Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAU8_LEIDO

TriTrypDb:

LdBPK_171370.1 , LdCL_170019900 , LDHU3_17.1890

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAU8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0051536	iron-sulfur cluster binding	3	7
GO:0051540	metal cluster binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.464
CLV_C14_Caspase3-7	221	225	PF00656	0.456
CLV_NRD_NRD_1	301	303	PF00675	0.564
CLV_NRD_NRD_1	49	51	PF00675	0.767
CLV_NRD_NRD_1	81	83	PF00675	0.578
CLV_NRD_NRD_1	93	95	PF00675	0.596
CLV_PCSK_FUR_1	258	262	PF00082	0.684
CLV_PCSK_KEX2_1	260	262	PF00082	0.677
CLV_PCSK_KEX2_1	28	30	PF00082	0.651
CLV_PCSK_KEX2_1	301	303	PF00082	0.564
CLV_PCSK_KEX2_1	49	51	PF00082	0.720
CLV_PCSK_KEX2_1	81	83	PF00082	0.580
CLV_PCSK_KEX2_1	93	95	PF00082	0.605
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.677
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.651
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DOC_CDC14_PxL_1	31	39	PF14671	0.725
DOC_CYCLIN_yCln2_LP_2	185	188	PF00134	0.480
DOC_MAPK_gen_1	111	119	PF00069	0.465
DOC_MAPK_MEF2A_6	111	119	PF00069	0.462
DOC_MAPK_MEF2A_6	130	139	PF00069	0.479
DOC_MAPK_MEF2A_6	200	209	PF00069	0.603
DOC_PP1_RVXF_1	272	278	PF00149	0.622
DOC_PP2B_LxvP_1	185	188	PF13499	0.461
DOC_PP2B_LxvP_1	2	5	PF13499	0.597
DOC_USP7_MATH_1	162	166	PF00917	0.575
DOC_USP7_MATH_1	87	91	PF00917	0.576
LIG_14-3-3_CanoR_1	200	207	PF00244	0.536
LIG_14-3-3_CanoR_1	212	219	PF00244	0.306
LIG_14-3-3_CanoR_1	52	61	PF00244	0.596
LIG_14-3-3_CanoR_1	93	101	PF00244	0.617
LIG_Actin_WH2_2	223	241	PF00022	0.483
LIG_CaM_IQ_9	44	60	PF13499	0.593
LIG_DCNL_PONY_1	1	4	PF03556	0.608
LIG_FHA_1	110	116	PF00498	0.558
LIG_FHA_1	218	224	PF00498	0.418
LIG_FHA_1	233	239	PF00498	0.563
LIG_FHA_2	139	145	PF00498	0.448
LIG_FHA_2	271	277	PF00498	0.552
LIG_FHA_2	306	312	PF00498	0.581
LIG_LIR_Apic_2	131	135	PF02991	0.481
LIG_LIR_Gen_1	192	201	PF02991	0.501
LIG_LIR_Gen_1	280	289	PF02991	0.544
LIG_LIR_Gen_1	295	304	PF02991	0.504
LIG_LIR_Nem_3	192	196	PF02991	0.442
LIG_LIR_Nem_3	243	248	PF02991	0.576
LIG_LIR_Nem_3	263	268	PF02991	0.386
LIG_LIR_Nem_3	280	284	PF02991	0.501
LIG_LIR_Nem_3	287	292	PF02991	0.486
LIG_LIR_Nem_3	295	300	PF02991	0.491
LIG_LIR_Nem_3	311	316	PF02991	0.415
LIG_Pex14_1	285	289	PF04695	0.516
LIG_Pex14_2	209	213	PF04695	0.549
LIG_Pex14_2	277	281	PF04695	0.587
LIG_SH2_CRK	193	197	PF00017	0.455
LIG_SH2_CRK	31	35	PF00017	0.585
LIG_SH2_GRB2like	297	300	PF00017	0.651
LIG_SH2_NCK_1	38	42	PF00017	0.587
LIG_SH2_SRC	289	292	PF00017	0.515
LIG_SH2_STAT5	193	196	PF00017	0.434
LIG_SH3_1	261	267	PF00018	0.579
LIG_SH3_3	261	267	PF00018	0.563
LIG_SH3_3	272	278	PF00018	0.533
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.364
LIG_SUMO_SIM_par_1	112	118	PF11976	0.398
LIG_TYR_ITSM	285	292	PF00017	0.620
LIG_ULM_U2AF65_1	49	54	PF00076	0.723
MOD_CK2_1	305	311	PF00069	0.608
MOD_Cter_Amidation	79	82	PF01082	0.615
MOD_GlcNHglycan	144	148	PF01048	0.476
MOD_GlcNHglycan	24	27	PF01048	0.600
MOD_GlcNHglycan	82	85	PF01048	0.711
MOD_GSK3_1	105	112	PF00069	0.594
MOD_NEK2_1	22	27	PF00069	0.675
MOD_NEK2_1	238	243	PF00069	0.564
MOD_NEK2_1	284	289	PF00069	0.614
MOD_NEK2_1	44	49	PF00069	0.577
MOD_PIKK_1	44	50	PF00454	0.588
MOD_PIKK_1	93	99	PF00454	0.590
MOD_PK_1	113	119	PF00069	0.381
MOD_PKA_1	93	99	PF00069	0.624
MOD_PKA_2	199	205	PF00069	0.541
MOD_PKA_2	211	217	PF00069	0.309
MOD_PKA_2	238	244	PF00069	0.577
MOD_PKA_2	51	57	PF00069	0.748
MOD_PKA_2	80	86	PF00069	0.577
MOD_PKA_2	93	99	PF00069	0.529
MOD_Plk_1	135	141	PF00069	0.453
MOD_Plk_1	191	197	PF00069	0.450
MOD_Plk_1	205	211	PF00069	0.465
MOD_Plk_1	87	93	PF00069	0.580
MOD_Plk_2-3	178	184	PF00069	0.475
MOD_Plk_4	138	144	PF00069	0.435
MOD_Plk_4	17	23	PF00069	0.606
MOD_SUMO_rev_2	107	112	PF00179	0.564
MOD_SUMO_rev_2	96	105	PF00179	0.633
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.444
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.502
TRG_ENDOCYTIC_2	193	196	PF00928	0.434
TRG_ENDOCYTIC_2	289	292	PF00928	0.495
TRG_ENDOCYTIC_2	297	300	PF00928	0.539
TRG_ENDOCYTIC_2	31	34	PF00928	0.583
TRG_ENDOCYTIC_2	38	41	PF00928	0.549
TRG_ER_diArg_1	300	302	PF00400	0.585
TRG_ER_diArg_1	49	52	PF00400	0.728
TRG_ER_diArg_1	93	95	PF00400	0.663
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDS7	Leptomonas seymouri	85%	100%
A0A0S4JAC0	Bodo saltans	67%	100%
A0A1X0NSZ4	Trypanosomatidae	82%	100%
A4H986	Leishmania braziliensis	92%	100%
A4HXK4	Leishmania infantum	100%	100%
C9ZP94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	98%
E9AR99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QE64	Leishmania major	97%	100%
V5BET1	Trypanosoma cruzi	84%	100%