LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IAV0_LEIDO
TriTrypDb:
LdBPK_280450.1 , LdCL_280008000 , LDHU3_28.0400
Length:
317

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A0A3Q8IAV0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAV0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 133 135 PF00675 0.579
CLV_NRD_NRD_1 59 61 PF00675 0.511
CLV_PCSK_FUR_1 57 61 PF00082 0.524
CLV_PCSK_KEX2_1 133 135 PF00082 0.578
CLV_PCSK_KEX2_1 57 59 PF00082 0.521
CLV_PCSK_SKI1_1 108 112 PF00082 0.585
CLV_PCSK_SKI1_1 253 257 PF00082 0.258
CLV_PCSK_SKI1_1 28 32 PF00082 0.469
CLV_PCSK_SKI1_1 41 45 PF00082 0.397
DOC_CKS1_1 122 127 PF01111 0.406
DOC_CYCLIN_yCln2_LP_2 290 296 PF00134 0.356
DOC_MAPK_gen_1 251 258 PF00069 0.498
DOC_MAPK_MEF2A_6 145 152 PF00069 0.348
DOC_MAPK_MEF2A_6 227 235 PF00069 0.321
DOC_PP1_RVXF_1 50 57 PF00149 0.634
DOC_PP2B_LxvP_1 150 153 PF13499 0.427
DOC_PP2B_LxvP_1 256 259 PF13499 0.321
DOC_USP7_MATH_1 284 288 PF00917 0.436
DOC_USP7_UBL2_3 313 317 PF12436 0.663
DOC_WW_Pin1_4 121 126 PF00397 0.405
DOC_WW_Pin1_4 202 207 PF00397 0.369
DOC_WW_Pin1_4 236 241 PF00397 0.472
DOC_WW_Pin1_4 69 74 PF00397 0.734
LIG_14-3-3_CanoR_1 85 94 PF00244 0.505
LIG_BRCT_BRCA1_1 195 199 PF00533 0.358
LIG_deltaCOP1_diTrp_1 243 252 PF00928 0.592
LIG_deltaCOP1_diTrp_1 84 92 PF00928 0.665
LIG_FHA_1 159 165 PF00498 0.376
LIG_FHA_1 24 30 PF00498 0.619
LIG_FHA_1 309 315 PF00498 0.741
LIG_FHA_2 70 76 PF00498 0.737
LIG_LIR_Gen_1 269 280 PF02991 0.530
LIG_LIR_Nem_3 269 275 PF02991 0.591
LIG_LIR_Nem_3 88 93 PF02991 0.495
LIG_LYPXL_S_1 92 96 PF13949 0.420
LIG_LYPXL_yS_3 93 96 PF13949 0.420
LIG_Pex14_1 246 250 PF04695 0.564
LIG_SH2_NCK_1 272 276 PF00017 0.435
LIG_SH2_SRC 272 275 PF00017 0.440
LIG_SH2_STAP1 160 164 PF00017 0.420
LIG_SH2_STAP1 207 211 PF00017 0.332
LIG_SH2_STAP1 25 29 PF00017 0.599
LIG_SH2_STAT5 101 104 PF00017 0.365
LIG_SH2_STAT5 160 163 PF00017 0.427
LIG_SH2_STAT5 166 169 PF00017 0.579
LIG_SH2_STAT5 25 28 PF00017 0.601
LIG_SH3_3 119 125 PF00018 0.395
LIG_SH3_3 143 149 PF00018 0.348
LIG_SH3_3 225 231 PF00018 0.427
LIG_SUMO_SIM_anti_2 11 22 PF11976 0.644
LIG_SUMO_SIM_par_1 160 165 PF11976 0.382
LIG_TYR_ITIM 99 104 PF00017 0.439
MOD_CK1_1 184 190 PF00069 0.345
MOD_CK1_1 205 211 PF00069 0.338
MOD_Cter_Amidation 131 134 PF01082 0.596
MOD_GlcNHglycan 35 38 PF01048 0.512
MOD_GSK3_1 14 21 PF00069 0.699
MOD_GSK3_1 158 165 PF00069 0.338
MOD_GSK3_1 29 36 PF00069 0.618
MOD_NEK2_1 113 118 PF00069 0.394
MOD_NEK2_1 162 167 PF00069 0.376
MOD_NEK2_1 192 197 PF00069 0.495
MOD_NEK2_1 267 272 PF00069 0.427
MOD_NEK2_1 77 82 PF00069 0.728
MOD_PIKK_1 190 196 PF00454 0.427
MOD_PIKK_1 23 29 PF00454 0.683
MOD_PIKK_1 274 280 PF00454 0.475
MOD_PKA_2 6 12 PF00069 0.729
MOD_Plk_1 12 18 PF00069 0.724
MOD_Plk_1 50 56 PF00069 0.715
MOD_Plk_4 138 144 PF00069 0.359
MOD_Plk_4 14 20 PF00069 0.692
MOD_Plk_4 181 187 PF00069 0.269
MOD_Plk_4 193 199 PF00069 0.468
MOD_Plk_4 221 227 PF00069 0.401
MOD_Plk_4 267 273 PF00069 0.427
MOD_Plk_4 284 290 PF00069 0.330
MOD_ProDKin_1 121 127 PF00069 0.403
MOD_ProDKin_1 202 208 PF00069 0.368
MOD_ProDKin_1 236 242 PF00069 0.471
MOD_ProDKin_1 69 75 PF00069 0.734
MOD_SUMO_for_1 309 312 PF00179 0.555
TRG_DiLeu_BaLyEn_6 228 233 PF01217 0.346
TRG_ENDOCYTIC_2 101 104 PF00928 0.427
TRG_ENDOCYTIC_2 272 275 PF00928 0.479
TRG_ENDOCYTIC_2 93 96 PF00928 0.427
TRG_ER_diArg_1 133 135 PF00400 0.381
TRG_ER_diArg_1 5 8 PF00400 0.692
TRG_ER_diArg_1 56 59 PF00400 0.719
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.531

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P732 Leptomonas seymouri 59% 92%
A0A1X0NVF3 Trypanosomatidae 34% 100%
A0A3R7KTP8 Trypanosoma rangeli 38% 100%
A4HG72 Leishmania braziliensis 84% 100%
A4I3B5 Leishmania infantum 100% 100%
D0A7T4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AZJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q8N9 Leishmania major 94% 100%
V5DAH6 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS