PPPDE putative peptidase domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PPPDE putative peptidase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAW2_LEIDO

TriTrypDb:

LdBPK_091360.1 , LdCL_090020000 , LDHU3_09.1610

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAW2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016579	protein deubiquitination	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070646	protein modification by small protein removal	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0008233	peptidase activity	3	15
GO:0016787	hydrolase activity	2	15
GO:0140096	catalytic activity, acting on a protein	2	15
GO:0019783	ubiquitin-like protein peptidase activity	4	2
GO:0101005	deubiquitinase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.498
CLV_PCSK_SKI1_1	157	161	PF00082	0.566
DOC_CYCLIN_yCln2_LP_2	146	149	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	184	187	PF00134	0.409
DOC_PP2B_LxvP_1	146	149	PF13499	0.518
DOC_PP2B_LxvP_1	184	187	PF13499	0.390
DOC_PP4_FxxP_1	215	218	PF00568	0.525
DOC_USP7_MATH_1	15	19	PF00917	0.593
DOC_USP7_MATH_1	159	163	PF00917	0.655
DOC_USP7_MATH_1	187	191	PF00917	0.512
DOC_USP7_MATH_1	3	7	PF00917	0.717
DOC_WW_Pin1_4	86	91	PF00397	0.475
LIG_BIR_III_4	29	33	PF00653	0.338
LIG_EH_1	212	216	PF12763	0.546
LIG_eIF4E_1	179	185	PF01652	0.412
LIG_EVH1_2	90	94	PF00568	0.453
LIG_LIR_Apic_2	212	218	PF02991	0.499
LIG_MAD2	82	90	PF02301	0.415
LIG_MYND_1	182	186	PF01753	0.394
LIG_Pex14_2	94	98	PF04695	0.535
LIG_SH2_CRK	128	132	PF00017	0.472
LIG_SH2_CRK	179	183	PF00017	0.406
LIG_SH2_NCK_1	27	31	PF00017	0.420
LIG_SH2_SRC	27	30	PF00017	0.432
LIG_SH2_SRC	70	73	PF00017	0.556
LIG_SH2_STAP1	195	199	PF00017	0.582
LIG_SH2_STAP1	27	31	PF00017	0.607
LIG_SH2_STAP1	66	70	PF00017	0.541
LIG_SH2_STAT5	199	202	PF00017	0.550
LIG_SH3_3	18	24	PF00018	0.533
LIG_SH3_3	180	186	PF00018	0.393
LIG_SH3_3	80	86	PF00018	0.460
MOD_CK1_1	6	12	PF00069	0.658
MOD_CK2_1	103	109	PF00069	0.466
MOD_GlcNHglycan	105	108	PF01048	0.358
MOD_GlcNHglycan	11	14	PF01048	0.625
MOD_GlcNHglycan	165	168	PF01048	0.583
MOD_GlcNHglycan	5	8	PF01048	0.629
MOD_GlcNHglycan	76	81	PF01048	0.341
MOD_GSK3_1	11	18	PF00069	0.588
MOD_GSK3_1	155	162	PF00069	0.513
MOD_GSK3_1	187	194	PF00069	0.525
MOD_GSK3_1	3	10	PF00069	0.635
MOD_GSK3_1	46	53	PF00069	0.522
MOD_NEK2_1	1	6	PF00069	0.712
MOD_NEK2_1	11	16	PF00069	0.655
MOD_PIKK_1	100	106	PF00454	0.509
MOD_PKA_2	119	125	PF00069	0.463
MOD_Plk_4	195	201	PF00069	0.597
MOD_Plk_4	46	52	PF00069	0.503
MOD_ProDKin_1	86	92	PF00069	0.475
TRG_DiLeu_BaEn_1	109	114	PF01217	0.520
TRG_ENDOCYTIC_2	128	131	PF00928	0.479
TRG_ENDOCYTIC_2	42	45	PF00928	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVE7	Leptomonas seymouri	54%	89%
A0A0N1PCI8	Leptomonas seymouri	65%	97%
A0A1X0NHT4	Trypanosomatidae	39%	75%
A0A3S7WQX3	Leishmania donovani	60%	86%
A0A422NZN2	Trypanosoma rangeli	40%	89%
A4H5V8	Leishmania braziliensis	76%	100%
A4HU52	Leishmania infantum	99%	100%
A4HU53	Leishmania infantum	59%	100%
D0A9N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	92%
E9AMY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AMY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
Q4QHP4	Leishmania major	59%	100%
Q4QHP5	Leishmania major	92%	100%