LeishMANIAdb
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tRNA (Uracil-5-)-methyltransferase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
tRNA (Uracil-5-)-methyltransferase family protein
Gene product:
tRNA (Uracil-5-)-methyltransferase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IAY6_LEIDO
TriTrypDb:
LdBPK_201680.1 , LdCL_200021600 , LDHU3_20.2050
Length:
603

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAY6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAY6

Function

Biological processes
TermNameLevelCount
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006396 RNA processing 6 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 11
GO:0008168 methyltransferase activity 4 11
GO:0008173 RNA methyltransferase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016741 transferase activity, transferring one-carbon groups 3 11
GO:0140098 catalytic activity, acting on RNA 3 11
GO:0140640 catalytic activity, acting on a nucleic acid 2 11
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 129 133 PF00656 0.609
CLV_C14_Caspase3-7 593 597 PF00656 0.602
CLV_NRD_NRD_1 125 127 PF00675 0.591
CLV_NRD_NRD_1 150 152 PF00675 0.353
CLV_NRD_NRD_1 161 163 PF00675 0.348
CLV_NRD_NRD_1 274 276 PF00675 0.324
CLV_NRD_NRD_1 441 443 PF00675 0.364
CLV_NRD_NRD_1 504 506 PF00675 0.246
CLV_NRD_NRD_1 561 563 PF00675 0.497
CLV_PCSK_FUR_1 151 155 PF00082 0.394
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I1V8 Leptomonas seymouri 76% 100%
A0A1X0NXG3 Trypanosomatidae 58% 100%
A0A3R7L6W3 Trypanosoma rangeli 62% 100%
A4HZ00 Leishmania infantum 100% 100%
A4QP75 Danio rerio 31% 100%
A5IBU7 Legionella pneumophila (strain Corby) 25% 100%
C9ZIM3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AIL9 Leishmania braziliensis 85% 100%
E9AUV2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O31503 Bacillus subtilis (strain 168) 26% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS