Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB18_LEIDO

TriTrypDb:

LdBPK_210460.1 , LdCL_210009400 , LDHU3_21.0490

Length:

721

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IB18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB18

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.635
CLV_C14_Caspase3-7	432	436	PF00656	0.402
CLV_NRD_NRD_1	149	151	PF00675	0.666
CLV_NRD_NRD_1	19	21	PF00675	0.670
CLV_NRD_NRD_1	636	638	PF00675	0.330
CLV_NRD_NRD_1	679	681	PF00675	0.382
CLV_PCSK_KEX2_1	149	151	PF00082	0.690
CLV_PCSK_KEX2_1	19	21	PF00082	0.640
CLV_PCSK_KEX2_1	196	198	PF00082	0.569
CLV_PCSK_KEX2_1	546	548	PF00082	0.284
CLV_PCSK_KEX2_1	636	638	PF00082	0.304
CLV_PCSK_KEX2_1	679	681	PF00082	0.382
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.569
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.264
CLV_PCSK_SKI1_1	339	343	PF00082	0.320
CLV_PCSK_SKI1_1	526	530	PF00082	0.382
CLV_PCSK_SKI1_1	554	558	PF00082	0.297
CLV_PCSK_SKI1_1	692	696	PF00082	0.454
DEG_APCC_DBOX_1	284	292	PF00400	0.290
DEG_APCC_DBOX_1	635	643	PF00400	0.382
DEG_APCC_KENBOX_2	418	422	PF00400	0.264
DEG_SCF_FBW7_1	94	101	PF00400	0.554
DEG_SPOP_SBC_1	601	605	PF00917	0.354
DEG_SPOP_SBC_1	621	625	PF00917	0.212
DEG_SPOP_SBC_1	707	711	PF00917	0.302
DOC_MAPK_gen_1	396	403	PF00069	0.264
DOC_MAPK_gen_1	559	566	PF00069	0.257
DOC_MAPK_gen_1	589	599	PF00069	0.154
DOC_MAPK_HePTP_8	477	489	PF00069	0.382
DOC_MAPK_HePTP_8	556	568	PF00069	0.284
DOC_MAPK_MEF2A_6	113	121	PF00069	0.586
DOC_MAPK_MEF2A_6	480	489	PF00069	0.284
DOC_MAPK_MEF2A_6	559	568	PF00069	0.337
DOC_MAPK_RevD_3	531	547	PF00069	0.248
DOC_PP4_FxxP_1	504	507	PF00568	0.290
DOC_PP4_FxxP_1	698	701	PF00568	0.382
DOC_USP7_MATH_1	12	16	PF00917	0.577
DOC_USP7_MATH_1	128	132	PF00917	0.680
DOC_USP7_MATH_1	208	212	PF00917	0.579
DOC_USP7_MATH_1	220	224	PF00917	0.615
DOC_USP7_MATH_1	431	435	PF00917	0.298
DOC_USP7_MATH_1	601	605	PF00917	0.302
DOC_USP7_MATH_1	621	625	PF00917	0.427
DOC_USP7_MATH_1	65	69	PF00917	0.655
DOC_USP7_MATH_1	98	102	PF00917	0.615
DOC_USP7_UBL2_3	335	339	PF12436	0.368
DOC_WW_Pin1_4	101	106	PF00397	0.537
DOC_WW_Pin1_4	140	145	PF00397	0.685
DOC_WW_Pin1_4	167	172	PF00397	0.619
DOC_WW_Pin1_4	178	183	PF00397	0.501
DOC_WW_Pin1_4	201	206	PF00397	0.584
DOC_WW_Pin1_4	233	238	PF00397	0.545
DOC_WW_Pin1_4	240	245	PF00397	0.466
DOC_WW_Pin1_4	39	44	PF00397	0.655
DOC_WW_Pin1_4	452	457	PF00397	0.290
DOC_WW_Pin1_4	60	65	PF00397	0.669
DOC_WW_Pin1_4	94	99	PF00397	0.549
LIG_14-3-3_CanoR_1	100	105	PF00244	0.578
LIG_14-3-3_CanoR_1	149	157	PF00244	0.667
LIG_14-3-3_CanoR_1	188	193	PF00244	0.574
LIG_14-3-3_CanoR_1	19	28	PF00244	0.518
LIG_APCC_ABBAyCdc20_2	480	486	PF00400	0.382
LIG_BIR_III_4	703	707	PF00653	0.382
LIG_BRCT_BRCA1_1	132	136	PF00533	0.745
LIG_BRCT_BRCA1_1	399	403	PF00533	0.365
LIG_CaM_IQ_9	545	561	PF13499	0.355
LIG_FHA_1	158	164	PF00498	0.742
LIG_FHA_1	248	254	PF00498	0.520
LIG_FHA_1	362	368	PF00498	0.326
LIG_FHA_1	467	473	PF00498	0.308
LIG_FHA_1	493	499	PF00498	0.442
LIG_FHA_1	528	534	PF00498	0.382
LIG_FHA_1	61	67	PF00498	0.786
LIG_FHA_1	650	656	PF00498	0.382
LIG_FHA_1	709	715	PF00498	0.273
LIG_FHA_1	71	77	PF00498	0.504
LIG_FHA_2	170	176	PF00498	0.665
LIG_FHA_2	430	436	PF00498	0.365
LIG_FHA_2	476	482	PF00498	0.328
LIG_FHA_2	575	581	PF00498	0.387
LIG_FHA_2	686	692	PF00498	0.301
LIG_LIR_Apic_2	502	507	PF02991	0.326
LIG_LIR_Apic_2	88	94	PF02991	0.639
LIG_LIR_Gen_1	250	260	PF02991	0.418
LIG_LIR_Gen_1	362	371	PF02991	0.266
LIG_LIR_Gen_1	481	492	PF02991	0.280
LIG_LIR_Gen_1	710	721	PF02991	0.280
LIG_LIR_Nem_3	250	255	PF02991	0.459
LIG_LIR_Nem_3	290	295	PF02991	0.348
LIG_LIR_Nem_3	362	366	PF02991	0.266
LIG_LIR_Nem_3	481	487	PF02991	0.325
LIG_LIR_Nem_3	710	716	PF02991	0.280
LIG_PCNA_PIPBox_1	569	578	PF02747	0.382
LIG_PTB_Apo_2	264	271	PF02174	0.228
LIG_PTB_Phospho_1	264	270	PF10480	0.245
LIG_SH2_CRK	539	543	PF00017	0.266
LIG_SH2_CRK	91	95	PF00017	0.647
LIG_SH2_NCK_1	717	721	PF00017	0.308
LIG_SH2_PTP2	713	716	PF00017	0.290
LIG_SH2_SRC	83	86	PF00017	0.606
LIG_SH2_STAP1	539	543	PF00017	0.274
LIG_SH2_STAP1	717	721	PF00017	0.326
LIG_SH2_STAT3	673	676	PF00017	0.375
LIG_SH2_STAT5	270	273	PF00017	0.297
LIG_SH2_STAT5	295	298	PF00017	0.431
LIG_SH2_STAT5	509	512	PF00017	0.382
LIG_SH2_STAT5	575	578	PF00017	0.340
LIG_SH2_STAT5	667	670	PF00017	0.257
LIG_SH2_STAT5	697	700	PF00017	0.346
LIG_SH2_STAT5	713	716	PF00017	0.190
LIG_SH2_STAT5	83	86	PF00017	0.606
LIG_SH2_STAT5	91	94	PF00017	0.642
LIG_SH3_2	144	149	PF14604	0.604
LIG_SH3_3	135	141	PF00018	0.635
LIG_SH3_3	202	208	PF00018	0.684
LIG_SH3_3	50	56	PF00018	0.556
LIG_SH3_3	561	567	PF00018	0.304
LIG_SUMO_SIM_anti_2	315	321	PF11976	0.336
LIG_SUMO_SIM_par_1	54	60	PF11976	0.501
LIG_TRAF2_1	479	482	PF00917	0.244
LIG_TRAF2_1	631	634	PF00917	0.372
LIG_TYR_ITIM	715	720	PF00017	0.295
LIG_UBA3_1	316	322	PF00899	0.266
LIG_UBA3_1	541	546	PF00899	0.260
MOD_CDC14_SPxK_1	146	149	PF00782	0.604
MOD_CDK_SPxK_1	143	149	PF00069	0.604
MOD_CDK_SPxK_1	94	100	PF00069	0.552
MOD_CDK_SPxxK_3	143	150	PF00069	0.607
MOD_CDK_SPxxK_3	178	185	PF00069	0.571
MOD_CDK_SPxxK_3	60	67	PF00069	0.556
MOD_CK1_1	101	107	PF00069	0.664
MOD_CK1_1	131	137	PF00069	0.712
MOD_CK1_1	143	149	PF00069	0.682
MOD_CK1_1	169	175	PF00069	0.614
MOD_CK1_1	178	184	PF00069	0.594
MOD_CK1_1	204	210	PF00069	0.603
MOD_CK1_1	230	236	PF00069	0.668
MOD_CK1_1	243	249	PF00069	0.542
MOD_CK1_1	414	420	PF00069	0.316
MOD_CK1_1	488	494	PF00069	0.415
MOD_CK1_1	51	57	PF00069	0.591
MOD_CK1_1	6	12	PF00069	0.667
MOD_CK1_1	60	66	PF00069	0.571
MOD_CK1_1	603	609	PF00069	0.356
MOD_CK1_1	624	630	PF00069	0.365
MOD_CK1_1	70	76	PF00069	0.625
MOD_CK2_1	169	175	PF00069	0.639
MOD_CK2_1	19	25	PF00069	0.708
MOD_CK2_1	299	305	PF00069	0.300
MOD_CK2_1	414	420	PF00069	0.363
MOD_CK2_1	475	481	PF00069	0.366
MOD_CK2_1	574	580	PF00069	0.387
MOD_CK2_1	685	691	PF00069	0.303
MOD_GlcNHglycan	106	109	PF01048	0.738
MOD_GlcNHglycan	12	15	PF01048	0.655
MOD_GlcNHglycan	152	155	PF01048	0.719
MOD_GlcNHglycan	218	221	PF01048	0.670
MOD_GlcNHglycan	240	243	PF01048	0.640
MOD_GlcNHglycan	301	304	PF01048	0.405
MOD_GlcNHglycan	427	430	PF01048	0.272
MOD_GlcNHglycan	450	453	PF01048	0.340
MOD_GlcNHglycan	59	62	PF01048	0.669
MOD_GlcNHglycan	605	608	PF01048	0.364
MOD_GlcNHglycan	610	613	PF01048	0.409
MOD_GlcNHglycan	663	666	PF01048	0.328
MOD_GlcNHglycan	67	70	PF01048	0.628
MOD_GlcNHglycan	8	11	PF01048	0.669
MOD_GSK3_1	139	146	PF00069	0.656
MOD_GSK3_1	162	169	PF00069	0.600
MOD_GSK3_1	188	195	PF00069	0.583
MOD_GSK3_1	2	9	PF00069	0.610
MOD_GSK3_1	204	211	PF00069	0.487
MOD_GSK3_1	216	223	PF00069	0.553
MOD_GSK3_1	227	234	PF00069	0.664
MOD_GSK3_1	238	245	PF00069	0.601
MOD_GSK3_1	320	327	PF00069	0.414
MOD_GSK3_1	397	404	PF00069	0.328
MOD_GSK3_1	425	432	PF00069	0.308
MOD_GSK3_1	44	51	PF00069	0.731
MOD_GSK3_1	448	455	PF00069	0.367
MOD_GSK3_1	488	495	PF00069	0.459
MOD_GSK3_1	620	627	PF00069	0.422
MOD_GSK3_1	72	79	PF00069	0.707
MOD_GSK3_1	85	92	PF00069	0.531
MOD_GSK3_1	94	101	PF00069	0.592
MOD_N-GLC_1	155	160	PF02516	0.616
MOD_N-GLC_1	166	171	PF02516	0.507
MOD_N-GLC_1	2	7	PF02516	0.584
MOD_N-GLC_1	324	329	PF02516	0.382
MOD_N-GLC_1	475	480	PF02516	0.326
MOD_N-GLC_1	608	613	PF02516	0.245
MOD_N-GLC_1	619	624	PF02516	0.239
MOD_N-GLC_2	267	269	PF02516	0.228
MOD_NEK2_1	121	126	PF00069	0.600
MOD_NEK2_1	129	134	PF00069	0.546
MOD_NEK2_1	177	182	PF00069	0.581
MOD_NEK2_1	192	197	PF00069	0.516
MOD_NEK2_1	231	236	PF00069	0.710
MOD_NEK2_1	253	258	PF00069	0.455
MOD_NEK2_1	320	325	PF00069	0.342
MOD_NEK2_1	401	406	PF00069	0.381
MOD_NEK2_1	423	428	PF00069	0.374
MOD_NEK2_1	590	595	PF00069	0.194
MOD_NEK2_1	649	654	PF00069	0.293
MOD_NEK2_1	89	94	PF00069	0.692
MOD_NEK2_2	208	213	PF00069	0.542
MOD_NEK2_2	265	270	PF00069	0.266
MOD_NEK2_2	527	532	PF00069	0.382
MOD_NMyristoyl	1	7	PF02799	0.562
MOD_PIKK_1	111	117	PF00454	0.704
MOD_PIKK_1	121	127	PF00454	0.683
MOD_PIKK_1	19	25	PF00454	0.708
MOD_PIKK_1	590	596	PF00454	0.327
MOD_PKA_1	19	25	PF00069	0.501
MOD_PKA_1	397	403	PF00069	0.365
MOD_PKA_2	19	25	PF00069	0.640
MOD_Plk_1	208	214	PF00069	0.655
MOD_Plk_1	305	311	PF00069	0.284
MOD_Plk_1	361	367	PF00069	0.330
MOD_Plk_1	391	397	PF00069	0.414
MOD_Plk_1	485	491	PF00069	0.284
MOD_Plk_1	582	588	PF00069	0.284
MOD_Plk_1	682	688	PF00069	0.267
MOD_Plk_1	98	104	PF00069	0.572
MOD_Plk_2-3	574	580	PF00069	0.382
MOD_Plk_4	270	276	PF00069	0.354
MOD_Plk_4	305	311	PF00069	0.293
MOD_Plk_4	312	318	PF00069	0.326
MOD_Plk_4	493	499	PF00069	0.367
MOD_Plk_4	85	91	PF00069	0.632
MOD_ProDKin_1	101	107	PF00069	0.538
MOD_ProDKin_1	140	146	PF00069	0.684
MOD_ProDKin_1	167	173	PF00069	0.617
MOD_ProDKin_1	178	184	PF00069	0.500
MOD_ProDKin_1	201	207	PF00069	0.580
MOD_ProDKin_1	233	239	PF00069	0.563
MOD_ProDKin_1	240	246	PF00069	0.479
MOD_ProDKin_1	39	45	PF00069	0.654
MOD_ProDKin_1	452	458	PF00069	0.290
MOD_ProDKin_1	60	66	PF00069	0.672
MOD_ProDKin_1	94	100	PF00069	0.552
MOD_SUMO_for_1	347	350	PF00179	0.277
MOD_SUMO_for_1	389	392	PF00179	0.264
MOD_SUMO_rev_2	414	423	PF00179	0.310
MOD_SUMO_rev_2	519	524	PF00179	0.304
MOD_SUMO_rev_2	79	89	PF00179	0.544
TRG_DiLeu_BaEn_2	361	367	PF01217	0.266
TRG_DiLeu_BaEn_2	649	655	PF01217	0.382
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.290
TRG_ENDOCYTIC_2	539	542	PF00928	0.266
TRG_ENDOCYTIC_2	697	700	PF00928	0.355
TRG_ENDOCYTIC_2	713	716	PF00928	0.192
TRG_ENDOCYTIC_2	717	720	PF00928	0.302
TRG_ER_diArg_1	18	20	PF00400	0.508
TRG_ER_diArg_1	284	287	PF00400	0.273
TRG_ER_diArg_1	635	637	PF00400	0.304
TRG_ER_diArg_1	678	680	PF00400	0.382
TRG_NLS_MonoExtN_4	636	641	PF00514	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z2	Leptomonas seymouri	23%	90%
A0A0N0P852	Leptomonas seymouri	62%	95%
A0A422MZT5	Trypanosoma rangeli	41%	100%
A4HBN8	Leishmania braziliensis	74%	99%
A4HZ39	Leishmania infantum	99%	100%
A4IBF1	Leishmania infantum	24%	100%
D0A1P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AV07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCH5	Leishmania major	95%	100%
Q6FQF0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	20%	81%
V5DGZ8	Trypanosoma cruzi	40%	100%