Zinc-finger protein ZPR1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein ZPR1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB01_LEIDO

TriTrypDb:

LdBPK_171530.1 , LdCL_170021600 , LDHU3_17.2080

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IB01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB01

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.494
CLV_NRD_NRD_1	163	165	PF00675	0.265
CLV_NRD_NRD_1	272	274	PF00675	0.325
CLV_NRD_NRD_1	32	34	PF00675	0.506
CLV_PCSK_KEX2_1	272	274	PF00082	0.287
CLV_PCSK_KEX2_1	32	34	PF00082	0.506
CLV_PCSK_KEX2_1	331	333	PF00082	0.246
CLV_PCSK_KEX2_1	99	101	PF00082	0.315
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.246
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.315
CLV_PCSK_SKI1_1	232	236	PF00082	0.455
CLV_PCSK_SKI1_1	332	336	PF00082	0.267
CLV_PCSK_SKI1_1	393	397	PF00082	0.298
DEG_APCC_DBOX_1	370	378	PF00400	0.437
DOC_MAPK_gen_1	316	324	PF00069	0.463
DOC_MAPK_gen_1	99	107	PF00069	0.449
DOC_MAPK_JIP1_4	273	279	PF00069	0.417
DOC_MAPK_MEF2A_6	232	239	PF00069	0.479
DOC_MAPK_MEF2A_6	316	324	PF00069	0.463
DOC_PP2B_LxvP_1	132	135	PF13499	0.449
DOC_PP2B_LxvP_1	342	345	PF13499	0.437
DOC_PP2B_LxvP_1	432	435	PF13499	0.522
DOC_USP7_MATH_1	200	204	PF00917	0.449
DOC_USP7_MATH_1	384	388	PF00917	0.487
DOC_USP7_UBL2_3	247	251	PF12436	0.465
DOC_WW_Pin1_4	6	11	PF00397	0.669
LIG_14-3-3_CanoR_1	319	323	PF00244	0.473
LIG_14-3-3_CanoR_1	61	70	PF00244	0.485
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_FHA_1	122	128	PF00498	0.437
LIG_FHA_1	191	197	PF00498	0.442
LIG_FHA_1	260	266	PF00498	0.486
LIG_FHA_1	319	325	PF00498	0.455
LIG_FHA_1	32	38	PF00498	0.529
LIG_FHA_1	337	343	PF00498	0.412
LIG_FHA_1	411	417	PF00498	0.437
LIG_FHA_1	57	63	PF00498	0.449
LIG_FHA_2	193	199	PF00498	0.476
LIG_FHA_2	219	225	PF00498	0.441
LIG_FHA_2	226	232	PF00498	0.453
LIG_FHA_2	244	250	PF00498	0.547
LIG_FHA_2	392	398	PF00498	0.491
LIG_FHA_2	446	452	PF00498	0.576
LIG_LIR_Apic_2	203	207	PF02991	0.468
LIG_LIR_Apic_2	210	214	PF02991	0.477
LIG_LIR_Gen_1	120	130	PF02991	0.449
LIG_LIR_Gen_1	170	180	PF02991	0.439
LIG_LIR_Gen_1	255	265	PF02991	0.480
LIG_LIR_Gen_1	410	420	PF02991	0.517
LIG_LIR_Nem_3	120	125	PF02991	0.449
LIG_LIR_Nem_3	151	157	PF02991	0.549
LIG_LIR_Nem_3	170	175	PF02991	0.324
LIG_LIR_Nem_3	255	261	PF02991	0.526
LIG_LIR_Nem_3	298	302	PF02991	0.432
LIG_LIR_Nem_3	410	415	PF02991	0.517
LIG_MYND_1	214	218	PF01753	0.532
LIG_NRBOX	401	407	PF00104	0.449
LIG_Pex14_2	92	96	PF04695	0.449
LIG_SH2_CRK	154	158	PF00017	0.487
LIG_SH2_NCK_1	172	176	PF00017	0.515
LIG_SH2_PTP2	204	207	PF00017	0.523
LIG_SH2_SRC	204	207	PF00017	0.437
LIG_SH2_STAP1	103	107	PF00017	0.437
LIG_SH2_STAT3	103	106	PF00017	0.498
LIG_SH2_STAT3	286	289	PF00017	0.523
LIG_SH2_STAT5	204	207	PF00017	0.437
LIG_SH2_STAT5	286	289	PF00017	0.431
LIG_SH2_STAT5	299	302	PF00017	0.449
LIG_SH2_STAT5	36	39	PF00017	0.553
LIG_SH2_STAT5	424	427	PF00017	0.437
LIG_SH2_STAT5	447	450	PF00017	0.463
LIG_SH3_5	207	211	PF00018	0.573
LIG_SUMO_SIM_par_1	123	129	PF11976	0.523
LIG_SUMO_SIM_par_1	192	198	PF11976	0.498
LIG_SUMO_SIM_par_1	337	346	PF11976	0.478
LIG_SUMO_SIM_par_1	403	411	PF11976	0.487
LIG_TRAF2_1	246	249	PF00917	0.612
LIG_TRAF2_1	489	492	PF00917	0.666
LIG_UBA3_1	46	53	PF00899	0.416
LIG_WRC_WIRS_1	182	187	PF05994	0.505
LIG_WRC_WIRS_1	75	80	PF05994	0.437
MOD_CK1_1	184	190	PF00069	0.504
MOD_CK1_1	259	265	PF00069	0.578
MOD_CK2_1	200	206	PF00069	0.437
MOD_CK2_1	218	224	PF00069	0.434
MOD_CK2_1	243	249	PF00069	0.566
MOD_CK2_1	358	364	PF00069	0.430
MOD_CK2_1	391	397	PF00069	0.479
MOD_CK2_1	445	451	PF00069	0.573
MOD_CK2_1	471	477	PF00069	0.567
MOD_CK2_1	73	79	PF00069	0.441
MOD_GlcNHglycan	154	157	PF01048	0.284
MOD_GlcNHglycan	186	189	PF01048	0.311
MOD_GlcNHglycan	386	389	PF01048	0.247
MOD_GSK3_1	117	124	PF00069	0.437
MOD_GSK3_1	334	341	PF00069	0.435
MOD_GSK3_1	359	366	PF00069	0.431
MOD_GSK3_1	6	13	PF00069	0.564
MOD_NEK2_1	150	155	PF00069	0.502
MOD_NEK2_1	287	292	PF00069	0.437
MOD_NEK2_1	318	323	PF00069	0.481
MOD_NEK2_1	46	51	PF00069	0.522
MOD_NEK2_1	57	62	PF00069	0.422
MOD_NEK2_1	63	68	PF00069	0.386
MOD_NEK2_1	92	97	PF00069	0.498
MOD_NEK2_2	458	463	PF00069	0.551
MOD_PIKK_1	135	141	PF00454	0.437
MOD_PIKK_1	259	265	PF00454	0.572
MOD_PIKK_1	365	371	PF00454	0.498
MOD_PKA_2	31	37	PF00069	0.584
MOD_PKA_2	318	324	PF00069	0.473
MOD_Plk_1	150	156	PF00069	0.542
MOD_Plk_1	259	265	PF00069	0.583
MOD_Plk_1	410	416	PF00069	0.523
MOD_Plk_4	200	206	PF00069	0.437
MOD_Plk_4	287	293	PF00069	0.437
MOD_Plk_4	338	344	PF00069	0.491
MOD_Plk_4	391	397	PF00069	0.472
MOD_ProDKin_1	6	12	PF00069	0.670
MOD_SUMO_for_1	118	121	PF00179	0.462
MOD_SUMO_for_1	180	183	PF00179	0.473
MOD_SUMO_for_1	295	298	PF00179	0.487
MOD_SUMO_for_1	324	327	PF00179	0.461
MOD_SUMO_for_1	440	443	PF00179	0.558
MOD_SUMO_rev_2	244	253	PF00179	0.596
MOD_SUMO_rev_2	304	309	PF00179	0.437
MOD_SUMO_rev_2	436	442	PF00179	0.533
TRG_DiLeu_BaEn_1	401	406	PF01217	0.458
TRG_DiLeu_BaEn_2	409	415	PF01217	0.487
TRG_DiLeu_BaEn_3	410	416	PF01217	0.487
TRG_ENDOCYTIC_2	154	157	PF00928	0.542
TRG_ENDOCYTIC_2	172	175	PF00928	0.342
TRG_ER_diArg_1	100	103	PF00400	0.515
TRG_ER_diArg_1	272	274	PF00400	0.487
TRG_NLS_MonoExtC_3	98	104	PF00514	0.523
TRG_NLS_MonoExtN_4	98	103	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6X5	Leptomonas seymouri	82%	93%
A0A0S4J2U4	Bodo saltans	58%	100%
A0A1X0NSX4	Trypanosomatidae	70%	100%
A0A3S5IQV9	Trypanosoma rangeli	68%	100%
A4H998	Leishmania braziliensis	83%	100%
A4HXL9	Leishmania infantum	99%	100%
A9CB27	Papio anubis	41%	100%
C9ZPB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9ARB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O13724	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
O16999	Caenorhabditis elegans	41%	100%
O75312	Homo sapiens	40%	100%
P53303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q2TBX0	Bos taurus	41%	100%
Q4QE48	Leishmania major	94%	100%
Q55E13	Dictyostelium discoideum	42%	100%
Q62384	Mus musculus	41%	100%
Q9W379	Drosophila melanogaster	39%	100%
V5BJH3	Trypanosoma cruzi	64%	100%