Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB15_LEIDO

TriTrypDb:

LdBPK_281820.1 , LdCL_280023200 , LDHU3_28.2410

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IB15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.575
CLV_PCSK_KEX2_1	157	159	PF00082	0.576
CLV_PCSK_SKI1_1	117	121	PF00082	0.569
CLV_PCSK_SKI1_1	126	130	PF00082	0.431
CLV_PCSK_SKI1_1	174	178	PF00082	0.531
CLV_PCSK_SKI1_1	21	25	PF00082	0.620
CLV_PCSK_SKI1_1	343	347	PF00082	0.556
CLV_PCSK_SKI1_1	374	378	PF00082	0.418
CLV_PCSK_SKI1_1	459	463	PF00082	0.581
CLV_PCSK_SKI1_1	93	97	PF00082	0.417
DEG_ODPH_VHL_1	208	219	PF01847	0.518
DEG_SCF_FBW7_1	79	85	PF00400	0.443
DEG_SPOP_SBC_1	192	196	PF00917	0.732
DOC_CKS1_1	79	84	PF01111	0.511
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.367
DOC_MAPK_DCC_7	158	168	PF00069	0.516
DOC_MAPK_DCC_7	93	103	PF00069	0.437
DOC_MAPK_gen_1	88	96	PF00069	0.381
DOC_MAPK_MEF2A_6	343	351	PF00069	0.405
DOC_PP1_RVXF_1	91	97	PF00149	0.402
DOC_PP2B_LxvP_1	109	112	PF13499	0.561
DOC_PP2B_LxvP_1	24	27	PF13499	0.615
DOC_PP2B_LxvP_1	347	350	PF13499	0.389
DOC_PP2B_LxvP_1	415	418	PF13499	0.492
DOC_USP7_MATH_1	192	196	PF00917	0.741
DOC_USP7_MATH_1	203	207	PF00917	0.680
DOC_USP7_MATH_1	331	335	PF00917	0.763
DOC_USP7_MATH_1	336	340	PF00917	0.551
DOC_USP7_MATH_1	39	43	PF00917	0.741
DOC_USP7_MATH_1	61	65	PF00917	0.585
DOC_USP7_MATH_1	66	70	PF00917	0.505
DOC_USP7_UBL2_3	384	388	PF12436	0.436
DOC_WW_Pin1_4	194	199	PF00397	0.699
DOC_WW_Pin1_4	52	57	PF00397	0.593
DOC_WW_Pin1_4	78	83	PF00397	0.547
DOC_WW_Pin1_4	94	99	PF00397	0.341
LIG_14-3-3_CanoR_1	323	331	PF00244	0.701
LIG_14-3-3_CanoR_1	33	43	PF00244	0.726
LIG_14-3-3_CanoR_1	378	385	PF00244	0.471
LIG_14-3-3_CanoR_1	431	435	PF00244	0.464
LIG_BRCT_BRCA1_1	298	302	PF00533	0.280
LIG_eIF4E_1	283	289	PF01652	0.445
LIG_FHA_1	116	122	PF00498	0.465
LIG_FHA_1	15	21	PF00498	0.675
LIG_FHA_1	259	265	PF00498	0.361
LIG_FHA_1	295	301	PF00498	0.427
LIG_FHA_1	365	371	PF00498	0.337
LIG_FHA_1	456	462	PF00498	0.570
LIG_FHA_2	118	124	PF00498	0.487
LIG_FHA_2	263	269	PF00498	0.429
LIG_FHA_2	35	41	PF00498	0.700
LIG_LIR_Apic_2	69	74	PF02991	0.504
LIG_LIR_Gen_1	212	219	PF02991	0.439
LIG_LIR_Gen_1	293	303	PF02991	0.364
LIG_LIR_Nem_3	212	216	PF02991	0.457
LIG_LIR_Nem_3	248	254	PF02991	0.557
LIG_LIR_Nem_3	293	298	PF02991	0.357
LIG_LYPXL_yS_3	251	254	PF13949	0.551
LIG_MYND_1	405	409	PF01753	0.507
LIG_PAM2_1	61	73	PF00658	0.523
LIG_Pex14_2	430	434	PF04695	0.453
LIG_SH2_CRK	136	140	PF00017	0.442
LIG_SH2_CRK	213	217	PF00017	0.537
LIG_SH2_CRK	227	231	PF00017	0.397
LIG_SH2_CRK	71	75	PF00017	0.530
LIG_SH2_GRB2like	213	216	PF00017	0.546
LIG_SH2_GRB2like	283	286	PF00017	0.385
LIG_SH2_NCK_1	227	231	PF00017	0.503
LIG_SH2_NCK_1	71	75	PF00017	0.516
LIG_SH2_SRC	134	137	PF00017	0.478
LIG_SH2_STAP1	213	217	PF00017	0.534
LIG_SH2_STAP1	390	394	PF00017	0.432
LIG_SH2_STAT3	152	155	PF00017	0.463
LIG_SH2_STAT3	283	286	PF00017	0.519
LIG_SH2_STAT3	426	429	PF00017	0.512
LIG_SH2_STAT5	134	137	PF00017	0.375
LIG_SH2_STAT5	152	155	PF00017	0.607
LIG_SH2_STAT5	283	286	PF00017	0.413
LIG_SH2_STAT5	365	368	PF00017	0.399
LIG_SH3_1	57	63	PF00018	0.662
LIG_SH3_2	338	343	PF14604	0.577
LIG_SH3_3	195	201	PF00018	0.672
LIG_SH3_3	306	312	PF00018	0.576
LIG_SH3_3	313	319	PF00018	0.697
LIG_SH3_3	335	341	PF00018	0.668
LIG_SH3_3	53	59	PF00018	0.592
LIG_SH3_3	60	66	PF00018	0.455
LIG_SH3_3	73	79	PF00018	0.359
LIG_SH3_4	384	391	PF00018	0.486
LIG_SUMO_SIM_par_1	117	123	PF11976	0.429
LIG_SUMO_SIM_par_1	138	143	PF11976	0.476
LIG_SUMO_SIM_par_1	296	301	PF11976	0.325
LIG_TRAF2_1	102	105	PF00917	0.476
LIG_TRAF2_1	112	115	PF00917	0.399
LIG_TRAF2_1	319	322	PF00917	0.557
LIG_TRAF2_1	389	392	PF00917	0.406
LIG_TYR_ITIM	211	216	PF00017	0.457
LIG_UBA3_1	235	239	PF00899	0.445
LIG_UBA3_1	43	51	PF00899	0.516
LIG_WRC_WIRS_1	83	88	PF05994	0.396
LIG_WW_2	60	63	PF00397	0.557
LIG_WW_3	416	420	PF00397	0.558
MOD_CDK_SPK_2	52	57	PF00069	0.544
MOD_CDK_SPK_2	94	99	PF00069	0.422
MOD_CK1_1	194	200	PF00069	0.662
MOD_CK1_1	339	345	PF00069	0.650
MOD_CK1_1	383	389	PF00069	0.411
MOD_CK2_1	117	123	PF00069	0.504
MOD_CK2_1	262	268	PF00069	0.418
MOD_CK2_1	298	304	PF00069	0.367
MOD_CK2_1	34	40	PF00069	0.776
MOD_CK2_1	386	392	PF00069	0.415
MOD_DYRK1A_RPxSP_1	78	82	PF00069	0.543
MOD_GlcNHglycan	205	208	PF01048	0.714
MOD_GlcNHglycan	333	336	PF01048	0.715
MOD_GlcNHglycan	412	415	PF01048	0.627
MOD_GlcNHglycan	447	450	PF01048	0.596
MOD_GlcNHglycan	47	50	PF01048	0.686
MOD_GSK3_1	187	194	PF00069	0.593
MOD_GSK3_1	258	265	PF00069	0.380
MOD_GSK3_1	290	297	PF00069	0.454
MOD_GSK3_1	325	332	PF00069	0.741
MOD_GSK3_1	35	42	PF00069	0.717
MOD_GSK3_1	364	371	PF00069	0.399
MOD_GSK3_1	43	50	PF00069	0.597
MOD_GSK3_1	78	85	PF00069	0.540
MOD_NEK2_1	187	192	PF00069	0.511
MOD_NEK2_1	19	24	PF00069	0.695
MOD_NEK2_1	193	198	PF00069	0.539
MOD_NEK2_1	294	299	PF00069	0.363
MOD_NEK2_1	43	48	PF00069	0.675
MOD_NEK2_1	430	435	PF00069	0.461
MOD_NEK2_2	82	87	PF00069	0.404
MOD_PIKK_1	1	7	PF00454	0.703
MOD_PIKK_1	336	342	PF00454	0.636
MOD_PKA_2	329	335	PF00069	0.563
MOD_PKA_2	377	383	PF00069	0.420
MOD_PKA_2	430	436	PF00069	0.451
MOD_PKA_2	8	14	PF00069	0.731
MOD_Plk_1	39	45	PF00069	0.525
MOD_Plk_4	298	304	PF00069	0.428
MOD_Plk_4	39	45	PF00069	0.646
MOD_Plk_4	66	72	PF00069	0.502
MOD_ProDKin_1	194	200	PF00069	0.696
MOD_ProDKin_1	52	58	PF00069	0.591
MOD_ProDKin_1	78	84	PF00069	0.536
MOD_ProDKin_1	94	100	PF00069	0.346
MOD_SUMO_rev_2	386	394	PF00179	0.448
TRG_DiLeu_BaEn_1	104	109	PF01217	0.497
TRG_DiLeu_BaEn_4	104	110	PF01217	0.502
TRG_ENDOCYTIC_2	213	216	PF00928	0.458
TRG_ENDOCYTIC_2	251	254	PF00928	0.551
TRG_ER_diArg_1	146	149	PF00400	0.390
TRG_ER_diArg_1	156	158	PF00400	0.421
TRG_ER_diArg_1	6	9	PF00400	0.561
TRG_NES_CRM1_1	290	304	PF08389	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F3	Leptomonas seymouri	57%	90%
A0A1X0NSE8	Trypanosomatidae	35%	100%
A0A422NZ46	Trypanosoma rangeli	35%	100%
D0A8B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AHG6	Leishmania infantum	100%	100%
E9AZY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q896	Leishmania major	92%	100%
V5DBC1	Trypanosoma cruzi	35%	100%