SET_domain_containing_protein_putative/Pfam:PF008 56

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAX9_LEIDO

TriTrypDb:

LdBPK_230560.1 , LdCL_230011100 , LDHU3_23.0780

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IAX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.461
CLV_PCSK_KEX2_1	28	30	PF00082	0.464
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.464
CLV_PCSK_SKI1_1	7	11	PF00082	0.404
DEG_APCC_DBOX_1	6	14	PF00400	0.467
DEG_SPOP_SBC_1	257	261	PF00917	0.525
DOC_CKS1_1	235	240	PF01111	0.536
DOC_MAPK_MEF2A_6	125	133	PF00069	0.496
DOC_PP1_RVXF_1	342	348	PF00149	0.389
DOC_PP2B_LxvP_1	182	185	PF13499	0.496
DOC_PP2B_LxvP_1	255	258	PF13499	0.496
DOC_PP2B_LxvP_1	98	101	PF13499	0.536
DOC_PP4_FxxP_1	285	288	PF00568	0.455
DOC_USP7_MATH_1	106	110	PF00917	0.461
DOC_USP7_MATH_1	113	117	PF00917	0.411
DOC_USP7_MATH_1	119	123	PF00917	0.448
DOC_USP7_MATH_1	191	195	PF00917	0.524
DOC_USP7_MATH_1	233	237	PF00917	0.518
DOC_USP7_MATH_1	258	262	PF00917	0.497
DOC_USP7_MATH_1	274	278	PF00917	0.463
DOC_WW_Pin1_4	12	17	PF00397	0.460
DOC_WW_Pin1_4	149	154	PF00397	0.522
DOC_WW_Pin1_4	234	239	PF00397	0.455
DOC_WW_Pin1_4	43	48	PF00397	0.579
LIG_14-3-3_CanoR_1	29	37	PF00244	0.484
LIG_eIF4E_1	58	64	PF01652	0.475
LIG_FHA_1	308	314	PF00498	0.572
LIG_FHA_1	79	85	PF00498	0.536
LIG_FHA_2	200	206	PF00498	0.473
LIG_LIR_Apic_2	284	288	PF02991	0.536
LIG_LIR_Gen_1	159	165	PF02991	0.469
LIG_LIR_Gen_1	168	179	PF02991	0.415
LIG_LIR_Gen_1	34	43	PF02991	0.388
LIG_LIR_Gen_1	93	103	PF02991	0.460
LIG_LIR_Nem_3	159	163	PF02991	0.469
LIG_LIR_Nem_3	168	174	PF02991	0.415
LIG_LIR_Nem_3	197	201	PF02991	0.477
LIG_LIR_Nem_3	22	26	PF02991	0.412
LIG_LIR_Nem_3	34	40	PF02991	0.438
LIG_LIR_Nem_3	93	99	PF02991	0.504
LIG_PCNA_PIPBox_1	192	201	PF02747	0.473
LIG_PCNA_yPIPBox_3	121	134	PF02747	0.458
LIG_PCNA_yPIPBox_3	189	199	PF02747	0.487
LIG_PCNA_yPIPBox_3	50	64	PF02747	0.432
LIG_SH2_GRB2like	160	163	PF00017	0.473
LIG_SH2_STAP1	212	216	PF00017	0.536
LIG_SH2_STAP1	218	222	PF00017	0.536
LIG_SH2_STAT3	232	235	PF00017	0.536
LIG_SH2_STAT5	137	140	PF00017	0.449
LIG_SH2_STAT5	160	163	PF00017	0.442
LIG_SH2_STAT5	198	201	PF00017	0.401
LIG_SH2_STAT5	26	29	PF00017	0.359
LIG_SH2_STAT5	42	45	PF00017	0.452
LIG_SH2_STAT5	58	61	PF00017	0.452
LIG_SH3_3	276	282	PF00018	0.443
LIG_SH3_3	300	306	PF00018	0.555
LIG_SH3_3	310	316	PF00018	0.557
LIG_SH3_3	73	79	PF00018	0.500
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.455
MOD_CDK_SPxxK_3	234	241	PF00069	0.496
MOD_CDK_SPxxK_3	43	50	PF00069	0.468
MOD_CK1_1	105	111	PF00069	0.461
MOD_CK1_1	194	200	PF00069	0.544
MOD_CK1_1	260	266	PF00069	0.531
MOD_CK1_1	268	274	PF00069	0.554
MOD_CK1_1	3	9	PF00069	0.518
MOD_CK2_1	199	205	PF00069	0.484
MOD_CK2_1	293	299	PF00069	0.463
MOD_GlcNHglycan	104	107	PF01048	0.337
MOD_GlcNHglycan	149	152	PF01048	0.296
MOD_GlcNHglycan	189	192	PF01048	0.320
MOD_GlcNHglycan	260	263	PF01048	0.320
MOD_GlcNHglycan	270	273	PF01048	0.390
MOD_GSK3_1	102	109	PF00069	0.497
MOD_GSK3_1	187	194	PF00069	0.539
MOD_GSK3_1	256	263	PF00069	0.488
MOD_GSK3_1	307	314	PF00069	0.529
MOD_N-GLC_1	274	279	PF02516	0.291
MOD_N-GLC_1	293	298	PF02516	0.191
MOD_NEK2_1	19	24	PF00069	0.479
MOD_NEK2_1	199	204	PF00069	0.469
MOD_NEK2_1	216	221	PF00069	0.403
MOD_NEK2_1	246	251	PF00069	0.487
MOD_NEK2_1	332	337	PF00069	0.439
MOD_NEK2_2	265	270	PF00069	0.461
MOD_NEK2_2	319	324	PF00069	0.439
MOD_PIKK_1	199	205	PF00454	0.484
MOD_PKA_2	147	153	PF00069	0.401
MOD_PKA_2	30	36	PF00069	0.350
MOD_PKA_2	307	313	PF00069	0.461
MOD_PKB_1	29	37	PF00069	0.350
MOD_Plk_1	119	125	PF00069	0.458
MOD_Plk_1	274	280	PF00069	0.495
MOD_Plk_1	330	336	PF00069	0.480
MOD_Plk_4	19	25	PF00069	0.474
MOD_Plk_4	194	200	PF00069	0.474
MOD_Plk_4	274	280	PF00069	0.536
MOD_ProDKin_1	12	18	PF00069	0.456
MOD_ProDKin_1	149	155	PF00069	0.522
MOD_ProDKin_1	234	240	PF00069	0.455
MOD_ProDKin_1	43	49	PF00069	0.591
MOD_SUMO_for_1	327	330	PF00179	0.530
MOD_SUMO_for_1	70	73	PF00179	0.461
TRG_DiLeu_BaEn_2	158	164	PF01217	0.461
TRG_ENDOCYTIC_2	137	140	PF00928	0.442
TRG_ENDOCYTIC_2	160	163	PF00928	0.442
TRG_ENDOCYTIC_2	198	201	PF00928	0.401
TRG_ENDOCYTIC_2	218	221	PF00928	0.513
TRG_ER_diArg_1	29	32	PF00400	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P305	Leptomonas seymouri	72%	99%
A0A0S4JT92	Bodo saltans	29%	100%
A0A1X0NX61	Trypanosomatidae	48%	100%
A4HCR7	Leishmania braziliensis	87%	99%
A4I091	Leishmania infantum	100%	100%
C9ZV09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AW55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QBC2	Leishmania major	97%	100%
V5BCF3	Trypanosoma cruzi	50%	100%