Citrate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Citrate synthase

Gene product:

citrate synthase, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IB05_LEIDO

TriTrypDb:

LdBPK_180700.1 , LdCL_180012100 , LDHU3_18.0930

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005759	mitochondrial matrix	5	4
GO:0020023	kinetoplast	2	2
GO:0031974	membrane-enclosed lumen	2	4
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	4
GO:0070013	intracellular organelle lumen	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8IB05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB05

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006082	organic acid metabolic process	3	1
GO:0006099	tricarboxylic acid cycle	3	4
GO:0006101	citrate metabolic process	7	1
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	4
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	2
GO:0072350	tricarboxylic acid metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016740	transferase activity	2	16
GO:0016746	acyltransferase activity	3	16
GO:0046912	acyltransferase activity, acyl groups converted into alkyl on transfer	4	16
GO:0004108	citrate (Si)-synthase activity	6	2
GO:0036440	citrate synthase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.525
CLV_NRD_NRD_1	119	121	PF00675	0.288
CLV_NRD_NRD_1	15	17	PF00675	0.541
CLV_NRD_NRD_1	27	29	PF00675	0.591
CLV_NRD_NRD_1	338	340	PF00675	0.355
CLV_PCSK_KEX2_1	119	121	PF00082	0.288
CLV_PCSK_KEX2_1	15	17	PF00082	0.510
CLV_PCSK_SKI1_1	314	318	PF00082	0.259
CLV_PCSK_SKI1_1	49	53	PF00082	0.275
CLV_PCSK_SKI1_1	70	74	PF00082	0.261
DEG_SPOP_SBC_1	252	256	PF00917	0.555
DEG_SPOP_SBC_1	437	441	PF00917	0.582
DOC_ANK_TNKS_1	297	304	PF00023	0.552
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.527
DOC_MAPK_gen_1	198	206	PF00069	0.528
DOC_MAPK_gen_1	298	306	PF00069	0.475
DOC_MAPK_MEF2A_6	232	241	PF00069	0.512
DOC_MAPK_NFAT4_5	232	240	PF00069	0.454
DOC_PIKK_1	19	27	PF02985	0.483
DOC_PP2B_LxvP_1	206	209	PF13499	0.547
DOC_USP7_MATH_1	165	169	PF00917	0.481
DOC_USP7_MATH_1	207	211	PF00917	0.527
DOC_USP7_UBL2_3	167	171	PF12436	0.528
DOC_USP7_UBL2_3	314	318	PF12436	0.503
DOC_USP7_UBL2_3	377	381	PF12436	0.479
DOC_WW_Pin1_4	185	190	PF00397	0.475
LIG_14-3-3_CanoR_1	236	242	PF00244	0.515
LIG_14-3-3_CanoR_1	344	351	PF00244	0.496
LIG_14-3-3_CanoR_1	436	445	PF00244	0.532
LIG_APCC_ABBA_1	239	244	PF00400	0.475
LIG_APCC_ABBA_1	304	309	PF00400	0.519
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_deltaCOP1_diTrp_1	213	220	PF00928	0.476
LIG_FHA_1	186	192	PF00498	0.499
LIG_FHA_1	252	258	PF00498	0.476
LIG_FHA_1	318	324	PF00498	0.508
LIG_FHA_1	440	446	PF00498	0.542
LIG_FHA_1	50	56	PF00498	0.475
LIG_FHA_1	99	105	PF00498	0.473
LIG_FHA_2	170	176	PF00498	0.555
LIG_FHA_2	438	444	PF00498	0.471
LIG_FHA_2	71	77	PF00498	0.469
LIG_GBD_Chelix_1	364	372	PF00786	0.257
LIG_IBAR_NPY_1	384	386	PF08397	0.555
LIG_LIR_Gen_1	155	164	PF02991	0.527
LIG_LIR_Gen_1	263	273	PF02991	0.488
LIG_LIR_Gen_1	320	329	PF02991	0.475
LIG_LIR_Gen_1	342	353	PF02991	0.457
LIG_LIR_Gen_1	367	376	PF02991	0.455
LIG_LIR_Nem_3	155	159	PF02991	0.527
LIG_LIR_Nem_3	172	176	PF02991	0.489
LIG_LIR_Nem_3	263	269	PF02991	0.475
LIG_LIR_Nem_3	320	324	PF02991	0.470
LIG_LIR_Nem_3	342	348	PF02991	0.451
LIG_LIR_Nem_3	359	365	PF02991	0.475
LIG_LIR_Nem_3	93	99	PF02991	0.506
LIG_LYPXL_yS_3	386	389	PF13949	0.550
LIG_LYPXL_yS_3	408	411	PF13949	0.538
LIG_NRBOX	288	294	PF00104	0.545
LIG_PCNA_yPIPBox_3	285	298	PF02747	0.495
LIG_PCNA_yPIPBox_3	354	365	PF02747	0.417
LIG_Pex14_1	216	220	PF04695	0.475
LIG_PTB_Apo_2	363	370	PF02174	0.555
LIG_PTB_Phospho_1	363	369	PF10480	0.555
LIG_Rb_LxCxE_1	73	93	PF01857	0.528
LIG_SH2_CRK	345	349	PF00017	0.499
LIG_SH2_SRC	56	59	PF00017	0.527
LIG_SH2_STAP1	156	160	PF00017	0.555
LIG_SH2_STAP1	319	323	PF00017	0.552
LIG_SH2_STAT5	238	241	PF00017	0.475
LIG_SH2_STAT5	266	269	PF00017	0.475
LIG_SH2_STAT5	291	294	PF00017	0.475
LIG_SH2_STAT5	319	322	PF00017	0.552
LIG_SH2_STAT5	345	348	PF00017	0.475
LIG_SH2_STAT5	449	452	PF00017	0.592
LIG_SH3_3	52	58	PF00018	0.490
LIG_SH3_3	79	85	PF00018	0.527
LIG_SUMO_SIM_par_1	149	155	PF11976	0.556
LIG_TRAF2_1	105	108	PF00917	0.582
LIG_TRAF2_1	284	287	PF00917	0.475
LIG_TRAF2_1	294	297	PF00917	0.475
LIG_UBA3_1	292	300	PF00899	0.327
LIG_UBA3_1	371	377	PF00899	0.301
MOD_CK1_1	251	257	PF00069	0.344
MOD_CK1_1	260	266	PF00069	0.302
MOD_CK1_1	439	445	PF00069	0.445
MOD_CK2_1	169	175	PF00069	0.404
MOD_CK2_1	291	297	PF00069	0.402
MOD_CK2_1	437	443	PF00069	0.420
MOD_CK2_1	70	76	PF00069	0.320
MOD_GlcNHglycan	250	253	PF01048	0.335
MOD_GlcNHglycan	259	262	PF01048	0.314
MOD_GlcNHglycan	269	272	PF01048	0.243
MOD_GlcNHglycan	325	328	PF01048	0.440
MOD_GlcNHglycan	392	395	PF01048	0.322
MOD_GlcNHglycan	62	65	PF01048	0.474
MOD_GSK3_1	165	172	PF00069	0.363
MOD_GSK3_1	248	255	PF00069	0.332
MOD_GSK3_1	56	63	PF00069	0.299
MOD_N-GLC_1	248	253	PF02516	0.327
MOD_N-GLC_2	350	352	PF02516	0.467
MOD_NEK2_1	1	6	PF00069	0.559
MOD_NEK2_1	237	242	PF00069	0.370
MOD_NEK2_1	257	262	PF00069	0.143
MOD_NEK2_1	267	272	PF00069	0.310
MOD_NEK2_1	323	328	PF00069	0.440
MOD_NEK2_1	364	369	PF00069	0.352
MOD_NEK2_1	412	417	PF00069	0.324
MOD_PKA_2	197	203	PF00069	0.359
MOD_PKA_2	343	349	PF00069	0.358
MOD_PKB_1	68	76	PF00069	0.347
MOD_Plk_1	178	184	PF00069	0.349
MOD_Plk_1	37	43	PF00069	0.455
MOD_Plk_2-3	103	109	PF00069	0.402
MOD_Plk_4	1	7	PF00069	0.454
MOD_Plk_4	169	175	PF00069	0.440
MOD_Plk_4	253	259	PF00069	0.329
MOD_Plk_4	364	370	PF00069	0.330
MOD_Plk_4	56	62	PF00069	0.342
MOD_Plk_4	70	76	PF00069	0.327
MOD_ProDKin_1	185	191	PF00069	0.328
MOD_SUMO_rev_2	19	24	PF00179	0.521
TRG_ENDOCYTIC_2	156	159	PF00928	0.440
TRG_ENDOCYTIC_2	238	241	PF00928	0.327
TRG_ENDOCYTIC_2	266	269	PF00928	0.347
TRG_ENDOCYTIC_2	345	348	PF00928	0.302
TRG_ENDOCYTIC_2	369	372	PF00928	0.316
TRG_ENDOCYTIC_2	386	389	PF00928	0.419
TRG_ENDOCYTIC_2	408	411	PF00928	0.321
TRG_ENDOCYTIC_2	45	48	PF00928	0.422
TRG_ER_diArg_1	119	121	PF00400	0.247
TRG_ER_diArg_1	14	16	PF00400	0.525
TRG_NES_CRM1_1	89	103	PF08389	0.440
TRG_NLS_Bipartite_1	15	32	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I014	Leptomonas seymouri	82%	97%
A0A0S3QTD0	Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6)	49%	100%
A0A1X0P7W7	Trypanosomatidae	66%	96%
A0A3Q8IB38	Leishmania donovani	98%	97%
A0A422P1U5	Trypanosoma rangeli	66%	96%
A4H9H8	Leishmania braziliensis	85%	100%
A4H9H9	Leishmania braziliensis	85%	100%
A4HXU4	Leishmania infantum	97%	100%
A4HXU5	Leishmania infantum	100%	100%
B0YD89	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	48%	98%
C7C435	Fusarium solani	49%	96%
C7C436	Gibberella moniliformis	49%	96%
C9ZZW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	94%
D4GS06	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	28%	100%
E9ARK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9ARK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
H8F0D7	Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)	26%	100%
I6Y9Q3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
O00098	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	57%	96%
O33915	Rhizobium meliloti (strain 1021)	29%	100%
O34002	Antarctic bacterium DS2-3R	26%	100%
O68883	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	28%	100%
O75390	Homo sapiens	54%	97%
O80433	Daucus carota	54%	96%
P00889	Sus scrofa	54%	98%
P00890	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	95%
P08679	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	54%	99%
P09948	Rickettsia prowazekii (strain Madrid E)	26%	100%
P0ABH7	Escherichia coli (strain K12)	28%	100%
P0ABH8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	28%	100%
P0C1Z2	Macaca fascicularis	54%	97%
P14165	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	100%
P18789	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	29%	100%
P20115	Arabidopsis thaliana	52%	96%
P20901	Acetobacter aceti	26%	100%
P20902	Acinetobacter calcoaceticus subsp. anitratus	26%	100%
P21553	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	27%	100%
P23007	Gallus gallus	52%	100%
P24118	Tetrahymena thermophila	46%	98%
P27660	Weizmannia coagulans	26%	100%
P31660	Escherichia coli (strain K12)	25%	100%
P34085	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	56%	97%
P34575	Caenorhabditis elegans	53%	97%
P39119	Bacillus subtilis (strain 168)	24%	100%
P39120	Bacillus subtilis (strain 168)	25%	100%
P42457	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	26%	100%
P43635	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	93%
P45858	Bacillus subtilis (strain 168)	24%	100%
P49298	Citrus maxima	53%	96%
P49299	Cucurbita maxima	25%	88%
P51031	Bartonella bacilliformis	28%	100%
P51032	Bartonella elizabethae	28%	100%
P51033	Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)	28%	100%
P51034	Bartonella quintana (strain Toulouse)	27%	100%
P51036	Bartonella vinsonii	29%	100%
P51037	Rhizobium tropici	28%	100%
P51038	Rhizobium tropici	28%	100%
P51039	Rickettsia australis	27%	100%
P51040	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	26%	100%
P51041	Rickettsia canadensis	26%	100%
P51042	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	26%	100%
P51043	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	26%	100%
P51044	Aspergillus niger	56%	96%
P51045	Acidithiobacillus ferridurans	25%	100%
P56062	Helicobacter pylori (strain ATCC 700392 / 26695)	29%	100%
P79024	Candida tropicalis	52%	97%
P80148	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	26%	100%
P83372	Fragaria ananassa	50%	97%
P94325	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	25%	100%
P9WPD4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WPD5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q0GNE0	Iguana iguana	52%	97%
Q0GNE1	Amblyrhynchus cristatus	52%	97%
Q0QHL3	Glossina morsitans morsitans	54%	98%
Q10306	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	94%
Q16P20	Aedes aegypti	53%	97%
Q17GM7	Aedes aegypti	53%	97%
Q1RGV8	Rickettsia bellii (strain RML369-C)	26%	100%
Q28DK1	Xenopus tropicalis	54%	97%
Q29RK1	Bos taurus	54%	97%
Q2TXF1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	25%	100%
Q43175	Solanum tuberosum	50%	96%
Q4QDX2	Leishmania major	95%	100%
Q4QDX3	Leishmania major	94%	100%
Q4S5X1	Tetraodon nigroviridis	53%	97%
Q50I20	Neosartorya fumigata	48%	98%
Q53554	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	25%	100%
Q553V1	Dictyostelium discoideum	54%	99%
Q56063	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	100%
Q59136	Rickettsia conorii subsp. caspia (strain A-167)	27%	100%
Q59198	Bartonella doshiae	29%	100%
Q59258	Bartonella taylorii	28%	100%
Q59730	Rickettsia akari	25%	100%
Q59732	Rickettsia africae (strain ESF-5)	27%	100%
Q59734	Rickettsia bellii	27%	100%
Q59741	Rickettsia helvetica	27%	100%
Q59742	Rickettsia japonica	27%	100%
Q59748	Rickettsia massiliae	27%	100%
Q59759	Rickettsia parkeri	27%	100%
Q59768	Rickettsia rhipicephali	27%	100%
Q59776	Rickettsia slovaca (strain 13-B)	27%	100%
Q59778	Rickettsia sibirica (strain ATCC VR-151 / 246)	27%	100%
Q59939	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	28%	100%
Q59977	Synechocystis sp. (strain PCC 6803 / Kazusa)	27%	100%
Q61JF9	Caenorhabditis briggsae	53%	97%
Q6C793	Yarrowia lipolytica (strain CLIB 122 / E 150)	53%	98%
Q6S9V5	Kajikia audax	53%	97%
Q6S9V6	Xiphias gladius	53%	97%
Q6S9V7	Katsuwonus pelamis	53%	97%
Q6S9V8	Thunnus obesus	53%	97%
Q6S9V9	Thunnus albacares	53%	97%
Q7ZVY5	Danio rerio	54%	97%
Q7ZWZ5	Xenopus laevis	54%	97%
Q86AV6	Dictyostelium discoideum	27%	89%
Q8EJW2	Shewanella oneidensis (strain MR-1)	23%	100%
Q8MQU6	Dictyostelium discoideum	24%	92%
Q8NSH7	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	26%	100%
Q8NSL1	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	28%	100%
Q8VHF5	Rattus norvegicus	52%	97%
Q937N9	Cupriavidus necator	24%	100%
Q9CZU6	Mus musculus	53%	98%
Q9LXS6	Arabidopsis thaliana	26%	88%
Q9LXS7	Arabidopsis thaliana	23%	95%
Q9M1D3	Arabidopsis thaliana	52%	98%
Q9RWB2	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	28%	100%
Q9SJH7	Arabidopsis thaliana	25%	89%
Q9TEM3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	48%	99%
Q9W401	Drosophila melanogaster	54%	98%
Q9ZN37	Helicobacter pylori (strain J99 / ATCC 700824)	29%	100%
V5BWC7	Trypanosoma cruzi	66%	96%