DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB20_LEIDO

TriTrypDb:

LdBPK_180320.1 , LdCL_180008100 , LDHU3_18.0400

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IB20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.336
CLV_NRD_NRD_1	105	107	PF00675	0.267
CLV_NRD_NRD_1	255	257	PF00675	0.472
CLV_NRD_NRD_1	92	94	PF00675	0.267
CLV_PCSK_KEX2_1	250	252	PF00082	0.492
CLV_PCSK_KEX2_1	254	256	PF00082	0.459
CLV_PCSK_KEX2_1	73	75	PF00082	0.442
CLV_PCSK_KEX2_1	92	94	PF00082	0.153
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.613
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.450
CLV_PCSK_PC7_1	251	257	PF00082	0.462
CLV_PCSK_SKI1_1	97	101	PF00082	0.360
CLV_Separin_Metazoa	129	133	PF03568	0.423
DEG_Nend_Nbox_1	1	3	PF02207	0.524
DOC_MAPK_gen_1	73	81	PF00069	0.296
DOC_MAPK_MEF2A_6	132	140	PF00069	0.565
DOC_MAPK_MEF2A_6	74	83	PF00069	0.267
DOC_PP1_RVXF_1	42	49	PF00149	0.408
DOC_PP1_RVXF_1	90	97	PF00149	0.267
DOC_WW_Pin1_4	132	137	PF00397	0.471
LIG_14-3-3_CanoR_1	106	112	PF00244	0.256
LIG_14-3-3_CanoR_1	18	23	PF00244	0.439
LIG_14-3-3_CanoR_1	189	195	PF00244	0.383
LIG_14-3-3_CanoR_1	217	225	PF00244	0.316
LIG_14-3-3_CanoR_1	62	67	PF00244	0.376
LIG_14-3-3_CterR_2	256	260	PF00244	0.451
LIG_FHA_1	133	139	PF00498	0.580
LIG_FHA_1	220	226	PF00498	0.344
LIG_FHA_1	3	9	PF00498	0.462
LIG_HP1_1	136	140	PF01393	0.426
LIG_LIR_Gen_1	17	26	PF02991	0.389
LIG_LIR_Nem_3	146	151	PF02991	0.410
LIG_LIR_Nem_3	17	22	PF02991	0.385
LIG_LIR_Nem_3	230	236	PF02991	0.418
LIG_Pex14_1	96	100	PF04695	0.282
LIG_Pex14_2	169	173	PF04695	0.267
LIG_SH2_CRK	63	67	PF00017	0.360
LIG_SH2_GRB2like	32	35	PF00017	0.443
LIG_SH2_STAP1	126	130	PF00017	0.487
LIG_SH2_STAP1	63	67	PF00017	0.355
LIG_SH2_STAT5	233	236	PF00017	0.472
LIG_SH2_STAT5	32	35	PF00017	0.422
LIG_SH3_3	196	202	PF00018	0.301
LIG_SUMO_SIM_par_1	135	142	PF11976	0.457
LIG_TRAF2_1	227	230	PF00917	0.425
LIG_UBA3_1	147	156	PF00899	0.360
MOD_CK1_1	110	116	PF00069	0.276
MOD_CK1_1	164	170	PF00069	0.412
MOD_CK1_1	17	23	PF00069	0.395
MOD_CK2_1	236	242	PF00069	0.495
MOD_CK2_1	62	68	PF00069	0.445
MOD_Cter_Amidation	248	251	PF01082	0.617
MOD_GlcNHglycan	206	210	PF01048	0.291
MOD_GlcNHglycan	244	247	PF01048	0.512
MOD_GSK3_1	14	21	PF00069	0.434
MOD_GSK3_1	159	166	PF00069	0.268
MOD_GSK3_1	50	57	PF00069	0.438
MOD_N-GLC_1	107	112	PF02516	0.410
MOD_N-GLC_1	218	223	PF02516	0.429
MOD_N-GLC_1	33	38	PF02516	0.442
MOD_N-GLC_2	120	122	PF02516	0.282
MOD_NEK2_1	100	105	PF00069	0.304
MOD_NEK2_1	163	168	PF00069	0.267
MOD_NEK2_1	236	241	PF00069	0.497
MOD_NEK2_1	33	38	PF00069	0.367
MOD_NEK2_2	182	187	PF00069	0.278
MOD_PK_1	107	113	PF00069	0.301
MOD_PK_1	18	24	PF00069	0.435
MOD_PK_1	62	68	PF00069	0.410
MOD_PKA_2	17	23	PF00069	0.395
MOD_PKA_2	182	188	PF00069	0.278
MOD_PKA_2	2	8	PF00069	0.510
MOD_PKA_2	202	208	PF00069	0.432
MOD_PKA_2	50	56	PF00069	0.350
MOD_PKA_2	61	67	PF00069	0.462
MOD_Plk_1	107	113	PF00069	0.419
MOD_Plk_1	218	224	PF00069	0.508
MOD_Plk_1	236	242	PF00069	0.499
MOD_Plk_1	33	39	PF00069	0.472
MOD_Plk_4	18	24	PF00069	0.435
MOD_Plk_4	62	68	PF00069	0.426
MOD_ProDKin_1	132	138	PF00069	0.470
TRG_DiLeu_BaEn_4	229	235	PF01217	0.453
TRG_ENDOCYTIC_2	233	236	PF00928	0.472
TRG_ENDOCYTIC_2	28	31	PF00928	0.428
TRG_ENDOCYTIC_2	63	66	PF00928	0.361
TRG_ER_diArg_1	186	189	PF00400	0.324
TRG_ER_diArg_1	253	256	PF00400	0.466
TRG_ER_diArg_1	92	94	PF00400	0.304
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIG6	Leptomonas seymouri	73%	100%
A0A0S4JHH1	Bodo saltans	51%	100%
A0A1X0P874	Trypanosomatidae	68%	100%
A0A422NWN7	Trypanosoma rangeli	72%	100%
A4H9D6	Leishmania braziliensis	90%	100%
D0A038	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AGQ2	Leishmania infantum	100%	100%
E9ARG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B6F4	Trypanosoma cruzi	68%	100%