Amino acid permease 24, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease 24

Species:

Leishmania donovani

UniProt:

A0A3Q8IB21_LEIDO

TriTrypDb:

LdBPK_100770.1 , LdCL_100014400 , LDHU3_10.1110

Length:

488

Annotations

LeishMANIAdb annotations

Related to animal and plant proton-coupled amino acid transporters. The family has modestly expanded in kinetoplastid parazites.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19
GO:0005774	vacuolar membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2

Expansion

Sequence features

A0A3Q8IB21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB21

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	2
GO:0006810	transport	3	2
GO:0006865	amino acid transport	5	2
GO:0009987	cellular process	1	2
GO:0015849	organic acid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0015171	amino acid transmembrane transporter activity	5	2
GO:0015179	L-amino acid transmembrane transporter activity	6	2
GO:0022857	transmembrane transporter activity	2	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.629
CLV_C14_Caspase3-7	7	11	PF00656	0.726
CLV_NRD_NRD_1	24	26	PF00675	0.514
CLV_PCSK_KEX2_1	296	298	PF00082	0.338
CLV_PCSK_KEX2_1	462	464	PF00082	0.373
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.353
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.415
CLV_PCSK_SKI1_1	301	305	PF00082	0.307
CLV_PCSK_SKI1_1	347	351	PF00082	0.327
CLV_PCSK_SKI1_1	450	454	PF00082	0.357
CLV_PCSK_SKI1_1	88	92	PF00082	0.247
DEG_APCC_KENBOX_2	80	84	PF00400	0.625
DOC_MAPK_FxFP_2	356	359	PF00069	0.348
DOC_MAPK_gen_1	196	205	PF00069	0.306
DOC_MAPK_gen_1	374	383	PF00069	0.476
DOC_MAPK_gen_1	462	472	PF00069	0.483
DOC_MAPK_HePTP_8	373	385	PF00069	0.515
DOC_MAPK_MEF2A_6	133	142	PF00069	0.367
DOC_MAPK_MEF2A_6	196	205	PF00069	0.322
DOC_MAPK_MEF2A_6	347	356	PF00069	0.347
DOC_MAPK_MEF2A_6	376	385	PF00069	0.468
DOC_MAPK_MEF2A_6	386	393	PF00069	0.271
DOC_MAPK_MEF2A_6	463	472	PF00069	0.485
DOC_MAPK_NFAT4_5	386	394	PF00069	0.348
DOC_PP1_RVXF_1	345	351	PF00149	0.354
DOC_PP4_FxxP_1	103	106	PF00568	0.307
DOC_PP4_FxxP_1	356	359	PF00568	0.348
DOC_USP7_MATH_1	224	228	PF00917	0.326
DOC_USP7_MATH_1	230	234	PF00917	0.326
DOC_USP7_MATH_1	414	418	PF00917	0.397
DOC_WW_Pin1_4	337	342	PF00397	0.326
LIG_14-3-3_CanoR_1	23	29	PF00244	0.713
LIG_14-3-3_CanoR_1	3	13	PF00244	0.775
LIG_14-3-3_CanoR_1	443	447	PF00244	0.543
LIG_BIR_II_1	1	5	PF00653	0.749
LIG_BRCT_BRCA1_1	203	207	PF00533	0.436
LIG_EH1_1	113	121	PF00400	0.320
LIG_EH1_1	348	356	PF00400	0.181
LIG_FHA_1	130	136	PF00498	0.403
LIG_FHA_1	229	235	PF00498	0.355
LIG_FHA_1	302	308	PF00498	0.490
LIG_FHA_1	318	324	PF00498	0.262
LIG_FHA_1	328	334	PF00498	0.252
LIG_FHA_1	355	361	PF00498	0.354
LIG_FHA_1	400	406	PF00498	0.333
LIG_FHA_1	479	485	PF00498	0.339
LIG_FHA_2	15	21	PF00498	0.689
LIG_FHA_2	186	192	PF00498	0.338
LIG_FHA_2	25	31	PF00498	0.722
LIG_FHA_2	5	11	PF00498	0.762
LIG_GBD_Chelix_1	115	123	PF00786	0.394
LIG_GBD_Chelix_1	311	319	PF00786	0.437
LIG_LIR_Apic_2	100	106	PF02991	0.326
LIG_LIR_Gen_1	148	157	PF02991	0.509
LIG_LIR_Gen_1	198	208	PF02991	0.321
LIG_LIR_Gen_1	233	244	PF02991	0.378
LIG_LIR_Gen_1	30	38	PF02991	0.716
LIG_LIR_Gen_1	60	68	PF02991	0.746
LIG_LIR_Gen_1	89	98	PF02991	0.364
LIG_LIR_Nem_3	148	153	PF02991	0.468
LIG_LIR_Nem_3	198	203	PF02991	0.329
LIG_LIR_Nem_3	233	239	PF02991	0.383
LIG_LIR_Nem_3	30	35	PF02991	0.746
LIG_LIR_Nem_3	320	325	PF02991	0.374
LIG_LIR_Nem_3	379	383	PF02991	0.492
LIG_LIR_Nem_3	460	464	PF02991	0.547
LIG_LIR_Nem_3	89	94	PF02991	0.364
LIG_PALB2_WD40_1	265	273	PF16756	0.315
LIG_PDZ_Class_3	483	488	PF00595	0.419
LIG_Pex14_1	313	317	PF04695	0.371
LIG_Pex14_1	449	453	PF04695	0.593
LIG_Pex14_2	207	211	PF04695	0.374
LIG_PTB_Apo_2	350	357	PF02174	0.383
LIG_SH2_CRK	150	154	PF00017	0.489
LIG_SH2_CRK	181	185	PF00017	0.390
LIG_SH2_CRK	236	240	PF00017	0.417
LIG_SH2_NCK_1	482	486	PF00017	0.400
LIG_SH2_PTP2	467	470	PF00017	0.440
LIG_SH2_STAP1	181	185	PF00017	0.355
LIG_SH2_STAT3	358	361	PF00017	0.326
LIG_SH2_STAT5	114	117	PF00017	0.331
LIG_SH2_STAT5	156	159	PF00017	0.490
LIG_SH2_STAT5	181	184	PF00017	0.279
LIG_SH2_STAT5	200	203	PF00017	0.348
LIG_SH2_STAT5	314	317	PF00017	0.324
LIG_SH2_STAT5	322	325	PF00017	0.341
LIG_SH2_STAT5	467	470	PF00017	0.316
LIG_SH2_STAT5	61	64	PF00017	0.753
LIG_SH3_3	433	439	PF00018	0.532
LIG_SH3_3	451	457	PF00018	0.627
LIG_SUMO_SIM_anti_2	217	224	PF11976	0.487
LIG_SUMO_SIM_anti_2	281	287	PF11976	0.371
LIG_SUMO_SIM_par_1	221	227	PF11976	0.496
LIG_SUMO_SIM_par_1	303	308	PF11976	0.408
LIG_TYR_ITIM	179	184	PF00017	0.354
LIG_TYR_ITIM	234	239	PF00017	0.417
LIG_TYR_ITSM	146	153	PF00017	0.532
LIG_UBA3_1	427	433	PF00899	0.258
LIG_WRC_WIRS_1	105	110	PF05994	0.354
MOD_CK1_1	145	151	PF00069	0.506
MOD_CK1_1	328	334	PF00069	0.327
MOD_CK1_1	6	12	PF00069	0.739
MOD_CK2_1	14	20	PF00069	0.662
MOD_CK2_1	185	191	PF00069	0.338
MOD_CK2_1	24	30	PF00069	0.733
MOD_CK2_1	31	37	PF00069	0.720
MOD_CK2_1	480	486	PF00069	0.349
MOD_CK2_1	6	12	PF00069	0.726
MOD_GlcNHglycan	363	366	PF01048	0.365
MOD_GlcNHglycan	402	405	PF01048	0.516
MOD_GlcNHglycan	88	91	PF01048	0.301
MOD_GSK3_1	142	149	PF00069	0.548
MOD_GSK3_1	214	221	PF00069	0.364
MOD_GSK3_1	224	231	PF00069	0.329
MOD_GSK3_1	301	308	PF00069	0.511
MOD_GSK3_1	325	332	PF00069	0.319
MOD_GSK3_1	337	344	PF00069	0.257
MOD_GSK3_1	400	407	PF00069	0.443
MOD_GSK3_1	480	487	PF00069	0.378
MOD_N-GLC_1	142	147	PF02516	0.356
MOD_N-GLC_1	218	223	PF02516	0.278
MOD_NEK2_1	179	184	PF00069	0.351
MOD_NEK2_1	185	190	PF00069	0.309
MOD_NEK2_1	195	200	PF00069	0.215
MOD_NEK2_1	201	206	PF00069	0.314
MOD_NEK2_1	242	247	PF00069	0.346
MOD_NEK2_1	305	310	PF00069	0.408
MOD_NEK2_1	317	322	PF00069	0.291
MOD_NEK2_1	329	334	PF00069	0.221
MOD_NEK2_1	354	359	PF00069	0.348
MOD_NEK2_2	230	235	PF00069	0.442
MOD_NEK2_2	342	347	PF00069	0.318
MOD_NEK2_2	457	462	PF00069	0.631
MOD_OFUCOSY	210	215	PF10250	0.378
MOD_PIKK_1	14	20	PF00454	0.693
MOD_PIKK_1	148	154	PF00454	0.514
MOD_PIKK_1	179	185	PF00454	0.351
MOD_PIKK_1	247	253	PF00454	0.335
MOD_PIKK_1	291	297	PF00454	0.522
MOD_PKA_2	24	30	PF00069	0.712
MOD_PKA_2	442	448	PF00069	0.537
MOD_Plk_1	129	135	PF00069	0.348
MOD_Plk_1	145	151	PF00069	0.484
MOD_Plk_1	218	224	PF00069	0.478
MOD_Plk_1	369	375	PF00069	0.527
MOD_Plk_1	68	74	PF00069	0.649
MOD_Plk_4	104	110	PF00069	0.324
MOD_Plk_4	114	120	PF00069	0.324
MOD_Plk_4	185	191	PF00069	0.237
MOD_Plk_4	201	207	PF00069	0.340
MOD_Plk_4	218	224	PF00069	0.400
MOD_Plk_4	230	236	PF00069	0.318
MOD_Plk_4	24	30	PF00069	0.727
MOD_Plk_4	242	248	PF00069	0.278
MOD_Plk_4	301	307	PF00069	0.482
MOD_Plk_4	329	335	PF00069	0.255
MOD_Plk_4	404	410	PF00069	0.279
MOD_Plk_4	423	429	PF00069	0.192
MOD_Plk_4	68	74	PF00069	0.685
MOD_ProDKin_1	337	343	PF00069	0.326
MOD_SUMO_rev_2	50	58	PF00179	0.787
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.374
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.414
TRG_ENDOCYTIC_2	150	153	PF00928	0.453
TRG_ENDOCYTIC_2	181	184	PF00928	0.362
TRG_ENDOCYTIC_2	200	203	PF00928	0.198
TRG_ENDOCYTIC_2	236	239	PF00928	0.378
TRG_ENDOCYTIC_2	314	317	PF00928	0.327
TRG_ENDOCYTIC_2	467	470	PF00928	0.337
TRG_ENDOCYTIC_2	61	64	PF00928	0.753
TRG_NLS_Bipartite_1	450	466	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H0	Leptomonas seymouri	71%	100%
A0A0N0P8T9	Leptomonas seymouri	21%	98%
A0A0N1PCP5	Leptomonas seymouri	69%	100%
A0A1X0NHS6	Trypanosomatidae	46%	100%
A0A1X0NKS5	Trypanosomatidae	21%	100%
A0A1X0NKV2	Trypanosomatidae	23%	98%
A0A1X0NRL3	Trypanosomatidae	24%	100%
A0A1X0NYI3	Trypanosomatidae	22%	98%
A0A1X0NZK6	Trypanosomatidae	49%	100%
A0A1X0P7Z8	Trypanosomatidae	31%	78%
A0A381MBS1	Leishmania infantum	99%	100%
A0A3Q8IFZ0	Leishmania donovani	23%	95%
A0A3S5H6G5	Leishmania donovani	100%	100%
A0A3S5H6T4	Leishmania donovani	23%	96%
A0A3S5ISG3	Trypanosoma rangeli	25%	99%
A0A3S7WQ39	Leishmania donovani	21%	100%
A0A422MW74	Trypanosoma rangeli	21%	95%
A0A422MZQ8	Trypanosoma rangeli	35%	82%
A4H565	Leishmania braziliensis	21%	100%
A4H662	Leishmania braziliensis	79%	100%
A4HJ07	Leishmania braziliensis	22%	98%
A4HKQ7	Leishmania braziliensis	23%	100%
A4HNZ6	Leishmania braziliensis	30%	100%
A4HTE2	Leishmania infantum	21%	100%
A4HUI4	Leishmania infantum	99%	100%
A4I6K0	Leishmania infantum	23%	95%
C9ZW15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A2X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	85%
E9AN82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AYW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
F4ILY9	Arabidopsis thaliana	23%	100%
O22719	Arabidopsis thaliana	20%	100%
P36062	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	71%
Q10074	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	74%
Q495M3	Homo sapiens	21%	100%
Q495N2	Homo sapiens	23%	100%
Q4KL91	Xenopus laevis	22%	93%
Q4Q6M8	Leishmania major	24%	95%
Q4QHE2	Leishmania major	94%	100%
Q4QHE4	Leishmania major	94%	100%
Q4QIH0	Leishmania major	22%	100%
Q4V8B1	Rattus norvegicus	24%	100%
Q6YBV0	Homo sapiens	21%	97%
Q7Z2H8	Homo sapiens	22%	100%
Q811P0	Mus musculus	23%	100%
Q8CH36	Mus musculus	22%	98%
Q8K415	Rattus norvegicus	22%	100%
Q8K4D3	Mus musculus	23%	100%
Q924A5	Rattus norvegicus	22%	100%
Q9SF09	Arabidopsis thaliana	21%	100%
Q9SS86	Arabidopsis thaliana	21%	100%
Q9SVG0	Arabidopsis thaliana	24%	100%
Q9VT04	Drosophila melanogaster	21%	100%
Q9W056	Drosophila melanogaster	25%	100%
V5BHF0	Trypanosoma cruzi	43%	100%
V5BJY7	Trypanosoma cruzi	34%	82%