Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB26_LEIDO

TriTrypDb:

LdBPK_180500.1 , LdCL_180009900 , LDHU3_18.0620

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IB26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.549
CLV_NRD_NRD_1	239	241	PF00675	0.496
CLV_NRD_NRD_1	418	420	PF00675	0.424
CLV_PCSK_KEX2_1	107	109	PF00082	0.510
CLV_PCSK_KEX2_1	239	241	PF00082	0.496
CLV_PCSK_KEX2_1	30	32	PF00082	0.563
CLV_PCSK_KEX2_1	417	419	PF00082	0.396
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.563
CLV_PCSK_SKI1_1	253	257	PF00082	0.425
CLV_Separin_Metazoa	293	297	PF03568	0.451
DEG_SCF_TRCP1_1	55	61	PF00400	0.480
DEG_SPOP_SBC_1	174	178	PF00917	0.475
DOC_CKS1_1	355	360	PF01111	0.470
DOC_CYCLIN_yCln2_LP_2	325	331	PF00134	0.458
DOC_MAPK_gen_1	107	114	PF00069	0.530
DOC_PP1_RVXF_1	91	97	PF00149	0.550
DOC_PP4_FxxP_1	221	224	PF00568	0.435
DOC_USP7_MATH_1	174	178	PF00917	0.710
DOC_USP7_MATH_1	185	189	PF00917	0.542
DOC_USP7_MATH_1	242	246	PF00917	0.424
DOC_USP7_MATH_1	321	325	PF00917	0.590
DOC_USP7_MATH_1	345	349	PF00917	0.632
DOC_USP7_MATH_1	351	355	PF00917	0.615
DOC_USP7_MATH_1	48	52	PF00917	0.677
DOC_USP7_MATH_1	53	57	PF00917	0.666
DOC_USP7_MATH_1	59	63	PF00917	0.613
DOC_USP7_MATH_1	79	83	PF00917	0.735
DOC_WW_Pin1_4	340	345	PF00397	0.593
DOC_WW_Pin1_4	347	352	PF00397	0.555
DOC_WW_Pin1_4	354	359	PF00397	0.404
DOC_WW_Pin1_4	37	42	PF00397	0.749
DOC_WW_Pin1_4	49	54	PF00397	0.468
LIG_14-3-3_CanoR_1	122	130	PF00244	0.371
LIG_14-3-3_CanoR_1	353	358	PF00244	0.430
LIG_deltaCOP1_diTrp_1	139	147	PF00928	0.452
LIG_deltaCOP1_diTrp_1	249	256	PF00928	0.335
LIG_EVH1_1	183	187	PF00568	0.475
LIG_FHA_1	126	132	PF00498	0.451
LIG_FHA_1	198	204	PF00498	0.355
LIG_FHA_2	328	334	PF00498	0.551
LIG_LIR_Gen_1	210	220	PF02991	0.489
LIG_LIR_Gen_1	254	264	PF02991	0.340
LIG_LIR_Gen_1	365	373	PF02991	0.295
LIG_LIR_Gen_1	398	407	PF02991	0.353
LIG_LIR_Nem_3	210	215	PF02991	0.494
LIG_LIR_Nem_3	254	259	PF02991	0.311
LIG_LIR_Nem_3	365	369	PF02991	0.302
LIG_LIR_Nem_3	398	404	PF02991	0.350
LIG_Pex14_1	252	256	PF04695	0.439
LIG_SH2_CRK	366	370	PF00017	0.317
LIG_SH2_CRK	401	405	PF00017	0.357
LIG_SH2_STAP1	366	370	PF00017	0.317
LIG_SH2_STAP1	401	405	PF00017	0.357
LIG_SH2_STAT5	130	133	PF00017	0.343
LIG_SH2_STAT5	258	261	PF00017	0.516
LIG_SH3_2	184	189	PF14604	0.438
LIG_SH3_3	181	187	PF00018	0.546
LIG_SH3_3	221	227	PF00018	0.445
LIG_SH3_3	355	361	PF00018	0.379
LIG_SUMO_SIM_par_1	2	7	PF11976	0.435
LIG_SUMO_SIM_par_1	403	409	PF11976	0.352
LIG_TRAF2_1	309	312	PF00917	0.404
LIG_TYR_ITIM	364	369	PF00017	0.325
LIG_UBA3_1	369	378	PF00899	0.326
MOD_CDC14_SPxK_1	350	353	PF00782	0.503
MOD_CDK_SPxK_1	347	353	PF00069	0.500
MOD_CK1_1	110	116	PF00069	0.714
MOD_CK1_1	163	169	PF00069	0.562
MOD_CK1_1	177	183	PF00069	0.454
MOD_CK1_1	243	249	PF00069	0.650
MOD_CK1_1	332	338	PF00069	0.615
MOD_CK1_1	343	349	PF00069	0.477
MOD_CK1_1	354	360	PF00069	0.441
MOD_CK1_1	365	371	PF00069	0.453
MOD_CK1_1	380	386	PF00069	0.232
MOD_CK1_1	46	52	PF00069	0.606
MOD_CK1_1	82	88	PF00069	0.701
MOD_CK2_1	243	249	PF00069	0.516
MOD_GlcNHglycan	116	119	PF01048	0.607
MOD_GlcNHglycan	123	126	PF01048	0.547
MOD_GlcNHglycan	168	171	PF01048	0.579
MOD_GlcNHglycan	189	192	PF01048	0.481
MOD_GlcNHglycan	244	248	PF01048	0.550
MOD_GlcNHglycan	253	256	PF01048	0.356
MOD_GlcNHglycan	33	36	PF01048	0.623
MOD_GlcNHglycan	347	350	PF01048	0.583
MOD_GlcNHglycan	382	385	PF01048	0.366
MOD_GlcNHglycan	55	58	PF01048	0.674
MOD_GlcNHglycan	81	84	PF01048	0.654
MOD_GSK3_1	110	117	PF00069	0.493
MOD_GSK3_1	121	128	PF00069	0.436
MOD_GSK3_1	130	137	PF00069	0.436
MOD_GSK3_1	165	172	PF00069	0.591
MOD_GSK3_1	173	180	PF00069	0.652
MOD_GSK3_1	332	339	PF00069	0.580
MOD_GSK3_1	343	350	PF00069	0.432
MOD_GSK3_1	353	360	PF00069	0.466
MOD_GSK3_1	365	372	PF00069	0.452
MOD_GSK3_1	44	51	PF00069	0.674
MOD_N-GLC_2	276	278	PF02516	0.263
MOD_NEK2_1	10	15	PF00069	0.539
MOD_NEK2_1	406	411	PF00069	0.506
MOD_PIKK_1	18	24	PF00454	0.642
MOD_PKA_1	107	113	PF00069	0.474
MOD_PKA_2	107	113	PF00069	0.599
MOD_PKA_2	121	127	PF00069	0.368
MOD_PKA_2	59	65	PF00069	0.774
MOD_Plk_1	125	131	PF00069	0.465
MOD_Plk_1	148	154	PF00069	0.458
MOD_Plk_1	268	274	PF00069	0.498
MOD_Plk_4	126	132	PF00069	0.390
MOD_Plk_4	365	371	PF00069	0.319
MOD_ProDKin_1	340	346	PF00069	0.595
MOD_ProDKin_1	347	353	PF00069	0.556
MOD_ProDKin_1	354	360	PF00069	0.396
MOD_ProDKin_1	37	43	PF00069	0.754
MOD_ProDKin_1	49	55	PF00069	0.468
TRG_DiLeu_BaEn_1	210	215	PF01217	0.314
TRG_ENDOCYTIC_2	366	369	PF00928	0.320
TRG_ENDOCYTIC_2	401	404	PF00928	0.353
TRG_ER_diArg_1	17	20	PF00400	0.552
TRG_ER_diArg_1	239	241	PF00400	0.346
TRG_ER_diArg_1	417	419	PF00400	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D0	Leptomonas seymouri	53%	98%
A0A0S4JE52	Bodo saltans	24%	100%
A0A1X0P6Z6	Trypanosomatidae	38%	100%
A0A422NJ49	Trypanosoma rangeli	38%	100%
A4H9F8	Leishmania braziliensis	78%	100%
A4HXS5	Leishmania infantum	100%	100%
D0A057	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ARI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDZ2	Leishmania major	94%	100%
V5BRN6	Trypanosoma cruzi	35%	100%