GBBH-like_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF971), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAY8_LEIDO

TriTrypDb:

LdCL_210022200 , LDHU3_21.1960

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAY8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.615
CLV_NRD_NRD_1	141	143	PF00675	0.641
CLV_NRD_NRD_1	179	181	PF00675	0.514
CLV_NRD_NRD_1	343	345	PF00675	0.286
CLV_NRD_NRD_1	401	403	PF00675	0.470
CLV_PCSK_FUR_1	114	118	PF00082	0.543
CLV_PCSK_FUR_1	398	402	PF00082	0.439
CLV_PCSK_KEX2_1	114	116	PF00082	0.760
CLV_PCSK_KEX2_1	141	143	PF00082	0.539
CLV_PCSK_KEX2_1	179	181	PF00082	0.514
CLV_PCSK_KEX2_1	343	345	PF00082	0.260
CLV_PCSK_KEX2_1	400	402	PF00082	0.462
CLV_PCSK_KEX2_1	408	410	PF00082	0.488
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.475
CLV_PCSK_PC7_1	404	410	PF00082	0.455
CLV_PCSK_SKI1_1	142	146	PF00082	0.513
CLV_PCSK_SKI1_1	173	177	PF00082	0.505
CLV_PCSK_SKI1_1	258	262	PF00082	0.625
CLV_PCSK_SKI1_1	344	348	PF00082	0.226
CLV_PCSK_SKI1_1	360	364	PF00082	0.338
CLV_Separin_Metazoa	230	234	PF03568	0.435
CLV_Separin_Metazoa	246	250	PF03568	0.530
DEG_Nend_UBRbox_4	1	3	PF02207	0.469
DEG_SPOP_SBC_1	119	123	PF00917	0.564
DEG_SPOP_SBC_1	143	147	PF00917	0.514
DEG_SPOP_SBC_1	248	252	PF00917	0.644
DEG_SPOP_SBC_1	265	269	PF00917	0.518
DOC_MAPK_gen_1	215	222	PF00069	0.390
DOC_MAPK_MEF2A_6	77	86	PF00069	0.474
DOC_PP1_RVXF_1	358	364	PF00149	0.392
DOC_PP4_FxxP_1	13	16	PF00568	0.473
DOC_PP4_FxxP_1	222	225	PF00568	0.398
DOC_USP7_MATH_1	119	123	PF00917	0.595
DOC_USP7_MATH_1	134	138	PF00917	0.542
DOC_USP7_MATH_1	143	147	PF00917	0.483
DOC_USP7_MATH_1	188	192	PF00917	0.520
DOC_USP7_MATH_1	239	243	PF00917	0.594
DOC_USP7_MATH_1	248	252	PF00917	0.591
DOC_USP7_MATH_1	264	268	PF00917	0.538
DOC_USP7_MATH_1	272	276	PF00917	0.518
DOC_USP7_MATH_1	282	286	PF00917	0.558
DOC_USP7_MATH_1	353	357	PF00917	0.429
DOC_USP7_MATH_1	5	9	PF00917	0.446
DOC_USP7_MATH_1	61	65	PF00917	0.491
DOC_USP7_MATH_1	75	79	PF00917	0.493
DOC_WW_Pin1_4	120	125	PF00397	0.612
DOC_WW_Pin1_4	126	131	PF00397	0.567
DOC_WW_Pin1_4	18	23	PF00397	0.478
DOC_WW_Pin1_4	301	306	PF00397	0.572
DOC_WW_Pin1_4	323	328	PF00397	0.441
DOC_WW_Pin1_4	379	384	PF00397	0.358
DOC_WW_Pin1_4	70	75	PF00397	0.578
DOC_WW_Pin1_4	95	100	PF00397	0.481
LIG_14-3-3_CanoR_1	114	124	PF00244	0.786
LIG_14-3-3_CanoR_1	141	149	PF00244	0.510
LIG_14-3-3_CanoR_1	186	196	PF00244	0.522
LIG_14-3-3_CanoR_1	233	238	PF00244	0.552
LIG_14-3-3_CanoR_1	258	263	PF00244	0.623
LIG_14-3-3_CanoR_1	266	272	PF00244	0.566
LIG_14-3-3_CanoR_1	28	32	PF00244	0.499
LIG_14-3-3_CanoR_1	281	290	PF00244	0.563
LIG_14-3-3_CanoR_1	296	300	PF00244	0.494
LIG_14-3-3_CanoR_1	391	399	PF00244	0.338
LIG_Actin_WH2_2	345	362	PF00022	0.460
LIG_BH_BH3_1	141	157	PF00452	0.528
LIG_BRCT_BRCA1_1	122	126	PF00533	0.705
LIG_BRCT_BRCA1_1	154	158	PF00533	0.352
LIG_FHA_1	143	149	PF00498	0.501
LIG_FHA_1	313	319	PF00498	0.366
LIG_FHA_1	347	353	PF00498	0.466
LIG_FHA_2	221	227	PF00498	0.351
LIG_FHA_2	88	94	PF00498	0.473
LIG_LIR_Apic_2	11	16	PF02991	0.464
LIG_LIR_Apic_2	221	225	PF02991	0.405
LIG_LIR_Apic_2	36	41	PF02991	0.439
LIG_LIR_Gen_1	216	225	PF02991	0.375
LIG_LIR_Gen_1	373	380	PF02991	0.512
LIG_LIR_Gen_1	412	423	PF02991	0.414
LIG_LIR_Nem_3	216	222	PF02991	0.385
LIG_LIR_Nem_3	298	302	PF02991	0.525
LIG_LIR_Nem_3	373	379	PF02991	0.512
LIG_LIR_Nem_3	7	12	PF02991	0.455
LIG_Pex14_2	9	13	PF04695	0.469
LIG_SH2_CRK	374	378	PF00017	0.448
LIG_SH2_CRK	38	42	PF00017	0.460
LIG_SH2_NCK_1	38	42	PF00017	0.460
LIG_SH2_STAP1	357	361	PF00017	0.460
LIG_SH2_STAP1	372	376	PF00017	0.470
LIG_SH2_STAP1	415	419	PF00017	0.469
LIG_SH2_STAT5	112	115	PF00017	0.555
LIG_SH2_STAT5	219	222	PF00017	0.368
LIG_SH2_STAT5	321	324	PF00017	0.494
LIG_SH2_STAT5	325	328	PF00017	0.472
LIG_SH2_STAT5	372	375	PF00017	0.497
LIG_SH2_STAT5	376	379	PF00017	0.497
LIG_SH2_STAT5	38	41	PF00017	0.448
LIG_SH2_STAT5	393	396	PF00017	0.489
LIG_SH3_2	244	249	PF14604	0.590
LIG_SH3_3	172	178	PF00018	0.511
LIG_SH3_3	238	244	PF00018	0.583
LIG_SH3_3	302	308	PF00018	0.741
LIG_SH3_3	9	15	PF00018	0.479
LIG_SUMO_SIM_anti_2	226	233	PF11976	0.401
LIG_SUMO_SIM_par_1	16	21	PF11976	0.473
LIG_TRFH_1	126	130	PF08558	0.574
LIG_WW_3	246	250	PF00397	0.598
MOD_CDK_SPK_2	126	131	PF00069	0.485
MOD_CDK_SPxxK_3	379	386	PF00069	0.355
MOD_CDK_SPxxK_3	70	77	PF00069	0.573
MOD_CDK_SPxxK_3	95	102	PF00069	0.481
MOD_CK1_1	147	153	PF00069	0.576
MOD_CK1_1	242	248	PF00069	0.733
MOD_CK1_1	252	258	PF00069	0.576
MOD_CK1_1	30	36	PF00069	0.500
MOD_CK1_1	382	388	PF00069	0.490
MOD_CK1_1	422	428	PF00069	0.374
MOD_CK1_1	69	75	PF00069	0.490
MOD_CK1_1	8	14	PF00069	0.453
MOD_CK2_1	188	194	PF00069	0.483
MOD_CK2_1	220	226	PF00069	0.343
MOD_CK2_1	30	36	PF00069	0.503
MOD_CK2_1	87	93	PF00069	0.446
MOD_Cter_Amidation	341	344	PF01082	0.290
MOD_DYRK1A_RPxSP_1	323	327	PF00069	0.290
MOD_GlcNHglycan	136	139	PF01048	0.600
MOD_GlcNHglycan	251	254	PF01048	0.618
MOD_GlcNHglycan	268	271	PF01048	0.555
MOD_GlcNHglycan	284	287	PF01048	0.545
MOD_GlcNHglycan	308	311	PF01048	0.496
MOD_GlcNHglycan	367	370	PF01048	0.311
MOD_GlcNHglycan	421	424	PF01048	0.349
MOD_GlcNHglycan	95	98	PF01048	0.498
MOD_GSK3_1	115	122	PF00069	0.593
MOD_GSK3_1	143	150	PF00069	0.518
MOD_GSK3_1	248	255	PF00069	0.651
MOD_GSK3_1	26	33	PF00069	0.502
MOD_GSK3_1	361	368	PF00069	0.266
MOD_GSK3_1	378	385	PF00069	0.523
MOD_GSK3_1	4	11	PF00069	0.438
MOD_GSK3_1	66	73	PF00069	0.500
MOD_N-GLC_1	188	193	PF02516	0.517
MOD_NEK2_1	144	149	PF00069	0.701
MOD_NEK2_1	152	157	PF00069	0.457
MOD_NEK2_1	158	163	PF00069	0.376
MOD_NEK2_1	24	29	PF00069	0.484
MOD_NEK2_1	87	92	PF00069	0.575
MOD_PIKK_1	158	164	PF00454	0.417
MOD_PIKK_1	36	42	PF00454	0.474
MOD_PK_1	409	415	PF00069	0.445
MOD_PKA_1	115	121	PF00069	0.618
MOD_PKA_1	400	406	PF00069	0.431
MOD_PKA_2	115	121	PF00069	0.618
MOD_PKA_2	248	254	PF00069	0.607
MOD_PKA_2	265	271	PF00069	0.514
MOD_PKA_2	27	33	PF00069	0.500
MOD_PKA_2	295	301	PF00069	0.474
MOD_PKA_2	400	406	PF00069	0.431
MOD_PKB_1	398	406	PF00069	0.480
MOD_Plk_1	188	194	PF00069	0.513
MOD_Plk_1	220	226	PF00069	0.408
MOD_Plk_4	108	114	PF00069	0.545
MOD_Plk_4	144	150	PF00069	0.493
MOD_Plk_4	8	14	PF00069	0.497
MOD_ProDKin_1	120	126	PF00069	0.617
MOD_ProDKin_1	18	24	PF00069	0.479
MOD_ProDKin_1	301	307	PF00069	0.565
MOD_ProDKin_1	323	329	PF00069	0.265
MOD_ProDKin_1	379	385	PF00069	0.357
MOD_ProDKin_1	70	76	PF00069	0.576
MOD_ProDKin_1	95	101	PF00069	0.483
MOD_SUMO_rev_2	165	175	PF00179	0.550
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.468
TRG_ENDOCYTIC_2	219	222	PF00928	0.368
TRG_ENDOCYTIC_2	374	377	PF00928	0.351
TRG_ENDOCYTIC_2	387	390	PF00928	0.431
TRG_ENDOCYTIC_2	415	418	PF00928	0.407
TRG_ER_diArg_1	113	116	PF00400	0.752
TRG_ER_diArg_1	141	143	PF00400	0.539
TRG_ER_diArg_1	178	180	PF00400	0.511
TRG_ER_diArg_1	202	205	PF00400	0.468
TRG_ER_diArg_1	313	316	PF00400	0.384
TRG_ER_diArg_1	397	400	PF00400	0.423
TRG_ER_diArg_1	401	404	PF00400	0.451
TRG_NES_CRM1_1	227	240	PF08389	0.380
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HBZ0	Leishmania braziliensis	67%	96%
A4HZD8	Leishmania infantum	99%	100%
D0A147	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QC54	Leishmania major	87%	100%