PUA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IAU3_LEIDO

TriTrypDb:

LdBPK_210790.1 , LdCL_210012800 , LDHU3_21.0890

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IAU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IAU3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008914	leucyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016755	aminoacyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.471
CLV_NRD_NRD_1	153	155	PF00675	0.581
CLV_NRD_NRD_1	174	176	PF00675	0.411
CLV_NRD_NRD_1	187	189	PF00675	0.436
CLV_NRD_NRD_1	307	309	PF00675	0.465
CLV_NRD_NRD_1	318	320	PF00675	0.430
CLV_NRD_NRD_1	371	373	PF00675	0.570
CLV_NRD_NRD_1	377	379	PF00675	0.571
CLV_PCSK_KEX2_1	187	189	PF00082	0.496
CLV_PCSK_KEX2_1	318	320	PF00082	0.478
CLV_PCSK_KEX2_1	362	364	PF00082	0.621
CLV_PCSK_KEX2_1	376	378	PF00082	0.534
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.630
CLV_PCSK_PC7_1	372	378	PF00082	0.493
CLV_PCSK_SKI1_1	154	158	PF00082	0.486
CLV_PCSK_SKI1_1	212	216	PF00082	0.496
CLV_PCSK_SKI1_1	362	366	PF00082	0.636
CLV_PCSK_SKI1_1	93	97	PF00082	0.346
DEG_APCC_DBOX_1	199	207	PF00400	0.394
DOC_CDC14_PxL_1	107	115	PF14671	0.385
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.431
DOC_MAPK_gen_1	175	182	PF00069	0.463
DOC_MAPK_gen_1	223	232	PF00069	0.509
DOC_MAPK_gen_1	296	306	PF00069	0.476
DOC_MAPK_gen_1	372	381	PF00069	0.512
DOC_MAPK_gen_1	69	78	PF00069	0.570
DOC_MAPK_MEF2A_6	93	102	PF00069	0.417
DOC_PP2B_LxvP_1	108	111	PF13499	0.439
DOC_PP2B_LxvP_1	195	198	PF13499	0.473
DOC_PP4_FxxP_1	207	210	PF00568	0.444
DOC_PP4_FxxP_1	53	56	PF00568	0.470
DOC_USP7_MATH_1	160	164	PF00917	0.553
DOC_USP7_MATH_1	317	321	PF00917	0.429
DOC_USP7_MATH_1	56	60	PF00917	0.505
DOC_USP7_UBL2_3	212	216	PF12436	0.488
DOC_USP7_UBL2_3	309	313	PF12436	0.386
DOC_USP7_UBL2_3	357	361	PF12436	0.633
DOC_USP7_UBL2_3	362	366	PF12436	0.590
DOC_WW_Pin1_4	233	238	PF00397	0.598
DOC_WW_Pin1_4	76	81	PF00397	0.394
LIG_14-3-3_CanoR_1	129	133	PF00244	0.413
LIG_14-3-3_CanoR_1	296	302	PF00244	0.523
LIG_BRCT_BRCA1_1	105	109	PF00533	0.241
LIG_BRCT_BRCA1_1	78	82	PF00533	0.366
LIG_CaM_IQ_9	3	19	PF13499	0.512
LIG_FHA_1	213	219	PF00498	0.355
LIG_FHA_2	63	69	PF00498	0.471
LIG_LIR_Apic_2	51	56	PF02991	0.482
LIG_LIR_Gen_1	168	173	PF02991	0.394
LIG_LIR_Nem_3	168	172	PF02991	0.390
LIG_LIR_Nem_3	181	186	PF02991	0.358
LIG_LIR_Nem_3	75	81	PF02991	0.409
LIG_PDZ_Class_2	376	381	PF00595	0.531
LIG_Pex14_2	78	82	PF04695	0.382
LIG_SH2_CRK	227	231	PF00017	0.477
LIG_SH2_GRB2like	227	230	PF00017	0.514
LIG_SH2_NCK_1	227	231	PF00017	0.477
LIG_SH2_NCK_1	257	261	PF00017	0.383
LIG_SH2_STAP1	213	217	PF00017	0.440
LIG_SH2_STAT5	251	254	PF00017	0.362
LIG_SH2_STAT5	264	267	PF00017	0.318
LIG_SH2_STAT5	329	332	PF00017	0.492
LIG_SH2_STAT5	5	8	PF00017	0.477
LIG_SH3_3	301	307	PF00018	0.404
LIG_SUMO_SIM_par_1	177	184	PF11976	0.508
LIG_UBA3_1	326	335	PF00899	0.565
LIG_WRC_WIRS_1	50	55	PF05994	0.513
MOD_CK1_1	233	239	PF00069	0.566
MOD_CK2_1	62	68	PF00069	0.444
MOD_GlcNHglycan	232	235	PF01048	0.525
MOD_GlcNHglycan	258	261	PF01048	0.366
MOD_GlcNHglycan	266	269	PF01048	0.349
MOD_GlcNHglycan	282	285	PF01048	0.382
MOD_GlcNHglycan	315	318	PF01048	0.520
MOD_GSK3_1	150	157	PF00069	0.493
MOD_GSK3_1	161	168	PF00069	0.398
MOD_GSK3_1	208	215	PF00069	0.523
MOD_GSK3_1	264	271	PF00069	0.379
MOD_GSK3_1	313	320	PF00069	0.468
MOD_N-GLC_1	160	165	PF02516	0.518
MOD_NEK2_1	1	6	PF00069	0.496
MOD_NEK2_1	150	155	PF00069	0.453
MOD_NEK2_1	272	277	PF00069	0.419
MOD_PIKK_1	355	361	PF00454	0.685
MOD_PKA_1	154	160	PF00069	0.543
MOD_PKA_2	128	134	PF00069	0.519
MOD_PKA_2	317	323	PF00069	0.533
MOD_PKA_2	7	13	PF00069	0.479
MOD_PKB_1	223	231	PF00069	0.493
MOD_Plk_1	103	109	PF00069	0.260
MOD_Plk_2-3	62	68	PF00069	0.498
MOD_Plk_4	1	7	PF00069	0.555
MOD_Plk_4	103	109	PF00069	0.400
MOD_Plk_4	49	55	PF00069	0.524
MOD_Plk_4	82	88	PF00069	0.461
MOD_ProDKin_1	233	239	PF00069	0.584
MOD_ProDKin_1	76	82	PF00069	0.390
MOD_SUMO_for_1	364	367	PF00179	0.623
TRG_DiLeu_BaEn_1	248	253	PF01217	0.400
TRG_ENDOCYTIC_2	227	230	PF00928	0.538
TRG_ER_diArg_1	186	188	PF00400	0.493
TRG_ER_diArg_1	222	225	PF00400	0.360
TRG_ER_diArg_1	376	378	PF00400	0.563
TRG_NLS_Bipartite_1	298	312	PF00514	0.434
TRG_NLS_MonoExtC_3	360	365	PF00514	0.639
TRG_NLS_MonoExtN_4	307	312	PF00514	0.470
TRG_NLS_MonoExtN_4	361	366	PF00514	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U9	Leptomonas seymouri	57%	77%
A0A0S4JCB2	Bodo saltans	43%	99%
A0A1X0NY04	Trypanosomatidae	45%	100%
A0A3R7KMU3	Trypanosoma rangeli	48%	100%
A4HBR8	Leishmania braziliensis	83%	100%
A4HZ72	Leishmania infantum	99%	100%
D0A1G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AV39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCE2	Leishmania major	93%	100%
V5BIF1	Trypanosoma cruzi	46%	100%