Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IAX6_LEIDO

TriTrypDb:

LdBPK_201520.1 , LdCL_200019900 , LDHU3_20.1890

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.477
CLV_NRD_NRD_1	261	263	PF00675	0.519
CLV_NRD_NRD_1	357	359	PF00675	0.735
CLV_NRD_NRD_1	400	402	PF00675	0.709
CLV_NRD_NRD_1	44	46	PF00675	0.542
CLV_NRD_NRD_1	444	446	PF00675	0.628
CLV_PCSK_FUR_1	42	46	PF00082	0.537
CLV_PCSK_KEX2_1	10	12	PF00082	0.458
CLV_PCSK_KEX2_1	261	263	PF00082	0.519
CLV_PCSK_KEX2_1	357	359	PF00082	0.735
CLV_PCSK_KEX2_1	381	383	PF00082	0.667
CLV_PCSK_KEX2_1	44	46	PF00082	0.542
CLV_PCSK_KEX2_1	444	446	PF00082	0.628
CLV_PCSK_KEX2_1	450	452	PF00082	0.558
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.667
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.481
CLV_PCSK_PC7_1	377	383	PF00082	0.650
CLV_PCSK_SKI1_1	107	111	PF00082	0.526
CLV_PCSK_SKI1_1	157	161	PF00082	0.527
CLV_PCSK_SKI1_1	346	350	PF00082	0.730
CLV_PCSK_SKI1_1	415	419	PF00082	0.357
CLV_Separin_Metazoa	258	262	PF03568	0.685
DEG_Nend_Nbox_1	1	3	PF02207	0.746
DOC_CKS1_1	418	423	PF01111	0.411
DOC_CYCLIN_RxL_1	222	230	PF00134	0.695
DOC_CYCLIN_RxL_1	343	352	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	436	442	PF00134	0.724
DOC_CYCLIN_yCln2_LP_2	72	78	PF00134	0.781
DOC_MAPK_gen_1	357	363	PF00069	0.527
DOC_MAPK_gen_1	87	95	PF00069	0.710
DOC_MAPK_MEF2A_6	274	282	PF00069	0.669
DOC_MAPK_MEF2A_6	30	37	PF00069	0.638
DOC_PP2B_LxvP_1	436	439	PF13499	0.643
DOC_PP2B_LxvP_1	510	513	PF13499	0.512
DOC_PP2B_LxvP_1	72	75	PF13499	0.810
DOC_PP2B_LxvP_1	93	96	PF13499	0.745
DOC_USP7_MATH_1	164	168	PF00917	0.746
DOC_USP7_MATH_1	221	225	PF00917	0.737
DOC_USP7_MATH_1	243	247	PF00917	0.681
DOC_USP7_MATH_1	33	37	PF00917	0.747
DOC_USP7_MATH_1	391	395	PF00917	0.567
DOC_WW_Pin1_4	213	218	PF00397	0.801
DOC_WW_Pin1_4	219	224	PF00397	0.737
DOC_WW_Pin1_4	417	422	PF00397	0.411
DOC_WW_Pin1_4	548	553	PF00397	0.465
DOC_WW_Pin1_4	61	66	PF00397	0.786
LIG_14-3-3_CanoR_1	137	146	PF00244	0.707
LIG_14-3-3_CanoR_1	262	270	PF00244	0.802
LIG_14-3-3_CanoR_1	334	340	PF00244	0.491
LIG_14-3-3_CanoR_1	61	65	PF00244	0.687
LIG_14-3-3_CanoR_1	92	96	PF00244	0.748
LIG_Actin_WH2_2	246	263	PF00022	0.504
LIG_BIR_III_4	190	194	PF00653	0.848
LIG_BRCT_BRCA1_1	295	299	PF00533	0.685
LIG_FAT_LD_1	555	563	PF03623	0.518
LIG_FHA_1	139	145	PF00498	0.705
LIG_FHA_1	275	281	PF00498	0.706
LIG_FHA_1	408	414	PF00498	0.570
LIG_FHA_1	418	424	PF00498	0.367
LIG_FHA_1	538	544	PF00498	0.508
LIG_FHA_2	202	208	PF00498	0.711
LIG_FHA_2	295	301	PF00498	0.711
LIG_LIR_Gen_1	143	154	PF02991	0.794
LIG_LIR_Gen_1	204	213	PF02991	0.706
LIG_LIR_Gen_1	26	35	PF02991	0.722
LIG_LIR_Gen_1	296	306	PF02991	0.728
LIG_LIR_Gen_1	564	573	PF02991	0.541
LIG_LIR_Nem_3	143	149	PF02991	0.720
LIG_LIR_Nem_3	204	208	PF02991	0.704
LIG_LIR_Nem_3	26	31	PF02991	0.707
LIG_LIR_Nem_3	296	302	PF02991	0.730
LIG_LIR_Nem_3	564	569	PF02991	0.466
LIG_LIR_Nem_3	574	579	PF02991	0.502
LIG_MAD2	137	145	PF02301	0.632
LIG_MLH1_MIPbox_1	295	299	PF16413	0.685
LIG_Pex14_1	295	299	PF04695	0.657
LIG_Pex14_1	426	430	PF04695	0.411
LIG_Pex14_2	208	212	PF04695	0.706
LIG_Pex14_2	299	303	PF04695	0.647
LIG_Pex14_2	485	489	PF04695	0.653
LIG_SH2_CRK	318	322	PF00017	0.512
LIG_SH2_CRK	566	570	PF00017	0.536
LIG_SH2_CRK	62	66	PF00017	0.790
LIG_SH2_NCK_1	62	66	PF00017	0.790
LIG_SH2_PTP2	196	199	PF00017	0.761
LIG_SH2_STAP1	318	322	PF00017	0.512
LIG_SH2_STAT5	196	199	PF00017	0.761
LIG_SH2_STAT5	379	382	PF00017	0.524
LIG_SH2_STAT5	484	487	PF00017	0.657
LIG_SH2_STAT5	572	575	PF00017	0.481
LIG_SH2_STAT5	62	65	PF00017	0.789
LIG_SH3_1	196	202	PF00018	0.753
LIG_SH3_1	237	243	PF00018	0.706
LIG_SH3_3	194	200	PF00018	0.762
LIG_SH3_3	237	243	PF00018	0.706
LIG_SH3_3	381	387	PF00018	0.533
LIG_SH3_3	437	443	PF00018	0.756
LIG_SH3_CIN85_PxpxPR_1	439	444	PF14604	0.678
LIG_SUMO_SIM_anti_2	230	235	PF11976	0.683
LIG_SUMO_SIM_par_1	230	235	PF11976	0.757
LIG_TRAF2_1	16	19	PF00917	0.789
LIG_TRFH_1	196	200	PF08558	0.808
MOD_CDC14_SPxK_1	222	225	PF00782	0.572
MOD_CDK_SPxK_1	219	225	PF00069	0.574
MOD_CDK_SPxK_1	548	554	PF00069	0.577
MOD_CK1_1	177	183	PF00069	0.694
MOD_CK1_1	375	381	PF00069	0.709
MOD_CK1_1	394	400	PF00069	0.732
MOD_CK1_1	403	409	PF00069	0.719
MOD_CK1_1	453	459	PF00069	0.698
MOD_CK1_1	51	57	PF00069	0.727
MOD_CK1_1	515	521	PF00069	0.403
MOD_CK2_1	265	271	PF00069	0.754
MOD_CK2_1	294	300	PF00069	0.648
MOD_CK2_1	476	482	PF00069	0.579
MOD_Cter_Amidation	355	358	PF01082	0.631
MOD_Cter_Amidation	399	402	PF01082	0.637
MOD_GlcNHglycan	234	237	PF01048	0.783
MOD_GlcNHglycan	267	270	PF01048	0.697
MOD_GlcNHglycan	271	274	PF01048	0.707
MOD_GlcNHglycan	354	357	PF01048	0.650
MOD_GlcNHglycan	393	396	PF01048	0.676
MOD_GlcNHglycan	4	7	PF01048	0.629
MOD_GlcNHglycan	403	406	PF01048	0.662
MOD_GlcNHglycan	452	455	PF01048	0.676
MOD_GlcNHglycan	46	49	PF01048	0.685
MOD_GlcNHglycan	479	482	PF01048	0.615
MOD_GSK3_1	174	181	PF00069	0.636
MOD_GSK3_1	2	9	PF00069	0.661
MOD_GSK3_1	203	210	PF00069	0.635
MOD_GSK3_1	215	222	PF00069	0.678
MOD_GSK3_1	260	267	PF00069	0.624
MOD_GSK3_1	294	301	PF00069	0.571
MOD_GSK3_1	33	40	PF00069	0.660
MOD_GSK3_1	348	355	PF00069	0.642
MOD_GSK3_1	389	396	PF00069	0.733
MOD_GSK3_1	400	407	PF00069	0.641
MOD_GSK3_1	44	51	PF00069	0.761
MOD_GSK3_1	450	457	PF00069	0.740
MOD_GSK3_1	61	68	PF00069	0.624
MOD_N-GLC_1	174	179	PF02516	0.635
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	260	265	PF00069	0.642
MOD_NEK2_1	298	303	PF00069	0.556
MOD_NEK2_1	372	377	PF00069	0.687
MOD_NEK2_1	50	55	PF00069	0.784
MOD_NEK2_2	243	248	PF00069	0.592
MOD_NEK2_2	33	38	PF00069	0.687
MOD_OFUCOSY	509	516	PF10250	0.471
MOD_PIKK_1	144	150	PF00454	0.755
MOD_PIKK_1	164	170	PF00454	0.467
MOD_PIKK_1	37	43	PF00454	0.660
MOD_PIKK_1	525	531	PF00454	0.580
MOD_PIKK_1	63	69	PF00454	0.650
MOD_PKA_1	401	407	PF00069	0.622
MOD_PKA_1	44	50	PF00069	0.687
MOD_PKA_1	450	456	PF00069	0.597
MOD_PKA_2	260	266	PF00069	0.480
MOD_PKA_2	333	339	PF00069	0.620
MOD_PKA_2	400	406	PF00069	0.811
MOD_PKA_2	407	413	PF00069	0.655
MOD_PKA_2	44	50	PF00069	0.706
MOD_PKA_2	450	456	PF00069	0.597
MOD_PKA_2	537	543	PF00069	0.639
MOD_PKA_2	60	66	PF00069	0.552
MOD_PKA_2	91	97	PF00069	0.796
MOD_PKB_1	42	50	PF00069	0.683
MOD_Plk_1	105	111	PF00069	0.775
MOD_Plk_1	51	57	PF00069	0.692
MOD_Plk_4	118	124	PF00069	0.733
MOD_Plk_4	294	300	PF00069	0.585
MOD_Plk_4	33	39	PF00069	0.688
MOD_Plk_4	455	461	PF00069	0.689
MOD_Plk_4	571	577	PF00069	0.606
MOD_ProDKin_1	213	219	PF00069	0.770
MOD_ProDKin_1	417	423	PF00069	0.411
MOD_ProDKin_1	548	554	PF00069	0.577
MOD_ProDKin_1	61	67	PF00069	0.748
MOD_SUMO_for_1	464	467	PF00179	0.574
TRG_DiLeu_BaEn_3	342	348	PF01217	0.601
TRG_ENDOCYTIC_2	318	321	PF00928	0.411
TRG_ENDOCYTIC_2	566	569	PF00928	0.598
TRG_ER_diArg_1	10	12	PF00400	0.604
TRG_ER_diArg_1	260	262	PF00400	0.624
TRG_ER_diArg_1	357	359	PF00400	0.682
TRG_ER_diArg_1	434	437	PF00400	0.613
TRG_ER_diArg_1	443	445	PF00400	0.725
TRG_ER_diArg_1	87	90	PF00400	0.753
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ42	Leptomonas seymouri	50%	100%
A4HYZ0	Leishmania infantum	97%	100%
E9AIK4	Leishmania braziliensis	75%	98%
E9AUT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QCP7	Leishmania major	89%	99%