Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB16_LEIDO

TriTrypDb:

LdBPK_180870.1 , LdCL_180013900 , LDHU3_18.1120

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IB16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.732
CLV_C14_Caspase3-7	383	387	PF00656	0.602
CLV_NRD_NRD_1	239	241	PF00675	0.503
CLV_NRD_NRD_1	299	301	PF00675	0.470
CLV_NRD_NRD_1	416	418	PF00675	0.600
CLV_NRD_NRD_1	436	438	PF00675	0.398
CLV_NRD_NRD_1	505	507	PF00675	0.599
CLV_NRD_NRD_1	51	53	PF00675	0.640
CLV_PCSK_KEX2_1	239	241	PF00082	0.523
CLV_PCSK_KEX2_1	416	418	PF00082	0.640
CLV_PCSK_KEX2_1	431	433	PF00082	0.476
CLV_PCSK_KEX2_1	505	507	PF00082	0.551
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.560
CLV_PCSK_PC7_1	501	507	PF00082	0.494
CLV_PCSK_SKI1_1	240	244	PF00082	0.330
CLV_PCSK_SKI1_1	263	267	PF00082	0.438
CLV_PCSK_SKI1_1	416	420	PF00082	0.738
CLV_PCSK_SKI1_1	501	505	PF00082	0.453
CLV_PCSK_SKI1_1	81	85	PF00082	0.406
DEG_APCC_DBOX_1	495	503	PF00400	0.453
DEG_Nend_UBRbox_3	1	3	PF02207	0.530
DEG_SPOP_SBC_1	422	426	PF00917	0.610
DOC_ANK_TNKS_1	504	511	PF00023	0.533
DOC_CYCLIN_RxL_1	105	117	PF00134	0.622
DOC_MAPK_gen_1	105	114	PF00069	0.660
DOC_MAPK_gen_1	496	504	PF00069	0.490
DOC_MAPK_HePTP_8	7	19	PF00069	0.486
DOC_MAPK_MEF2A_6	10	19	PF00069	0.483
DOC_MAPK_MEF2A_6	149	156	PF00069	0.460
DOC_MAPK_MEF2A_6	254	261	PF00069	0.406
DOC_MAPK_MEF2A_6	30	37	PF00069	0.227
DOC_MAPK_MEF2A_6	351	360	PF00069	0.469
DOC_MAPK_MEF2A_6	57	66	PF00069	0.507
DOC_PP1_RVXF_1	499	505	PF00149	0.464
DOC_PP2B_LxvP_1	215	218	PF13499	0.541
DOC_PP4_FxxP_1	261	264	PF00568	0.409
DOC_PP4_FxxP_1	526	529	PF00568	0.424
DOC_USP7_MATH_1	104	108	PF00917	0.661
DOC_USP7_MATH_1	205	209	PF00917	0.687
DOC_USP7_MATH_1	225	229	PF00917	0.622
DOC_USP7_MATH_1	345	349	PF00917	0.622
DOC_USP7_MATH_1	378	382	PF00917	0.660
DOC_USP7_MATH_1	421	425	PF00917	0.601
DOC_USP7_UBL2_3	438	442	PF12436	0.681
DOC_USP7_UBL2_3	513	517	PF12436	0.499
DOC_WW_Pin1_4	100	105	PF00397	0.604
DOC_WW_Pin1_4	174	179	PF00397	0.356
DOC_WW_Pin1_4	201	206	PF00397	0.640
DOC_WW_Pin1_4	213	218	PF00397	0.602
DOC_WW_Pin1_4	221	226	PF00397	0.647
DOC_WW_Pin1_4	491	496	PF00397	0.548
DOC_WW_Pin1_4	52	57	PF00397	0.649
LIG_14-3-3_CanoR_1	110	115	PF00244	0.663
LIG_14-3-3_CanoR_1	188	195	PF00244	0.565
LIG_14-3-3_CanoR_1	254	258	PF00244	0.359
LIG_14-3-3_CanoR_1	280	289	PF00244	0.490
LIG_14-3-3_CanoR_1	3	8	PF00244	0.537
LIG_14-3-3_CanoR_1	403	409	PF00244	0.799
LIG_14-3-3_CanoR_1	411	419	PF00244	0.665
LIG_14-3-3_CanoR_1	437	446	PF00244	0.579
LIG_14-3-3_CanoR_1	91	95	PF00244	0.556
LIG_Actin_WH2_2	69	87	PF00022	0.415
LIG_BIR_III_4	169	173	PF00653	0.481
LIG_BRCT_BRCA1_1	78	82	PF00533	0.399
LIG_BRCT_BRCA1_1	91	95	PF00533	0.536
LIG_CtBP_PxDLS_1	4	8	PF00389	0.461
LIG_EH1_1	469	477	PF00400	0.449
LIG_FHA_1	169	175	PF00498	0.534
LIG_FHA_1	188	194	PF00498	0.259
LIG_FHA_1	254	260	PF00498	0.408
LIG_FHA_1	284	290	PF00498	0.493
LIG_FHA_1	291	297	PF00498	0.516
LIG_FHA_1	32	38	PF00498	0.333
LIG_FHA_1	353	359	PF00498	0.412
LIG_FHA_1	522	528	PF00498	0.358
LIG_FHA_2	155	161	PF00498	0.467
LIG_FHA_2	377	383	PF00498	0.637
LIG_LIR_Apic_2	258	264	PF02991	0.395
LIG_LIR_Apic_2	523	529	PF02991	0.419
LIG_LIR_Gen_1	123	133	PF02991	0.586
LIG_LIR_Nem_3	123	129	PF02991	0.589
LIG_LIR_Nem_3	79	83	PF02991	0.434
LIG_MYND_3	508	512	PF01753	0.526
LIG_NRBOX	498	504	PF00104	0.537
LIG_PDZ_Class_1	530	535	PF00595	0.456
LIG_SH2_CRK	22	26	PF00017	0.509
LIG_SH2_CRK	80	84	PF00017	0.398
LIG_SH2_STAP1	166	170	PF00017	0.486
LIG_SH2_STAP1	522	526	PF00017	0.353
LIG_SH2_STAT5	251	254	PF00017	0.436
LIG_SH2_STAT5	28	31	PF00017	0.418
LIG_SH2_STAT5	36	39	PF00017	0.380
LIG_SH2_STAT5	522	525	PF00017	0.338
LIG_SH3_3	219	225	PF00018	0.628
LIG_SH3_3	339	345	PF00018	0.607
LIG_SH3_3	38	44	PF00018	0.408
LIG_SH3_3	98	104	PF00018	0.552
LIG_SUMO_SIM_anti_2	355	361	PF11976	0.413
LIG_SUMO_SIM_par_1	190	197	PF11976	0.299
LIG_SUMO_SIM_par_1	255	260	PF11976	0.396
LIG_SUMO_SIM_par_1	528	533	PF11976	0.374
LIG_TYR_ITIM	20	25	PF00017	0.503
MOD_CDK_SPK_2	100	105	PF00069	0.604
MOD_CDK_SPK_2	491	496	PF00069	0.502
MOD_CDK_SPK_2	52	57	PF00069	0.649
MOD_CDK_SPxK_1	201	207	PF00069	0.622
MOD_CDK_SPxxK_3	491	498	PF00069	0.527
MOD_CK1_1	103	109	PF00069	0.693
MOD_CK1_1	121	127	PF00069	0.775
MOD_CK1_1	136	142	PF00069	0.597
MOD_CK1_1	144	150	PF00069	0.599
MOD_CK1_1	194	200	PF00069	0.593
MOD_CK1_1	213	219	PF00069	0.550
MOD_CK1_1	220	226	PF00069	0.674
MOD_CK1_1	228	234	PF00069	0.616
MOD_CK1_1	318	324	PF00069	0.617
MOD_CK1_1	352	358	PF00069	0.444
MOD_CK1_1	391	397	PF00069	0.728
MOD_CK1_1	407	413	PF00069	0.782
MOD_CK1_1	451	457	PF00069	0.664
MOD_CK1_1	477	483	PF00069	0.485
MOD_CK1_1	55	61	PF00069	0.632
MOD_CK2_1	242	248	PF00069	0.473
MOD_CK2_1	365	371	PF00069	0.629
MOD_CK2_1	376	382	PF00069	0.653
MOD_Cter_Amidation	435	438	PF01082	0.560
MOD_GlcNHglycan	135	138	PF01048	0.669
MOD_GlcNHglycan	143	146	PF01048	0.631
MOD_GlcNHglycan	227	230	PF01048	0.651
MOD_GlcNHglycan	323	326	PF01048	0.661
MOD_GlcNHglycan	347	350	PF01048	0.577
MOD_GlcNHglycan	393	396	PF01048	0.779
MOD_GlcNHglycan	476	479	PF01048	0.403
MOD_GSK3_1	110	117	PF00069	0.569
MOD_GSK3_1	124	131	PF00069	0.710
MOD_GSK3_1	150	157	PF00069	0.472
MOD_GSK3_1	187	194	PF00069	0.444
MOD_GSK3_1	201	208	PF00069	0.557
MOD_GSK3_1	213	220	PF00069	0.667
MOD_GSK3_1	221	228	PF00069	0.652
MOD_GSK3_1	242	249	PF00069	0.438
MOD_GSK3_1	31	38	PF00069	0.333
MOD_GSK3_1	314	321	PF00069	0.662
MOD_GSK3_1	324	331	PF00069	0.563
MOD_GSK3_1	345	352	PF00069	0.551
MOD_GSK3_1	387	394	PF00069	0.587
MOD_GSK3_1	406	413	PF00069	0.768
MOD_GSK3_1	417	424	PF00069	0.527
MOD_GSK3_1	90	97	PF00069	0.470
MOD_GSK3_1	99	106	PF00069	0.656
MOD_N-GLC_1	491	496	PF02516	0.483
MOD_N-GLC_1	60	65	PF02516	0.553
MOD_NEK2_1	114	119	PF00069	0.639
MOD_NEK2_1	135	140	PF00069	0.656
MOD_NEK2_1	154	159	PF00069	0.268
MOD_NEK2_1	281	286	PF00069	0.495
MOD_NEK2_1	389	394	PF00069	0.682
MOD_NEK2_1	468	473	PF00069	0.389
MOD_NEK2_1	476	481	PF00069	0.385
MOD_PIKK_1	144	150	PF00454	0.658
MOD_PIKK_1	290	296	PF00454	0.493
MOD_PKA_1	437	443	PF00069	0.576
MOD_PKA_2	104	110	PF00069	0.664
MOD_PKA_2	187	193	PF00069	0.436
MOD_PKA_2	253	259	PF00069	0.350
MOD_PKA_2	387	393	PF00069	0.771
MOD_PKA_2	404	410	PF00069	0.557
MOD_PKA_2	90	96	PF00069	0.566
MOD_PKB_1	108	116	PF00069	0.659
MOD_PKB_1	435	443	PF00069	0.563
MOD_Plk_1	121	127	PF00069	0.709
MOD_Plk_1	31	37	PF00069	0.348
MOD_Plk_1	60	66	PF00069	0.537
MOD_Plk_2-3	328	334	PF00069	0.639
MOD_Plk_4	121	127	PF00069	0.574
MOD_Plk_4	150	156	PF00069	0.512
MOD_Plk_4	181	187	PF00069	0.384
MOD_Plk_4	217	223	PF00069	0.669
MOD_Plk_4	3	9	PF00069	0.486
MOD_Plk_4	521	527	PF00069	0.418
MOD_Plk_4	90	96	PF00069	0.543
MOD_ProDKin_1	100	106	PF00069	0.607
MOD_ProDKin_1	174	180	PF00069	0.358
MOD_ProDKin_1	201	207	PF00069	0.644
MOD_ProDKin_1	213	219	PF00069	0.601
MOD_ProDKin_1	221	227	PF00069	0.641
MOD_ProDKin_1	491	497	PF00069	0.541
MOD_ProDKin_1	52	58	PF00069	0.647
TRG_DiLeu_BaEn_4	311	317	PF01217	0.489
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.498
TRG_ENDOCYTIC_2	22	25	PF00928	0.444
TRG_ENDOCYTIC_2	80	83	PF00928	0.403
TRG_ER_diArg_1	108	111	PF00400	0.602
TRG_ER_diArg_1	206	209	PF00400	0.639
TRG_ER_diArg_1	238	240	PF00400	0.529
TRG_ER_diArg_1	495	498	PF00400	0.605
TRG_ER_diArg_1	504	506	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ2	Leptomonas seymouri	52%	92%
A4H9J5	Leishmania braziliensis	76%	100%
A4HXW1	Leishmania infantum	100%	100%
C9ZZU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ARM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
Q4QDV5	Leishmania major	94%	100%