SNARE associated Golgi protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNARE associated Golgi protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAW4_LEIDO

TriTrypDb:

LdBPK_280760.1 , LdCL_280012200 , LDHU3_28.0930

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005635	nuclear envelope	4	1
GO:0012505	endomembrane system	2	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1

Expansion

Sequence features

A0A3Q8IAW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAW4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.381
CLV_NRD_NRD_1	309	311	PF00675	0.336
CLV_NRD_NRD_1	465	467	PF00675	0.381
CLV_NRD_NRD_1	480	482	PF00675	0.345
CLV_NRD_NRD_1	569	571	PF00675	0.626
CLV_PCSK_KEX2_1	19	21	PF00082	0.381
CLV_PCSK_KEX2_1	309	311	PF00082	0.298
CLV_PCSK_KEX2_1	414	416	PF00082	0.414
CLV_PCSK_KEX2_1	465	467	PF00082	0.363
CLV_PCSK_KEX2_1	479	481	PF00082	0.331
CLV_PCSK_KEX2_1	569	571	PF00082	0.626
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.414
CLV_PCSK_PC7_1	565	571	PF00082	0.567
CLV_PCSK_SKI1_1	414	418	PF00082	0.402
CLV_PCSK_SKI1_1	520	524	PF00082	0.410
CLV_PCSK_SKI1_1	53	57	PF00082	0.324
CLV_PCSK_SKI1_1	569	573	PF00082	0.553
DEG_APCC_DBOX_1	18	26	PF00400	0.589
DEG_APCC_DBOX_1	29	37	PF00400	0.543
DOC_CYCLIN_RxL_1	50	58	PF00134	0.461
DOC_CYCLIN_RxL_1	517	524	PF00134	0.477
DOC_MAPK_FxFP_2	191	194	PF00069	0.338
DOC_MAPK_gen_1	223	230	PF00069	0.542
DOC_MAPK_gen_1	27	36	PF00069	0.548
DOC_MAPK_gen_1	517	527	PF00069	0.418
DOC_MAPK_gen_1	569	576	PF00069	0.421
DOC_MAPK_MEF2A_6	223	230	PF00069	0.605
DOC_MAPK_MEF2A_6	352	359	PF00069	0.314
DOC_MAPK_MEF2A_6	517	525	PF00069	0.591
DOC_MAPK_MEF2A_6	540	548	PF00069	0.430
DOC_PP4_FxxP_1	191	194	PF00568	0.338
DOC_PP4_FxxP_1	219	222	PF00568	0.535
DOC_PP4_FxxP_1	337	340	PF00568	0.242
DOC_USP7_MATH_1	408	412	PF00917	0.577
DOC_USP7_MATH_1	504	508	PF00917	0.623
DOC_USP7_MATH_1	97	101	PF00917	0.430
DOC_USP7_UBL2_3	352	356	PF12436	0.279
DOC_WW_Pin1_4	481	486	PF00397	0.651
DOC_WW_Pin1_4	74	79	PF00397	0.368
LIG_14-3-3_CanoR_1	126	132	PF00244	0.325
LIG_14-3-3_CanoR_1	27	36	PF00244	0.569
LIG_14-3-3_CanoR_1	379	389	PF00244	0.649
LIG_14-3-3_CanoR_1	520	526	PF00244	0.487
LIG_14-3-3_CanoR_1	540	545	PF00244	0.340
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	341	345	PF00533	0.296
LIG_CaM_NSCaTE_8	314	321	PF13499	0.322
LIG_deltaCOP1_diTrp_1	161	170	PF00928	0.384
LIG_FHA_1	29	35	PF00498	0.531
LIG_FHA_1	522	528	PF00498	0.336
LIG_FHA_1	545	551	PF00498	0.399
LIG_FHA_1	56	62	PF00498	0.358
LIG_FHA_1	9	15	PF00498	0.622
LIG_FHA_2	139	145	PF00498	0.405
LIG_FHA_2	422	428	PF00498	0.729
LIG_FHA_2	468	474	PF00498	0.650
LIG_FHA_2	487	493	PF00498	0.467
LIG_FHA_2	93	99	PF00498	0.362
LIG_LIR_Apic_2	216	222	PF02991	0.548
LIG_LIR_Apic_2	71	76	PF02991	0.424
LIG_LIR_Gen_1	100	107	PF02991	0.344
LIG_LIR_Nem_3	100	106	PF02991	0.344
LIG_LIR_Nem_3	166	172	PF02991	0.258
LIG_LIR_Nem_3	32	38	PF02991	0.597
LIG_LIR_Nem_3	390	394	PF02991	0.606
LIG_LIR_Nem_3	71	75	PF02991	0.427
LIG_LYPXL_yS_3	518	521	PF13949	0.541
LIG_MLH1_MIPbox_1	341	345	PF16413	0.296
LIG_NRBOX	545	551	PF00104	0.351
LIG_PDZ_Class_2	580	585	PF00595	0.407
LIG_Pex14_2	134	138	PF04695	0.309
LIG_Pex14_2	337	341	PF04695	0.254
LIG_Pex14_2	364	368	PF04695	0.279
LIG_REV1ctd_RIR_1	389	397	PF16727	0.528
LIG_SH2_CRK	103	107	PF00017	0.363
LIG_SH2_NCK_1	46	50	PF00017	0.623
LIG_SH2_PTP2	73	76	PF00017	0.515
LIG_SH2_SRC	46	49	PF00017	0.507
LIG_SH2_STAP1	103	107	PF00017	0.345
LIG_SH2_STAP1	271	275	PF00017	0.452
LIG_SH2_STAP1	46	50	PF00017	0.623
LIG_SH2_STAT3	38	41	PF00017	0.614
LIG_SH2_STAT3	535	538	PF00017	0.646
LIG_SH2_STAT5	148	151	PF00017	0.404
LIG_SH2_STAT5	248	251	PF00017	0.580
LIG_SH2_STAT5	553	556	PF00017	0.410
LIG_SH2_STAT5	582	585	PF00017	0.422
LIG_SH2_STAT5	73	76	PF00017	0.515
LIG_SH3_3	56	62	PF00018	0.293
LIG_SH3_3	72	78	PF00018	0.321
LIG_TRAF2_1	461	464	PF00917	0.569
LIG_TYR_ITIM	580	585	PF00017	0.378
LIG_TYR_ITIM	70	75	PF00017	0.306
LIG_WRC_WIRS_1	341	346	PF05994	0.242
LIG_WRC_WIRS_1	388	393	PF05994	0.648
LIG_WRC_WIRS_1	455	460	PF05994	0.551
MOD_CK1_1	101	107	PF00069	0.380
MOD_CK1_1	140	146	PF00069	0.444
MOD_CK1_1	241	247	PF00069	0.578
MOD_CK1_1	298	304	PF00069	0.496
MOD_CK1_1	383	389	PF00069	0.610
MOD_CK1_1	539	545	PF00069	0.428
MOD_CK2_1	138	144	PF00069	0.364
MOD_CK2_1	231	237	PF00069	0.616
MOD_CK2_1	241	247	PF00069	0.495
MOD_CK2_1	3	9	PF00069	0.623
MOD_CK2_1	421	427	PF00069	0.731
MOD_CK2_1	450	456	PF00069	0.517
MOD_CK2_1	458	464	PF00069	0.517
MOD_CK2_1	467	473	PF00069	0.521
MOD_CK2_1	486	492	PF00069	0.469
MOD_CK2_1	92	98	PF00069	0.397
MOD_GlcNHglycan	186	189	PF01048	0.279
MOD_GlcNHglycan	289	292	PF01048	0.373
MOD_GlcNHglycan	345	348	PF01048	0.415
MOD_GlcNHglycan	368	371	PF01048	0.362
MOD_GlcNHglycan	382	385	PF01048	0.358
MOD_GlcNHglycan	402	405	PF01048	0.430
MOD_GlcNHglycan	420	424	PF01048	0.391
MOD_GlcNHglycan	83	86	PF01048	0.610
MOD_GSK3_1	180	187	PF00069	0.279
MOD_GSK3_1	339	346	PF00069	0.309
MOD_GSK3_1	379	386	PF00069	0.586
MOD_GSK3_1	450	457	PF00069	0.577
MOD_GSK3_1	536	543	PF00069	0.429
MOD_GSK3_1	97	104	PF00069	0.412
MOD_N-GLC_1	301	306	PF02516	0.336
MOD_NEK2_1	238	243	PF00069	0.563
MOD_NEK2_1	287	292	PF00069	0.576
MOD_NEK2_1	29	34	PF00069	0.514
MOD_NEK2_1	345	350	PF00069	0.279
MOD_NEK2_1	36	41	PF00069	0.524
MOD_NEK2_1	380	385	PF00069	0.585
MOD_NEK2_1	450	455	PF00069	0.537
MOD_NEK2_1	521	526	PF00069	0.367
MOD_NEK2_1	544	549	PF00069	0.369
MOD_NEK2_1	55	60	PF00069	0.347
MOD_NEK2_1	8	13	PF00069	0.507
MOD_NEK2_2	340	345	PF00069	0.242
MOD_PIKK_1	231	237	PF00454	0.547
MOD_PIKK_1	8	14	PF00454	0.497
MOD_PKA_2	29	35	PF00069	0.517
MOD_PKA_2	408	414	PF00069	0.560
MOD_PKA_2	539	545	PF00069	0.396
MOD_Plk_1	301	307	PF00069	0.521
MOD_Plk_1	467	473	PF00069	0.558
MOD_Plk_1	97	103	PF00069	0.308
MOD_Plk_2-3	467	473	PF00069	0.553
MOD_Plk_4	241	247	PF00069	0.544
MOD_Plk_4	29	35	PF00069	0.567
MOD_Plk_4	340	346	PF00069	0.259
MOD_Plk_4	383	389	PF00069	0.603
MOD_Plk_4	430	436	PF00069	0.576
MOD_Plk_4	443	449	PF00069	0.541
MOD_Plk_4	450	456	PF00069	0.425
MOD_Plk_4	467	473	PF00069	0.521
MOD_Plk_4	544	550	PF00069	0.325
MOD_Plk_4	55	61	PF00069	0.295
MOD_Plk_4	68	74	PF00069	0.264
MOD_Plk_4	98	104	PF00069	0.396
MOD_ProDKin_1	481	487	PF00069	0.654
MOD_ProDKin_1	74	80	PF00069	0.366
TRG_DiLeu_BaEn_1	430	435	PF01217	0.633
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.625
TRG_ENDOCYTIC_2	103	106	PF00928	0.343
TRG_ENDOCYTIC_2	169	172	PF00928	0.410
TRG_ENDOCYTIC_2	294	297	PF00928	0.442
TRG_ENDOCYTIC_2	518	521	PF00928	0.587
TRG_ENDOCYTIC_2	582	585	PF00928	0.420
TRG_ENDOCYTIC_2	72	75	PF00928	0.306
TRG_ER_diArg_1	222	225	PF00400	0.490
TRG_ER_diArg_1	308	310	PF00400	0.536
TRG_ER_diArg_1	406	409	PF00400	0.630
TRG_ER_diArg_1	478	481	PF00400	0.621
TRG_ER_diArg_1	568	570	PF00400	0.357
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S3	Leptomonas seymouri	65%	100%
A0A1X0NYV6	Trypanosomatidae	46%	100%
A0A422P1M7	Trypanosoma rangeli	46%	100%
A4HGB2	Leishmania braziliensis	81%	100%
A4I3E6	Leishmania infantum	100%	100%
D0A801	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AZN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q8J8	Leishmania major	93%	100%
V5B0S4	Trypanosoma cruzi	43%	100%