Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAY0_LEIDO

TriTrypDb:

LdBPK_211470.1 , LdCL_210020200 , LDHU3_21.1750

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

A0A3Q8IAY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAY0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.429
CLV_C14_Caspase3-7	350	354	PF00656	0.407
CLV_MEL_PAP_1	304	310	PF00089	0.382
CLV_MEL_PAP_1	55	61	PF00089	0.410
CLV_NRD_NRD_1	16	18	PF00675	0.569
CLV_NRD_NRD_1	224	226	PF00675	0.581
CLV_NRD_NRD_1	322	324	PF00675	0.546
CLV_NRD_NRD_1	437	439	PF00675	0.505
CLV_NRD_NRD_1	510	512	PF00675	0.595
CLV_NRD_NRD_1	540	542	PF00675	0.585
CLV_NRD_NRD_1	57	59	PF00675	0.487
CLV_NRD_NRD_1	9	11	PF00675	0.692
CLV_NRD_NRD_1	95	97	PF00675	0.441
CLV_PCSK_KEX2_1	16	18	PF00082	0.602
CLV_PCSK_KEX2_1	322	324	PF00082	0.546
CLV_PCSK_KEX2_1	330	332	PF00082	0.438
CLV_PCSK_KEX2_1	437	439	PF00082	0.505
CLV_PCSK_KEX2_1	510	512	PF00082	0.501
CLV_PCSK_KEX2_1	540	542	PF00082	0.585
CLV_PCSK_KEX2_1	57	59	PF00082	0.569
CLV_PCSK_KEX2_1	95	97	PF00082	0.441
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.602
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.472
CLV_PCSK_SKI1_1	186	190	PF00082	0.278
CLV_PCSK_SKI1_1	239	243	PF00082	0.346
CLV_PCSK_SKI1_1	44	48	PF00082	0.763
CLV_PCSK_SKI1_1	517	521	PF00082	0.497
DEG_APCC_DBOX_1	238	246	PF00400	0.353
DEG_APCC_DBOX_1	516	524	PF00400	0.493
DEG_Nend_UBRbox_1	1	4	PF02207	0.608
DEG_ODPH_VHL_1	97	108	PF01847	0.405
DOC_ANK_TNKS_1	95	102	PF00023	0.437
DOC_CKS1_1	1	6	PF01111	0.584
DOC_MAPK_gen_1	330	336	PF00069	0.424
DOC_MAPK_gen_1	537	547	PF00069	0.559
DOC_MAPK_MEF2A_6	239	246	PF00069	0.339
DOC_MAPK_MEF2A_6	464	472	PF00069	0.572
DOC_PP1_RVXF_1	569	575	PF00149	0.456
DOC_PP4_FxxP_1	361	364	PF00568	0.446
DOC_USP7_MATH_1	184	188	PF00917	0.509
DOC_USP7_MATH_1	218	222	PF00917	0.563
DOC_USP7_MATH_1	321	325	PF00917	0.629
DOC_USP7_MATH_1	352	356	PF00917	0.307
DOC_USP7_MATH_1	383	387	PF00917	0.652
DOC_USP7_MATH_1	422	426	PF00917	0.605
DOC_USP7_MATH_1	462	466	PF00917	0.573
DOC_USP7_MATH_1	9	13	PF00917	0.794
DOC_USP7_UBL2_3	508	512	PF12436	0.497
DOC_WW_Pin1_4	220	225	PF00397	0.560
DOC_WW_Pin1_4	475	480	PF00397	0.580
DOC_WW_Pin1_4	563	568	PF00397	0.539
LIG_14-3-3_CanoR_1	136	145	PF00244	0.418
LIG_14-3-3_CanoR_1	17	23	PF00244	0.658
LIG_14-3-3_CanoR_1	186	192	PF00244	0.471
LIG_14-3-3_CanoR_1	331	335	PF00244	0.481
LIG_14-3-3_CanoR_1	421	429	PF00244	0.661
LIG_14-3-3_CanoR_1	430	434	PF00244	0.508
LIG_14-3-3_CanoR_1	437	441	PF00244	0.470
LIG_14-3-3_CanoR_1	540	547	PF00244	0.735
LIG_14-3-3_CanoR_1	64	70	PF00244	0.429
LIG_Actin_WH2_2	123	138	PF00022	0.420
LIG_Actin_WH2_2	364	380	PF00022	0.607
LIG_BRCT_BRCA1_1	55	59	PF00533	0.466
LIG_deltaCOP1_diTrp_1	353	361	PF00928	0.395
LIG_FHA_1	129	135	PF00498	0.401
LIG_FHA_1	140	146	PF00498	0.446
LIG_FHA_1	207	213	PF00498	0.459
LIG_FHA_1	248	254	PF00498	0.323
LIG_FHA_1	271	277	PF00498	0.392
LIG_FHA_1	338	344	PF00498	0.471
LIG_FHA_1	540	546	PF00498	0.582
LIG_FHA_1	567	573	PF00498	0.498
LIG_FHA_1	80	86	PF00498	0.422
LIG_FHA_2	188	194	PF00498	0.459
LIG_FHA_2	348	354	PF00498	0.400
LIG_FHA_2	360	366	PF00498	0.481
LIG_FHA_2	46	52	PF00498	0.574
LIG_FHA_2	476	482	PF00498	0.578
LIG_FHA_2	493	499	PF00498	0.432
LIG_LIR_Gen_1	171	179	PF02991	0.402
LIG_RPA_C_Fungi	433	445	PF08784	0.561
LIG_RPA_C_Fungi	506	518	PF08784	0.506
LIG_SH2_STAP1	146	150	PF00017	0.334
LIG_SH2_STAP1	174	178	PF00017	0.342
LIG_SH2_STAP1	345	349	PF00017	0.423
LIG_SH2_STAT3	191	194	PF00017	0.317
LIG_SH2_STAT5	154	157	PF00017	0.351
LIG_SH2_STAT5	191	194	PF00017	0.343
LIG_SH2_STAT5	200	203	PF00017	0.268
LIG_SH3_3	1	7	PF00018	0.657
LIG_SUMO_SIM_anti_2	243	250	PF11976	0.349
LIG_SUMO_SIM_anti_2	332	338	PF11976	0.468
LIG_SUMO_SIM_anti_2	474	486	PF11976	0.562
LIG_SUMO_SIM_anti_2	576	583	PF11976	0.512
LIG_SUMO_SIM_par_1	243	250	PF11976	0.349
LIG_SUMO_SIM_par_1	526	533	PF11976	0.601
MOD_CDK_SPK_2	220	225	PF00069	0.559
MOD_CDK_SPxK_1	220	226	PF00069	0.561
MOD_CK1_1	187	193	PF00069	0.366
MOD_CK1_1	19	25	PF00069	0.670
MOD_CK1_1	257	263	PF00069	0.344
MOD_CK1_1	268	274	PF00069	0.413
MOD_CK1_1	332	338	PF00069	0.526
MOD_CK1_1	408	414	PF00069	0.673
MOD_CK1_1	42	48	PF00069	0.744
MOD_CK1_1	566	572	PF00069	0.523
MOD_CK1_1	63	69	PF00069	0.381
MOD_CK2_1	359	365	PF00069	0.455
MOD_CK2_1	366	372	PF00069	0.545
MOD_CK2_1	421	427	PF00069	0.621
MOD_CK2_1	492	498	PF00069	0.556
MOD_CK2_1	574	580	PF00069	0.517
MOD_CK2_1	87	93	PF00069	0.429
MOD_CMANNOS	356	359	PF00535	0.377
MOD_Cter_Amidation	14	17	PF01082	0.610
MOD_Cter_Amidation	328	331	PF01082	0.512
MOD_GlcNHglycan	111	114	PF01048	0.418
MOD_GlcNHglycan	18	21	PF01048	0.657
MOD_GlcNHglycan	202	205	PF01048	0.338
MOD_GlcNHglycan	220	223	PF01048	0.564
MOD_GlcNHglycan	258	262	PF01048	0.345
MOD_GlcNHglycan	294	297	PF01048	0.345
MOD_GlcNHglycan	323	326	PF01048	0.644
MOD_GlcNHglycan	403	406	PF01048	0.605
MOD_GlcNHglycan	407	410	PF01048	0.600
MOD_GlcNHglycan	416	419	PF01048	0.577
MOD_GlcNHglycan	44	47	PF01048	0.602
MOD_GlcNHglycan	512	515	PF01048	0.535
MOD_GlcNHglycan	560	563	PF01048	0.571
MOD_GlcNHglycan	65	68	PF01048	0.374
MOD_GlcNHglycan	89	92	PF01048	0.423
MOD_GSK3_1	135	142	PF00069	0.446
MOD_GSK3_1	189	196	PF00069	0.417
MOD_GSK3_1	19	26	PF00069	0.601
MOD_GSK3_1	202	209	PF00069	0.298
MOD_GSK3_1	213	220	PF00069	0.361
MOD_GSK3_1	266	273	PF00069	0.392
MOD_GSK3_1	302	309	PF00069	0.387
MOD_GSK3_1	401	408	PF00069	0.567
MOD_GSK3_1	412	419	PF00069	0.526
MOD_GSK3_1	429	436	PF00069	0.505
MOD_GSK3_1	45	52	PF00069	0.526
MOD_GSK3_1	462	469	PF00069	0.548
MOD_N-GLC_1	109	114	PF02516	0.416
MOD_N-GLC_1	359	364	PF02516	0.433
MOD_N-GLC_1	412	417	PF02516	0.587
MOD_N-GLC_2	37	39	PF02516	0.546
MOD_N-GLC_2	395	397	PF02516	0.561
MOD_NEK2_1	135	140	PF00069	0.477
MOD_NEK2_1	172	177	PF00069	0.566
MOD_NEK2_1	270	275	PF00069	0.413
MOD_NEK2_1	429	434	PF00069	0.539
MOD_NEK2_1	444	449	PF00069	0.559
MOD_PIKK_1	128	134	PF00454	0.396
MOD_PIKK_1	136	142	PF00454	0.380
MOD_PIKK_1	314	320	PF00454	0.466
MOD_PIKK_1	492	498	PF00454	0.531
MOD_PIKK_1	574	580	PF00454	0.517
MOD_PK_1	330	336	PF00069	0.399
MOD_PK_1	403	409	PF00069	0.616
MOD_PKA_1	16	22	PF00069	0.599
MOD_PKA_1	330	336	PF00069	0.399
MOD_PKA_1	510	516	PF00069	0.513
MOD_PKA_2	135	141	PF00069	0.430
MOD_PKA_2	16	22	PF00069	0.564
MOD_PKA_2	23	29	PF00069	0.505
MOD_PKA_2	306	312	PF00069	0.404
MOD_PKA_2	321	327	PF00069	0.572
MOD_PKA_2	330	336	PF00069	0.474
MOD_PKA_2	389	395	PF00069	0.618
MOD_PKA_2	429	435	PF00069	0.529
MOD_PKA_2	436	442	PF00069	0.515
MOD_PKA_2	510	516	PF00069	0.513
MOD_PKA_2	539	545	PF00069	0.734
MOD_PKA_2	558	564	PF00069	0.470
MOD_PKA_2	63	69	PF00069	0.413
MOD_PKA_2	9	15	PF00069	0.706
MOD_Plk_1	213	219	PF00069	0.461
MOD_Plk_1	257	263	PF00069	0.351
MOD_Plk_1	265	271	PF00069	0.383
MOD_Plk_1	359	365	PF00069	0.502
MOD_Plk_4	240	246	PF00069	0.331
MOD_Plk_4	271	277	PF00069	0.370
MOD_Plk_4	282	288	PF00069	0.363
MOD_Plk_4	289	295	PF00069	0.358
MOD_Plk_4	332	338	PF00069	0.620
MOD_Plk_4	541	547	PF00069	0.581
MOD_ProDKin_1	220	226	PF00069	0.561
MOD_ProDKin_1	475	481	PF00069	0.578
MOD_ProDKin_1	563	569	PF00069	0.535
MOD_SUMO_rev_2	187	196	PF00179	0.342
MOD_SUMO_rev_2	424	429	PF00179	0.576
TRG_DiLeu_BaEn_4	372	378	PF01217	0.603
TRG_ENDOCYTIC_2	165	168	PF00928	0.546
TRG_ENDOCYTIC_2	174	177	PF00928	0.416
TRG_ER_diArg_1	197	200	PF00400	0.282
TRG_ER_diArg_1	539	541	PF00400	0.584
TRG_ER_diArg_1	57	59	PF00400	0.539
TRG_ER_diArg_1	94	96	PF00400	0.460
TRG_ER_diLys_1	597	601	PF00400	0.558
TRG_NES_CRM1_1	570	585	PF08389	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P386	Leptomonas seymouri	54%	100%
A4HZC0	Leishmania infantum	100%	100%
E9AVA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QC73	Leishmania major	91%	100%