La_RNA_binding_protein_putative/GeneDB:LmjF.21.05 40

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lupus La protein homolog, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB28_LEIDO

TriTrypDb:

LdBPK_210600.1 , LdCL_210011000 , LDHU3_21.0650

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A0A3Q8IB28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB28

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	1
GO:0008033	tRNA processing	8	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.468
CLV_NRD_NRD_1	125	127	PF00675	0.450
CLV_NRD_NRD_1	191	193	PF00675	0.663
CLV_NRD_NRD_1	330	332	PF00675	0.812
CLV_NRD_NRD_1	80	82	PF00675	0.488
CLV_NRD_NRD_1	9	11	PF00675	0.411
CLV_PCSK_KEX2_1	125	127	PF00082	0.451
CLV_PCSK_KEX2_1	193	195	PF00082	0.706
CLV_PCSK_KEX2_1	330	332	PF00082	0.730
CLV_PCSK_KEX2_1	80	82	PF00082	0.486
CLV_PCSK_KEX2_1	9	11	PF00082	0.411
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.704
CLV_PCSK_SKI1_1	23	27	PF00082	0.330
CLV_PCSK_SKI1_1	278	282	PF00082	0.621
CLV_PCSK_SKI1_1	82	86	PF00082	0.588
DOC_CKS1_1	210	215	PF01111	0.728
DOC_MAPK_gen_1	140	149	PF00069	0.451
DOC_MAPK_gen_1	7	14	PF00069	0.388
DOC_MAPK_HePTP_8	137	149	PF00069	0.591
DOC_MAPK_MEF2A_6	140	149	PF00069	0.437
DOC_PP1_RVXF_1	8	15	PF00149	0.523
DOC_USP7_MATH_1	103	107	PF00917	0.491
DOC_USP7_MATH_1	136	140	PF00917	0.610
DOC_USP7_MATH_1	216	220	PF00917	0.516
DOC_USP7_MATH_1	63	67	PF00917	0.577
DOC_WW_Pin1_4	209	214	PF00397	0.637
LIG_14-3-3_CanoR_1	278	283	PF00244	0.545
LIG_14-3-3_CanoR_1	49	54	PF00244	0.534
LIG_APCC_ABBA_1	259	264	PF00400	0.470
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BIR_III_2	83	87	PF00653	0.567
LIG_FHA_1	102	108	PF00498	0.459
LIG_FHA_1	174	180	PF00498	0.477
LIG_FHA_1	93	99	PF00498	0.448
LIG_FHA_2	151	157	PF00498	0.438
LIG_FHA_2	252	258	PF00498	0.619
LIG_LIR_Apic_2	95	100	PF02991	0.444
LIG_LIR_Gen_1	13	22	PF02991	0.531
LIG_LIR_Gen_1	144	150	PF02991	0.424
LIG_LIR_Gen_1	230	240	PF02991	0.492
LIG_LIR_Gen_1	46	53	PF02991	0.540
LIG_LIR_Nem_3	13	19	PF02991	0.531
LIG_LIR_Nem_3	144	149	PF02991	0.417
LIG_LIR_Nem_3	230	235	PF02991	0.483
LIG_LIR_Nem_3	36	41	PF02991	0.523
LIG_LIR_Nem_3	46	50	PF02991	0.523
LIG_Pex14_1	124	128	PF04695	0.450
LIG_SH2_CRK	165	169	PF00017	0.627
LIG_SH2_PTP2	97	100	PF00017	0.454
LIG_SH2_SRC	178	181	PF00017	0.661
LIG_SH2_STAT5	127	130	PF00017	0.515
LIG_SH2_STAT5	15	18	PF00017	0.538
LIG_SH2_STAT5	178	181	PF00017	0.487
LIG_SH2_STAT5	249	252	PF00017	0.460
LIG_SH2_STAT5	97	100	PF00017	0.454
LIG_SH3_3	156	162	PF00018	0.621
LIG_SH3_3	207	213	PF00018	0.656
LIG_SH3_3	247	253	PF00018	0.469
LIG_TRAF2_1	240	243	PF00917	0.495
LIG_TRAF2_1	254	257	PF00917	0.492
LIG_WRC_WIRS_1	44	49	PF05994	0.523
LIG_WW_1	162	165	PF00397	0.522
MOD_CK1_1	274	280	PF00069	0.677
MOD_CK1_1	88	94	PF00069	0.486
MOD_CK2_1	150	156	PF00069	0.390
MOD_CK2_1	251	257	PF00069	0.625
MOD_Cter_Amidation	328	331	PF01082	0.783
MOD_GlcNHglycan	114	117	PF01048	0.583
MOD_GlcNHglycan	170	173	PF01048	0.616
MOD_GlcNHglycan	206	209	PF01048	0.801
MOD_GlcNHglycan	223	226	PF01048	0.434
MOD_GSK3_1	112	119	PF00069	0.520
MOD_GSK3_1	217	224	PF00069	0.508
MOD_GSK3_1	274	281	PF00069	0.620
MOD_GSK3_1	88	95	PF00069	0.473
MOD_N-GLC_1	217	222	PF02516	0.557
MOD_NEK2_1	26	31	PF00069	0.622
MOD_NEK2_1	271	276	PF00069	0.607
MOD_PIKK_1	185	191	PF00454	0.671
MOD_PKA_2	221	227	PF00069	0.500
MOD_Plk_1	217	223	PF00069	0.535
MOD_Plk_1	92	98	PF00069	0.523
MOD_Plk_4	116	122	PF00069	0.571
MOD_Plk_4	141	147	PF00069	0.438
MOD_Plk_4	92	98	PF00069	0.446
MOD_ProDKin_1	209	215	PF00069	0.618
MOD_SUMO_rev_2	230	238	PF00179	0.584
MOD_SUMO_rev_2	242	247	PF00179	0.389
MOD_SUMO_rev_2	293	300	PF00179	0.544
MOD_SUMO_rev_2	52	60	PF00179	0.566
TRG_ENDOCYTIC_2	165	168	PF00928	0.550
TRG_ENDOCYTIC_2	249	252	PF00928	0.474
TRG_ER_diArg_1	124	126	PF00400	0.437
TRG_ER_diArg_1	192	195	PF00400	0.649
TRG_ER_diArg_1	79	81	PF00400	0.455
TRG_ER_diArg_1	8	10	PF00400	0.611
TRG_ER_FFAT_2	108	119	PF00635	0.554
TRG_NLS_MonoExtC_3	191	196	PF00514	0.683
TRG_NLS_MonoExtN_4	190	196	PF00514	0.677
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU8	Leptomonas seymouri	84%	98%
A0A0S4JIJ0	Bodo saltans	60%	97%
A0A1X0NXX1	Trypanosomatidae	63%	100%
A0A3R7NHU1	Trypanosoma rangeli	63%	99%
A4HBQ1	Leishmania braziliensis	93%	100%
A4HZ53	Leishmania infantum	100%	100%
D0A1Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AV21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P10881	Bos taurus	29%	83%
P32067	Mus musculus	27%	81%
P38656	Rattus norvegicus	27%	81%
P40796	Drosophila melanogaster	25%	86%
Q4QCG1	Leishmania major	97%	100%
V5DH11	Trypanosoma cruzi	60%	100%