LeishMANIAdb
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Mitochondrial carrier protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial carrier protein, putative
Gene product:
mitochondrial carrier protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IB24_LEIDO
TriTrypDb:
LdBPK_181280.1 * , LdCL_180017900 , LDHU3_18.1600
Length:
287

Annotations

LeishMANIAdb annotations

Homologous to animal mitochondrial 2-oxoglutarate/malate carriers.. For some reason, these genes duplicated in Leishmaniidae and other pathogenic lineages.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 20
GO:0110165 cellular anatomical entity 1 20
GO:0005654 nucleoplasm 2 4
GO:0005737 cytoplasm 2 4
GO:0005739 mitochondrion 5 4
GO:0020023 kinetoplast 2 4
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 4
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0043229 intracellular organelle 3 4
GO:0043231 intracellular membrane-bounded organelle 4 4
GO:0097014 ciliary plasm 5 4
GO:0099568 cytoplasmic region 3 4

Expansion

Sequence features

A0A3Q8IB24
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB24

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 4
GO:0006811 monoatomic ion transport 4 4
GO:0006817 phosphate ion transport 7 4
GO:0006820 monoatomic anion transport 5 4
GO:0006835 dicarboxylic acid transport 7 4
GO:0008272 sulfate transport 5 4
GO:0009987 cellular process 1 4
GO:0015698 inorganic anion transport 6 4
GO:0015709 thiosulfate transport 5 4
GO:0015711 organic anion transport 5 4
GO:0015729 oxaloacetate transport 6 4
GO:0015740 C4-dicarboxylate transport 8 4
GO:0015743 malate transport 6 4
GO:0015744 succinate transport 6 4
GO:0015849 organic acid transport 5 4
GO:0034220 monoatomic ion transmembrane transport 3 4
GO:0035435 phosphate ion transmembrane transport 6 4
GO:0046942 carboxylic acid transport 6 4
GO:0051179 localization 1 4
GO:0051234 establishment of localization 2 4
GO:0055085 transmembrane transport 2 4
GO:0071422 succinate transmembrane transport 5 4
GO:0071423 malate transmembrane transport 5 4
GO:0071702 organic substance transport 4 4
GO:0072348 sulfur compound transport 4 4
GO:0098656 monoatomic anion transmembrane transport 4 4
GO:0098660 inorganic ion transmembrane transport 4 4
GO:0098661 inorganic anion transmembrane transport 5 4
GO:1903825 organic acid transmembrane transport 3 4
GO:1905039 carboxylic acid transmembrane transport 4 4
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 4
GO:0005310 dicarboxylic acid transmembrane transporter activity 5 4
GO:0005342 organic acid transmembrane transporter activity 3 4
GO:0008509 monoatomic anion transmembrane transporter activity 4 4
GO:0008514 organic anion transmembrane transporter activity 5 4
GO:0015075 monoatomic ion transmembrane transporter activity 3 4
GO:0015103 inorganic anion transmembrane transporter activity 4 4
GO:0015116 sulfate transmembrane transporter activity 4 4
GO:0015117 thiosulfate transmembrane transporter activity 4 4
GO:0015131 oxaloacetate transmembrane transporter activity 6 4
GO:0015140 malate transmembrane transporter activity 6 4
GO:0015141 succinate transmembrane transporter activity 6 4
GO:0015291 secondary active transmembrane transporter activity 4 4
GO:0015297 antiporter activity 5 4
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 4
GO:0015556 C4-dicarboxylate transmembrane transporter activity 6 4
GO:0022804 active transmembrane transporter activity 3 4
GO:0022857 transmembrane transporter activity 2 4
GO:0046943 carboxylic acid transmembrane transporter activity 4 4
GO:1901682 sulfur compound transmembrane transporter activity 3 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 25 29 PF00656 0.640
CLV_C14_Caspase3-7 62 66 PF00656 0.593
CLV_NRD_NRD_1 171 173 PF00675 0.267
CLV_NRD_NRD_1 225 227 PF00675 0.517
CLV_NRD_NRD_1 34 36 PF00675 0.454
CLV_PCSK_KEX2_1 173 175 PF00082 0.266
CLV_PCSK_KEX2_1 177 179 PF00082 0.393
CLV_PCSK_KEX2_1 225 227 PF00082 0.525
CLV_PCSK_PC1ET2_1 173 175 PF00082 0.316
CLV_PCSK_PC1ET2_1 177 179 PF00082 0.434
CLV_PCSK_SKI1_1 137 141 PF00082 0.317
CLV_PCSK_SKI1_1 152 156 PF00082 0.192
CLV_PCSK_SKI1_1 174 178 PF00082 0.430
CLV_PCSK_SKI1_1 236 240 PF00082 0.523
DEG_APCC_DBOX_1 151 159 PF00400 0.464
DEG_Nend_Nbox_1 1 3 PF02207 0.435
DOC_CYCLIN_yCln2_LP_2 104 110 PF00134 0.465
DOC_PP4_FxxP_1 6 9 PF00568 0.520
DOC_USP7_MATH_1 148 152 PF00917 0.434
DOC_USP7_MATH_1 22 26 PF00917 0.616
DOC_USP7_MATH_1 93 97 PF00917 0.503
DOC_USP7_UBL2_3 173 177 PF12436 0.618
DOC_WW_Pin1_4 103 108 PF00397 0.436
DOC_WW_Pin1_4 83 88 PF00397 0.597
LIG_14-3-3_CanoR_1 123 127 PF00244 0.545
LIG_14-3-3_CanoR_1 210 219 PF00244 0.357
LIG_14-3-3_CanoR_1 256 265 PF00244 0.334
LIG_FHA_1 201 207 PF00498 0.256
LIG_FHA_1 22 28 PF00498 0.665
LIG_FHA_1 270 276 PF00498 0.521
LIG_FHA_1 52 58 PF00498 0.575
LIG_FHA_2 84 90 PF00498 0.491
LIG_LIR_Gen_1 224 234 PF02991 0.345
LIG_LIR_Nem_3 140 146 PF02991 0.505
LIG_LIR_Nem_3 224 230 PF02991 0.311
LIG_LIR_Nem_3 248 253 PF02991 0.247
LIG_LRP6_Inhibitor_1 281 287 PF00058 0.393
LIG_Pex14_2 2 6 PF04695 0.537
LIG_Rb_pABgroove_1 241 249 PF01858 0.288
LIG_SH2_CRK 227 231 PF00017 0.244
LIG_SH2_CRK 39 43 PF00017 0.601
LIG_SH2_GRB2like 227 230 PF00017 0.294
LIG_SH2_STAP1 247 251 PF00017 0.271
LIG_SH2_STAT5 250 253 PF00017 0.338
LIG_SH2_STAT5 270 273 PF00017 0.401
LIG_SH2_STAT5 39 42 PF00017 0.649
LIG_SH2_STAT5 52 55 PF00017 0.559
LIG_SH3_3 199 205 PF00018 0.402
LIG_WRC_WIRS_1 100 105 PF05994 0.508
LIG_WRC_WIRS_1 60 65 PF05994 0.590
MOD_CDK_SPxxK_3 83 90 PF00069 0.534
MOD_CK1_1 102 108 PF00069 0.460
MOD_CK1_1 192 198 PF00069 0.320
MOD_CK1_1 200 206 PF00069 0.325
MOD_CK2_1 103 109 PF00069 0.491
MOD_GlcNHglycan 143 146 PF01048 0.312
MOD_GlcNHglycan 199 202 PF01048 0.325
MOD_GlcNHglycan 213 216 PF01048 0.483
MOD_GlcNHglycan 219 222 PF01048 0.472
MOD_GlcNHglycan 43 46 PF01048 0.336
MOD_GlcNHglycan 78 81 PF01048 0.469
MOD_GlcNHglycan 95 98 PF01048 0.189
MOD_GSK3_1 133 140 PF00069 0.514
MOD_GSK3_1 22 29 PF00069 0.636
MOD_GSK3_1 252 259 PF00069 0.392
MOD_GSK3_1 37 44 PF00069 0.583
MOD_GSK3_1 99 106 PF00069 0.466
MOD_NEK2_1 114 119 PF00069 0.465
MOD_NEK2_1 197 202 PF00069 0.372
MOD_NEK2_1 246 251 PF00069 0.314
MOD_NEK2_1 30 35 PF00069 0.616
MOD_NEK2_1 50 55 PF00069 0.398
MOD_PIKK_1 156 162 PF00454 0.550
MOD_PIKK_1 22 28 PF00454 0.585
MOD_PIKK_1 256 262 PF00454 0.431
MOD_PKA_2 122 128 PF00069 0.553
MOD_PKA_2 211 217 PF00069 0.275
MOD_Plk_4 122 128 PF00069 0.508
MOD_Plk_4 13 19 PF00069 0.534
MOD_Plk_4 166 172 PF00069 0.487
MOD_Plk_4 189 195 PF00069 0.363
MOD_Plk_4 246 252 PF00069 0.280
MOD_Plk_4 258 264 PF00069 0.309
MOD_Plk_4 99 105 PF00069 0.480
MOD_ProDKin_1 103 109 PF00069 0.436
MOD_ProDKin_1 83 89 PF00069 0.590
MOD_SUMO_for_1 238 241 PF00179 0.357
MOD_SUMO_rev_2 214 220 PF00179 0.354
TRG_ENDOCYTIC_2 227 230 PF00928 0.244
TRG_ENDOCYTIC_2 39 42 PF00928 0.596
TRG_ENDOCYTIC_2 60 63 PF00928 0.535
TRG_ER_diArg_1 171 174 PF00400 0.464
TRG_ER_diArg_1 210 213 PF00400 0.277
TRG_ER_diArg_1 225 227 PF00400 0.147
TRG_Pf-PMV_PEXEL_1 273 277 PF00026 0.291

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8W6 Leptomonas seymouri 24% 84%
A0A0N1PCE4 Leptomonas seymouri 79% 93%
A0A0S4JNY1 Bodo saltans 43% 80%
A0A1X0P7C0 Trypanosomatidae 58% 91%
A0A3Q8IEB7 Leishmania donovani 94% 93%
A0A3R7KWT0 Trypanosoma rangeli 60% 93%
A0A3S5H742 Leishmania donovani 99% 91%
A0A3S5H7M7 Leishmania donovani 24% 85%
A0PC02 Ochotona dauurica 28% 94%
A2ADF7 Mus musculus 26% 90%
A3KPP4 Danio rerio 24% 96%
A4H9N5 Leishmania braziliensis 85% 100%
A4H9N6 Leishmania braziliensis 82% 100%
A4HI60 Leishmania braziliensis 24% 85%
A4HXZ9 Leishmania infantum 98% 100%
A4HY01 Leishmania infantum 94% 100%
A4I5D6 Leishmania infantum 24% 100%
B0G143 Dictyostelium discoideum 26% 98%
D0A5A6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 94%
E9ARR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9ARR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9B0N4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
F1RFX9 Sus scrofa 27% 86%
F4HT41 Arabidopsis thaliana 24% 83%
G5EE96 Caenorhabditis elegans 26% 99%
K3VFR5 Fusarium pseudograminearum (strain CS3096) 27% 97%
O77792 Bos taurus 25% 92%
O81845 Arabidopsis thaliana 28% 94%
O89035 Rattus norvegicus 26% 100%
O95258 Homo sapiens 26% 88%
O95847 Homo sapiens 25% 89%
O97562 Sus scrofa 27% 93%
O97649 Sus scrofa 27% 93%
P04575 Mesocricetus auratus 26% 93%
P04633 Rattus norvegicus 25% 93%
P0C582 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 26% 87%
P10861 Bos taurus 29% 93%
P12242 Mus musculus 25% 93%
P14271 Oryctolagus cuniculus 28% 94%
P22292 Bos taurus 25% 91%
P25874 Homo sapiens 29% 93%
P33303 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 89%
P34519 Caenorhabditis elegans 26% 92%
P40464 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 92%
P55851 Homo sapiens 26% 93%
P55916 Homo sapiens 26% 92%
P56499 Rattus norvegicus 27% 93%
P56500 Rattus norvegicus 26% 93%
P56501 Mus musculus 27% 93%
P70406 Mus musculus 26% 93%
P90992 Caenorhabditis elegans 29% 94%
P97700 Rattus norvegicus 25% 91%
Q02978 Homo sapiens 26% 91%
Q06143 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 96%
Q18P97 Suncus murinus 28% 93%
Q27257 Caenorhabditis elegans 25% 92%
Q3SZI5 Bos taurus 26% 93%
Q3SZK0 Bos taurus 24% 94%
Q4Q7J8 Leishmania major 25% 100%
Q4QDQ9 Leishmania major 92% 100%
Q4QDR2 Leishmania major 96% 100%
Q4QDR4 Leishmania major 97% 100%
Q4QDR6 Leishmania major 97% 100%
Q54BM3 Dictyostelium discoideum 23% 96%
Q54FE6 Dictyostelium discoideum 24% 100%
Q54FU9 Dictyostelium discoideum 24% 87%
Q54PY7 Dictyostelium discoideum 26% 90%
Q55DY8 Dictyostelium discoideum 24% 93%
Q5PQM9 Rattus norvegicus 25% 99%
Q5R5A8 Pongo abelii 26% 93%
Q5SVS4 Homo sapiens 25% 99%
Q5SWT3 Mus musculus 23% 96%
Q5XGI1 Xenopus tropicalis 24% 99%
Q5XIF9 Rattus norvegicus 25% 90%
Q6FTN2 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 26% 97%
Q6GQ22 Xenopus laevis 24% 99%
Q6PIV7 Homo sapiens 24% 94%
Q7K566 Drosophila melanogaster 26% 95%
Q8HXE3 Macaca fascicularis 25% 99%
Q8K404 Dicrostonyx groenlandicus 26% 93%
Q8R0Z5 Mus musculus 25% 79%
Q94AG6 Arabidopsis thaliana 25% 88%
Q96A46 Homo sapiens 25% 79%
Q9C5M0 Arabidopsis thaliana 24% 96%
Q9CR58 Mus musculus 25% 99%
Q9CR62 Mus musculus 26% 91%
Q9ER18 Phodopus sungorus 26% 93%
Q9FY68 Arabidopsis thaliana 24% 85%
Q9GMZ1 Canis lupus familiaris 28% 93%
Q9N2I9 Canis lupus familiaris 25% 92%
Q9N2J1 Canis lupus familiaris 26% 93%
Q9QZD8 Mus musculus 25% 100%
Q9SB52 Arabidopsis thaliana 27% 92%
Q9SJY5 Arabidopsis thaliana 31% 92%
Q9UBX3 Homo sapiens 27% 100%
Q9UTN1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 90%
Q9VMK1 Drosophila melanogaster 24% 86%
Q9VQ37 Drosophila melanogaster 24% 79%
Q9W720 Danio rerio 25% 93%
Q9W725 Cyprinus carpio 26% 93%
Q9XI74 Arabidopsis thaliana 26% 94%
Q9Z2B2 Mus musculus 26% 88%
Q9ZWG1 Arabidopsis thaliana 27% 94%
V5BNM4 Trypanosoma cruzi 61% 88%
W5PSH7 Ovis aries 29% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS