Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAX8_LEIDO

TriTrypDb:

LdBPK_180520.1 , LdCL_180010100 , LDHU3_18.0640

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.710
CLV_C14_Caspase3-7	227	231	PF00656	0.760
CLV_C14_Caspase3-7	362	366	PF00656	0.735
CLV_C14_Caspase3-7	531	535	PF00656	0.661
CLV_NRD_NRD_1	157	159	PF00675	0.706
CLV_NRD_NRD_1	231	233	PF00675	0.759
CLV_NRD_NRD_1	484	486	PF00675	0.651
CLV_NRD_NRD_1	487	489	PF00675	0.633
CLV_NRD_NRD_1	5	7	PF00675	0.617
CLV_NRD_NRD_1	564	566	PF00675	0.369
CLV_NRD_NRD_1	596	598	PF00675	0.648
CLV_NRD_NRD_1	621	623	PF00675	0.617
CLV_NRD_NRD_1	667	669	PF00675	0.611
CLV_NRD_NRD_1	715	717	PF00675	0.611
CLV_NRD_NRD_1	77	79	PF00675	0.713
CLV_PCSK_FUR_1	485	489	PF00082	0.621
CLV_PCSK_KEX2_1	157	159	PF00082	0.706
CLV_PCSK_KEX2_1	286	288	PF00082	0.757
CLV_PCSK_KEX2_1	486	488	PF00082	0.669
CLV_PCSK_KEX2_1	5	7	PF00082	0.617
CLV_PCSK_KEX2_1	596	598	PF00082	0.648
CLV_PCSK_KEX2_1	621	623	PF00082	0.617
CLV_PCSK_KEX2_1	714	716	PF00082	0.622
CLV_PCSK_KEX2_1	76	78	PF00082	0.712
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.749
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.619
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.712
CLV_PCSK_SKI1_1	152	156	PF00082	0.779
CLV_PCSK_SKI1_1	341	345	PF00082	0.819
CLV_PCSK_SKI1_1	503	507	PF00082	0.634
CLV_PCSK_SKI1_1	597	601	PF00082	0.626
CLV_PCSK_SKI1_1	668	672	PF00082	0.641
CLV_Separin_Metazoa	605	609	PF03568	0.606
DEG_APCC_DBOX_1	596	604	PF00400	0.625
DEG_SPOP_SBC_1	172	176	PF00917	0.608
DEG_SPOP_SBC_1	278	282	PF00917	0.759
DEG_SPOP_SBC_1	319	323	PF00917	0.754
DEG_SPOP_SBC_1	409	413	PF00917	0.732
DEG_SPOP_SBC_1	655	659	PF00917	0.651
DOC_CYCLIN_yCln2_LP_2	364	370	PF00134	0.740
DOC_CYCLIN_yCln2_LP_2	649	655	PF00134	0.746
DOC_MAPK_gen_1	626	634	PF00069	0.566
DOC_MAPK_gen_1	714	723	PF00069	0.614
DOC_MAPK_MEF2A_6	106	114	PF00069	0.679
DOC_PP2B_LxvP_1	649	652	PF13499	0.756
DOC_USP7_MATH_1	124	128	PF00917	0.729
DOC_USP7_MATH_1	147	151	PF00917	0.742
DOC_USP7_MATH_1	193	197	PF00917	0.745
DOC_USP7_MATH_1	23	27	PF00917	0.684
DOC_USP7_MATH_1	278	282	PF00917	0.756
DOC_USP7_MATH_1	312	316	PF00917	0.729
DOC_USP7_MATH_1	320	324	PF00917	0.835
DOC_USP7_MATH_1	326	330	PF00917	0.697
DOC_USP7_MATH_1	339	343	PF00917	0.659
DOC_USP7_MATH_1	391	395	PF00917	0.773
DOC_USP7_MATH_1	408	412	PF00917	0.757
DOC_USP7_MATH_1	545	549	PF00917	0.709
DOC_USP7_MATH_1	556	560	PF00917	0.511
DOC_USP7_MATH_1	67	71	PF00917	0.643
DOC_USP7_MATH_1	83	87	PF00917	0.597
DOC_USP7_MATH_2	660	666	PF00917	0.619
DOC_USP7_UBL2_3	285	289	PF12436	0.753
DOC_WW_Pin1_4	106	111	PF00397	0.675
DOC_WW_Pin1_4	173	178	PF00397	0.772
DOC_WW_Pin1_4	185	190	PF00397	0.602
DOC_WW_Pin1_4	293	298	PF00397	0.757
DOC_WW_Pin1_4	301	306	PF00397	0.716
DOC_WW_Pin1_4	308	313	PF00397	0.624
DOC_WW_Pin1_4	315	320	PF00397	0.768
DOC_WW_Pin1_4	332	337	PF00397	0.764
DOC_WW_Pin1_4	353	358	PF00397	0.854
DOC_WW_Pin1_4	410	415	PF00397	0.730
DOC_WW_Pin1_4	656	661	PF00397	0.766
LIG_14-3-3_CanoR_1	157	162	PF00244	0.745
LIG_14-3-3_CanoR_1	223	229	PF00244	0.751
LIG_14-3-3_CanoR_1	298	306	PF00244	0.643
LIG_14-3-3_CanoR_1	313	319	PF00244	0.816
LIG_14-3-3_CanoR_1	459	466	PF00244	0.578
LIG_14-3-3_CanoR_1	577	585	PF00244	0.616
LIG_14-3-3_CanoR_1	60	66	PF00244	0.646
LIG_14-3-3_CanoR_1	714	724	PF00244	0.614
LIG_14-3-3_CanoR_1	77	81	PF00244	0.551
LIG_Actin_WH2_2	563	581	PF00022	0.604
LIG_Actin_WH2_2	603	620	PF00022	0.555
LIG_APCC_ABBA_1	112	117	PF00400	0.683
LIG_APCC_ABBA_1	376	381	PF00400	0.757
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_CaM_IQ_9	610	625	PF13499	0.607
LIG_eIF4E_1	363	369	PF01652	0.721
LIG_FHA_1	359	365	PF00498	0.763
LIG_FHA_1	504	510	PF00498	0.628
LIG_FHA_1	523	529	PF00498	0.502
LIG_FHA_1	562	568	PF00498	0.609
LIG_FHA_1	641	647	PF00498	0.616
LIG_FHA_1	716	722	PF00498	0.609
LIG_FHA_2	158	164	PF00498	0.722
LIG_FHA_2	495	501	PF00498	0.435
LIG_LIR_Apic_2	204	209	PF02991	0.736
LIG_LIR_Nem_3	425	431	PF02991	0.719
LIG_SH2_CRK	206	210	PF00017	0.792
LIG_SH2_SRC	363	366	PF00017	0.735
LIG_SH2_STAP1	699	703	PF00017	0.575
LIG_SH2_STAT3	724	727	PF00017	0.606
LIG_SH2_STAT5	221	224	PF00017	0.623
LIG_SH2_STAT5	363	366	PF00017	0.787
LIG_SH2_STAT5	619	622	PF00017	0.642
LIG_SH3_2	336	341	PF14604	0.791
LIG_SH3_3	313	319	PF00018	0.702
LIG_SH3_3	330	336	PF00018	0.779
LIG_SH3_3	649	655	PF00018	0.746
LIG_SH3_3	77	83	PF00018	0.659
LIG_TRAF2_1	399	402	PF00917	0.787
LIG_TRAF2_1	660	663	PF00917	0.682
LIG_UBA3_1	345	349	PF00899	0.768
MOD_CDK_SPK_2	173	178	PF00069	0.725
MOD_CDK_SPK_2	293	298	PF00069	0.771
MOD_CDK_SPK_2	308	313	PF00069	0.650
MOD_CDK_SPxxK_3	293	300	PF00069	0.793
MOD_CDK_SPxxK_3	301	308	PF00069	0.725
MOD_CK1_1	142	148	PF00069	0.714
MOD_CK1_1	196	202	PF00069	0.756
MOD_CK1_1	224	230	PF00069	0.805
MOD_CK1_1	257	263	PF00069	0.661
MOD_CK1_1	304	310	PF00069	0.814
MOD_CK1_1	311	317	PF00069	0.720
MOD_CK1_1	318	324	PF00069	0.840
MOD_CK1_1	325	331	PF00069	0.701
MOD_CK1_1	33	39	PF00069	0.668
MOD_CK1_1	412	418	PF00069	0.775
MOD_CK1_1	522	528	PF00069	0.735
MOD_CK1_1	543	549	PF00069	0.626
MOD_CK1_1	590	596	PF00069	0.688
MOD_CK1_1	62	68	PF00069	0.678
MOD_CK1_1	70	76	PF00069	0.614
MOD_CK1_1	99	105	PF00069	0.684
MOD_CK2_1	33	39	PF00069	0.704
MOD_CK2_1	494	500	PF00069	0.440
MOD_CK2_1	556	562	PF00069	0.677
MOD_CK2_1	62	68	PF00069	0.678
MOD_CK2_1	656	662	PF00069	0.679
MOD_CK2_1	684	690	PF00069	0.609
MOD_CK2_1	723	729	PF00069	0.612
MOD_Cter_Amidation	230	233	PF01082	0.729
MOD_Cter_Amidation	3	6	PF01082	0.618
MOD_DYRK1A_RPxSP_1	106	110	PF00069	0.675
MOD_GlcNHglycan	189	192	PF01048	0.803
MOD_GlcNHglycan	198	201	PF01048	0.714
MOD_GlcNHglycan	203	206	PF01048	0.633
MOD_GlcNHglycan	241	244	PF01048	0.773
MOD_GlcNHglycan	25	28	PF01048	0.686
MOD_GlcNHglycan	268	271	PF01048	0.806
MOD_GlcNHglycan	324	327	PF01048	0.795
MOD_GlcNHglycan	521	524	PF01048	0.643
MOD_GlcNHglycan	531	534	PF01048	0.666
MOD_GlcNHglycan	547	550	PF01048	0.619
MOD_GlcNHglycan	553	556	PF01048	0.682
MOD_GlcNHglycan	741	744	PF01048	0.702
MOD_GlcNHglycan	90	93	PF01048	0.710
MOD_GlcNHglycan	98	101	PF01048	0.622
MOD_GSK3_1	133	140	PF00069	0.666
MOD_GSK3_1	217	224	PF00069	0.822
MOD_GSK3_1	239	246	PF00069	0.776
MOD_GSK3_1	254	261	PF00069	0.631
MOD_GSK3_1	262	269	PF00069	0.697
MOD_GSK3_1	272	279	PF00069	0.560
MOD_GSK3_1	304	311	PF00069	0.753
MOD_GSK3_1	314	321	PF00069	0.810
MOD_GSK3_1	322	329	PF00069	0.578
MOD_GSK3_1	353	360	PF00069	0.823
MOD_GSK3_1	408	415	PF00069	0.784
MOD_GSK3_1	540	547	PF00069	0.689
MOD_GSK3_1	67	74	PF00069	0.634
MOD_GSK3_1	723	730	PF00069	0.612
MOD_GSK3_1	95	102	PF00069	0.665
MOD_LATS_1	274	280	PF00433	0.788
MOD_LATS_1	448	454	PF00433	0.539
MOD_N-GLC_1	266	271	PF02516	0.766
MOD_NEK2_1	521	526	PF00069	0.694
MOD_NEK2_1	528	533	PF00069	0.626
MOD_NEK2_1	551	556	PF00069	0.752
MOD_NEK2_1	59	64	PF00069	0.679
MOD_NEK2_1	617	622	PF00069	0.561
MOD_NEK2_1	723	728	PF00069	0.609
MOD_NEK2_2	339	344	PF00069	0.810
MOD_NEK2_2	494	499	PF00069	0.440
MOD_NEK2_2	71	76	PF00069	0.634
MOD_PIKK_1	147	153	PF00454	0.795
MOD_PIKK_1	221	227	PF00454	0.799
MOD_PIKK_1	556	562	PF00454	0.625
MOD_PIKK_1	590	596	PF00454	0.583
MOD_PIKK_1	723	729	PF00454	0.612
MOD_PK_1	540	546	PF00069	0.604
MOD_PK_1	566	572	PF00069	0.358
MOD_PK_1	76	82	PF00069	0.713
MOD_PKA_1	157	163	PF00069	0.698
MOD_PKA_1	714	720	PF00069	0.611
MOD_PKA_1	76	82	PF00069	0.713
MOD_PKA_2	157	163	PF00069	0.698
MOD_PKA_2	257	263	PF00069	0.686
MOD_PKA_2	312	318	PF00069	0.730
MOD_PKA_2	458	464	PF00069	0.578
MOD_PKA_2	528	534	PF00069	0.706
MOD_PKA_2	59	65	PF00069	0.677
MOD_PKA_2	590	596	PF00069	0.636
MOD_PKA_2	617	623	PF00069	0.612
MOD_PKA_2	714	720	PF00069	0.611
MOD_PKA_2	76	82	PF00069	0.549
MOD_PKB_1	575	583	PF00069	0.605
MOD_Plk_1	162	168	PF00069	0.605
MOD_Plk_1	217	223	PF00069	0.638
MOD_Plk_1	33	39	PF00069	0.704
MOD_Plk_1	662	668	PF00069	0.613
MOD_Plk_1	690	696	PF00069	0.602
MOD_Plk_1	71	77	PF00069	0.610
MOD_Plk_2-3	162	168	PF00069	0.600
MOD_ProDKin_1	106	112	PF00069	0.677
MOD_ProDKin_1	173	179	PF00069	0.770
MOD_ProDKin_1	185	191	PF00069	0.602
MOD_ProDKin_1	293	299	PF00069	0.758
MOD_ProDKin_1	301	307	PF00069	0.716
MOD_ProDKin_1	308	314	PF00069	0.624
MOD_ProDKin_1	315	321	PF00069	0.767
MOD_ProDKin_1	332	338	PF00069	0.762
MOD_ProDKin_1	353	359	PF00069	0.856
MOD_ProDKin_1	410	416	PF00069	0.730
MOD_ProDKin_1	656	662	PF00069	0.762
MOD_SUMO_for_1	251	254	PF00179	0.712
MOD_SUMO_for_1	507	510	PF00179	0.636
MOD_SUMO_rev_2	282	292	PF00179	0.746
TRG_DiLeu_BaEn_4	500	506	PF01217	0.615
TRG_DiLeu_BaEn_4	629	635	PF01217	0.619
TRG_DiLeu_BaEn_4	662	668	PF01217	0.665
TRG_ER_diArg_1	125	128	PF00400	0.691
TRG_ER_diArg_1	157	159	PF00400	0.701
TRG_ER_diArg_1	183	186	PF00400	0.654
TRG_ER_diArg_1	297	300	PF00400	0.724
TRG_ER_diArg_1	485	488	PF00400	0.668
TRG_ER_diArg_1	694	697	PF00400	0.607
TRG_ER_diArg_1	714	716	PF00400	0.342
TRG_NLS_MonoExtN_4	485	490	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	708	713	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H9G0	Leishmania braziliensis	67%	100%
A4HXS7	Leishmania infantum	100%	100%
E9ARI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QDZ0	Leishmania major	89%	100%