RNA recognition motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAX1_LEIDO

TriTrypDb:

LdBPK_180170.1 , LdCL_180006600 , LDHU3_18.0180

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	3
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IAX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAX1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0003723	RNA binding	4	14
GO:0005488	binding	1	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	3
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2
GO:0070717	poly-purine tract binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.552
CLV_NRD_NRD_1	145	147	PF00675	0.409
CLV_NRD_NRD_1	164	166	PF00675	0.333
CLV_NRD_NRD_1	255	257	PF00675	0.568
CLV_PCSK_KEX2_1	163	165	PF00082	0.355
CLV_PCSK_KEX2_1	210	212	PF00082	0.618
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.549
CLV_PCSK_SKI1_1	120	124	PF00082	0.448
CLV_PCSK_SKI1_1	146	150	PF00082	0.336
CLV_PCSK_SKI1_1	165	169	PF00082	0.423
CLV_PCSK_SKI1_1	43	47	PF00082	0.361
DEG_Nend_UBRbox_3	1	3	PF02207	0.564
DEG_SCF_FBW7_1	279	286	PF00400	0.565
DEG_SPOP_SBC_1	321	325	PF00917	0.555
DOC_CKS1_1	20	25	PF01111	0.500
DOC_MAPK_gen_1	10	20	PF00069	0.494
DOC_MAPK_gen_1	115	123	PF00069	0.515
DOC_MAPK_gen_1	163	171	PF00069	0.519
DOC_MAPK_gen_1	82	92	PF00069	0.504
DOC_MAPK_MEF2A_6	163	171	PF00069	0.528
DOC_PP1_RVXF_1	162	169	PF00149	0.556
DOC_PP4_FxxP_1	20	23	PF00568	0.528
DOC_USP7_MATH_1	141	145	PF00917	0.478
DOC_USP7_MATH_1	206	210	PF00917	0.598
DOC_USP7_MATH_1	216	220	PF00917	0.644
DOC_USP7_MATH_1	236	240	PF00917	0.673
DOC_USP7_MATH_1	283	287	PF00917	0.704
DOC_USP7_MATH_1	321	325	PF00917	0.579
DOC_USP7_MATH_1	8	12	PF00917	0.508
DOC_WW_Pin1_4	1	6	PF00397	0.617
DOC_WW_Pin1_4	106	111	PF00397	0.585
DOC_WW_Pin1_4	137	142	PF00397	0.478
DOC_WW_Pin1_4	19	24	PF00397	0.494
DOC_WW_Pin1_4	227	232	PF00397	0.669
DOC_WW_Pin1_4	261	266	PF00397	0.653
DOC_WW_Pin1_4	279	284	PF00397	0.625
DOC_WW_Pin1_4	300	305	PF00397	0.737
LIG_14-3-3_CanoR_1	146	151	PF00244	0.459
LIG_14-3-3_CanoR_1	256	261	PF00244	0.541
LIG_14-3-3_CanoR_1	322	329	PF00244	0.622
LIG_Actin_WH2_2	30	45	PF00022	0.528
LIG_APCC_ABBA_1	148	153	PF00400	0.528
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.528
LIG_BIR_III_4	86	90	PF00653	0.497
LIG_BRCT_BRCA1_1	329	333	PF00533	0.598
LIG_FHA_1	152	158	PF00498	0.517
LIG_FHA_1	67	73	PF00498	0.531
LIG_FHA_1	94	100	PF00498	0.524
LIG_FHA_2	168	174	PF00498	0.546
LIG_IBAR_NPY_1	336	338	PF08397	0.636
LIG_LIR_Gen_1	44	52	PF02991	0.478
LIG_LIR_Nem_3	140	145	PF02991	0.510
LIG_LIR_Nem_3	26	32	PF02991	0.394
LIG_LIR_Nem_3	44	49	PF02991	0.487
LIG_LIR_Nem_3	69	74	PF02991	0.529
LIG_PCNA_yPIPBox_3	285	298	PF02747	0.538
LIG_PDZ_Class_1	342	347	PF00595	0.514
LIG_SH2_CRK	142	146	PF00017	0.561
LIG_SH2_CRK	338	342	PF00017	0.515
LIG_SH2_SRC	74	77	PF00017	0.478
LIG_SH2_STAP1	329	333	PF00017	0.537
LIG_SH2_STAT3	62	65	PF00017	0.497
LIG_SH2_STAT5	21	24	PF00017	0.465
LIG_SH2_STAT5	32	35	PF00017	0.484
LIG_SH3_3	239	245	PF00018	0.748
LIG_SH3_3	304	310	PF00018	0.631
LIG_SH3_CIN85_PxpxPR_1	304	309	PF14604	0.542
LIG_SUMO_SIM_par_1	126	134	PF11976	0.565
LIG_SxIP_EBH_1	237	247	PF03271	0.491
LIG_TRAF2_1	111	114	PF00917	0.601
LIG_TRAF2_1	274	277	PF00917	0.544
LIG_WRC_WIRS_1	168	173	PF05994	0.528
LIG_WRC_WIRS_1	260	265	PF05994	0.547
MOD_CDK_SPxK_1	279	285	PF00069	0.566
MOD_CK1_1	221	227	PF00069	0.676
MOD_CK1_1	235	241	PF00069	0.697
MOD_CK1_1	259	265	PF00069	0.638
MOD_CK1_1	275	281	PF00069	0.685
MOD_CK1_1	300	306	PF00069	0.735
MOD_CK1_1	315	321	PF00069	0.606
MOD_CK1_1	325	331	PF00069	0.661
MOD_CK1_1	63	69	PF00069	0.524
MOD_CK2_1	167	173	PF00069	0.528
MOD_CK2_1	270	276	PF00069	0.635
MOD_GlcNHglycan	234	237	PF01048	0.634
MOD_GlcNHglycan	46	49	PF01048	0.408
MOD_GlcNHglycan	62	65	PF01048	0.281
MOD_GSK3_1	137	144	PF00069	0.497
MOD_GSK3_1	19	26	PF00069	0.507
MOD_GSK3_1	214	221	PF00069	0.677
MOD_GSK3_1	225	232	PF00069	0.607
MOD_GSK3_1	252	259	PF00069	0.797
MOD_GSK3_1	271	278	PF00069	0.695
MOD_GSK3_1	279	286	PF00069	0.720
MOD_GSK3_1	312	319	PF00069	0.643
MOD_GSK3_1	321	328	PF00069	0.656
MOD_GSK3_1	9	16	PF00069	0.632
MOD_N-GLC_1	151	156	PF02516	0.328
MOD_N-GLC_1	214	219	PF02516	0.747
MOD_N-GLC_1	232	237	PF02516	0.483
MOD_N-GLC_1	252	257	PF02516	0.536
MOD_N-GLC_2	186	188	PF02516	0.356
MOD_NEK2_1	214	219	PF00069	0.538
MOD_NEK2_1	252	257	PF00069	0.624
MOD_NEK2_1	9	14	PF00069	0.546
MOD_NEK2_1	93	98	PF00069	0.553
MOD_NEK2_2	141	146	PF00069	0.492
MOD_PIKK_1	13	19	PF00454	0.760
MOD_PIKK_1	263	269	PF00454	0.568
MOD_PK_1	218	224	PF00069	0.649
MOD_PK_1	95	101	PF00069	0.595
MOD_PKA_1	146	152	PF00069	0.528
MOD_PKA_1	256	262	PF00069	0.535
MOD_PKA_2	236	242	PF00069	0.576
MOD_PKA_2	321	327	PF00069	0.563
MOD_PKA_2	9	15	PF00069	0.581
MOD_Plk_1	275	281	PF00069	0.605
MOD_Plk_1	316	322	PF00069	0.637
MOD_Plk_1	325	331	PF00069	0.536
MOD_Plk_4	336	342	PF00069	0.605
MOD_Plk_4	52	58	PF00069	0.522
MOD_ProDKin_1	1	7	PF00069	0.617
MOD_ProDKin_1	106	112	PF00069	0.584
MOD_ProDKin_1	137	143	PF00069	0.478
MOD_ProDKin_1	19	25	PF00069	0.487
MOD_ProDKin_1	227	233	PF00069	0.671
MOD_ProDKin_1	261	267	PF00069	0.654
MOD_ProDKin_1	279	285	PF00069	0.628
MOD_ProDKin_1	300	306	PF00069	0.738
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.478
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.497
TRG_ENDOCYTIC_2	142	145	PF00928	0.565
TRG_ENDOCYTIC_2	338	341	PF00928	0.537
TRG_ER_diArg_1	163	165	PF00400	0.564
TRG_ER_diArg_1	211	214	PF00400	0.626
TRG_NLS_MonoExtN_4	208	214	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P516	Leptomonas seymouri	57%	93%
A0A3Q8IAV4	Leishmania donovani	48%	100%
A0A3R7NAH9	Trypanosoma rangeli	27%	71%
A4H9C2	Leishmania braziliensis	79%	100%
A4HXP3	Leishmania infantum	100%	100%
A4HXP5	Leishmania infantum	48%	100%
E9ARF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9ARF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9ARF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
Q4Q774	Leishmania major	26%	70%
Q4QE24	Leishmania major	76%	100%
Q4QE25	Leishmania major	96%	100%