltans	33%	100%
A0A0S4JCG2	Bodo saltans	36%	74%
A0A0S4JER5	Bodo saltans	43%	73%
A0A0S4JI67	Bodo saltans	29%	73%
A0A0S4JK24	Bodo saltans	30%	76%
A0A0S4JPZ1	Bodo saltans	29%	74%
A0A0S4JTJ8	Bodo saltans	32%	73%
A0A0S4JUJ2	Bodo saltans	32%	100%
A0A0S4JWD5	Bodo saltans	35%	85%
A0A0S4KFT7	Bodo saltans	76%	99%
A0A0S4KMV7	Bodo saltans	31%	100%
A0A0S4KN74	Bodo saltans	29%	100%
A0A1X0NF53	Trypanosomatidae	26%	72%
A0A1X0NFW4	Trypanosomatidae	32%	70%
A0A1X0NG10	Trypanosomatidae	30%	100%
A0A1X0NIA0	Trypanosomatidae	28%	77%
A0A1X0NIX2	Trypanosomatidae	29%	76%
A0A1X0NQ63	Trypanosomatidae	33%	100%
A0A1X0NRZ9	Trypanosomatidae	32%	90%
A0A1X0NTR6	Trypanosomatidae	29%	94%
A0A1X0NUQ4	Trypanosomatidae	30%	88%
A0A1X0NWB9	Trypanosomatidae	28%	69%
A0A1X0NY93	Trypanosomatidae	32%	85%
A0A1X0NYK8	Trypanosomatidae	34%	100%
A0A1X0P1A2	Trypanosomatidae	29%	72%
A0A1X0P3J5	Trypanosomatidae	44%	72%
A0A1X0P527	Trypanosomatidae	30%	75%
A0A1X0P549	Trypanosomatidae	30%	70%
A0A1X0P5B1	Trypanosomatidae	60%	100%
A0A1X0P5F2	Trypanosomatidae	60%	100%
A0A1X0P6V1	Trypanosomatidae	34%	100%
A0A1X0P735	Trypanosomatidae	32%	100%
A0A1X0P7V0	Trypanosomatidae	77%	99%
A0A1X0P8F7	Trypanosomatidae	30%	76%
A0A1X0P963	Trypanosomatidae	28%	69%
A0A1X0P994	Trypanosomatidae	30%	67%
A0A1X0P9C4	Trypanosomatidae	33%	66%
A0A3Q8IAQ1	Leishmania donovani	29%	100%
A0A3Q8IBT5	Leishmania donovani	28%	100%
A0A3Q8IC87	Leishmania donovani	32%	89%
A0A3Q8IEH3	Leishmania donovani	34%	100%
A0A3Q8IFK8	Leishmania donovani	30%	75%
A0A3Q8IFW0	Leishmania donovani	29%	77%
A0A3Q8IHH8	Leishmania donovani	31%	66%
A0A3Q8INQ4	Leishmania donovani	33%	85%
A0A3Q8INS5	Leishmania donovani	26%	100%
A0A3R7K109	Trypanosoma rangeli	31%	70%
A0A3R7K5P9	Trypanosoma rangeli	30%	89%
A0A3R7KCZ4	Trypanosoma rangeli	28%	82%
A0A3R7KRP1	Trypanosoma rangeli	26%	70%
A0A3R7M5C7	Trypanosoma rangeli	34%	100%
A0A3R7MHW5	Trypanosoma rangeli	29%	83%
A0A3R7MJP3	Trypanosoma rangeli	29%	100%
A0A3R7MKG5	Trypanosoma rangeli	29%	75%
A0A3R7N4D8	Trypanosoma rangeli	31%	82%
A0A3R7N5S4	Trypanosoma rangeli	31%	88%
A0A3R7NKI8	Trypanosoma rangeli	30%	100%
A0A3R7RIN5	Trypanosoma rangeli	33%	66%
A0A3R7RLL1	Trypanosoma rangeli	31%	77%
A0A3S5H5G0	Leishmania donovani	28%	100%
A0A3S5H5U5	Leishmania donovani	31%	73%
A0A3S5H606	Leishmania donovani	33%	100%
A0A3S7WTN9	Leishmania donovani	30%	86%
A0A3S7WUX5	Leishmania donovani	34%	100%
A0A3S7WVE9	Leishmania donovani	29%	100%
A0A3S7WYP4	Leishmania donovani	30%	95%
A0A3S7X123	Leishmania donovani	23%	100%
A0A3S7X6T8	Leishmania donovani	28%	74%
A0A3S7X8Z8	Leishmania donovani	25%	100%
A0A3S7X9R4	Leishmania donovani	58%	89%
A0A3S7X9S2	Leishmania donovani	58%	98%
A0A3S7XAX0	Leishmania donovani	33%	70%
A0A422MYB4	Trypanosoma rangeli	60%	100%
A0A422NCP0	Trypanosoma rangeli	30%	67%
A0A422NUF0	Trypanosoma rangeli	29%	83%
A0A422P0J2	Trypanosoma rangeli	71%	99%
A0A422P0N6	Trypanosoma rangeli	32%	100%
A0A422P1R5	Trypanosoma rangeli	35%	100%
A0A422P270	Trypanosoma rangeli	29%	75%
A0A422P4V9	Trypanosoma rangeli	43%	72%
A0A8I3S724	Canis lupus familiaris	36%	82%
A2VDV2	Bos taurus	35%	71%
A3B529	Oryza sativa subsp. japonica	33%	76%
A4H459	Leishmania braziliensis	27%	100%
A4H4S9	Leishmania braziliensis	31%	100%
A4H539	Leishmania braziliensis	32%	100%
A4H8C4	Leishmania braziliensis	30%	100%
A4H8V2	Leishmania braziliensis	33%	67%
A4H9H4	Leishmania braziliensis	34%	100%
A4H9L8	Leishmania braziliensis	96%	100%
A4H9X2	Leishmania braziliensis	28%	100%
A4HBL4	Leishmania braziliensis	22%	100%
A4HCD7	Leishmania braziliensis	32%	78%
A4HCE6	Leishmania braziliensis	29%	100%
A4HDU3	Leishmania braziliensis	31%	95%
A4HED7	Leishmania braziliensis	34%	100%
A4HEL2	Leishmania braziliensis	26%	100%
A4HG26	Leishmania braziliensis	25%	100%
A4HG92	Leishmania braziliensis	33%	100%
A4HJT5	Leishmania braziliensis	30%	75%
A4HJW2	Leishmania braziliensis	30%	77%
A4HLR0	Leishmania braziliensis	29%	74%
A4HN71	Leishmania braziliensis	58%	100%
A4HSE2	Leishmania infantum	28%	100%
A4HTB4	Leishmania infantum	33%	100%
A4HWP5	Leishmania infantum	30%	100%
A4HXU0	Leishmania infantum	34%	100%
A4HXY2	Leishmania infantum	100%	100%
A4HZV1	Leishmania infantum	32%	100%
A4HZW8	Leishmania infantum	29%	100%
A4I140	Leishmania infantum	30%	95%
A4I1T4	Leishmania infantum	33%	100%
A4I1U3	Leishmania infantum	26%	100%
A4I3C6	Leishmania infantum	34%	100%
A4I4X0	Leishmania infantum	31%	66%
A4I7A1	Leishmania infantum	30%	75%
A4I7C4	Leishmania infantum	29%	77%
A4I960	Leishmania infantum	28%	74%
A4IB02	Leishmania infantum	25%	100%
A4IBT4	Leishmania infantum	58%	100%
A4IBT9	Leishmania infantum	58%	100%
A4IDK3	Leishmania infantum	33%	70%
A4IGM9	Xenopus tropicalis	34%	92%
A5GFW1	Sus scrofa	36%	83%
A7MB74	Bos taurus	42%	77%
A8X6H4	Caenorhabditis briggsae	36%	93%
A8XJL7	Caenorhabditis briggsae	34%	70%
A8XJQ6	Caenorhabditis briggsae	44%	86%
A8XNJ6	Caenorhabditis briggsae	43%	72%
A8XW88	Caenorhabditis briggsae	57%	89%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	82%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	79%
C9ZMH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	75%
C9ZN29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	68%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	72%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZW46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	70%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	77%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	75%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	85%
C9ZYS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	84%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	83%
C9ZZX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZZX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A2M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	71%
D0A2Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	68%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
D0A820	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D7UQM5	Patiria pectinifera	39%	82%
E9ACW6	Leishmania major	23%	100%
E9AEB9	Leishmania major	31%	66%
E9AET0	Leishmania major	26%	100%
E9AFM1	Leishmania major	58%	100%
E9AG71	Leishmania infantum	31%	100%
E9AGR7	Leishmania infantum	29%	100%
E9AII8	Leishmania braziliensis	26%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ALG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	66%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ARK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9ARW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	68%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AX78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	95%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AXY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AZF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	75%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	77%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	74%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
O00141	Homo sapiens	42%	77%
O01427	Caenorhabditis elegans	32%	100%
O13310	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	71%
O14965	Homo sapiens	36%	82%
O22932	Arabidopsis thaliana	38%	76%
O22971	Arabidopsis thaliana	33%	66%
O43930	Homo sapiens	59%	100%
O55099	Rattus norvegicus	36%	97%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	94%
O64629	Arabidopsis thaliana	38%	100%
O65554	Arabidopsis thaliana	38%	75%
O70126	Mus musculus	37%	96%
O70150	Rattus norvegicus	39%	97%
O88445	Mus musculus	36%	100%
P00517	Bos taurus	54%	95%
P05131	Bos taurus	52%	95%
P05132	Mus musculus	53%	95%
P05383	Sus scrofa	52%	95%
P05986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	83%
P06244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	84%
P06245	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	87%
P12370	Drosophila melanogaster	54%	94%
P16911	Drosophila melanogaster	45%	94%
P17612	Homo sapiens	54%	95%
P21137	Caenorhabditis elegans	51%	82%
P21901	Aplysia californica	41%	95%
P22612	Homo sapiens	53%	95%
P22694	Homo sapiens	54%	95%
P25321	Cricetulus griseus	54%	95%
P25323	Dictyostelium discoideum	36%	100%
P27791	Rattus norvegicus	53%	95%
P28178	Dictyostelium discoideum	47%	69%
P31748	AKT8 murine leukemia virus	43%	66%
P31749	Homo sapiens	43%	69%
P31750	Mus musculus	43%	69%
P31751	Homo sapiens	41%	69%
P36887	Sus scrofa	54%	95%
P38991	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	90%
P42818	Arabidopsis thaliana	44%	71%
P47196	Rattus norvegicus	43%	69%
P47197	Rattus norvegicus	39%	69%
P49673	Ascaris suum	50%	99%
P51817	Homo sapiens	53%	93%
P54644	Dictyostelium discoideum	41%	75%
P59241	Rattus norvegicus	36%	84%
P68180	Cricetulus griseus	52%	95%
P68181	Mus musculus	52%	95%
P68182	Rattus norvegicus	52%	95%
P92937	Arabidopsis thaliana	36%	79%
P97477	Mus musculus	35%	84%
Q00771	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	80%
Q01314	Bos taurus	43%	69%
Q06226	Rattus norvegicus	42%	77%
Q0JI49	Oryza sativa subsp. japonica	35%	66%
Q10LQ2	Oryza sativa subsp. japonica	37%	74%
Q10SC8	Oryza sativa subsp. japonica	39%	73%
Q12706	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	76%
Q14012	Homo sapiens	37%	90%
Q15208	Homo sapiens	35%	71%
Q27687	Leishmania major	99%	100%
Q2KJ16	Bos taurus	33%	82%
Q2L6W9	Caenorhabditis elegans	33%	70%
Q2LZZ7	Drosophila pseudoobscura pseudoobscura	34%	72%
Q2PJ68	Caenorhabditis elegans	44%	72%
Q2QY53	Oryza sativa subsp. japonica	37%	76%
Q2QYM3	Oryza sativa subsp. japonica	34%	76%
Q2RAX3	Oryza sativa subsp. japonica	37%	73%
Q2RBF0	Oryza sativa subsp. japonica	35%	76%
Q2TA06	Bos taurus	36%	83%
Q2V452	Arabidopsis thaliana	37%	75%
Q39030	Arabidopsis thaliana	42%	70%
Q4Q1J2	Leishmania major	33%	70%
Q4Q3Y9	Leishmania major	28%	74%
Q4Q5T9	Leishmania major	30%	77%
Q4Q5W2	Leishmania major	30%	75%
Q4Q9I7	Leishmania major	27%	100%
Q4Q9K2	Leishmania major	33%	100%
Q4QBQ2	Leishmania major	29%	100%
Q4QBR6	Leishmania major	32%	100%
Q4QCK0	Leishmania major	22%	100%
Q4QCR2	Leishmania major	28%	100%
Q4QDK6	Leishmania major	29%	100%
Q4QDX7	Leishmania major	34%	100%
Q4QF23	Leishmania major	30%	100%
Q4QIJ7	Leishmania major	33%	100%
Q4QIV8	Leishmania major	30%	100%
Q4QJJ0	Leishmania major	28%	100%
Q4R633	Macaca fascicularis	41%	77%
Q4V3C8	Arabidopsis thaliana	36%	68%
Q501V0	Danio rerio	37%	79%
Q54CY9	Dictyostelium discoideum	34%	100%
Q54L81	Dictyostelium discoideum	34%	72%
Q54UZ1	Dictyostelium discoideum	31%	81%
Q54WX4	Dictyostelium discoideum	35%	86%
Q5BKK4	Xenopus tropicalis	42%	79%
Q5JLD8	Oryza sativa subsp. japonica	34%	74%
Q5JLQ9	Oryza sativa subsp. japonica	32%	70%
Q5Q0U5	Fundulus heteroclitus	41%	77%
Q5R7A7	Pongo abelii	41%	67%
Q5R8M1	Pongo abelii	35%	71%
Q5W736	Oryza sativa subsp. japonica	36%	73%
Q60823	Mus musculus	39%	69%
Q60EY8	Oryza sativa subsp. japonica	35%	71%
Q61XD3	Caenorhabditis briggsae	33%	100%
Q63450	Rattus norvegicus	37%	89%
Q63484	Rattus norvegicus	45%	69%
Q683C9	Arabidopsis thaliana	37%	100%
Q69Q47	Oryza sativa subsp. japonica	36%	73%
Q6A1A2	Homo sapiens	38%	84%
Q6BVA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	39%	81%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	41%	89%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	38%	92%
Q6DE08	Xenopus laevis	35%	92%
Q6ERS0	Oryza sativa subsp. japonica	35%	82%
Q6ERS4	Oryza sativa subsp. japonica	34%	73%
Q6FV07	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	38%	93%
Q6GLY8	Xenopus laevis	42%	76%
Q6GPL3	Xenopus laevis	34%	90%
Q6GPN6	Xenopus laevis	42%	76%
Q6H7U5	Oryza sativa subsp. japonica	33%	67%
Q6IP76	Xenopus laevis	41%	68%
Q6NW76	Danio rerio	35%	100%
Q6P2M8	Homo sapiens	39%	97%
Q6U1I9	Gallus gallus	42%	77%
Q6X4A2	Oryza sativa subsp. japonica	36%	74%
Q6Z9F4	Oryza sativa subsp. japonica	36%	74%
Q6ZLP5	Oryza sativa subsp. japonica	36%	74%
Q755C4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	39%	90%
Q75L42	Oryza sativa subsp. japonica	35%	73%
Q7JP68	Caenorhabditis elegans	46%	83%
Q7TNJ7	Rattus norvegicus	37%	70%
Q7TSE6	Mus musculus	35%	72%
Q7X996	Oryza sativa subsp. japonica	35%	75%
Q7YRC6	Bos taurus	37%	97%
Q7ZTW4	Danio rerio	41%	77%
Q7ZX15	Xenopus laevis	41%	68%
Q84VQ3	Arabidopsis thaliana	37%	76%
Q869W6	Dictyostelium discoideum	34%	95%
Q86UX6	Homo sapiens	32%	68%
Q8BGW6	Mus musculus	33%	83%
Q8BW96	Mus musculus	36%	86%
Q8IU85	Homo sapiens	39%	86%
Q8LIG4	Oryza sativa subsp. japonica	36%	75%
Q8MJ44	Canis lupus familiaris	52%	95%
Q8MYF1	Dictyostelium discoideum	42%	73%
Q8QZV4	Mus musculus	32%	68%
Q8R4U9	Rattus norvegicus	43%	90%
Q8R4V0	Rattus norvegicus	41%	67%
Q8RWC9	Arabidopsis thaliana	34%	75%
Q8SRK8	Encephalitozoon cuniculi (strain GB-M1)	41%	100%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	38%	100%
Q8W1D5	Arabidopsis thaliana	38%	68%
Q8WU08	Homo sapiens	33%	84%
Q91819	Xenopus laevis	36%	81%
Q91820	Xenopus laevis	37%	82%
Q91VB2	Mus musculus	37%	70%
Q91VJ4	Mus musculus	35%	71%
Q91YS8	Mus musculus	37%	89%
Q922R0	Mus musculus	52%	94%
Q93VD3	Arabidopsis thaliana	34%	69%
Q94C40	Arabidopsis thaliana	34%	77%
Q94CG0	Arabidopsis thaliana	35%	80%
Q96BR1	Homo sapiens	41%	67%
Q96GD4	Homo sapiens	37%	97%
Q96NX5	Homo sapiens	37%	70%
Q96QS6	Homo sapiens	36%	86%
Q98TY9	Xenopus laevis	42%	69%
Q9C562	Arabidopsis thaliana	35%	69%
Q9ERE3	Mus musculus	41%	67%
Q9FJ54	Arabidopsis thaliana	35%	76%
Q9FJ55	Arabidopsis thaliana	34%	69%
Q9FLZ3	Arabidopsis thaliana	37%	67%
Q9GNR4	Leishmania major	59%	100%
Q9HBY8	Homo sapiens	42%	90%
Q9JJX8	Mus musculus	33%	80%
Q9LDI3	Arabidopsis thaliana	35%	74%
Q9LEU7	Arabidopsis thaliana	37%	75%
Q9LGV5	Oryza sativa subsp. japonica	37%	72%
Q9LWM4	Oryza sativa subsp. japonica	36%	72%
Q9M077	Arabidopsis thaliana	36%	100%
Q9MAM1	Arabidopsis thaliana	37%	74%
Q9MZD9	Ovis aries	54%	95%
Q9N0X0	Sus scrofa	37%	97%
Q9N2N1	Leishmania major	34%	100%
Q9NBK5	Drosophila melanogaster	34%	72%
Q9NY57	Homo sapiens	32%	80%
Q9P7I2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	99%
Q9QYK9	Mus musculus	39%	97%
Q9QYZ3	Mus musculus	36%	69%
Q9QZS5	Mus musculus	43%	90%
Q9SEZ7	Arabidopsis thaliana	34%	71%
Q9SN43	Arabidopsis thaliana	36%	68%
Q9STV4	Arabidopsis thaliana	35%	75%
Q9SUL7	Arabidopsis thaliana	33%	78%
Q9TXJ0	Caenorhabditis elegans	36%	95%
Q9UBS0	Homo sapiens	39%	69%
Q9UQB9	Homo sapiens	37%	100%
Q9VKN7	Drosophila melanogaster	36%	100%
Q9WUA6	Mus musculus	45%	69%
Q9WVC6	Mus musculus	41%	77%
Q9XF67	Arabidopsis thaliana	36%	68%
Q9XIW0	Arabidopsis thaliana	31%	77%
Q9XT18	Oryctolagus cuniculus	41%	77%
Q9Y243	Homo sapiens	43%	69%
Q9Y2H1	Homo sapiens	35%	72%
Q9Z1M4	Mus musculus	40%	68%
V5B141	Trypanosoma cruzi	32%	70%
V5B871	Trypanosoma cruzi	32%	78%
V5BAZ8	Trypanosoma cruzi	31%	86%
V5BC28	Trypanosoma cruzi	29%	66%
V5BC61	Trypanosoma cruzi	33%	100%
V5BCH2	Trypanosoma cruzi	33%	85%
V5BEK5	Trypanosoma cruzi	74%	99%
V5BG98	Trypanosoma cruzi	34%	100%
V5BI43	Trypanosoma cruzi	32%	66%
V5BNV8	Trypanosoma cruzi	33%	100%
V5BPJ0	Trypanosoma cruzi	30%	67%
V5BQH6	Trypanosoma cruzi	31%	76%
V5BWC2	Trypanosoma cruzi	31%	100%
V5C224	Trypanosoma cruzi	32%	66%
V5D579	Trypanosoma cruzi	28%	77%
V5DI55	Trypanosoma cruzi	29%	80%
V5DMJ4	Trypanosoma cruzi	30%	98%
V5DPP5	Trypanosoma cruzi	31%	77%
V5DQT5	Trypanosoma cruzi	42%	72%
W0LYS5	Macrobrachium nipponense	38%	96%