Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAW9_LEIDO

TriTrypDb:

LdBPK_230390.1 , LdCL_230009300 , LDHU3_23.0570

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.510
CLV_NRD_NRD_1	19	21	PF00675	0.697
CLV_NRD_NRD_1	23	25	PF00675	0.727
CLV_NRD_NRD_1	270	272	PF00675	0.581
CLV_PCSK_KEX2_1	138	140	PF00082	0.580
CLV_PCSK_KEX2_1	154	156	PF00082	0.411
CLV_PCSK_KEX2_1	19	21	PF00082	0.547
CLV_PCSK_KEX2_1	205	207	PF00082	0.538
CLV_PCSK_KEX2_1	23	25	PF00082	0.725
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.587
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.577
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.641
CLV_PCSK_PC7_1	134	140	PF00082	0.544
CLV_PCSK_PC7_1	19	25	PF00082	0.627
CLV_PCSK_SKI1_1	142	146	PF00082	0.603
CLV_PCSK_SKI1_1	171	175	PF00082	0.624
CLV_PCSK_SKI1_1	176	180	PF00082	0.593
CLV_PCSK_SKI1_1	247	251	PF00082	0.627
CLV_PCSK_SKI1_1	57	61	PF00082	0.549
CLV_PCSK_SKI1_1	90	94	PF00082	0.540
DEG_SCF_TRCP1_1	35	41	PF00400	0.524
DEG_SPOP_SBC_1	58	62	PF00917	0.478
DOC_MAPK_gen_1	138	146	PF00069	0.562
DOC_MAPK_gen_1	201	210	PF00069	0.558
DOC_MAPK_MEF2A_6	204	212	PF00069	0.612
DOC_PP1_RVXF_1	110	116	PF00149	0.451
DOC_PP1_RVXF_1	169	175	PF00149	0.518
DOC_PP4_FxxP_1	72	75	PF00568	0.422
DOC_USP7_MATH_1	220	224	PF00917	0.681
DOC_USP7_MATH_1	9	13	PF00917	0.596
DOC_USP7_UBL2_3	138	142	PF12436	0.574
DOC_USP7_UBL2_3	201	205	PF12436	0.628
DOC_USP7_UBL2_3	272	276	PF12436	0.549
DOC_WW_Pin1_4	212	217	PF00397	0.782
DOC_WW_Pin1_4	218	223	PF00397	0.586
LIG_14-3-3_CanoR_1	57	66	PF00244	0.606
LIG_Actin_WH2_2	77	95	PF00022	0.435
LIG_BRCT_BRCA1_1	60	64	PF00533	0.543
LIG_FHA_1	58	64	PF00498	0.522
LIG_FHA_2	131	137	PF00498	0.574
LIG_FHA_2	182	188	PF00498	0.557
LIG_FHA_2	192	198	PF00498	0.512
LIG_FHA_2	256	262	PF00498	0.560
LIG_LIR_Apic_2	123	129	PF02991	0.609
LIG_LIR_Apic_2	48	54	PF02991	0.643
LIG_LIR_Gen_1	280	289	PF02991	0.609
LIG_LIR_Nem_3	148	152	PF02991	0.454
LIG_LIR_Nem_3	280	286	PF02991	0.629
LIG_LIR_Nem_3	287	292	PF02991	0.584
LIG_Pex14_1	141	145	PF04695	0.445
LIG_SH2_GRB2like	105	108	PF00017	0.454
LIG_SH2_STAT5	126	129	PF00017	0.678
LIG_SH2_STAT5	152	155	PF00017	0.524
LIG_SH2_STAT5	257	260	PF00017	0.615
LIG_TRAF2_1	194	197	PF00917	0.577
MOD_CK1_1	221	227	PF00069	0.610
MOD_CK1_1	36	42	PF00069	0.606
MOD_CK2_1	130	136	PF00069	0.514
MOD_CK2_1	181	187	PF00069	0.538
MOD_CK2_1	191	197	PF00069	0.485
MOD_Cter_Amidation	136	139	PF01082	0.492
MOD_Cter_Amidation	14	17	PF01082	0.656
MOD_Cter_Amidation	21	24	PF01082	0.606
MOD_GlcNHglycan	35	38	PF01048	0.722
MOD_GSK3_1	253	260	PF00069	0.571
MOD_GSK3_1	277	284	PF00069	0.612
MOD_GSK3_1	35	42	PF00069	0.668
MOD_GSK3_1	92	99	PF00069	0.462
MOD_LATS_1	275	281	PF00433	0.612
MOD_NEK2_1	59	64	PF00069	0.511
MOD_NEK2_1	92	97	PF00069	0.444
MOD_PIKK_1	36	42	PF00454	0.604
MOD_PKA_2	281	287	PF00069	0.728
MOD_PKA_2	82	88	PF00069	0.475
MOD_Plk_1	191	197	PF00069	0.610
MOD_Plk_2-3	118	124	PF00069	0.475
MOD_Plk_4	127	133	PF00069	0.671
MOD_Plk_4	59	65	PF00069	0.539
MOD_ProDKin_1	212	218	PF00069	0.783
MOD_SUMO_for_1	234	237	PF00179	0.528
MOD_SUMO_rev_2	117	127	PF00179	0.592
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.523
TRG_NLS_Bipartite_1	124	143	PF00514	0.524
TRG_NLS_MonoExtC_3	137	142	PF00514	0.494
TRG_NLS_MonoExtC_3	15	20	PF00514	0.633
TRG_NLS_MonoExtC_3	203	209	PF00514	0.627
TRG_NLS_MonoExtN_4	13	20	PF00514	0.632
TRG_NLS_MonoExtN_4	138	143	PF00514	0.475
TRG_NLS_MonoExtN_4	201	208	PF00514	0.638
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P555	Leptomonas seymouri	60%	84%
A0A0S4IRA8	Bodo saltans	26%	93%
A0A1X0NX54	Trypanosomatidae	38%	100%
A0A422NW66	Trypanosoma rangeli	40%	100%
A4HCP9	Leishmania braziliensis	73%	100%
A4I075	Leishmania infantum	100%	100%
C9ZUZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AW38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QBD9	Leishmania major	94%	100%