Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IAW3_LEIDO

TriTrypDb:

LdBPK_211130.1 , LdCL_210016300 , LDHU3_21.1330

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.659
CLV_NRD_NRD_1	13	15	PF00675	0.702
CLV_NRD_NRD_1	332	334	PF00675	0.672
CLV_NRD_NRD_1	399	401	PF00675	0.737
CLV_NRD_NRD_1	54	56	PF00675	0.792
CLV_PCSK_KEX2_1	13	15	PF00082	0.706
CLV_PCSK_KEX2_1	216	218	PF00082	0.802
CLV_PCSK_KEX2_1	331	333	PF00082	0.675
CLV_PCSK_KEX2_1	399	401	PF00082	0.737
CLV_PCSK_KEX2_1	54	56	PF00082	0.792
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.802
CLV_PCSK_PC7_1	212	218	PF00082	0.763
CLV_PCSK_SKI1_1	108	112	PF00082	0.590
CLV_PCSK_SKI1_1	262	266	PF00082	0.621
CLV_PCSK_SKI1_1	326	330	PF00082	0.642
CLV_PCSK_SKI1_1	400	404	PF00082	0.718
DEG_APCC_DBOX_1	103	111	PF00400	0.697
DEG_APCC_DBOX_1	242	250	PF00400	0.711
DEG_Nend_Nbox_1	1	3	PF02207	0.760
DEG_SPOP_SBC_1	61	65	PF00917	0.743
DOC_CDC14_PxL_1	350	358	PF14671	0.715
DOC_CYCLIN_RxL_1	163	171	PF00134	0.737
DOC_MAPK_gen_1	358	367	PF00069	0.559
DOC_MAPK_MEF2A_6	360	369	PF00069	0.618
DOC_PP1_RVXF_1	164	171	PF00149	0.638
DOC_PP2B_LxvP_1	115	118	PF13499	0.574
DOC_PP2B_LxvP_1	289	292	PF13499	0.697
DOC_USP7_MATH_1	141	145	PF00917	0.805
DOC_USP7_MATH_1	149	153	PF00917	0.679
DOC_USP7_MATH_1	188	192	PF00917	0.748
DOC_USP7_MATH_1	200	204	PF00917	0.638
DOC_USP7_MATH_1	24	28	PF00917	0.645
DOC_USP7_MATH_1	257	261	PF00917	0.681
DOC_USP7_MATH_1	292	296	PF00917	0.736
DOC_USP7_MATH_1	349	353	PF00917	0.738
DOC_USP7_MATH_1	61	65	PF00917	0.780
DOC_USP7_MATH_1	69	73	PF00917	0.624
DOC_USP7_MATH_1	84	88	PF00917	0.535
DOC_WW_Pin1_4	158	163	PF00397	0.544
DOC_WW_Pin1_4	186	191	PF00397	0.700
DOC_WW_Pin1_4	20	25	PF00397	0.635
DOC_WW_Pin1_4	274	279	PF00397	0.719
DOC_WW_Pin1_4	290	295	PF00397	0.668
LIG_14-3-3_CanoR_1	14	24	PF00244	0.686
LIG_14-3-3_CanoR_1	201	208	PF00244	0.804
LIG_14-3-3_CanoR_1	262	272	PF00244	0.733
LIG_14-3-3_CanoR_1	399	408	PF00244	0.751
LIG_BRCT_BRCA1_1	272	276	PF00533	0.731
LIG_FHA_1	119	125	PF00498	0.665
LIG_FHA_1	149	155	PF00498	0.662
LIG_FHA_1	75	81	PF00498	0.677
LIG_FHA_2	137	143	PF00498	0.703
LIG_FHA_2	229	235	PF00498	0.692
LIG_FHA_2	278	284	PF00498	0.679
LIG_FHA_2	302	308	PF00498	0.758
LIG_LIR_Gen_1	206	215	PF02991	0.766
LIG_LIR_Gen_1	317	325	PF02991	0.680
LIG_LIR_Gen_1	374	384	PF02991	0.685
LIG_LIR_Gen_1	421	425	PF02991	0.745
LIG_LIR_Nem_3	181	185	PF02991	0.672
LIG_LIR_Nem_3	206	211	PF02991	0.814
LIG_LIR_Nem_3	260	264	PF02991	0.692
LIG_LIR_Nem_3	3	7	PF02991	0.577
LIG_LIR_Nem_3	317	321	PF02991	0.679
LIG_LIR_Nem_3	374	380	PF02991	0.598
LIG_LIR_Nem_3	421	425	PF02991	0.745
LIG_MYND_1	294	298	PF01753	0.786
LIG_NRBOX	106	112	PF00104	0.546
LIG_PCNA_PIPBox_1	100	109	PF02747	0.700
LIG_PCNA_yPIPBox_3	322	333	PF02747	0.638
LIG_Pex3_1	116	127	PF04882	0.529
LIG_SH2_PTP2	318	321	PF00017	0.699
LIG_SH2_SRC	208	211	PF00017	0.760
LIG_SH2_SRC	314	317	PF00017	0.711
LIG_SH2_STAP1	338	342	PF00017	0.752
LIG_SH2_STAP1	377	381	PF00017	0.678
LIG_SH2_STAT5	167	170	PF00017	0.752
LIG_SH2_STAT5	314	317	PF00017	0.614
LIG_SH2_STAT5	318	321	PF00017	0.602
LIG_SH2_STAT5	338	341	PF00017	0.432
LIG_SH2_STAT5	94	97	PF00017	0.613
LIG_SH3_3	291	297	PF00018	0.677
LIG_SH3_3	351	357	PF00018	0.643
LIG_SH3_3	364	370	PF00018	0.481
LIG_SH3_3	87	93	PF00018	0.718
LIG_SH3_5	334	338	PF00018	0.759
MOD_CDK_SPxxK_3	274	281	PF00069	0.746
MOD_CK1_1	133	139	PF00069	0.809
MOD_CK1_1	189	195	PF00069	0.795
MOD_CK1_1	277	283	PF00069	0.803
MOD_CK1_1	290	296	PF00069	0.596
MOD_CK1_1	63	69	PF00069	0.781
MOD_CK1_1	71	77	PF00069	0.721
MOD_CK2_1	200	206	PF00069	0.774
MOD_CK2_1	277	283	PF00069	0.699
MOD_CK2_1	301	307	PF00069	0.661
MOD_GlcNHglycan	142	146	PF01048	0.809
MOD_GlcNHglycan	151	154	PF01048	0.663
MOD_GlcNHglycan	162	165	PF01048	0.444
MOD_GlcNHglycan	196	199	PF01048	0.761
MOD_GlcNHglycan	26	29	PF01048	0.746
MOD_GlcNHglycan	272	275	PF01048	0.779
MOD_GlcNHglycan	289	292	PF01048	0.766
MOD_GlcNHglycan	351	354	PF01048	0.706
MOD_GlcNHglycan	387	390	PF01048	0.631
MOD_GlcNHglycan	65	68	PF01048	0.766
MOD_GlcNHglycan	7	10	PF01048	0.635
MOD_GlcNHglycan	86	89	PF01048	0.740
MOD_GSK3_1	130	137	PF00069	0.796
MOD_GSK3_1	154	161	PF00069	0.703
MOD_GSK3_1	20	27	PF00069	0.693
MOD_GSK3_1	270	277	PF00069	0.757
MOD_GSK3_1	292	299	PF00069	0.785
MOD_GSK3_1	310	317	PF00069	0.629
MOD_GSK3_1	332	339	PF00069	0.736
MOD_GSK3_1	35	42	PF00069	0.457
MOD_GSK3_1	371	378	PF00069	0.630
MOD_GSK3_1	59	66	PF00069	0.716
MOD_GSK3_1	84	91	PF00069	0.689
MOD_NEK2_1	120	125	PF00069	0.616
MOD_NEK2_1	168	173	PF00069	0.746
MOD_NEK2_1	39	44	PF00069	0.727
MOD_NEK2_1	412	417	PF00069	0.706
MOD_NEK2_1	60	65	PF00069	0.794
MOD_NEK2_2	257	262	PF00069	0.686
MOD_PIKK_1	156	162	PF00454	0.720
MOD_PKA_1	332	338	PF00069	0.664
MOD_PKA_2	15	21	PF00069	0.608
MOD_PKA_2	200	206	PF00069	0.804
MOD_PKA_2	332	338	PF00069	0.664
MOD_PKA_2	385	391	PF00069	0.626
MOD_PKA_2	5	11	PF00069	0.664
MOD_Plk_4	228	234	PF00069	0.746
MOD_Plk_4	301	307	PF00069	0.661
MOD_Plk_4	310	316	PF00069	0.631
MOD_ProDKin_1	158	164	PF00069	0.542
MOD_ProDKin_1	186	192	PF00069	0.701
MOD_ProDKin_1	20	26	PF00069	0.635
MOD_ProDKin_1	274	280	PF00069	0.718
MOD_ProDKin_1	290	296	PF00069	0.665
MOD_SUMO_rev_2	210	218	PF00179	0.761
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.689
TRG_DiLeu_LyEn_5	248	253	PF01217	0.700
TRG_ENDOCYTIC_2	167	170	PF00928	0.752
TRG_ENDOCYTIC_2	208	211	PF00928	0.810
TRG_ENDOCYTIC_2	318	321	PF00928	0.699
TRG_ENDOCYTIC_2	377	380	PF00928	0.586
TRG_ENDOCYTIC_2	422	425	PF00928	0.749
TRG_ER_diArg_1	13	16	PF00400	0.712
TRG_ER_diArg_1	330	333	PF00400	0.673
TRG_ER_diArg_1	357	360	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR9	Leptomonas seymouri	36%	96%
E9AGV7	Leishmania infantum	99%	100%
E9AV73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%
Q4QCA8	Leishmania major	89%	100%