Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAY3_LEIDO

TriTrypDb:

LdBPK_281170.1 , LdCL_280016300 , LDHU3_28.1450

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IAY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	449	453	PF00656	0.414
CLV_NRD_NRD_1	126	128	PF00675	0.553
CLV_NRD_NRD_1	353	355	PF00675	0.449
CLV_NRD_NRD_1	424	426	PF00675	0.613
CLV_NRD_NRD_1	434	436	PF00675	0.391
CLV_NRD_NRD_1	692	694	PF00675	0.625
CLV_NRD_NRD_1	7	9	PF00675	0.592
CLV_NRD_NRD_1	84	86	PF00675	0.577
CLV_PCSK_FUR_1	124	128	PF00082	0.562
CLV_PCSK_KEX2_1	124	126	PF00082	0.552
CLV_PCSK_KEX2_1	190	192	PF00082	0.464
CLV_PCSK_KEX2_1	386	388	PF00082	0.468
CLV_PCSK_KEX2_1	426	428	PF00082	0.661
CLV_PCSK_KEX2_1	692	694	PF00082	0.628
CLV_PCSK_KEX2_1	7	9	PF00082	0.686
CLV_PCSK_KEX2_1	84	86	PF00082	0.699
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.443
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.360
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.530
CLV_PCSK_SKI1_1	150	154	PF00082	0.418
CLV_PCSK_SKI1_1	251	255	PF00082	0.541
CLV_PCSK_SKI1_1	355	359	PF00082	0.417
CLV_PCSK_SKI1_1	435	439	PF00082	0.527
CLV_PCSK_SKI1_1	465	469	PF00082	0.400
CLV_PCSK_SKI1_1	510	514	PF00082	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.645
DEG_SPOP_SBC_1	36	40	PF00917	0.566
DOC_CKS1_1	475	480	PF01111	0.603
DOC_CKS1_1	545	550	PF01111	0.579
DOC_CKS1_1	584	589	PF01111	0.686
DOC_CYCLIN_yCln2_LP_2	274	277	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	468	474	PF00134	0.591
DOC_MAPK_FxFP_2	472	475	PF00069	0.559
DOC_MAPK_gen_1	108	115	PF00069	0.513
DOC_MAPK_gen_1	116	123	PF00069	0.519
DOC_MAPK_gen_1	296	305	PF00069	0.548
DOC_MAPK_gen_1	711	719	PF00069	0.624
DOC_MAPK_MEF2A_6	298	307	PF00069	0.536
DOC_MAPK_MEF2A_6	711	719	PF00069	0.633
DOC_PP1_RVXF_1	138	144	PF00149	0.484
DOC_PP1_RVXF_1	148	155	PF00149	0.413
DOC_PP2B_LxvP_1	206	209	PF13499	0.443
DOC_PP2B_LxvP_1	274	277	PF13499	0.405
DOC_PP2B_LxvP_1	543	546	PF13499	0.636
DOC_PP4_FxxP_1	143	146	PF00568	0.496
DOC_PP4_FxxP_1	217	220	PF00568	0.464
DOC_PP4_FxxP_1	472	475	PF00568	0.483
DOC_USP7_MATH_1	23	27	PF00917	0.704
DOC_USP7_MATH_1	36	40	PF00917	0.667
DOC_USP7_MATH_1	550	554	PF00917	0.616
DOC_USP7_MATH_1	556	560	PF00917	0.668
DOC_USP7_MATH_1	573	577	PF00917	0.691
DOC_USP7_MATH_1	588	592	PF00917	0.687
DOC_USP7_MATH_1	593	597	PF00917	0.767
DOC_USP7_MATH_1	654	658	PF00917	0.718
DOC_USP7_MATH_1	80	84	PF00917	0.635
DOC_USP7_MATH_2	277	283	PF00917	0.411
DOC_WW_Pin1_4	21	26	PF00397	0.616
DOC_WW_Pin1_4	32	37	PF00397	0.697
DOC_WW_Pin1_4	474	479	PF00397	0.551
DOC_WW_Pin1_4	544	549	PF00397	0.600
DOC_WW_Pin1_4	583	588	PF00397	0.643
DOC_WW_Pin1_4	697	702	PF00397	0.645
LIG_14-3-3_CanoR_1	162	166	PF00244	0.447
LIG_14-3-3_CanoR_1	175	183	PF00244	0.362
LIG_14-3-3_CanoR_1	244	254	PF00244	0.544
LIG_14-3-3_CanoR_1	328	332	PF00244	0.566
LIG_14-3-3_CanoR_1	456	461	PF00244	0.442
LIG_14-3-3_CanoR_1	55	61	PF00244	0.643
LIG_14-3-3_CanoR_1	74	80	PF00244	0.538
LIG_14-3-3_CanoR_1	84	88	PF00244	0.545
LIG_APCC_ABBA_1	399	404	PF00400	0.420
LIG_BRCT_BRCA1_1	281	285	PF00533	0.541
LIG_deltaCOP1_diTrp_1	212	217	PF00928	0.526
LIG_deltaCOP1_diTrp_1	279	285	PF00928	0.431
LIG_DLG_GKlike_1	456	463	PF00625	0.415
LIG_eIF4E_1	269	275	PF01652	0.427
LIG_FHA_1	216	222	PF00498	0.438
LIG_FHA_1	333	339	PF00498	0.316
LIG_FHA_1	357	363	PF00498	0.344
LIG_FHA_1	653	659	PF00498	0.743
LIG_FHA_1	679	685	PF00498	0.637
LIG_FHA_2	208	214	PF00498	0.383
LIG_FHA_2	55	61	PF00498	0.551
LIG_FHA_2	619	625	PF00498	0.638
LIG_FHA_2	663	669	PF00498	0.739
LIG_FHA_2	702	708	PF00498	0.636
LIG_LIR_Apic_2	215	220	PF02991	0.477
LIG_LIR_Apic_2	469	475	PF02991	0.606
LIG_LIR_Apic_2	581	587	PF02991	0.633
LIG_LIR_Gen_1	178	188	PF02991	0.403
LIG_LIR_Gen_1	212	221	PF02991	0.473
LIG_LIR_Gen_1	259	270	PF02991	0.464
LIG_LIR_Gen_1	454	463	PF02991	0.493
LIG_LIR_Gen_1	483	493	PF02991	0.445
LIG_LIR_Gen_1	535	546	PF02991	0.546
LIG_LIR_Nem_3	178	184	PF02991	0.398
LIG_LIR_Nem_3	212	217	PF02991	0.393
LIG_LIR_Nem_3	259	265	PF02991	0.416
LIG_LIR_Nem_3	282	288	PF02991	0.453
LIG_LIR_Nem_3	378	382	PF02991	0.393
LIG_LIR_Nem_3	454	460	PF02991	0.473
LIG_LIR_Nem_3	469	473	PF02991	0.437
LIG_LIR_Nem_3	483	489	PF02991	0.339
LIG_LIR_Nem_3	495	500	PF02991	0.505
LIG_LIR_Nem_3	535	541	PF02991	0.520
LIG_MYND_3	275	279	PF01753	0.443
LIG_PCNA_yPIPBox_3	328	341	PF02747	0.475
LIG_PDZ_Class_2	717	722	PF00595	0.665
LIG_Pex14_1	281	285	PF04695	0.439
LIG_Pex14_1	75	79	PF04695	0.553
LIG_Pex14_2	470	474	PF04695	0.552
LIG_PTB_Apo_2	506	513	PF02174	0.660
LIG_RPA_C_Fungi	113	125	PF08784	0.435
LIG_SH2_CRK	457	461	PF00017	0.483
LIG_SH2_CRK	497	501	PF00017	0.572
LIG_SH2_SRC	531	534	PF00017	0.579
LIG_SH2_STAP1	231	235	PF00017	0.408
LIG_SH2_STAP1	312	316	PF00017	0.420
LIG_SH2_STAT3	129	132	PF00017	0.512
LIG_SH2_STAT5	264	267	PF00017	0.407
LIG_SH2_STAT5	269	272	PF00017	0.430
LIG_SH2_STAT5	441	444	PF00017	0.536
LIG_SH2_STAT5	473	476	PF00017	0.577
LIG_SH2_STAT5	490	493	PF00017	0.281
LIG_SH2_STAT5	604	607	PF00017	0.623
LIG_SH2_STAT5	63	66	PF00017	0.494
LIG_SH2_STAT5	97	100	PF00017	0.539
LIG_SH3_3	149	155	PF00018	0.507
LIG_SH3_3	291	297	PF00018	0.469
LIG_SH3_3	472	478	PF00018	0.566
LIG_SH3_3	539	545	PF00018	0.600
LIG_SH3_3	681	687	PF00018	0.709
LIG_TRAF2_1	330	333	PF00917	0.546
LIG_TRAF2_1	413	416	PF00917	0.536
LIG_TRAF2_1	524	527	PF00917	0.526
LIG_TRAF2_1	621	624	PF00917	0.547
LIG_TRFH_1	474	478	PF08558	0.527
LIG_TRFH_1	541	545	PF08558	0.619
LIG_UBA3_1	184	190	PF00899	0.453
LIG_UBA3_1	511	519	PF00899	0.404
MOD_CDK_SPK_2	26	31	PF00069	0.602
MOD_CDK_SPxK_1	583	589	PF00069	0.613
MOD_CDK_SPxxK_3	26	33	PF00069	0.586
MOD_CK1_1	21	27	PF00069	0.768
MOD_CK1_1	237	243	PF00069	0.409
MOD_CK1_1	246	252	PF00069	0.397
MOD_CK1_1	327	333	PF00069	0.526
MOD_CK1_1	35	41	PF00069	0.580
MOD_CK1_1	410	416	PF00069	0.447
MOD_CK1_1	451	457	PF00069	0.456
MOD_CK1_1	560	566	PF00069	0.652
MOD_CK1_1	571	577	PF00069	0.605
MOD_CK1_1	591	597	PF00069	0.769
MOD_CK1_1	638	644	PF00069	0.756
MOD_CK1_1	709	715	PF00069	0.658
MOD_CK1_1	83	89	PF00069	0.561
MOD_CK2_1	327	333	PF00069	0.421
MOD_CK2_1	365	371	PF00069	0.413
MOD_CK2_1	410	416	PF00069	0.538
MOD_CK2_1	521	527	PF00069	0.461
MOD_CK2_1	618	624	PF00069	0.652
MOD_CK2_1	654	660	PF00069	0.718
MOD_CK2_1	662	668	PF00069	0.731
MOD_CK2_1	701	707	PF00069	0.634
MOD_Cter_Amidation	423	426	PF01082	0.480
MOD_Cter_Amidation	433	436	PF01082	0.393
MOD_DYRK1A_RPxSP_1	697	701	PF00069	0.621
MOD_GlcNHglycan	25	28	PF01048	0.561
MOD_GlcNHglycan	504	507	PF01048	0.639
MOD_GlcNHglycan	552	555	PF01048	0.662
MOD_GlcNHglycan	560	563	PF01048	0.600
MOD_GlcNHglycan	570	573	PF01048	0.587
MOD_GSK3_1	157	164	PF00069	0.461
MOD_GSK3_1	175	182	PF00069	0.537
MOD_GSK3_1	21	28	PF00069	0.569
MOD_GSK3_1	215	222	PF00069	0.442
MOD_GSK3_1	234	241	PF00069	0.436
MOD_GSK3_1	243	250	PF00069	0.362
MOD_GSK3_1	301	308	PF00069	0.453
MOD_GSK3_1	32	39	PF00069	0.542
MOD_GSK3_1	552	559	PF00069	0.617
MOD_GSK3_1	560	567	PF00069	0.595
MOD_GSK3_1	574	581	PF00069	0.734
MOD_GSK3_1	589	596	PF00069	0.719
MOD_GSK3_1	654	661	PF00069	0.672
MOD_GSK3_1	697	704	PF00069	0.678
MOD_GSK3_1	74	81	PF00069	0.519
MOD_LATS_1	651	657	PF00433	0.538
MOD_N-GLC_1	158	163	PF02516	0.583
MOD_N-GLC_1	638	643	PF02516	0.618
MOD_NEK2_1	157	162	PF00069	0.521
MOD_NEK2_1	229	234	PF00069	0.507
MOD_NEK2_1	245	250	PF00069	0.426
MOD_NEK2_1	270	275	PF00069	0.498
MOD_NEK2_1	382	387	PF00069	0.346
MOD_NEK2_1	499	504	PF00069	0.486
MOD_NEK2_1	65	70	PF00069	0.588
MOD_NEK2_1	688	693	PF00069	0.556
MOD_NEK2_2	257	262	PF00069	0.453
MOD_NEK2_2	418	423	PF00069	0.448
MOD_PIKK_1	407	413	PF00454	0.497
MOD_PIKK_1	451	457	PF00454	0.449
MOD_PIKK_1	593	599	PF00454	0.632
MOD_PIKK_1	678	684	PF00454	0.657
MOD_PKA_1	108	114	PF00069	0.592
MOD_PKA_1	426	432	PF00069	0.543
MOD_PKA_2	161	167	PF00069	0.456
MOD_PKA_2	174	180	PF00069	0.372
MOD_PKA_2	243	249	PF00069	0.523
MOD_PKA_2	327	333	PF00069	0.568
MOD_PKA_2	418	424	PF00069	0.572
MOD_PKA_2	426	432	PF00069	0.575
MOD_PKA_2	54	60	PF00069	0.751
MOD_PKA_2	574	580	PF00069	0.641
MOD_PKA_2	73	79	PF00069	0.666
MOD_PKA_2	83	89	PF00069	0.690
MOD_PKB_1	693	701	PF00069	0.631
MOD_Plk_1	119	125	PF00069	0.600
MOD_Plk_1	158	164	PF00069	0.564
MOD_Plk_1	270	276	PF00069	0.460
MOD_Plk_1	615	621	PF00069	0.624
MOD_Plk_2-3	521	527	PF00069	0.518
MOD_Plk_4	161	167	PF00069	0.535
MOD_Plk_4	234	240	PF00069	0.464
MOD_Plk_4	257	263	PF00069	0.443
MOD_Plk_4	375	381	PF00069	0.498
MOD_Plk_4	59	65	PF00069	0.724
MOD_ProDKin_1	21	27	PF00069	0.616
MOD_ProDKin_1	32	38	PF00069	0.694
MOD_ProDKin_1	474	480	PF00069	0.541
MOD_ProDKin_1	544	550	PF00069	0.600
MOD_ProDKin_1	583	589	PF00069	0.645
MOD_ProDKin_1	697	703	PF00069	0.645
MOD_SUMO_rev_2	101	111	PF00179	0.527
MOD_SUMO_rev_2	136	141	PF00179	0.515
MOD_SUMO_rev_2	351	357	PF00179	0.550
MOD_SUMO_rev_2	368	375	PF00179	0.375
MOD_SUMO_rev_2	378	388	PF00179	0.473
MOD_SUMO_rev_2	410	418	PF00179	0.514
MOD_SUMO_rev_2	638	643	PF00179	0.669
TRG_DiLeu_BaEn_1	333	338	PF01217	0.410
TRG_DiLeu_BaEn_2	191	197	PF01217	0.440
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.603
TRG_ENDOCYTIC_2	242	245	PF00928	0.519
TRG_ENDOCYTIC_2	420	423	PF00928	0.434
TRG_ENDOCYTIC_2	457	460	PF00928	0.482
TRG_ENDOCYTIC_2	473	476	PF00928	0.393
TRG_ENDOCYTIC_2	490	493	PF00928	0.480
TRG_ENDOCYTIC_2	497	500	PF00928	0.595
TRG_ENDOCYTIC_2	538	541	PF00928	0.672
TRG_ER_diArg_1	115	118	PF00400	0.485
TRG_ER_diArg_1	123	126	PF00400	0.528
TRG_ER_diArg_1	30	33	PF00400	0.680
TRG_ER_diArg_1	6	8	PF00400	0.570
TRG_ER_diArg_1	692	695	PF00400	0.641
TRG_ER_diArg_1	87	90	PF00400	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J5	Leptomonas seymouri	43%	100%
A0A1X0NYQ6	Trypanosomatidae	30%	100%
A0A3R7LLJ8	Trypanosoma rangeli	29%	100%
A4HGF2	Leishmania braziliensis	72%	100%
A4I3I3	Leishmania infantum	100%	100%
D0A7W0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AZS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8F9	Leishmania major	93%	100%
V5DAI7	Trypanosoma cruzi	32%	100%