HJURP_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IAY2_LEIDO

TriTrypDb:

LdBPK_100130.1 , LdCL_100006500 , LDHU3_10.0230

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IAY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	263	268	PF00400	0.543
DEG_SPOP_SBC_1	271	275	PF00917	0.651
DOC_CDC14_PxL_1	184	192	PF14671	0.643
DOC_CKS1_1	169	174	PF01111	0.677
DOC_CKS1_1	266	271	PF01111	0.555
DOC_PP2B_LxvP_1	152	155	PF13499	0.634
DOC_USP7_MATH_1	23	27	PF00917	0.681
DOC_USP7_MATH_1	270	274	PF00917	0.654
DOC_USP7_MATH_1	289	293	PF00917	0.488
DOC_USP7_MATH_1	312	316	PF00917	0.678
DOC_USP7_MATH_1	82	86	PF00917	0.645
DOC_WW_Pin1_4	168	173	PF00397	0.585
DOC_WW_Pin1_4	175	180	PF00397	0.550
DOC_WW_Pin1_4	190	195	PF00397	0.622
DOC_WW_Pin1_4	210	215	PF00397	0.428
DOC_WW_Pin1_4	225	230	PF00397	0.600
DOC_WW_Pin1_4	261	266	PF00397	0.537
DOC_WW_Pin1_4	272	277	PF00397	0.584
DOC_WW_Pin1_4	329	334	PF00397	0.604
DOC_WW_Pin1_4	348	353	PF00397	0.642
LIG_14-3-3_CanoR_1	283	287	PF00244	0.662
LIG_14-3-3_CanoR_1	313	321	PF00244	0.700
LIG_14-3-3_CterR_2	367	372	PF00244	0.572
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_BRCT_BRCA1_1	20	24	PF00533	0.659
LIG_BRCT_BRCA1_1	50	54	PF00533	0.625
LIG_EVH1_1	152	156	PF00568	0.630
LIG_EVH1_2	199	203	PF00568	0.535
LIG_FHA_1	14	20	PF00498	0.629
LIG_FHA_1	243	249	PF00498	0.545
LIG_FHA_1	316	322	PF00498	0.567
LIG_FHA_1	349	355	PF00498	0.678
LIG_FHA_2	30	36	PF00498	0.691
LIG_LIR_Apic_2	264	270	PF02991	0.545
LIG_LIR_Gen_1	51	60	PF02991	0.713
LIG_LIR_Nem_3	51	57	PF02991	0.620
LIG_NRBOX	72	78	PF00104	0.517
LIG_PCNA_yPIPBox_3	70	81	PF02747	0.587
LIG_PROFILIN_1	153	159	PF00235	0.620
LIG_PROFILIN_1	160	166	PF00235	0.618
LIG_PTB_Apo_2	9	16	PF02174	0.569
LIG_PTB_Phospho_1	9	15	PF10480	0.569
LIG_SH2_CRK	119	123	PF00017	0.647
LIG_SH2_CRK	169	173	PF00017	0.632
LIG_SH2_CRK	184	188	PF00017	0.700
LIG_SH2_CRK	267	271	PF00017	0.559
LIG_SH2_CRK	284	288	PF00017	0.566
LIG_SH2_GRB2like	180	183	PF00017	0.639
LIG_SH2_NCK_1	123	127	PF00017	0.647
LIG_SH2_NCK_1	146	150	PF00017	0.675
LIG_SH2_NCK_1	169	173	PF00017	0.662
LIG_SH2_NCK_1	267	271	PF00017	0.597
LIG_SH2_NCK_1	284	288	PF00017	0.698
LIG_SH2_PTP2	234	237	PF00017	0.633
LIG_SH2_SRC	234	237	PF00017	0.573
LIG_SH2_STAP1	146	150	PF00017	0.653
LIG_SH2_STAP1	180	184	PF00017	0.671
LIG_SH2_STAP1	341	345	PF00017	0.602
LIG_SH2_STAP1	40	44	PF00017	0.532
LIG_SH2_STAT5	123	126	PF00017	0.643
LIG_SH2_STAT5	15	18	PF00017	0.602
LIG_SH2_STAT5	234	237	PF00017	0.633
LIG_SH2_STAT5	267	270	PF00017	0.591
LIG_SH2_STAT5	334	337	PF00017	0.619
LIG_SH3_3	112	118	PF00018	0.617
LIG_SH3_3	150	156	PF00018	0.584
LIG_SH3_3	157	163	PF00018	0.556
LIG_SH3_3	173	179	PF00018	0.578
LIG_SH3_3	195	201	PF00018	0.749
LIG_SH3_3	233	239	PF00018	0.561
LIG_SH3_3	260	266	PF00018	0.551
LIG_SH3_3	274	280	PF00018	0.529
LIG_SH3_3	322	328	PF00018	0.629
LIG_SH3_3	363	369	PF00018	0.692
LIG_SH3_5	36	40	PF00018	0.522
LIG_SUMO_SIM_anti_2	88	96	PF11976	0.557
LIG_TRAF2_1	223	226	PF00917	0.645
LIG_TRAF2_1	241	244	PF00917	0.623
LIG_TRAF2_1	59	62	PF00917	0.645
LIG_TRFH_1	255	259	PF08558	0.478
LIG_TRFH_1	284	288	PF08558	0.600
LIG_UBA3_1	256	262	PF00899	0.532
LIG_WW_1	166	169	PF00397	0.596
LIG_WW_1	358	361	PF00397	0.566
MOD_CDK_SPxxK_3	190	197	PF00069	0.651
MOD_CDK_SPxxK_3	276	283	PF00069	0.655
MOD_CK1_1	145	151	PF00069	0.654
MOD_CK1_1	170	176	PF00069	0.706
MOD_CK1_1	221	227	PF00069	0.704
MOD_CK1_1	261	267	PF00069	0.595
MOD_CK1_1	315	321	PF00069	0.682
MOD_CK1_1	353	359	PF00069	0.668
MOD_CK2_1	14	20	PF00069	0.747
MOD_CK2_1	199	205	PF00069	0.570
MOD_CK2_1	313	319	PF00069	0.684
MOD_GlcNHglycan	147	150	PF01048	0.683
MOD_GlcNHglycan	16	19	PF01048	0.772
MOD_GlcNHglycan	184	187	PF01048	0.668
MOD_GlcNHglycan	20	23	PF01048	0.741
MOD_GlcNHglycan	335	338	PF01048	0.590
MOD_GlcNHglycan	41	45	PF01048	0.540
MOD_GSK3_1	14	21	PF00069	0.712
MOD_GSK3_1	144	151	PF00069	0.638
MOD_GSK3_1	189	196	PF00069	0.681
MOD_GSK3_1	206	213	PF00069	0.519
MOD_GSK3_1	221	228	PF00069	0.547
MOD_GSK3_1	261	268	PF00069	0.537
MOD_GSK3_1	272	279	PF00069	0.565
MOD_GSK3_1	289	296	PF00069	0.596
MOD_GSK3_1	329	336	PF00069	0.594
MOD_GSK3_1	344	351	PF00069	0.711
MOD_N-GLC_1	142	147	PF02516	0.652
MOD_NEK2_1	13	18	PF00069	0.516
MOD_NEK2_1	218	223	PF00069	0.728
MOD_NEK2_1	248	253	PF00069	0.560
MOD_NEK2_1	302	307	PF00069	0.627
MOD_NEK2_1	335	340	PF00069	0.658
MOD_NEK2_2	49	54	PF00069	0.623
MOD_PIKK_1	221	227	PF00454	0.652
MOD_PK_1	313	319	PF00069	0.595
MOD_PKA_2	248	254	PF00069	0.576
MOD_PKA_2	282	288	PF00069	0.661
MOD_PKA_2	312	318	PF00069	0.686
MOD_Plk_1	142	148	PF00069	0.656
MOD_Plk_2-3	96	102	PF00069	0.648
MOD_Plk_4	213	219	PF00069	0.652
MOD_Plk_4	242	248	PF00069	0.616
MOD_Plk_4	303	309	PF00069	0.679
MOD_Plk_4	49	55	PF00069	0.680
MOD_ProDKin_1	168	174	PF00069	0.583
MOD_ProDKin_1	175	181	PF00069	0.552
MOD_ProDKin_1	190	196	PF00069	0.588
MOD_ProDKin_1	210	216	PF00069	0.430
MOD_ProDKin_1	225	231	PF00069	0.598
MOD_ProDKin_1	261	267	PF00069	0.540
MOD_ProDKin_1	272	278	PF00069	0.583
MOD_ProDKin_1	329	335	PF00069	0.606
MOD_ProDKin_1	348	354	PF00069	0.642
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.574
TRG_ENDOCYTIC_2	123	126	PF00928	0.653
TRG_ENDOCYTIC_2	184	187	PF00928	0.703
TRG_ENDOCYTIC_2	323	326	PF00928	0.581
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX5	Leptomonas seymouri	57%	100%
A4H5Z6	Leishmania braziliensis	79%	99%
A4HUC2	Leishmania infantum	99%	99%
C9ZVG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AN21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QHK5	Leishmania major	96%	100%
V5BE36	Trypanosoma cruzi	35%	100%