Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB10_LEIDO

TriTrypDb:

LdBPK_210250.1 , LdCL_210007300 , LDHU3_21.0250

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

A0A3Q8IB10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.646
CLV_C14_Caspase3-7	154	158	PF00656	0.727
CLV_C14_Caspase3-7	235	239	PF00656	0.680
CLV_C14_Caspase3-7	520	524	PF00656	0.685
CLV_NRD_NRD_1	400	402	PF00675	0.514
CLV_NRD_NRD_1	456	458	PF00675	0.535
CLV_NRD_NRD_1	5	7	PF00675	0.626
CLV_NRD_NRD_1	596	598	PF00675	0.668
CLV_PCSK_KEX2_1	400	402	PF00082	0.514
CLV_PCSK_KEX2_1	456	458	PF00082	0.532
CLV_PCSK_KEX2_1	5	7	PF00082	0.613
CLV_PCSK_KEX2_1	596	598	PF00082	0.668
CLV_PCSK_SKI1_1	164	168	PF00082	0.597
CLV_PCSK_SKI1_1	261	265	PF00082	0.426
CLV_PCSK_SKI1_1	271	275	PF00082	0.474
CLV_PCSK_SKI1_1	308	312	PF00082	0.460
CLV_PCSK_SKI1_1	355	359	PF00082	0.395
CLV_PCSK_SKI1_1	511	515	PF00082	0.683
CLV_PCSK_SKI1_1	533	537	PF00082	0.627
CLV_PCSK_SKI1_1	575	579	PF00082	0.417
CLV_PCSK_SKI1_1	605	609	PF00082	0.540
CLV_PCSK_SKI1_1	95	99	PF00082	0.607
CLV_Separin_Metazoa	556	560	PF03568	0.382
DEG_ODPH_VHL_1	550	563	PF01847	0.446
DEG_SCF_FBW7_2	649	655	PF00400	0.522
DOC_CKS1_1	621	626	PF01111	0.467
DOC_CKS1_1	649	654	PF01111	0.517
DOC_CYCLIN_RxL_1	268	278	PF00134	0.558
DOC_CYCLIN_RxL_1	572	582	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	544	547	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	609	612	PF00134	0.596
DOC_MAPK_gen_1	400	410	PF00069	0.375
DOC_MAPK_gen_1	425	433	PF00069	0.508
DOC_MAPK_gen_1	5	11	PF00069	0.571
DOC_MAPK_gen_1	93	101	PF00069	0.554
DOC_MAPK_MEF2A_6	634	641	PF00069	0.464
DOC_MAPK_MEF2A_6	95	103	PF00069	0.599
DOC_PP1_RVXF_1	4	11	PF00149	0.593
DOC_PP2B_LxvP_1	274	277	PF13499	0.495
DOC_PP2B_LxvP_1	544	547	PF13499	0.541
DOC_PP2B_LxvP_1	608	611	PF13499	0.602
DOC_USP7_MATH_1	130	134	PF00917	0.643
DOC_USP7_MATH_1	136	140	PF00917	0.735
DOC_USP7_MATH_1	141	145	PF00917	0.509
DOC_USP7_MATH_1	281	285	PF00917	0.590
DOC_USP7_MATH_1	338	342	PF00917	0.629
DOC_USP7_MATH_1	406	410	PF00917	0.479
DOC_USP7_MATH_1	446	450	PF00917	0.484
DOC_USP7_MATH_1	538	542	PF00917	0.606
DOC_USP7_MATH_1	601	605	PF00917	0.666
DOC_USP7_MATH_1	625	629	PF00917	0.556
DOC_USP7_MATH_1	76	80	PF00917	0.695
DOC_WW_Pin1_4	126	131	PF00397	0.723
DOC_WW_Pin1_4	156	161	PF00397	0.576
DOC_WW_Pin1_4	206	211	PF00397	0.775
DOC_WW_Pin1_4	521	526	PF00397	0.646
DOC_WW_Pin1_4	59	64	PF00397	0.622
DOC_WW_Pin1_4	620	625	PF00397	0.654
DOC_WW_Pin1_4	648	653	PF00397	0.524
DOC_WW_Pin1_4	72	77	PF00397	0.709
DOC_WW_Pin1_4	78	83	PF00397	0.728
LIG_14-3-3_CanoR_1	191	200	PF00244	0.546
LIG_14-3-3_CanoR_1	252	257	PF00244	0.518
LIG_14-3-3_CanoR_1	271	277	PF00244	0.571
LIG_14-3-3_CanoR_1	282	286	PF00244	0.586
LIG_14-3-3_CanoR_1	345	350	PF00244	0.482
LIG_14-3-3_CanoR_1	407	411	PF00244	0.389
LIG_14-3-3_CanoR_1	432	437	PF00244	0.468
LIG_14-3-3_CanoR_1	456	462	PF00244	0.520
LIG_14-3-3_CanoR_1	511	521	PF00244	0.746
LIG_14-3-3_CanoR_1	559	564	PF00244	0.464
LIG_14-3-3_CanoR_1	575	585	PF00244	0.331
LIG_14-3-3_CanoR_1	689	697	PF00244	0.547
LIG_14-3-3_CanoR_1	84	89	PF00244	0.735
LIG_Actin_WH2_2	419	434	PF00022	0.489
LIG_Actin_WH2_2	632	647	PF00022	0.487
LIG_Actin_WH2_2	676	691	PF00022	0.489
LIG_AP_GAE_1	361	367	PF02883	0.484
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_BIR_III_2	157	161	PF00653	0.571
LIG_BIR_III_4	616	620	PF00653	0.683
LIG_BRCT_BRCA1_1	395	399	PF00533	0.524
LIG_BRCT_BRCA1_1	68	72	PF00533	0.650
LIG_Clathr_ClatBox_1	124	128	PF01394	0.752
LIG_deltaCOP1_diTrp_1	675	684	PF00928	0.459
LIG_FHA_1	161	167	PF00498	0.533
LIG_FHA_1	195	201	PF00498	0.688
LIG_FHA_1	324	330	PF00498	0.559
LIG_FHA_1	346	352	PF00498	0.501
LIG_FHA_1	50	56	PF00498	0.641
LIG_FHA_1	558	564	PF00498	0.455
LIG_FHA_1	59	65	PF00498	0.636
LIG_FHA_1	621	627	PF00498	0.623
LIG_FHA_1	717	723	PF00498	0.596
LIG_FHA_2	348	354	PF00498	0.501
LIG_FHA_2	412	418	PF00498	0.426
LIG_FHA_2	518	524	PF00498	0.691
LIG_GBD_Chelix_1	573	581	PF00786	0.521
LIG_HP1_1	525	529	PF01393	0.600
LIG_Integrin_RGD_1	236	238	PF01839	0.711
LIG_Integrin_RGD_1	290	292	PF01839	0.571
LIG_IRF3_LxIS_1	684	691	PF10401	0.469
LIG_LIR_Gen_1	170	179	PF02991	0.510
LIG_LIR_Gen_1	246	256	PF02991	0.534
LIG_LIR_Gen_1	471	480	PF02991	0.421
LIG_LIR_Gen_1	494	503	PF02991	0.551
LIG_LIR_Gen_1	540	550	PF02991	0.544
LIG_LIR_Gen_1	576	586	PF02991	0.454
LIG_LIR_Gen_1	635	644	PF02991	0.347
LIG_LIR_Gen_1	651	660	PF02991	0.515
LIG_LIR_Gen_1	675	685	PF02991	0.459
LIG_LIR_Nem_3	170	176	PF02991	0.497
LIG_LIR_Nem_3	246	251	PF02991	0.550
LIG_LIR_Nem_3	361	367	PF02991	0.450
LIG_LIR_Nem_3	471	477	PF02991	0.424
LIG_LIR_Nem_3	494	498	PF02991	0.512
LIG_LIR_Nem_3	540	545	PF02991	0.581
LIG_LIR_Nem_3	635	639	PF02991	0.348
LIG_LIR_Nem_3	651	656	PF02991	0.542
LIG_LIR_Nem_3	675	681	PF02991	0.465
LIG_LIR_Nem_3	703	708	PF02991	0.468
LIG_Pex14_2	342	346	PF04695	0.590
LIG_RPA_C_Fungi	389	401	PF08784	0.485
LIG_SH2_CRK	248	252	PF00017	0.545
LIG_SH2_CRK	474	478	PF00017	0.513
LIG_SH2_CRK	622	626	PF00017	0.689
LIG_SH2_GRB2like	314	317	PF00017	0.555
LIG_SH2_NCK_1	140	144	PF00017	0.600
LIG_SH2_SRC	304	307	PF00017	0.314
LIG_SH2_SRC	381	384	PF00017	0.483
LIG_SH2_STAP1	314	318	PF00017	0.507
LIG_SH2_STAP1	632	636	PF00017	0.434
LIG_SH2_STAT5	173	176	PF00017	0.567
LIG_SH2_STAT5	373	376	PF00017	0.501
LIG_SH2_STAT5	404	407	PF00017	0.474
LIG_SH2_STAT5	442	445	PF00017	0.496
LIG_SH2_STAT5	476	479	PF00017	0.513
LIG_SH2_STAT5	622	625	PF00017	0.607
LIG_SH3_3	163	169	PF00018	0.582
LIG_SH3_3	180	186	PF00018	0.334
LIG_SH3_3	618	624	PF00018	0.495
LIG_SH3_CIN85_PxpxPR_1	277	282	PF14604	0.432
LIG_Sin3_3	365	372	PF02671	0.468
LIG_SUMO_SIM_anti_2	348	353	PF11976	0.456
LIG_SUMO_SIM_anti_2	505	510	PF11976	0.673
LIG_SUMO_SIM_par_1	252	258	PF11976	0.523
LIG_SUMO_SIM_par_1	272	278	PF11976	0.316
LIG_SUMO_SIM_par_1	347	353	PF11976	0.449
LIG_SUMO_SIM_par_1	365	370	PF11976	0.322
LIG_SUMO_SIM_par_1	582	588	PF11976	0.431
LIG_TRFH_1	542	546	PF08558	0.544
LIG_TYR_ITIM	171	176	PF00017	0.501
MOD_CDK_SPxK_1	78	84	PF00069	0.700
MOD_CK1_1	139	145	PF00069	0.665
MOD_CK1_1	220	226	PF00069	0.811
MOD_CK1_1	323	329	PF00069	0.413
MOD_CK1_1	411	417	PF00069	0.435
MOD_CK1_1	576	582	PF00069	0.498
MOD_CK1_1	75	81	PF00069	0.759
MOD_CK2_1	252	258	PF00069	0.495
MOD_CK2_1	411	417	PF00069	0.425
MOD_CK2_1	446	452	PF00069	0.524
MOD_CK2_1	576	582	PF00069	0.447
MOD_Cter_Amidation	3	6	PF01082	0.623
MOD_GlcNHglycan	132	135	PF01048	0.602
MOD_GlcNHglycan	141	144	PF01048	0.651
MOD_GlcNHglycan	153	156	PF01048	0.665
MOD_GlcNHglycan	2	5	PF01048	0.611
MOD_GlcNHglycan	222	225	PF01048	0.693
MOD_GlcNHglycan	240	243	PF01048	0.431
MOD_GlcNHglycan	395	398	PF01048	0.421
MOD_GlcNHglycan	470	473	PF01048	0.481
MOD_GlcNHglycan	498	501	PF01048	0.456
MOD_GlcNHglycan	68	71	PF01048	0.659
MOD_GSK3_1	10	17	PF00069	0.516
MOD_GSK3_1	126	133	PF00069	0.664
MOD_GSK3_1	156	163	PF00069	0.529
MOD_GSK3_1	281	288	PF00069	0.654
MOD_GSK3_1	319	326	PF00069	0.481
MOD_GSK3_1	475	482	PF00069	0.517
MOD_GSK3_1	513	520	PF00069	0.690
MOD_GSK3_1	559	566	PF00069	0.556
MOD_GSK3_1	576	583	PF00069	0.342
MOD_GSK3_1	684	691	PF00069	0.539
MOD_GSK3_1	712	719	PF00069	0.499
MOD_GSK3_1	72	79	PF00069	0.762
MOD_N-GLC_1	457	462	PF02516	0.521
MOD_N-GLC_1	511	516	PF02516	0.632
MOD_N-GLC_1	700	705	PF02516	0.370
MOD_NEK2_1	10	15	PF00069	0.506
MOD_NEK2_1	151	156	PF00069	0.551
MOD_NEK2_1	285	290	PF00069	0.634
MOD_NEK2_1	367	372	PF00069	0.389
MOD_NEK2_1	41	46	PF00069	0.587
MOD_NEK2_1	431	436	PF00069	0.418
MOD_NEK2_1	513	518	PF00069	0.754
MOD_NEK2_1	573	578	PF00069	0.473
MOD_NEK2_1	58	63	PF00069	0.658
MOD_NEK2_1	684	689	PF00069	0.429
MOD_NEK2_2	141	146	PF00069	0.553
MOD_PIKK_1	285	291	PF00454	0.627
MOD_PIKK_1	323	329	PF00454	0.607
MOD_PIKK_1	514	520	PF00454	0.739
MOD_PK_1	320	326	PF00069	0.525
MOD_PK_1	457	463	PF00069	0.505
MOD_PK_1	559	565	PF00069	0.470
MOD_PKA_2	220	226	PF00069	0.779
MOD_PKA_2	232	238	PF00069	0.597
MOD_PKA_2	281	287	PF00069	0.468
MOD_PKA_2	393	399	PF00069	0.473
MOD_PKA_2	406	412	PF00069	0.400
MOD_PKA_2	431	437	PF00069	0.414
MOD_PKA_2	538	544	PF00069	0.625
MOD_PKA_2	688	694	PF00069	0.525
MOD_Plk_1	338	344	PF00069	0.641
MOD_Plk_1	457	463	PF00069	0.523
MOD_Plk_1	700	706	PF00069	0.427
MOD_Plk_2-3	113	119	PF00069	0.697
MOD_Plk_4	14	20	PF00069	0.552
MOD_Plk_4	178	184	PF00069	0.539
MOD_Plk_4	243	249	PF00069	0.537
MOD_Plk_4	314	320	PF00069	0.530
MOD_Plk_4	347	353	PF00069	0.523
MOD_Plk_4	457	463	PF00069	0.477
MOD_Plk_4	580	586	PF00069	0.527
MOD_Plk_4	627	633	PF00069	0.527
MOD_Plk_4	701	707	PF00069	0.467
MOD_Plk_4	718	724	PF00069	0.541
MOD_ProDKin_1	126	132	PF00069	0.722
MOD_ProDKin_1	156	162	PF00069	0.566
MOD_ProDKin_1	206	212	PF00069	0.772
MOD_ProDKin_1	521	527	PF00069	0.638
MOD_ProDKin_1	59	65	PF00069	0.621
MOD_ProDKin_1	620	626	PF00069	0.640
MOD_ProDKin_1	648	654	PF00069	0.527
MOD_ProDKin_1	72	78	PF00069	0.712
MOD_SUMO_for_1	50	53	PF00179	0.694
MOD_SUMO_rev_2	66	75	PF00179	0.712
TRG_DiLeu_BaEn_1	540	545	PF01217	0.599
TRG_DiLeu_BaEn_4	53	59	PF01217	0.596
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.366
TRG_DiLeu_BaLyEn_6	549	554	PF01217	0.347
TRG_ENDOCYTIC_2	173	176	PF00928	0.508
TRG_ENDOCYTIC_2	248	251	PF00928	0.524
TRG_ENDOCYTIC_2	295	298	PF00928	0.488
TRG_ENDOCYTIC_2	474	477	PF00928	0.470
TRG_ER_diArg_1	333	336	PF00400	0.642
TRG_ER_diArg_1	399	401	PF00400	0.456
TRG_ER_diArg_1	447	450	PF00400	0.518
TRG_ER_diArg_1	536	539	PF00400	0.627
TRG_NES_CRM1_1	661	676	PF08389	0.503
TRG_Pf-PMV_PEXEL_1	378	383	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	575	580	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWM2	Leptomonas seymouri	57%	99%
A0A1X0NXC5	Trypanosomatidae	35%	97%
A4HBL8	Leishmania braziliensis	85%	100%
A4HZA6	Leishmania infantum	99%	100%
D0A1L2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AUY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QCJ6	Leishmania major	95%	100%
V5BG13	Trypanosoma cruzi	29%	100%