Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAU7_LEIDO

TriTrypDb:

LdBPK_230030.1 , LdCL_230005200 , LDHU3_23.0050

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IAU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.528
CLV_NRD_NRD_1	204	206	PF00675	0.547
CLV_NRD_NRD_1	260	262	PF00675	0.437
CLV_PCSK_KEX2_1	260	262	PF00082	0.410
DOC_CKS1_1	10	15	PF01111	0.392
DOC_MAPK_gen_1	102	111	PF00069	0.579
DOC_PP1_RVXF_1	3	9	PF00149	0.669
DOC_PP4_FxxP_1	10	13	PF00568	0.492
DOC_PP4_FxxP_1	93	96	PF00568	0.525
DOC_USP7_MATH_1	136	140	PF00917	0.507
DOC_USP7_MATH_1	166	170	PF00917	0.511
DOC_USP7_MATH_1	249	253	PF00917	0.493
DOC_WW_Pin1_4	9	14	PF00397	0.420
DOC_WW_Pin1_4	91	96	PF00397	0.566
LIG_14-3-3_CanoR_1	191	199	PF00244	0.523
LIG_14-3-3_CanoR_1	71	76	PF00244	0.487
LIG_Actin_WH2_2	29	47	PF00022	0.575
LIG_AP2alpha_2	212	214	PF02296	0.461
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_BRCT_BRCA1_1	58	62	PF00533	0.520
LIG_FHA_1	27	33	PF00498	0.660
LIG_FHA_1	275	281	PF00498	0.491
LIG_FHA_1	285	291	PF00498	0.424
LIG_FHA_2	266	272	PF00498	0.496
LIG_LIR_Apic_2	7	13	PF02991	0.425
LIG_LIR_Gen_1	138	147	PF02991	0.497
LIG_LIR_Gen_1	7	16	PF02991	0.530
LIG_LIR_Nem_3	138	143	PF02991	0.463
LIG_LIR_Nem_3	7	11	PF02991	0.488
LIG_NRBOX	178	184	PF00104	0.439
LIG_PDZ_Class_2	287	292	PF00595	0.364
LIG_SH2_STAT5	192	195	PF00017	0.301
LIG_SH3_3	108	114	PF00018	0.384
LIG_SH3_3	160	166	PF00018	0.485
LIG_SH3_3	93	99	PF00018	0.480
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.393
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.397
LIG_SUMO_SIM_par_1	234	239	PF11976	0.470
LIG_SUMO_SIM_par_1	26	35	PF11976	0.644
LIG_TYR_ITIM	225	230	PF00017	0.362
MOD_CDK_SPK_2	9	14	PF00069	0.443
MOD_CK2_1	83	89	PF00069	0.529
MOD_GlcNHglycan	238	241	PF01048	0.503
MOD_GlcNHglycan	36	39	PF01048	0.633
MOD_GlcNHglycan	85	88	PF01048	0.615
MOD_GSK3_1	26	33	PF00069	0.560
MOD_GSK3_1	67	74	PF00069	0.472
MOD_N-GLC_2	17	19	PF02516	0.542
MOD_NEK2_1	284	289	PF00069	0.466
MOD_NEK2_1	62	67	PF00069	0.475
MOD_NEK2_1	83	88	PF00069	0.604
MOD_OFUCOSY	189	196	PF10250	0.421
MOD_PIKK_1	218	224	PF00454	0.454
MOD_PIKK_1	284	290	PF00454	0.467
MOD_PK_1	71	77	PF00069	0.538
MOD_PKA_2	204	210	PF00069	0.454
MOD_PKA_2	249	255	PF00069	0.481
MOD_Plk_1	25	31	PF00069	0.702
MOD_Plk_2-3	26	32	PF00069	0.636
MOD_Plk_2-3	265	271	PF00069	0.509
MOD_Plk_4	136	142	PF00069	0.565
MOD_Plk_4	204	210	PF00069	0.474
MOD_Plk_4	249	255	PF00069	0.566
MOD_Plk_4	265	271	PF00069	0.450
MOD_ProDKin_1	9	15	PF00069	0.419
MOD_ProDKin_1	91	97	PF00069	0.580
MOD_SUMO_rev_2	265	275	PF00179	0.496
TRG_ENDOCYTIC_2	227	230	PF00928	0.365
TRG_ER_diArg_1	259	261	PF00400	0.441
TRG_NES_CRM1_1	173	188	PF08389	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJU6	Leptomonas seymouri	36%	100%
A0A1X0NX74	Trypanosomatidae	31%	97%
A0A3R7KT29	Trypanosoma rangeli	25%	93%
A4HCL5	Leishmania braziliensis	74%	100%
A4I039	Leishmania infantum	99%	100%
C9ZUX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	96%
E9AW02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QBH4	Leishmania major	91%	100%
V5B6S5	Trypanosoma cruzi	29%	92%