DNA replication licensing factor MCM2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

minichromosome maintenance (MCM) complex subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAX4_LEIDO

TriTrypDb:

LdBPK_280940.1 , LdCL_280014000 , LDHU3_28.1120

Length:

972

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0032991	protein-containing complex	1	12
GO:0042555	MCM complex	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IAX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAX4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006268	DNA unwinding involved in DNA replication	9	12
GO:0006270	DNA replication initiation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	12
GO:0007049	cell cycle	2	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0010639	negative regulation of organelle organization	6	12
GO:0016043	cellular component organization	3	12
GO:0032392	DNA geometric change	7	12
GO:0032508	DNA duplex unwinding	8	12
GO:0032780	negative regulation of ATP-dependent activity	4	12
GO:0033043	regulation of organelle organization	5	12
GO:0033044	regulation of chromosome organization	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043086	negative regulation of catalytic activity	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043462	regulation of ATP-dependent activity	3	12
GO:0044092	negative regulation of molecular function	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0048519	negative regulation of biological process	3	12
GO:0048523	negative regulation of cellular process	4	12
GO:0050789	regulation of biological process	2	12
GO:0050790	regulation of catalytic activity	3	12
GO:0050794	regulation of cellular process	3	12
GO:0051095	regulation of helicase activity	4	12
GO:0051097	negative regulation of helicase activity	5	12
GO:0051128	regulation of cellular component organization	4	12
GO:0051129	negative regulation of cellular component organization	5	12
GO:0051276	chromosome organization	5	12
GO:0065007	biological regulation	1	12
GO:0065009	regulation of molecular function	2	12
GO:0071103	DNA conformation change	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1905462	regulation of DNA duplex unwinding	7	12
GO:1905463	negative regulation of DNA duplex unwinding	8	12
GO:1905774	regulation of DNA helicase activity	5	12
GO:1905775	negative regulation of DNA helicase activity	6	12
GO:2001251	negative regulation of chromosome organization	7	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0022402	cell cycle process	2	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:1902292	cell cycle DNA replication initiation	3	1
GO:1902315	nuclear cell cycle DNA replication initiation	4	1
GO:1902975	mitotic DNA replication initiation	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.763
CLV_C14_Caspase3-7	770	774	PF00656	0.530
CLV_NRD_NRD_1	11	13	PF00675	0.586
CLV_NRD_NRD_1	112	114	PF00675	0.221
CLV_NRD_NRD_1	123	125	PF00675	0.183
CLV_NRD_NRD_1	15	17	PF00675	0.597
CLV_NRD_NRD_1	216	218	PF00675	0.386
CLV_NRD_NRD_1	298	300	PF00675	0.230
CLV_NRD_NRD_1	31	33	PF00675	0.579
CLV_NRD_NRD_1	338	340	PF00675	0.202
CLV_NRD_NRD_1	470	472	PF00675	0.372
CLV_NRD_NRD_1	497	499	PF00675	0.212
CLV_NRD_NRD_1	755	757	PF00675	0.531
CLV_NRD_NRD_1	783	785	PF00675	0.213
CLV_NRD_NRD_1	880	882	PF00675	0.369
CLV_NRD_NRD_1	949	951	PF00675	0.513
CLV_PCSK_FUR_1	11	15	PF00082	0.578
CLV_PCSK_KEX2_1	11	13	PF00082	0.555
CLV_PCSK_KEX2_1	111	113	PF00082	0.218
CLV_PCSK_KEX2_1	123	125	PF00082	0.163
CLV_PCSK_KEX2_1	14	16	PF00082	0.568
CLV_PCSK_KEX2_1	216	218	PF00082	0.346
CLV_PCSK_KEX2_1	31	33	PF00082	0.666
CLV_PCSK_KEX2_1	338	340	PF00082	0.202
CLV_PCSK_KEX2_1	470	472	PF00082	0.382
CLV_PCSK_KEX2_1	755	757	PF00082	0.531
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.561
CLV_PCSK_PC7_1	7	13	PF00082	0.551
CLV_PCSK_SKI1_1	217	221	PF00082	0.317
CLV_PCSK_SKI1_1	499	503	PF00082	0.224
CLV_PCSK_SKI1_1	568	572	PF00082	0.202
CLV_PCSK_SKI1_1	700	704	PF00082	0.235
CLV_PCSK_SKI1_1	735	739	PF00082	0.427
CLV_PCSK_SKI1_1	785	789	PF00082	0.213
CLV_PCSK_SKI1_1	881	885	PF00082	0.518
CLV_Separin_Metazoa	213	217	PF03568	0.334
DEG_APCC_DBOX_1	188	196	PF00400	0.544
DEG_APCC_DBOX_1	681	689	PF00400	0.402
DEG_ODPH_VHL_1	505	517	PF01847	0.413
DEG_SCF_FBW7_1	675	681	PF00400	0.402
DOC_CKS1_1	675	680	PF01111	0.402
DOC_CYCLIN_RxL_1	493	504	PF00134	0.434
DOC_MAPK_gen_1	299	307	PF00069	0.413
DOC_MAPK_gen_1	319	328	PF00069	0.409
DOC_MAPK_gen_1	413	422	PF00069	0.402
DOC_MAPK_gen_1	429	438	PF00069	0.402
DOC_MAPK_gen_1	538	545	PF00069	0.402
DOC_MAPK_gen_1	895	902	PF00069	0.476
DOC_MAPK_HePTP_8	509	521	PF00069	0.402
DOC_MAPK_MEF2A_6	300	309	PF00069	0.403
DOC_MAPK_MEF2A_6	322	330	PF00069	0.408
DOC_MAPK_MEF2A_6	413	422	PF00069	0.402
DOC_MAPK_MEF2A_6	512	521	PF00069	0.402
DOC_MAPK_MEF2A_6	538	547	PF00069	0.402
DOC_MAPK_MEF2A_6	690	697	PF00069	0.413
DOC_MAPK_MEF2A_6	818	826	PF00069	0.402
DOC_MAPK_MEF2A_6	895	902	PF00069	0.488
DOC_MAPK_NFAT4_5	512	520	PF00069	0.404
DOC_MAPK_RevD_3	326	339	PF00069	0.402
DOC_PP1_RVXF_1	783	790	PF00149	0.453
DOC_PP4_FxxP_1	478	481	PF00568	0.429
DOC_USP7_MATH_1	354	358	PF00917	0.417
DOC_USP7_MATH_1	41	45	PF00917	0.417
DOC_USP7_MATH_1	665	669	PF00917	0.445
DOC_USP7_MATH_1	855	859	PF00917	0.508
DOC_USP7_MATH_1	933	937	PF00917	0.537
DOC_USP7_UBL2_3	560	564	PF12436	0.402
DOC_WW_Pin1_4	337	342	PF00397	0.402
DOC_WW_Pin1_4	491	496	PF00397	0.513
DOC_WW_Pin1_4	674	679	PF00397	0.402
LIG_14-3-3_CanoR_1	299	309	PF00244	0.500
LIG_14-3-3_CanoR_1	355	359	PF00244	0.424
LIG_14-3-3_CanoR_1	372	376	PF00244	0.373
LIG_14-3-3_CanoR_1	413	419	PF00244	0.430
LIG_14-3-3_CanoR_1	470	478	PF00244	0.429
LIG_14-3-3_CanoR_1	575	582	PF00244	0.402
LIG_14-3-3_CanoR_1	700	705	PF00244	0.493
LIG_14-3-3_CanoR_1	834	842	PF00244	0.426
LIG_Actin_WH2_2	858	875	PF00022	0.493
LIG_APCC_ABBA_1	235	240	PF00400	0.506
LIG_BIR_III_4	23	27	PF00653	0.576
LIG_BRCT_BRCA1_1	193	197	PF00533	0.554
LIG_BRCT_BRCA1_1	302	306	PF00533	0.506
LIG_BRCT_BRCA1_1	665	669	PF00533	0.438
LIG_BRCT_BRCA1_1	763	767	PF00533	0.507
LIG_BRCT_BRCA1_1	791	795	PF00533	0.506
LIG_BRCT_BRCA1_1	945	949	PF00533	0.362
LIG_BRCT_BRCA1_2	945	951	PF00533	0.360
LIG_Clathr_ClatBox_1	329	333	PF01394	0.402
LIG_FHA_1	289	295	PF00498	0.506
LIG_FHA_1	397	403	PF00498	0.413
LIG_FHA_1	421	427	PF00498	0.402
LIG_FHA_1	458	464	PF00498	0.379
LIG_FHA_1	470	476	PF00498	0.462
LIG_FHA_1	581	587	PF00498	0.406
LIG_FHA_1	632	638	PF00498	0.415
LIG_FHA_1	674	680	PF00498	0.402
LIG_FHA_1	718	724	PF00498	0.589
LIG_FHA_1	852	858	PF00498	0.512
LIG_FHA_1	886	892	PF00498	0.431
LIG_FHA_2	665	671	PF00498	0.506
LIG_FHA_2	714	720	PF00498	0.477
LIG_FHA_2	741	747	PF00498	0.451
LIG_FHA_2	847	853	PF00498	0.506
LIG_GBD_Chelix_1	206	214	PF00786	0.366
LIG_Integrin_RGD_1	189	191	PF01839	0.556
LIG_Integrin_RGD_1	366	368	PF01839	0.189
LIG_Integrin_RGD_1	540	542	PF01839	0.207
LIG_LIR_Apic_2	176	182	PF02991	0.683
LIG_LIR_Apic_2	65	69	PF02991	0.453
LIG_LIR_Gen_1	128	138	PF02991	0.444
LIG_LIR_Gen_1	256	264	PF02991	0.413
LIG_LIR_Gen_1	303	314	PF02991	0.561
LIG_LIR_Gen_1	556	566	PF02991	0.402
LIG_LIR_Gen_1	613	622	PF02991	0.402
LIG_LIR_Gen_1	681	689	PF02991	0.402
LIG_LIR_Nem_3	128	134	PF02991	0.444
LIG_LIR_Nem_3	256	260	PF02991	0.433
LIG_LIR_Nem_3	261	267	PF02991	0.446
LIG_LIR_Nem_3	291	295	PF02991	0.518
LIG_LIR_Nem_3	303	309	PF02991	0.530
LIG_LIR_Nem_3	320	324	PF02991	0.404
LIG_LIR_Nem_3	556	561	PF02991	0.402
LIG_LIR_Nem_3	681	686	PF02991	0.402
LIG_LIR_Nem_3	792	798	PF02991	0.516
LIG_LIR_Nem_3	877	883	PF02991	0.408
LIG_LIR_Nem_3	952	956	PF02991	0.358
LIG_LYPXL_S_1	342	346	PF13949	0.202
LIG_LYPXL_yS_3	343	346	PF13949	0.402
LIG_NRBOX	516	522	PF00104	0.413
LIG_PCNA_PIPBox_1	937	946	PF02747	0.508
LIG_PCNA_yPIPBox_3	200	210	PF02747	0.373
LIG_PCNA_yPIPBox_3	776	787	PF02747	0.345
LIG_PCNA_yPIPBox_3	937	951	PF02747	0.513
LIG_PDZ_Class_1	967	972	PF00595	0.398
LIG_Pex14_2	683	687	PF04695	0.402
LIG_Pex14_2	860	864	PF04695	0.402
LIG_PTB_Apo_2	218	225	PF02174	0.252
LIG_PTB_Phospho_1	218	224	PF10480	0.252
LIG_SH2_CRK	228	232	PF00017	0.417
LIG_SH2_CRK	264	268	PF00017	0.402
LIG_SH2_CRK	298	302	PF00017	0.406
LIG_SH2_CRK	953	957	PF00017	0.354
LIG_SH2_GRB2like	227	230	PF00017	0.413
LIG_SH2_NCK_1	944	948	PF00017	0.502
LIG_SH2_PTP2	810	813	PF00017	0.506
LIG_SH2_SRC	358	361	PF00017	0.426
LIG_SH2_SRC	663	666	PF00017	0.413
LIG_SH2_STAP1	238	242	PF00017	0.404
LIG_SH2_STAP1	264	268	PF00017	0.433
LIG_SH2_STAP1	931	935	PF00017	0.528
LIG_SH2_STAT5	187	190	PF00017	0.510
LIG_SH2_STAT5	230	233	PF00017	0.420
LIG_SH2_STAT5	289	292	PF00017	0.420
LIG_SH2_STAT5	358	361	PF00017	0.426
LIG_SH2_STAT5	66	69	PF00017	0.413
LIG_SH2_STAT5	786	789	PF00017	0.402
LIG_SH2_STAT5	810	813	PF00017	0.413
LIG_SH2_STAT5	847	850	PF00017	0.497
LIG_SH2_STAT5	931	934	PF00017	0.533
LIG_SH3_1	338	344	PF00018	0.402
LIG_SH3_2	27	32	PF14604	0.692
LIG_SH3_3	24	30	PF00018	0.689
LIG_SH3_3	270	276	PF00018	0.413
LIG_SH3_3	338	344	PF00018	0.402
LIG_SH3_3	545	551	PF00018	0.402
LIG_SH3_4	776	783	PF00018	0.372
LIG_SUMO_SIM_anti_2	417	423	PF11976	0.402
LIG_SUMO_SIM_par_1	277	285	PF11976	0.415
LIG_SUMO_SIM_par_1	398	404	PF11976	0.413
LIG_SUMO_SIM_par_1	487	492	PF11976	0.471
LIG_SUMO_SIM_par_1	544	550	PF11976	0.402
LIG_TRAF2_1	148	151	PF00917	0.569
LIG_TRAF2_1	432	435	PF00917	0.413
LIG_TRAF2_1	69	72	PF00917	0.496
LIG_TRAF2_1	716	719	PF00917	0.490
LIG_TRAF2_1	76	79	PF00917	0.498
LIG_TRFH_1	292	296	PF08558	0.224
LIG_TYR_ITIM	255	260	PF00017	0.237
LIG_UBA3_1	488	493	PF00899	0.252
LIG_UBA3_1	520	529	PF00899	0.237
LIG_WRC_WIRS_1	289	294	PF05994	0.382
LIG_WRC_WIRS_1	701	706	PF05994	0.216
LIG_WW_3	28	32	PF00397	0.718
MOD_CDK_SPxxK_3	491	498	PF00069	0.382
MOD_CK1_1	146	152	PF00069	0.728
MOD_CK1_1	378	384	PF00069	0.252
MOD_CK1_1	871	877	PF00069	0.350
MOD_CK1_1	92	98	PF00069	0.252
MOD_CK2_1	233	239	PF00069	0.271
MOD_CK2_1	42	48	PF00069	0.341
MOD_CK2_1	622	628	PF00069	0.237
MOD_CK2_1	713	719	PF00069	0.433
MOD_CK2_1	740	746	PF00069	0.474
MOD_CK2_1	762	768	PF00069	0.588
MOD_CK2_1	871	877	PF00069	0.350
MOD_CK2_1	883	889	PF00069	0.401
MOD_CK2_1	90	96	PF00069	0.382
MOD_GlcNHglycan	158	161	PF01048	0.615
MOD_GlcNHglycan	44	47	PF01048	0.385
MOD_GlcNHglycan	646	649	PF01048	0.252
MOD_GlcNHglycan	873	876	PF01048	0.367
MOD_GlcNHglycan	912	915	PF01048	0.415
MOD_GlcNHglycan	945	948	PF01048	0.497
MOD_GSK3_1	249	256	PF00069	0.237
MOD_GSK3_1	371	378	PF00069	0.245
MOD_GSK3_1	501	508	PF00069	0.264
MOD_GSK3_1	562	569	PF00069	0.271
MOD_GSK3_1	570	577	PF00069	0.204
MOD_GSK3_1	674	681	PF00069	0.237
MOD_GSK3_1	713	720	PF00069	0.481
MOD_GSK3_1	757	764	PF00069	0.599
MOD_GSK3_1	851	858	PF00069	0.306
MOD_GSK3_1	864	871	PF00069	0.291
MOD_GSK3_1	883	890	PF00069	0.538
MOD_GSK3_1	929	936	PF00069	0.426
MOD_N-GLC_1	673	678	PF02516	0.235
MOD_N-GLC_1	739	744	PF02516	0.462
MOD_N-GLC_1	933	938	PF02516	0.464
MOD_NEK2_1	156	161	PF00069	0.602
MOD_NEK2_1	449	454	PF00069	0.432
MOD_NEK2_1	501	506	PF00069	0.249
MOD_NEK2_1	582	587	PF00069	0.273
MOD_NEK2_1	789	794	PF00069	0.382
MOD_NEK2_1	864	869	PF00069	0.310
MOD_NEK2_2	566	571	PF00069	0.382
MOD_NEK2_2	855	860	PF00069	0.252
MOD_NEK2_2	901	906	PF00069	0.363
MOD_PIKK_1	553	559	PF00454	0.237
MOD_PIKK_1	713	719	PF00454	0.411
MOD_PIKK_1	864	870	PF00454	0.312
MOD_PIKK_1	916	922	PF00454	0.464
MOD_PIKK_1	933	939	PF00454	0.377
MOD_PKA_1	470	476	PF00069	0.508
MOD_PKA_2	1	7	PF00069	0.744
MOD_PKA_2	354	360	PF00069	0.267
MOD_PKA_2	371	377	PF00069	0.196
MOD_PKA_2	389	395	PF00069	0.396
MOD_PKA_2	469	475	PF00069	0.399
MOD_PKA_2	574	580	PF00069	0.237
MOD_PKA_2	622	628	PF00069	0.263
MOD_PKA_2	757	763	PF00069	0.474
MOD_PKA_2	796	802	PF00069	0.265
MOD_PKA_2	833	839	PF00069	0.271
MOD_Plk_1	143	149	PF00069	0.751
MOD_Plk_1	233	239	PF00069	0.339
MOD_Plk_1	249	255	PF00069	0.155
MOD_Plk_1	566	572	PF00069	0.382
MOD_Plk_1	621	627	PF00069	0.252
MOD_Plk_1	717	723	PF00069	0.631
MOD_Plk_1	729	735	PF00069	0.462
MOD_Plk_1	762	768	PF00069	0.623
MOD_Plk_1	89	95	PF00069	0.281
MOD_Plk_2-3	166	172	PF00069	0.502
MOD_Plk_2-3	616	622	PF00069	0.237
MOD_Plk_2-3	846	852	PF00069	0.382
MOD_Plk_2-3	90	96	PF00069	0.382
MOD_Plk_4	233	239	PF00069	0.271
MOD_Plk_4	263	269	PF00069	0.240
MOD_Plk_4	354	360	PF00069	0.252
MOD_Plk_4	396	402	PF00069	0.252
MOD_Plk_4	458	464	PF00069	0.331
MOD_Plk_4	700	706	PF00069	0.216
MOD_Plk_4	778	784	PF00069	0.408
MOD_Plk_4	828	834	PF00069	0.237
MOD_Plk_4	855	861	PF00069	0.323
MOD_ProDKin_1	337	343	PF00069	0.237
MOD_ProDKin_1	491	497	PF00069	0.392
MOD_ProDKin_1	674	680	PF00069	0.237
MOD_SUMO_rev_2	234	242	PF00179	0.281
MOD_SUMO_rev_2	508	517	PF00179	0.237
TRG_DiLeu_BaEn_1	598	603	PF01217	0.237
TRG_DiLeu_BaEn_1	718	723	PF01217	0.508
TRG_DiLeu_BaEn_4	121	127	PF01217	0.285
TRG_DiLeu_BaEn_4	52	58	PF01217	0.379
TRG_DiLeu_BaEn_4	718	724	PF01217	0.589
TRG_DiLeu_BaEn_4	729	735	PF01217	0.532
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.374
TRG_DiLeu_BaLyEn_6	951	956	PF01217	0.507
TRG_DiLeu_LyEn_5	718	723	PF01217	0.508
TRG_DiLeu_LyEn_5	889	894	PF01217	0.395
TRG_ENDOCYTIC_2	228	231	PF00928	0.258
TRG_ENDOCYTIC_2	257	260	PF00928	0.237
TRG_ENDOCYTIC_2	264	267	PF00928	0.237
TRG_ENDOCYTIC_2	289	292	PF00928	0.281
TRG_ENDOCYTIC_2	298	301	PF00928	0.291
TRG_ENDOCYTIC_2	343	346	PF00928	0.237
TRG_ENDOCYTIC_2	786	789	PF00928	0.330
TRG_ENDOCYTIC_2	810	813	PF00928	0.237
TRG_ENDOCYTIC_2	953	956	PF00928	0.349
TRG_ER_diArg_1	11	14	PF00400	0.597
TRG_ER_diArg_1	111	113	PF00400	0.344
TRG_ER_diArg_1	15	18	PF00400	0.603
TRG_ER_diArg_1	215	217	PF00400	0.343
TRG_ER_diArg_1	30	32	PF00400	0.498
TRG_ER_diArg_1	337	339	PF00400	0.237
TRG_ER_diArg_1	469	471	PF00400	0.366
TRG_ER_diArg_1	485	488	PF00400	0.202
TRG_ER_diArg_1	733	736	PF00400	0.518
TRG_ER_diArg_1	754	756	PF00400	0.489
TRG_ER_diArg_1	894	897	PF00400	0.510
TRG_ER_FFAT_2	924	936	PF00635	0.447
TRG_NES_CRM1_1	684	699	PF08389	0.252
TRG_NLS_MonoCore_2	11	16	PF00514	0.641
TRG_NLS_MonoExtC_3	11	16	PF00514	0.641
TRG_NLS_MonoExtN_4	11	17	PF00514	0.662
TRG_NLS_MonoExtN_4	495	502	PF00514	0.218
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.317
TRG_Pf-PMV_PEXEL_1	721	726	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	755	759	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	954	958	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P860	Leptomonas seymouri	87%	98%
A0A0N1I383	Leptomonas seymouri	32%	95%
A0A0S4IK09	Bodo saltans	64%	99%
A0A1X0NZT6	Trypanosomatidae	75%	100%
A0A3Q8IQ79	Leishmania donovani	28%	100%
A0A3R7K9K0	Trypanosoma rangeli	31%	100%
A0A3R7NBN0	Trypanosoma rangeli	76%	100%
A0A3S7WY81	Leishmania donovani	30%	100%
A0A3S7X726	Leishmania donovani	32%	100%
A0A422NDD9	Trypanosoma rangeli	29%	100%
A4FUD9	Bos taurus	33%	100%
A4H5K0	Leishmania braziliensis	31%	100%
A4HDE7	Leishmania braziliensis	31%	100%
A4HGC9	Leishmania braziliensis	92%	100%
A4HLY1	Leishmania braziliensis	31%	100%
A4I0T0	Leishmania infantum	30%	100%
A4I3G2	Leishmania infantum	100%	100%
A4I9B0	Leishmania infantum	32%	100%
A4IC27	Leishmania infantum	28%	100%
B8AZ99	Oryza sativa subsp. indica	34%	100%
B8BKI8	Oryza sativa subsp. indica	42%	100%
D0A7X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AMM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AWT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AZQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B4B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
F1M5F3	Rattus norvegicus	31%	86%
F1N2W9	Bos taurus	30%	85%
P25205	Homo sapiens	33%	100%
P25206	Mus musculus	33%	100%
P29469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P30666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P33991	Homo sapiens	30%	100%
P40377	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P41389	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P49735	Drosophila melanogaster	43%	100%
P49736	Homo sapiens	45%	100%
P55861	Xenopus laevis	43%	100%
P97310	Mus musculus	44%	100%
Q0DHC4	Oryza sativa subsp. japonica	34%	100%
Q21902	Caenorhabditis elegans	29%	100%
Q28BS0	Xenopus tropicalis	34%	100%
Q29JI9	Drosophila pseudoobscura pseudoobscura	31%	100%
Q2KHI9	Mus musculus	32%	86%
Q2R482	Oryza sativa subsp. japonica	42%	100%
Q43704	Zea mays	35%	100%
Q4Q3R6	Leishmania major	32%	100%
Q4Q8I2	Leishmania major	98%	100%
Q4QAP2	Leishmania major	30%	100%
Q54CP4	Dictyostelium discoideum	31%	100%
Q5R8G6	Pongo abelii	33%	100%
Q6DIH3	Xenopus tropicalis	43%	100%
Q6NRM6	Xenopus laevis	30%	85%
Q7ZXZ0	Xenopus laevis	35%	100%
Q9LPD9	Arabidopsis thaliana	45%	100%
Q9NXL9	Homo sapiens	30%	85%
Q9SF37	Arabidopsis thaliana	31%	100%
Q9SX03	Zea mays	35%	100%
Q9SX04	Zea mays	35%	100%
Q9V461	Drosophila melanogaster	32%	100%
Q9VGW6	Drosophila melanogaster	32%	100%
Q9XYU0	Drosophila melanogaster	33%	100%
V5BQA9	Trypanosoma cruzi	80%	100%