TPR repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IAV8_LEIDO

TriTrypDb:

LdBPK_280530.1 , LdCL_280010000 , LDHU3_28.0650

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAV8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.483
CLV_C14_Caspase3-7	170	174	PF00656	0.750
CLV_MEL_PAP_1	602	608	PF00089	0.570
CLV_NRD_NRD_1	208	210	PF00675	0.469
CLV_NRD_NRD_1	348	350	PF00675	0.580
CLV_NRD_NRD_1	549	551	PF00675	0.612
CLV_NRD_NRD_1	86	88	PF00675	0.595
CLV_PCSK_FUR_1	332	336	PF00082	0.581
CLV_PCSK_KEX2_1	207	209	PF00082	0.507
CLV_PCSK_KEX2_1	224	226	PF00082	0.460
CLV_PCSK_KEX2_1	334	336	PF00082	0.569
CLV_PCSK_KEX2_1	348	350	PF00082	0.365
CLV_PCSK_KEX2_1	549	551	PF00082	0.605
CLV_PCSK_KEX2_1	85	87	PF00082	0.595
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.616
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.619
CLV_PCSK_SKI1_1	291	295	PF00082	0.441
CLV_PCSK_SKI1_1	317	321	PF00082	0.505
CLV_PCSK_SKI1_1	366	370	PF00082	0.463
CLV_PCSK_SKI1_1	414	418	PF00082	0.538
CLV_PCSK_SKI1_1	550	554	PF00082	0.521
CLV_Separin_Metazoa	554	558	PF03568	0.463
CLV_Separin_Metazoa	670	674	PF03568	0.685
DEG_APCC_DBOX_1	134	142	PF00400	0.726
DEG_COP1_1	22	30	PF00400	0.726
DEG_Nend_UBRbox_3	1	3	PF02207	0.665
DEG_SPOP_SBC_1	159	163	PF00917	0.598
DOC_CYCLIN_RxL_1	314	324	PF00134	0.514
DOC_CYCLIN_RxL_1	411	419	PF00134	0.608
DOC_CYCLIN_yCln2_LP_2	151	157	PF00134	0.733
DOC_MAPK_gen_1	332	341	PF00069	0.553
DOC_MAPK_gen_1	458	467	PF00069	0.568
DOC_MAPK_gen_1	586	594	PF00069	0.467
DOC_PP1_RVXF_1	57	64	PF00149	0.692
DOC_PP4_FxxP_1	81	84	PF00568	0.694
DOC_USP7_MATH_1	159	163	PF00917	0.782
DOC_USP7_MATH_1	178	182	PF00917	0.697
DOC_USP7_MATH_1	248	252	PF00917	0.392
DOC_USP7_MATH_1	277	281	PF00917	0.523
DOC_USP7_MATH_1	374	378	PF00917	0.552
DOC_USP7_MATH_1	428	432	PF00917	0.583
DOC_USP7_MATH_1	67	71	PF00917	0.688
DOC_USP7_UBL2_3	334	338	PF12436	0.630
DOC_WW_Pin1_4	490	495	PF00397	0.678
DOC_WW_Pin1_4	615	620	PF00397	0.684
LIG_14-3-3_CanoR_1	110	116	PF00244	0.613
LIG_14-3-3_CanoR_1	117	123	PF00244	0.585
LIG_14-3-3_CanoR_1	129	138	PF00244	0.489
LIG_14-3-3_CanoR_1	186	191	PF00244	0.616
LIG_14-3-3_CanoR_1	207	212	PF00244	0.518
LIG_14-3-3_CanoR_1	247	256	PF00244	0.500
LIG_14-3-3_CanoR_1	504	514	PF00244	0.530
LIG_14-3-3_CanoR_1	521	527	PF00244	0.474
LIG_14-3-3_CanoR_1	557	567	PF00244	0.492
LIG_14-3-3_CanoR_1	605	613	PF00244	0.565
LIG_14-3-3_CanoR_1	689	694	PF00244	0.656
LIG_APCC_ABBA_1	577	582	PF00400	0.524
LIG_BRCT_BRCA1_1	369	373	PF00533	0.569
LIG_BRCT_BRCA1_1	563	567	PF00533	0.559
LIG_FHA_1	217	223	PF00498	0.520
LIG_FHA_1	284	290	PF00498	0.496
LIG_FHA_1	367	373	PF00498	0.502
LIG_FHA_1	404	410	PF00498	0.607
LIG_FHA_1	411	417	PF00498	0.554
LIG_FHA_1	501	507	PF00498	0.537
LIG_FHA_1	574	580	PF00498	0.487
LIG_FHA_1	645	651	PF00498	0.645
LIG_FHA_1	96	102	PF00498	0.566
LIG_FHA_2	161	167	PF00498	0.792
LIG_FHA_2	168	174	PF00498	0.758
LIG_FHA_2	612	618	PF00498	0.661
LIG_FHA_2	665	671	PF00498	0.687
LIG_FHA_2	678	684	PF00498	0.683
LIG_Integrin_isoDGR_2	384	386	PF01839	0.609
LIG_LIR_Apic_2	78	84	PF02991	0.685
LIG_LIR_Gen_1	106	116	PF02991	0.536
LIG_LIR_Gen_1	128	138	PF02991	0.720
LIG_LIR_Gen_1	558	567	PF02991	0.432
LIG_LIR_Gen_1	576	584	PF02991	0.352
LIG_LIR_Gen_1	60	67	PF02991	0.702
LIG_LIR_Gen_1	94	105	PF02991	0.555
LIG_LIR_Nem_3	106	111	PF02991	0.538
LIG_LIR_Nem_3	128	134	PF02991	0.718
LIG_LIR_Nem_3	210	214	PF02991	0.545
LIG_LIR_Nem_3	377	383	PF02991	0.582
LIG_LIR_Nem_3	558	563	PF02991	0.418
LIG_LIR_Nem_3	576	580	PF02991	0.356
LIG_LIR_Nem_3	597	602	PF02991	0.469
LIG_LIR_Nem_3	60	66	PF02991	0.641
LIG_LIR_Nem_3	70	76	PF02991	0.516
LIG_LIR_Nem_3	703	709	PF02991	0.650
LIG_LIR_Nem_3	94	100	PF02991	0.574
LIG_RPA_C_Fungi	247	259	PF08784	0.545
LIG_SH2_CRK	131	135	PF00017	0.713
LIG_SH2_CRK	380	384	PF00017	0.565
LIG_SH2_CRK	560	564	PF00017	0.448
LIG_SH2_CRK	97	101	PF00017	0.536
LIG_SH2_GRB2like	233	236	PF00017	0.542
LIG_SH2_SRC	343	346	PF00017	0.594
LIG_SH2_STAP1	303	307	PF00017	0.411
LIG_SH2_STAP1	343	347	PF00017	0.625
LIG_SH2_STAP1	97	101	PF00017	0.536
LIG_SH2_STAT5	256	259	PF00017	0.474
LIG_SH2_STAT5	283	286	PF00017	0.395
LIG_SH2_STAT5	437	440	PF00017	0.426
LIG_SH2_STAT5	97	100	PF00017	0.537
LIG_SH3_3	25	31	PF00018	0.655
LIG_SH3_3	39	45	PF00018	0.489
LIG_SH3_3	668	674	PF00018	0.697
LIG_SUMO_SIM_anti_2	607	614	PF11976	0.550
LIG_TRAF2_1	10	13	PF00917	0.742
LIG_TRAF2_1	237	240	PF00917	0.547
LIG_TRAF2_1	242	245	PF00917	0.583
LIG_TRAF2_1	484	487	PF00917	0.610
LIG_TRAF2_1	528	531	PF00917	0.606
LIG_TRAF2_1	697	700	PF00917	0.685
LIG_WRC_WIRS_1	678	683	PF05994	0.713
MOD_CK1_1	133	139	PF00069	0.694
MOD_CK1_1	189	195	PF00069	0.661
MOD_CK1_1	250	256	PF00069	0.424
MOD_CK1_1	431	437	PF00069	0.484
MOD_CK1_1	441	447	PF00069	0.451
MOD_CK1_1	480	486	PF00069	0.638
MOD_CK1_1	561	567	PF00069	0.555
MOD_CK1_1	569	575	PF00069	0.441
MOD_CK1_1	659	665	PF00069	0.649
MOD_CK2_1	136	142	PF00069	0.754
MOD_CK2_1	160	166	PF00069	0.736
MOD_CK2_1	480	486	PF00069	0.594
MOD_CK2_1	650	656	PF00069	0.557
MOD_CK2_1	664	670	PF00069	0.630
MOD_CK2_1	677	683	PF00069	0.707
MOD_CK2_1	68	74	PF00069	0.704
MOD_Cter_Amidation	222	225	PF01082	0.616
MOD_GlcNHglycan	135	138	PF01048	0.731
MOD_GlcNHglycan	201	204	PF01048	0.611
MOD_GlcNHglycan	312	315	PF01048	0.589
MOD_GlcNHglycan	376	379	PF01048	0.554
MOD_GlcNHglycan	433	436	PF01048	0.550
MOD_GlcNHglycan	479	482	PF01048	0.560
MOD_GlcNHglycan	683	686	PF01048	0.572
MOD_GSK3_1	125	132	PF00069	0.721
MOD_GSK3_1	517	524	PF00069	0.430
MOD_GSK3_1	555	562	PF00069	0.500
MOD_GSK3_1	565	572	PF00069	0.490
MOD_GSK3_1	611	618	PF00069	0.617
MOD_GSK3_1	656	663	PF00069	0.593
MOD_GSK3_1	677	684	PF00069	0.666
MOD_GSK3_1	91	98	PF00069	0.650
MOD_N-GLC_1	167	172	PF02516	0.767
MOD_N-GLC_1	431	436	PF02516	0.486
MOD_N-GLC_1	664	669	PF02516	0.677
MOD_N-GLC_2	664	666	PF02516	0.653
MOD_NEK2_1	302	307	PF00069	0.498
MOD_NEK2_1	33	38	PF00069	0.710
MOD_NEK2_1	416	421	PF00069	0.554
MOD_NEK2_1	475	480	PF00069	0.510
MOD_NEK2_1	522	527	PF00069	0.590
MOD_NEK2_1	555	560	PF00069	0.472
MOD_NEK2_1	660	665	PF00069	0.558
MOD_NEK2_1	677	682	PF00069	0.726
MOD_NEK2_2	130	135	PF00069	0.717
MOD_NEK2_2	343	348	PF00069	0.547
MOD_NEK2_2	438	443	PF00069	0.419
MOD_PIKK_1	453	459	PF00454	0.508
MOD_PK_1	588	594	PF00069	0.508
MOD_PKA_1	207	213	PF00069	0.564
MOD_PKA_1	216	222	PF00069	0.558
MOD_PKA_2	207	213	PF00069	0.564
MOD_PKA_2	248	254	PF00069	0.533
MOD_PKA_2	277	283	PF00069	0.510
MOD_PKA_2	604	610	PF00069	0.529
MOD_PKA_2	91	97	PF00069	0.622
MOD_Plk_1	167	173	PF00069	0.720
MOD_Plk_1	343	349	PF00069	0.540
MOD_Plk_1	431	437	PF00069	0.575
MOD_Plk_1	625	631	PF00069	0.557
MOD_Plk_1	68	74	PF00069	0.713
MOD_Plk_1	95	101	PF00069	0.541
MOD_Plk_2-3	573	579	PF00069	0.473
MOD_Plk_4	111	117	PF00069	0.554
MOD_Plk_4	522	528	PF00069	0.568
MOD_Plk_4	588	594	PF00069	0.495
MOD_Plk_4	656	662	PF00069	0.602
MOD_Plk_4	95	101	PF00069	0.541
MOD_ProDKin_1	490	496	PF00069	0.670
MOD_ProDKin_1	615	621	PF00069	0.682
MOD_SUMO_for_1	697	700	PF00179	0.658
MOD_SUMO_rev_2	121	125	PF00179	0.620
TRG_DiLeu_BaEn_1	12	17	PF01217	0.676
TRG_DiLeu_BaEn_1	551	556	PF01217	0.517
TRG_DiLeu_BaEn_1	656	661	PF01217	0.594
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.523
TRG_ENDOCYTIC_2	131	134	PF00928	0.711
TRG_ENDOCYTIC_2	336	339	PF00928	0.561
TRG_ENDOCYTIC_2	380	383	PF00928	0.548
TRG_ENDOCYTIC_2	536	539	PF00928	0.490
TRG_ENDOCYTIC_2	560	563	PF00928	0.387
TRG_ENDOCYTIC_2	97	100	PF00928	0.537
TRG_ER_diArg_1	207	209	PF00400	0.516
TRG_ER_diArg_1	347	349	PF00400	0.612
TRG_ER_diArg_1	458	461	PF00400	0.499
TRG_ER_diArg_1	688	691	PF00400	0.628
TRG_ER_diArg_1	84	87	PF00400	0.712
TRG_NLS_MonoExtC_3	333	338	PF00514	0.651
TRG_NLS_MonoExtN_4	332	338	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I228	Leptomonas seymouri	70%	100%
A0A0S4JB35	Bodo saltans	29%	96%
A0A1X0NZW8	Trypanosomatidae	30%	92%
A0A3R7KXE4	Trypanosoma rangeli	32%	100%
A4HG90	Leishmania braziliensis	87%	100%
A4I3C4	Leishmania infantum	99%	100%
D0A822	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	97%
E9AZL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q8M0	Leishmania major	96%	100%
V5DH70	Trypanosoma cruzi	32%	95%